Anticancer potential of rhizome extract and a labdane diterpenoid from Curcuma mutabilis plant endemic to Western Ghats of India
Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from Western Ghats of Kerala, India. Here, we report for the first time, the anticancer potential of petroleum ether extract from C. mutabili...
Uloženo v:
| Vydáno v: | Scientific reports Ročník 11; číslo 1; s. 552 - 20 |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
12.01.2021
Nature Publishing Group Nature Portfolio |
| Témata: | |
| ISSN: | 2045-2322, 2045-2322 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Zingiberaceae plants are well known for their use in ethnomedicine.
Curcuma mutabilis
Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from Western Ghats of Kerala, India. Here, we report for the first time, the anticancer potential of petroleum ether extract from
C. mutabilis
rhizome (CMRP) and a novel labdane diterpenoid, (
E
)-14, 15-epoxylabda-8(17), 12-dien-16-al (Cm epoxide) isolated from it. CMRP was found to be a mixture of potent bioactive compounds including Cm epoxide. Both the extract and the compound displayed superior antiproliferative activity against several human cancer cell lines, without any display of cytotoxicity towards normal human cells such as peripheral blood derived lymphocytes and erythrocytes. CMRP treatment resulted in phosphatidylserine externalization, increase in the levels of intracellular ROS, Ca
2+
, loss of mitochondrial membrane potential as well as fragmentation of genomic DNA. Analyses of transcript profiling and immunostained western blots of extract-treated cancer cells confirmed induction of apoptosis by both intrinsic and extrinsic pathways. The purified compound, Cm epoxide, was also found to induce apoptosis in many human cancer cell types tested. Both CMRP and the Cm epoxide were found to be pharmacologically safe in terms of acute toxicity assessment using Swiss albino mice model. Further, molecular docking interactions of Cm epoxide with selected proteins involved in cell survival and death were also indicative of its druggability. Overall, our findings reveal that the endemic
C. mutabilis
rhizome extract and the compound Cm epoxide isolated from it are potential candidates for development of future cancer chemotherapeutics. |
|---|---|
| AbstractList | Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from Western Ghats of Kerala, India. Here, we report for the first time, the anticancer potential of petroleum ether extract from C. mutabilis rhizome (CMRP) and a novel labdane diterpenoid, (E)-14, 15-epoxylabda-8(17), 12-dien-16-al (Cm epoxide) isolated from it. CMRP was found to be a mixture of potent bioactive compounds including Cm epoxide. Both the extract and the compound displayed superior antiproliferative activity against several human cancer cell lines, without any display of cytotoxicity towards normal human cells such as peripheral blood derived lymphocytes and erythrocytes. CMRP treatment resulted in phosphatidylserine externalization, increase in the levels of intracellular ROS, Ca2+, loss of mitochondrial membrane potential as well as fragmentation of genomic DNA. Analyses of transcript profiling and immunostained western blots of extract-treated cancer cells confirmed induction of apoptosis by both intrinsic and extrinsic pathways. The purified compound, Cm epoxide, was also found to induce apoptosis in many human cancer cell types tested. Both CMRP and the Cm epoxide were found to be pharmacologically safe in terms of acute toxicity assessment using Swiss albino mice model. Further, molecular docking interactions of Cm epoxide with selected proteins involved in cell survival and death were also indicative of its druggability. Overall, our findings reveal that the endemic C. mutabilis rhizome extract and the compound Cm epoxide isolated from it are potential candidates for development of future cancer chemotherapeutics.Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from Western Ghats of Kerala, India. Here, we report for the first time, the anticancer potential of petroleum ether extract from C. mutabilis rhizome (CMRP) and a novel labdane diterpenoid, (E)-14, 15-epoxylabda-8(17), 12-dien-16-al (Cm epoxide) isolated from it. CMRP was found to be a mixture of potent bioactive compounds including Cm epoxide. Both the extract and the compound displayed superior antiproliferative activity against several human cancer cell lines, without any display of cytotoxicity towards normal human cells such as peripheral blood derived lymphocytes and erythrocytes. CMRP treatment resulted in phosphatidylserine externalization, increase in the levels of intracellular ROS, Ca2+, loss of mitochondrial membrane potential as well as fragmentation of genomic DNA. Analyses of transcript profiling and immunostained western blots of extract-treated cancer cells confirmed induction of apoptosis by both intrinsic and extrinsic pathways. The purified compound, Cm epoxide, was also found to induce apoptosis in many human cancer cell types tested. Both CMRP and the Cm epoxide were found to be pharmacologically safe in terms of acute toxicity assessment using Swiss albino mice model. Further, molecular docking interactions of Cm epoxide with selected proteins involved in cell survival and death were also indicative of its druggability. Overall, our findings reveal that the endemic C. mutabilis rhizome extract and the compound Cm epoxide isolated from it are potential candidates for development of future cancer chemotherapeutics. Abstract Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from Western Ghats of Kerala, India. Here, we report for the first time, the anticancer potential of petroleum ether extract from C. mutabilis rhizome (CMRP) and a novel labdane diterpenoid, (E)-14, 15-epoxylabda-8(17), 12-dien-16-al (Cm epoxide) isolated from it. CMRP was found to be a mixture of potent bioactive compounds including Cm epoxide. Both the extract and the compound displayed superior antiproliferative activity against several human cancer cell lines, without any display of cytotoxicity towards normal human cells such as peripheral blood derived lymphocytes and erythrocytes. CMRP treatment resulted in phosphatidylserine externalization, increase in the levels of intracellular ROS, Ca2+, loss of mitochondrial membrane potential as well as fragmentation of genomic DNA. Analyses of transcript profiling and immunostained western blots of extract-treated cancer cells confirmed induction of apoptosis by both intrinsic and extrinsic pathways. The purified compound, Cm epoxide, was also found to induce apoptosis in many human cancer cell types tested. Both CMRP and the Cm epoxide were found to be pharmacologically safe in terms of acute toxicity assessment using Swiss albino mice model. Further, molecular docking interactions of Cm epoxide with selected proteins involved in cell survival and death were also indicative of its druggability. Overall, our findings reveal that the endemic C. mutabilis rhizome extract and the compound Cm epoxide isolated from it are potential candidates for development of future cancer chemotherapeutics. Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from Western Ghats of Kerala, India. Here, we report for the first time, the anticancer potential of petroleum ether extract from C. mutabilis rhizome (CMRP) and a novel labdane diterpenoid, (E)-14, 15-epoxylabda-8(17), 12-dien-16-al (Cm epoxide) isolated from it. CMRP was found to be a mixture of potent bioactive compounds including Cm epoxide. Both the extract and the compound displayed superior antiproliferative activity against several human cancer cell lines, without any display of cytotoxicity towards normal human cells such as peripheral blood derived lymphocytes and erythrocytes. CMRP treatment resulted in phosphatidylserine externalization, increase in the levels of intracellular ROS, Ca2+, loss of mitochondrial membrane potential as well as fragmentation of genomic DNA. Analyses of transcript profiling and immunostained western blots of extract-treated cancer cells confirmed induction of apoptosis by both intrinsic and extrinsic pathways. The purified compound, Cm epoxide, was also found to induce apoptosis in many human cancer cell types tested. Both CMRP and the Cm epoxide were found to be pharmacologically safe in terms of acute toxicity assessment using Swiss albino mice model. Further, molecular docking interactions of Cm epoxide with selected proteins involved in cell survival and death were also indicative of its druggability. Overall, our findings reveal that the endemic C. mutabilis rhizome extract and the compound Cm epoxide isolated from it are potential candidates for development of future cancer chemotherapeutics. Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from Western Ghats of Kerala, India. Here, we report for the first time, the anticancer potential of petroleum ether extract from C. mutabilis rhizome (CMRP) and a novel labdane diterpenoid, ( E )-14, 15-epoxylabda-8(17), 12-dien-16-al (Cm epoxide) isolated from it. CMRP was found to be a mixture of potent bioactive compounds including Cm epoxide. Both the extract and the compound displayed superior antiproliferative activity against several human cancer cell lines, without any display of cytotoxicity towards normal human cells such as peripheral blood derived lymphocytes and erythrocytes. CMRP treatment resulted in phosphatidylserine externalization, increase in the levels of intracellular ROS, Ca 2+ , loss of mitochondrial membrane potential as well as fragmentation of genomic DNA. Analyses of transcript profiling and immunostained western blots of extract-treated cancer cells confirmed induction of apoptosis by both intrinsic and extrinsic pathways. The purified compound, Cm epoxide, was also found to induce apoptosis in many human cancer cell types tested. Both CMRP and the Cm epoxide were found to be pharmacologically safe in terms of acute toxicity assessment using Swiss albino mice model. Further, molecular docking interactions of Cm epoxide with selected proteins involved in cell survival and death were also indicative of its druggability. Overall, our findings reveal that the endemic C. mutabilis rhizome extract and the compound Cm epoxide isolated from it are potential candidates for development of future cancer chemotherapeutics. Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from Western Ghats of Kerala, India. Here, we report for the first time, the anticancer potential of petroleum ether extract from C. mutabilis rhizome (CMRP) and a novel labdane diterpenoid, (E)-14, 15-epoxylabda-8(17), 12-dien-16-al (Cm epoxide) isolated from it. CMRP was found to be a mixture of potent bioactive compounds including Cm epoxide. Both the extract and the compound displayed superior antiproliferative activity against several human cancer cell lines, without any display of cytotoxicity towards normal human cells such as peripheral blood derived lymphocytes and erythrocytes. CMRP treatment resulted in phosphatidylserine externalization, increase in the levels of intracellular ROS, Ca , loss of mitochondrial membrane potential as well as fragmentation of genomic DNA. Analyses of transcript profiling and immunostained western blots of extract-treated cancer cells confirmed induction of apoptosis by both intrinsic and extrinsic pathways. The purified compound, Cm epoxide, was also found to induce apoptosis in many human cancer cell types tested. Both CMRP and the Cm epoxide were found to be pharmacologically safe in terms of acute toxicity assessment using Swiss albino mice model. Further, molecular docking interactions of Cm epoxide with selected proteins involved in cell survival and death were also indicative of its druggability. Overall, our findings reveal that the endemic C. mutabilis rhizome extract and the compound Cm epoxide isolated from it are potential candidates for development of future cancer chemotherapeutics. |
| ArticleNumber | 552 |
| Author | Klika, Karel D. Soumya, T. Jayasree, P. R. Lakshmipriya, T. Manish Kumar, P. R. |
| Author_xml | – sequence: 1 givenname: T. surname: Soumya fullname: Soumya, T. organization: Department of Biotechnology, University of Calicut – sequence: 2 givenname: T. surname: Lakshmipriya fullname: Lakshmipriya, T. organization: Department of Biotechnology, University of Calicut – sequence: 3 givenname: Karel D. surname: Klika fullname: Klika, Karel D. organization: Molecular Structure Analysis, German Cancer Research Center (DKFZ) – sequence: 4 givenname: P. R. surname: Jayasree fullname: Jayasree, P. R. organization: School of Health Sciences, University of Calicut – sequence: 5 givenname: P. R. orcidid: 0000-0002-8987-8439 surname: Manish Kumar fullname: Manish Kumar, P. R. email: prmanishkumar@uoc.ac.in organization: Department of Biotechnology, University of Calicut |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33436696$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UrtuFDEUHaEgEkJ-gAJZoqEZGD9mbDdI0QpCpEg0IErr-jFZr2bsxfYgoOLT8e6GkKSIG7_OOff6-DxvjkIMrmle4u4t7qh4lxnupWg70rVcMsxa8aQ5IR3rW0IJObqzPm7Oct50dfSkIuWz5phSRodBDifNn_NQvIFgXELbWFzdwYTiiNLa_46zQ-5nSWAKgmARoAm0heCQ9cWlrQvRWzSmOKPVkswyA5qXAtpPPqPtBKEgF6ybvUElom8uV1JAF2soeVfiMlgPL5qnI0zZnd3Mp83Xjx--rD61V58vLlfnV63pOS8taEcxYD7ojjDNieVGjAKoFmNHXC-psARwfa6WMFguNQetMabSaD5aCfS0uTzo2ggbtU1-hvRLRfBqfxDTtYJUrZic4hazodcUYwdMYpCsw0A5d8PABLGsar0_aG0XPTtrqmsJpnui92-CX6vr-ENx0VEuRBV4cyOQ4vel-qJmn42bqmUuLlkRxnmP-0GQCn39ALqJSwrVqj2qk5TxvqJe3e3otpV_H10B5AAwKeac3HgLwZ3aBUodAqVqoNQ-UGrXpnhAMr5A8XH3Kj89TqUHaq51wrVL_9t-hPUXp6XgYA |
