Effect of sleep deprivation on fractal and oscillatory spectral measures of the sleep EEG: A window on basic regulatory processes

•The reliable measurement of sleep regulatory processes is indisputable.•Sleep deprivation is an important method challenging the homeostatic process.•NREM sleep EEG spectral slope is a new, standardisable measure of sleep homeostasis.•Spindle frequency reflects putative circadian modulation under b...

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Vydané v:NeuroImage (Orlando, Fla.) Ročník 314; s. 121260
Hlavní autori: G․ Horváth, Csenge, Bódizs, Róbert
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Inc 01.07.2025
Elsevier Limited
Elsevier
Predmet:
Activity patterns
Adult
Aperiodic activity
Brain research
Circadian rhythm
Circadian rhythms
EEG
Electroencephalography
Electroencephalography - methods
Female
Fractals
Homeostasis
Humans
Male
NREM phase
NREM sleep
Oscillations
Radiology/Diagnostic Imaging
Regulation
Sleep - physiology
Sleep and wakefulness
Sleep deprivation
Sleep Deprivation - physiopathology
sleep EEG
Sleep spindles
Sleep Stages - physiology
Wakefulness - physiology
Young Adult
Young adults
NREM phase
Aperiodic activity
Homeostasis
Circadian rhythm
Sleep spindles
sleep EEG
Sleep deprivation
ISSN:1053-8119, 1095-9572, 1095-9572
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Shrnutí:•The reliable measurement of sleep regulatory processes is indisputable.•Sleep deprivation is an important method challenging the homeostatic process.•NREM sleep EEG spectral slope is a new, standardisable measure of sleep homeostasis.•Spindle frequency reflects putative circadian modulation under baseline conditions.•Sleep homeostasis can be reliably measured in home settings, outside the laboratory. Sleep is vital for sustaining life; therefore, reliable measurement of its regulatory processes is of significant importance in research and medicine. Here we examine the effect of extended wakefulness on the putative indicators of fundamental sleep regulatory processes (spectral slope and spindle frequency) proposed by the Fractal and Oscillatory Adjustment model of sleep regulation by involving a healthy young adult sample in a 35-hour long sleep deprivation protocol. Wearable headband EEG-derived results revealed that NREM sleep electroencephalogram (EEG) spectral slope estimated in the 2–48 Hz range is an accurate indicator of the predicted changes in sleep depth induced by sleep deprivation (steepened slopes in recovery sleep) or by the overnight dissipation of sleep pressure (flattening slopes during successive sleep cycles). While the baseline overnight dynamics of the center frequency of the sleep spindle oscillations followed a U-shaped curve, and the timing of its minimum (the presumed phase indicator) correlated with questionnaire-based chronotype metrics as predicted, a different picture emerged during recovery sleep. Advanced recovery sleep advanced the timing of the minima of the oscillatory spindle frequency, reduced considerably its relationship with chronotype, but retained partially its U-shaped overnight evolution. Overall, our study supports the use of the spectral slope of the sleep EEG as a homeostatic marker of wake-sleep regulation, in addition, encourages further research on the EEG-derived measure of the circadian rhythm, primarily focusing on its interaction with the homeostatic process.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2025.121260