Personal exposure to air pollutants and immune system biomarkers in pregnant women

The immune function is suspected to play an important role in the health effects of air pollution but it remains poorly investigated in pregnant women. One-week personal measurements of exposure to nitrogen dioxide (NO 2 ), particulate matter with an aerodynamic diameter of ≤ 2.5 µm mass concentrati...

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Bibliographic Details
Published in:Scientific reports Vol. 15; no. 1; pp. 17672 - 12
Main Authors: Marsal, Anouk, Frau, Laurene, Chaperot, Laurence, Amine, Ines, Lyon-Caen, Sarah, Boudier, Anne, Jaffrezo, Jean-Luc, Elazzouzi, Rhabira, Philippat, Claire, Supernant, Karine, Lepeule, Johanna, Quentin, Joane, Chartier, Ryan, Bayat, Sam, Slama, Remy, Uzu, Gaelle, Siroux, Valérie
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 21.05.2025
Nature Publishing Group
Nature Portfolio
Subjects:
692/308/174
692/499
Adaptive immunology
Adult
Air Pollutants - adverse effects
Air Pollutants - analysis
Air pollution
Air Pollution - adverse effects
Air pollution effects
Ascorbic acid
Biomarkers - blood
Cell activation
Chemokines
Cytokines
Cytokines - blood
Dendritic cells
Dithiothreitol
Ecology, environment
Environmental Exposure - adverse effects
Exposure
Female
Gynecology and obstetrics
Health
Human health and pathology
Humanities and Social Sciences
Humans
Immune response
Immune system
Immune System - drug effects
Immune System - metabolism
Immunology
Innate immunity
Interleukin 10
Life Sciences
Lymphocytes T
Maternal Exposure
multidisciplinary
Nitrogen dioxide
Nitrogen Dioxide - adverse effects
Oxidative potential
Particulate matter
Particulate Matter - adverse effects
Particulate Matter - analysis
Pollutants
Pregnancy
Regression analysis
Santé publique et épidémiologie
Science
Science (multidisciplinary)
Tumor necrosis factor-TNF
Pregnancy
Cytokines
Oxidative potential
Nitrogen dioxide
Particulate matter
Immune system
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:The immune function is suspected to play an important role in the health effects of air pollution but it remains poorly investigated in pregnant women. One-week personal measurements of exposure to nitrogen dioxide (NO 2 ), particulate matter with an aerodynamic diameter of ≤ 2.5 µm mass concentration (PM 2.5 ) and PM 2.5 oxidative potential (OP) were assessed in 270 pregnant women from the French cohort SEPAGES. PM filters were analyzed for PM 2.5 OP using the dithiothreitol (DTT) and the ascorbic acid (AA) assays. From a blood sample withdrawn at the end of the exposure measurement week, levels of 29 cytokines and chemokines were measured at baseline and after T cell and dendritic cell activation with phytohemagglutinin (PHA) and resiquimod (R848), respectively. Associations between each air pollutant and each cytokine were assessed using adjusted linear regression models. An increase in NO 2 exposure was associated with higher interleukin 10 (IL-10) and lower PHA-activated tumor necrosis factor (TNF). No association with PM 2.5 concentration was observed, but increased exposure to PM OP AA was associated with lower baseline and R848-activated IL-8 and increased exposure to PM OP DTT was associated with higher PHA-activated IL-17A. Our study provides insights into the relationships between air pollution exposure and immune function among pregnant women.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-025-98712-7