| CitedBy_id | crossref_primary_10_1177_1934578X251328289 crossref_primary_10_1016_j_heliyon_2025_e42249 crossref_primary_10_1016_j_hermed_2023_100837 crossref_primary_10_1038_s41598_025_10761_0 crossref_primary_10_1080_14786419_2022_2071886 crossref_primary_10_3390_molecules26247430 crossref_primary_10_3390_ph15121517 crossref_primary_10_1016_j_jddst_2022_103709 crossref_primary_10_1007_s13205_024_04096_2 crossref_primary_10_1080_14786419_2021_2024530 crossref_primary_10_1016_j_steroids_2024_109450 crossref_primary_10_1016_j_nexres_2025_100167 crossref_primary_10_3390_molecules30153193 crossref_primary_10_1016_j_bcab_2023_102819 crossref_primary_10_1007_s10495_023_01826_4 crossref_primary_10_3390_molecules27238263 crossref_primary_10_1155_sci5_3560781 crossref_primary_10_1007_s11274_024_04190_w crossref_primary_10_1007_s44187_025_00546_9 crossref_primary_10_1016_j_jksus_2021_101735 crossref_primary_10_1016_j_bioorg_2025_108931 crossref_primary_10_1016_j_bioorg_2023_106957 crossref_primary_10_1038_s41598_025_88572_6 |
| Cites_doi | 10.1080/14786419.2018.1533826 10.1111/j.1751-7915.2010.00221.x 10.1007/s11033-018-4258-9 10.1016/j.phymed.2008.12.018 10.1155/2014/289638 10.3389/fpls.2015.00799 10.3390/ijms19010263 10.1007/s10495-007-0720-1 10.3892/br.2017.909 10.1016/j.imr.2017.03.004 10.3892/mmr.2014.2531 10.1155/2013/257108 10.12659/MSMBR.893327 10.1080/22311866.2013.782757 10.1155/2015/142979 10.1016/j.jep.2010.08.032 10.3390/medicina55040110 10.1016/j.jep.2012.03.014 10.1016/0014-4827(88)90265-0 10.1101/cshperspect.a008730 10.1016/j.bcp.2012.07.015 10.1007/s00709-017-1137-5 10.1016/S1572-5995(01)80009-0 10.1002/jhet.5570430318 10.1006/meth.2001.1262 10.1007/s10895-018-2306-4 10.1016/S0031-9422(98)00298-2 10.1021/jo001695p 10.4103/0257-7941.131989 10.1016/j.jep.2012.05.051 10.1080/01926230701320337 10.1016/j.phrs.2017.07.019 10.1385/MB:26:3:249 10.1002/cyto.a.20357 10.3390/nano9020230 10.1021/acs.jnatprod.5b01055 10.1159/000443404 10.1016/j.jep.2013.10.062 10.1016/j.mrrev.2012.08.001 10.2147/OTT.S174498 10.1080/07357907.2016.1247166 10.1038/nprot.2006.339 10.1039/C6RA27830B 10.1016/j.abb.2010.07.025 10.1021/np970243d 10.1002/0471142735.ima03bs21 10.1007/s00280-004-0849-3 10.1016/j.fitote.2017.08.006 10.1007/978-1-60761-411-1_4 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2021 The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2021 – notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI Q9U 7X8 5PM DOA |
| DOI | 10.1038/s41598-020-79414-8 |
| DatabaseName | Springer Nature OA Free Journals CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Database ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database (ProQuest) Biological Science Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef PubMed Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 20 |
| ExternalDocumentID | oai_doaj_org_article_7d1465b311ea491a9401a377e66482d4 PMC7803788 33436696 10_1038_s41598_020_79414_8 |
| Genre | Journal Article |
| GeographicLocations | Western Ghats India |
| GeographicLocations_xml | – name: Western Ghats – name: India |
| GrantInformation_xml | – fundername: Department of Biotechnology, Ministry of Science and Technology, India funderid: http://dx.doi.org/10.13039/501100001407 – fundername: ; |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFFHD AFPKN CITATION PHGZM PHGZT PJZUB PPXIY PQGLB NPM 7XB 8FK K9. PKEHL PQEST PQUKI Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c577t-abe31a176b024b72d7c8f8a3b8f02e5938d2a1232b9a6d79b7abb1139cb7fd9a3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 25 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000621919500015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2045-2322 |
| IngestDate | Fri Oct 03 12:45:09 EDT 2025 Tue Nov 04 01:51:09 EST 2025 Thu Oct 02 12:02:21 EDT 2025 Tue Oct 07 07:40:48 EDT 2025 Thu Jan 02 22:57:11 EST 2025 Tue Nov 18 21:30:38 EST 2025 Sat Nov 29 02:20:45 EST 2025 Fri Feb 21 02:38:58 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c577t-abe31a176b024b72d7c8f8a3b8f02e5938d2a1232b9a6d79b7abb1139cb7fd9a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-8987-8439 |
