Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents

A novel series of substituted 4,6-dimethyl-2-oxo-1-(thiazol-2-ylamino)-1,2-dihydropyridine-3-carbonitrile derivatives 6 , 9 , 13 , 15 , and 17 was synthesized in a good to excellent yield from the reaction of 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2 H )-yl)thiourea with 2-oxo- N '-arylpropanehy...

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Vydané v:	Scientific reports Ročník 11; číslo 1; s. 7846 - 10
Hlavní autori:	Khidre, Rizk E., Radini, Ibrahim Ali M.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 12.04.2021 Nature Publishing Group Nature Portfolio
Predmet:	631/154 631/92 639/638 Antifungal activity Antifungal agents Antimicrobial agents Dihydropyridine DNA topoisomerase Humanities and Social Sciences Minimum inhibitory concentration multidisciplinary Pyridines Science Science (multidisciplinary) Thiazoles
ISSN:	2045-2322, 2045-2322
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