Interactive effects of AM251 and baclofen on synaptic plasticity in the rat dentate gyrus

Long-term potentiation (LTP), a form of synaptic plasticity, is considered to be a critical cellular mechanism that underlies learning and memory. Cannabinoid CB1 and metabotropic GABAB receptors display similar pharmacological effects and co-localize in certain brain regions. In this study, we exam...

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Bibliographic Details
Published in:	Brain research Vol. 1651; pp. 53 - 60
Main Authors:	Nazari, Masoumeh, Komaki, Alireza, Salehi, Iraj, Sarihi, Abdolrahman, Shahidi, Siamak, Komaki, Hamidreza, Ganji, Ahmad
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15.11.2016
Subjects:	AM251 Anesthetics, Intravenous - pharmacology Animals Baclofen Baclofen - pharmacology Cannabinoid Cannabinoid Receptor Antagonists - pharmacology Dentate Gyrus - drug effects Dentate Gyrus - physiology Drug Interactions Electric Stimulation Evoked Potentials - drug effects Evoked Potentials - physiology GABA-B Receptor Agonists - pharmacology GABAB GABAergic Long-term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Microelectrodes Neurology Piperidines - pharmacology Pyrazoles - pharmacology Random Allocation Rats, Wistar Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - metabolism Receptors, GABA-B - metabolism Synaptic Potentials - drug effects Synaptic Potentials - physiology Urethane - pharmacology GABAergic Cannabinoid AM251 Long-term potentiation GABAB Baclofen GABA B GABA(B)
ISSN:	0006-8993, 1872-6240, 1872-6240
Online Access:	Get full text
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