| OpenAccessLink | https://doaj.org/article/7d1465b311ea491a9401a377e66482d4 |
| PMID | 33436696 |
| PQID | 2477093475 |
| PQPubID | 2041939 |
| PageCount | 20 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7d1465b311ea491a9401a377e66482d4 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7803788 proquest_miscellaneous_2477515682 proquest_journals_2477093475 pubmed_primary_33436696 crossref_primary_10_1038_s41598_020_79414_8 crossref_citationtrail_10_1038_s41598_020_79414_8 springer_journals_10_1038_s41598_020_79414_8 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-01-12 |
| PublicationDateYYYYMMDD | 2021-01-12 |
| PublicationDate_xml | – month: 01 year: 2021 text: 2021-01-12 day: 12 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2021 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Allegra (CR9) 2016; 35 Bhat, Hegde, Hegde, Mulgund (CR6) 2014; 151 Livak, Schmittgen (CR51) 2001; 408 Collins (CR21) 2004; 26 Sundarraj, Thangam, Sreevani, Kaveri (CR43) 2012; 141 Sy, Brown (CR25) 1997; 60 Franken, Rodermond, Stap, Haveman, Van Bree (CR49) 2006; 1 Demain, Vaishnav (CR5) 2011; 4 Prasannan (CR12) 2012; 84 Tran, Wong, Chai (CR28) 2017; 124 Sy, Brown (CR26) 1998; 49 Wagner, Ulrich-merzenich (CR46) 2009; 16 Liu (CR42) 2018; 11 Sheeja, Nair (CR30) 2014; 53 Ma, Xie, Miao, Yang, Yang (CR29) 2017; 7 Seca, Pinto (CR3) 2018 Balentová (CR54) 2006; 43 Kumar, Asish, Sabu, Balachandran (CR10) 2013; 32 Silke, Meier (CR22) 2013; 5 Win, Itoa, Ngweb, Win, Okamoto, Tanaka, Asakawa, Ikuro Abe, Moritaa (CR31) 2017; 122 Kuo, Yang (CR38) 2008; 22 Liu, Liu, Liu, Wu (CR16) 2015; 21 Demetzos, Dimas (CR27) 2001; 25 Chirio (CR41) 2019; 9 Prasad, Tyagi (CR11) 2015 Strober (CR48) 1997 Wen, Gu, Zeng (CR44) 2018; 23 Koç, Çelik-uzuner, Uzuner, Çakmak (CR17) 2018; 28 Eroglu, Hruszkewycz, Curley, Harrison (CR40) 2012; 504 Majtnerová, Roušar (CR33) 2018; 45 Basak, Sarma, Rangan (CR13) 2010; 132 Cragg, Pezzuto (CR2) 2016; 25 CR18 Zhang (CR36) 2014; 10 Singh, McCoy, Ties, Schneider (CR50) 1988; 175 Klika (CR53) 2001; 66 Lakshmipriya, Soumya, Jayasree, Kumar (CR47) 2017; 255 Skornickova, Sabu, Prasanthkumar (CR14) 2004; 56 Elmore (CR37) 2007; 35 Galluzzi (CR20) 2007; 12 Kramer (CR39) 2013; 752 Mathur, Hoskins (CR4) 2017; 6 Klika (CR52) 2014; 2014 CR24 Kabeer, Rajalekshmi, Nair, Prathapan (CR35) 2017; 6 Liu (CR19) 2005; 55 Upadhya, Hegde, Bhat, Hurkadale (CR7) 2012; 142 Soumya, Jayasree, Deepak, Manish Kumar (CR15) 2019 Afzal, Oriqat, Khan, Jose (CR8) 2017; 3 Newman, Cragg (CR1) 2016; 79 Fridlender, Kapulnik, Koltai (CR23) 2015; 6 Kajstura, Halicka, Pryjma, Darzynkiewicz (CR34) 2007; 71A Pezzani (CR45) 2019; 55 Syed Abdul Rahman, Abdul Wahab, Abd Malek (CR32) 2013; 2013 AL Demain (79414_CR5) 2011; 4 P Bhat (79414_CR6) 2014; 151 N Kramer (79414_CR39) 2013; 752 GM Cragg (79414_CR2) 2016; 25 R Prasannan (79414_CR12) 2012; 84 C Demetzos (79414_CR27) 2001; 25 FA Kabeer (79414_CR35) 2017; 6 S Wen (79414_CR44) 2018; 23 V Upadhya (79414_CR7) 2012; 142 WJ Liu (79414_CR42) 2018; 11 QTN Tran (79414_CR28) 2017; 124 W Strober (79414_CR48) 1997 J Silke (79414_CR22) 2013; 5 L-K Sy (79414_CR25) 1997; 60 T Soumya (79414_CR15) 2019 KJ Livak (79414_CR51) 2001; 408 ADB Sheeja (79414_CR30) 2014; 53 A Eroglu (79414_CR40) 2012; 504 A Allegra (79414_CR9) 2016; 35 S Basak (79414_CR13) 2010; 132 K Liu (79414_CR16) 2015; 21 SN Syed Abdul Rahman (79414_CR32) 2013; 2013 S Prasad (79414_CR11) 2015 KD Klika (79414_CR53) 2001; 66 KP Kumar (79414_CR10) 2013; 32 M Fridlender (79414_CR23) 2015; 6 D Chirio (79414_CR41) 2019; 9 E Koç (79414_CR17) 2018; 28 LJ Kuo (79414_CR38) 2008; 22 G Zhang (79414_CR36) 2014; 10 79414_CR18 NN Win (79414_CR31) 2017; 122 H Wagner (79414_CR46) 2009; 16 M Skornickova (79414_CR14) 2004; 56 79414_CR24 M Kajstura (79414_CR34) 2007; 71A L-K Sy (79414_CR26) 1998; 49 S Mathur (79414_CR4) 2017; 6 S Sundarraj (79414_CR43) 2012; 141 NAP Franken (79414_CR49) 2006; 1 R Pezzani (79414_CR45) 2019; 55 L Galluzzi (79414_CR20) 2007; 12 AML Seca (79414_CR3) 2018 S Elmore (79414_CR37) 2007; 35 MJ Liu (79414_CR19) 2005; 55 T Lakshmipriya (79414_CR47) 2017; 255 DJ Newman (79414_CR1) 2016; 79 KD Klika (79414_CR52) 2014; 2014 X-N Ma (79414_CR29) 2017; 7 E Balentová (79414_CR54) 2006; 43 P Majtnerová (79414_CR33) 2018; 45 NP Singh (79414_CR50) 1988; 175 AR Collins (79414_CR21) 2004; 26 A Afzal (79414_CR8) 2017; 3 |
| References_xml | – year: 2019 ident: CR15 article-title: Chemical composition, antioxidant and antiproliferative activities of essential oil from rhizome and leaves of Škorničk., M. Sabu & Prasanthk., endemic to Western Ghats of India publication-title: Nat. Prod. Res. doi: 10.1080/14786419.2018.1533826 – volume: 4 start-page: 687 year: 2011 end-page: 699 ident: CR5 article-title: Natural products for cancer chemotherapy publication-title: Microb. Biotechnol. doi: 10.1111/j.1751-7915.2010.00221.x – volume: 45 start-page: 1469 year: 2018 end-page: 1478 ident: CR33 article-title: An overview of apoptosis assays detecting DNA fragmentation publication-title: Mol. Biol. Rep. doi: 10.1007/s11033-018-4258-9 – volume: 23 start-page: 965 year: 2018 end-page: 970 ident: CR44 article-title: Antitumour effects of beta-amyrin in Hep-G2 liver carcinoma cells are mediated via apoptosis induction, cell cycle disruption and activation of JNK and P38 signalling pathways publication-title: JBUON – volume: 16 start-page: 97 year: 2009 end-page: 110 ident: CR46 article-title: Synergy research: approaching a new generation of phytopharmaceuticals publication-title: Phytomedicine doi: 10.1016/j.phymed.2008.12.018 – volume: 2014 start-page: 289638 year: 2014 ident: CR52 article-title: The Application of simple and easy to implement decoupling pulse scheme combinations to effect decoupling of large values with reduced artifacts publication-title: Int. J. Spectrosc. doi: 10.1155/2014/289638 – volume: 6 start-page: 799 year: 2015 ident: CR23 article-title: Plant derived substances with anti-cancer activity: from folklore to practice publication-title: Front. Plant Sci. doi: 10.3389/fpls.2015.00799 – year: 2018 ident: CR3 article-title: Plant secondary metabolites as anticancer agents: Successes in clinical trials and therapeutic application publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19010263 – volume: 12 start-page: 803 year: 2007 end-page: 813 ident: CR20 article-title: Methods for the assessment of mitochondrial membrane permeabilization in apoptosis publication-title: Apoptosis doi: 10.1007/s10495-007-0720-1 – volume: 6 start-page: 612 year: 2017 end-page: 614 ident: CR4 article-title: Drug development: lessons from nature publication-title: Biomed. Rep. doi: 10.3892/br.2017.909 – volume: 6 start-page: 190 year: 2017 end-page: 206 ident: CR35 article-title: Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells publication-title: Integr. Med. Res. doi: 10.1016/j.imr.2017.03.004 – volume: 56 start-page: 43 year: 2004 end-page: 54 ident: CR14 article-title: (Zingiberaceae): a new species from South India publication-title: Gard. Bull. Singapore – volume: 10 start-page: 2365 year: 2014 end-page: 2371 ident: CR36 article-title: Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2014.2531 – volume: 2013 start-page: 257108 year: 2013 ident: CR32 article-title: morphological assessment of apoptosis induced by antiproliferative constituents from the rhizomes of publication-title: Evid. Based Complement. Altern. Med. doi: 10.1155/2013/257108 – volume: 21 start-page: 15 year: 2015 end-page: 20 ident: CR16 article-title: Dual AO/EB Staining to detect apoptosis in osteosarcoma cells compared with flow cytometry publication-title: Med. Sci. Monit. Basic. Res. doi: 10.12659/MSMBR.893327 – volume: 3 start-page: 1 year: 2017 end-page: 55 ident: CR8 article-title: Chemistry and biochemistry of terpenoids from and related species publication-title: J. Biol. Active Prod. Nat. doi: 10.1080/22311866.2013.782757 – year: 2015 ident: CR11 article-title: Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer publication-title: Gastroenterol. Res. Pract. doi: 10.1155/2015/142979 – volume: 22 start-page: 305 year: 2008 end-page: 310 ident: CR38 article-title: γ-H2AX—a novel biomarker for DNA double-strand breaks publication-title: In vivo – volume: 132 start-page: 286 year: 2010 end-page: 296 ident: CR13 article-title: Ethnomedical uses of Zingiberaceous plants of Northeast India publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2010.08.032 – volume: 55 start-page: 110 year: 2019 ident: CR45 article-title: Synergistic effects of plant derivatives and conventional chemotherapeutic agents: an update on the cancer perspective publication-title: Medicina. doi: 10.3390/medicina55040110 – volume: 141 start-page: 803 year: 2012 end-page: 809 ident: CR43 article-title: γ-Sitosterol from L. induces G2 / M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2012.03.014 – volume: 175 start-page: 184 year: 1988 end-page: 191 ident: CR50 article-title: A simple technique for quantitation of damage in individual of low levels of DNA cells publication-title: Exp. Cell Res. doi: 10.1016/0014-4827(88)90265-0 – volume: 5 start-page: a008730 year: 2013 ident: CR22 article-title: Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a008730 – volume: 84 start-page: 1268 year: 2012 end-page: 1276 ident: CR12 article-title: Key cell signaling pathways modulated by zerumbone: role in the prevention and treatment of cancer publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2012.07.015 – volume: 255 start-page: 203 year: 2017 end-page: 216 ident: CR47 article-title: Selective induction of DNA damage, G2 abrogation, and mitochondrial apoptosis by leaf extract of traditional medicinal plant in K562 cells publication-title: Protoplasma doi: 10.1007/s00709-017-1137-5 – volume: 25 start-page: 235 year: 2001 end-page: 292 ident: CR27 article-title: Labdane-type diterpenes: chemistry and biological activity publication-title: Stud. Nat. Prod. Chem. doi: 10.1016/S1572-5995(01)80009-0 – ident: CR18 – volume: 43 start-page: 645 year: 2006 end-page: 656 ident: CR54 article-title: Stereochemistry, tautomerism, and reactions of acridinylthiosemicarbazides in the synthesis of 1,3-thiazolidines publication-title: J. Heterocyclic Chem. doi: 10.1002/jhet.5570430318 – volume: 408 start-page: 402 year: 2001 end-page: 408 ident: CR51 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2 Method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 28 start-page: 1393 year: 2018 end-page: 1404 ident: CR17 article-title: The detailed comparison of cell death detected by Annexin V-PI counterstain using fluorescence microscope, flow cytometry and automated cell counter in mammalian and microalgae cells publication-title: J. Fluorsc. doi: 10.1007/s10895-018-2306-4 – volume: 49 start-page: 1741 year: 1998 end-page: 1744 ident: CR26 article-title: Determination of the absolute stereochemistry of the epoxide group in Alpinia epoxide by NMR publication-title: Phytochemistry doi: 10.1016/S0031-9422(98)00298-2 – volume: 66 start-page: 4416 year: 2001 end-page: 4418 ident: CR53 article-title: Unexpected formation of a spiro acridine and fused ring system from the reaction between an N-Acridinylmethyl-substituted thiourea and bromoacetonitrile under basic conditions publication-title: J. Org. Chem. doi: 10.1021/jo001695p – volume: 32 start-page: 253 year: 2013 end-page: 261 ident: CR10 article-title: Significance of gingers (Zingiberaceae) in Indian system of medicine—ayurveda: an overview publication-title: Ancient Sci. Life. doi: 10.4103/0257-7941.131989 – volume: 142 start-page: 557 year: 2012 end-page: 562 ident: CR7 article-title: Ethnomedicinal plants used to treat bone fracture from North-Central Western Ghats of India publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2012.05.051 – volume: 35 start-page: 496 year: 2007 end-page: 516 ident: CR37 article-title: Apoptosis: a reveiw of programmed cell death publication-title: Toxicol Pathol. doi: 10.1080/01926230701320337 – volume: 124 start-page: 43 year: 2017 end-page: 63 ident: CR28 article-title: Labdane diterpenoids as potential anti-inflammatory agents publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2017.07.019 – volume: 26 start-page: 249 year: 2004 end-page: 261 ident: CR21 article-title: The Comet assay for dna damage and repair publication-title: Mol. Biotech. doi: 10.1385/MB:26:3:249 – volume: 71A start-page: 125 year: 2007 end-page: 131 ident: CR34 article-title: Discontinuous fragmentation of nuclear dna during apoptosis revealed by discrete “Sub-G1” peaks on dna content histograms publication-title: Cytometry Part A. doi: 10.1002/cyto.a.20357 – volume: 9 start-page: 230 year: 2019 ident: CR41 article-title: Development of solid lipid nanoparticles by cold dilution of microemulsions: curcumin loading, preliminary studies, and biodistribution publication-title: Nanomaterials doi: 10.3390/nano9020230 – volume: 79 start-page: 629 year: 2016 end-page: 661 ident: CR1 article-title: Natural products as sources of new drugs from 1981 to 2014 publication-title: J. Nat. Prod. doi: 10.1021/acs.jnatprod.5b01055 – volume: 25 start-page: 41 year: 2016 end-page: 59 ident: CR2 article-title: Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents publication-title: Med. Princ. Pract. doi: 10.1159/000443404 – volume: 151 start-page: 493 year: 2014 end-page: 502 ident: CR6 article-title: Ethnomedicinal plants to cure skin diseases—an account of the traditional knowledge in the coastal parts of Central Western Ghats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2013.10.062 – volume: 752 start-page: 10 year: 2013 end-page: 24 ident: CR39 article-title: cell migration and invasion assays publication-title: Mutat. Res./Rev. Mutat. Res. doi: 10.1016/j.mrrev.2012.08.001 – volume: 11 start-page: 5429 year: 2018 end-page: 5439 ident: CR42 article-title: Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage publication-title: Onco Targets Ther. doi: 10.2147/OTT.S174498 – volume: 35 start-page: 1 year: 2016 end-page: 22 ident: CR9 article-title: Anticancer activity of curcumin and its analogues: preclinical and clinical studies publication-title: Cancer Invest. doi: 10.1080/07357907.2016.1247166 – volume: 53 start-page: 319 year: 2014 end-page: 324 ident: CR30 article-title: Facile isolation of ( ) -labda-8(17),12-diene-15,16-dial from C and its conversion to other biologically active compounds publication-title: Indian J. Chem. – volume: 1 start-page: 2315 year: 2006 end-page: 2319 ident: CR49 article-title: Clonogenic assay of cells publication-title: Nat. Protoc. doi: 10.1038/nprot.2006.339 – volume: 7 start-page: 14114 year: 2017 end-page: 14144 ident: CR29 article-title: An overview of chemical constituents from species in the last six decades publication-title: RSC Adv. doi: 10.1039/C6RA27830B – volume: 504 start-page: 11 year: 2012 end-page: 16 ident: CR40 article-title: The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2010.07.025 – volume: 60 start-page: 904 year: 1997 end-page: 908 ident: CR25 article-title: Labdanediterpenoids from publication-title: J. Nat. Prod. doi: 10.1021/np970243d – year: 1997 ident: CR48 article-title: Trypan blue exclusion test of cell viability publication-title: Curr. Protoc. Immun. doi: 10.1002/0471142735.ima03bs21 – volume: 55 start-page: 79 year: 2005 end-page: 90 ident: CR19 article-title: Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca homeostasis publication-title: Cancer Chemother. Pharmacol. doi: 10.1007/s00280-004-0849-3 – ident: CR24 – volume: 122 start-page: 34 year: 2017 end-page: 39 ident: CR31 article-title: Labdane diterpenoids from rhizomes collected in Myanmar and their antiproliferative activities publication-title: Fitoterapia doi: 10.1016/j.fitote.2017.08.006 – year: 2019 ident: 79414_CR15 publication-title: Nat. Prod. Res. doi: 10.1080/14786419.2018.1533826 – volume: 4 start-page: 687 year: 2011 ident: 79414_CR5 publication-title: Microb. Biotechnol. doi: 10.1111/j.1751-7915.2010.00221.x – volume: 122 start-page: 34 year: 2017 ident: 79414_CR31 publication-title: Fitoterapia doi: 10.1016/j.fitote.2017.08.006 – volume: 6 start-page: 612 year: 2017 ident: 79414_CR4 publication-title: Biomed. Rep. doi: 10.3892/br.2017.909 – volume: 60 start-page: 904 year: 1997 ident: 79414_CR25 publication-title: J. Nat. Prod. doi: 10.1021/np970243d – volume: 21 start-page: 15 year: 2015 ident: 79414_CR16 publication-title: Med. Sci. Monit. Basic. Res. doi: 10.12659/MSMBR.893327 – volume: 84 start-page: 1268 year: 2012 ident: 79414_CR12 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2012.07.015 – volume: 25 start-page: 41 year: 2016 ident: 79414_CR2 publication-title: Med. Princ. Pract. doi: 10.1159/000443404 – volume: 26 start-page: 249 year: 2004 ident: 79414_CR21 publication-title: Mol. Biotech. doi: 10.1385/MB:26:3:249 – volume: 2013 start-page: 257108 year: 2013 ident: 79414_CR32 publication-title: Evid. Based Complement. Altern. Med. doi: 10.1155/2013/257108 – ident: 79414_CR18 doi: 10.1007/978-1-60761-411-1_4 – volume: 71A start-page: 125 year: 2007 ident: 79414_CR34 publication-title: Cytometry Part A. doi: 10.1002/cyto.a.20357 – volume: 2014 start-page: 289638 year: 2014 ident: 79414_CR52 publication-title: Int. J. Spectrosc. doi: 10.1155/2014/289638 – volume: 132 start-page: 286 year: 2010 ident: 79414_CR13 publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2010.08.032 – volume: 16 start-page: 97 year: 2009 ident: 79414_CR46 publication-title: Phytomedicine doi: 10.1016/j.phymed.2008.12.018 – volume: 66 start-page: 4416 year: 2001 ident: 79414_CR53 publication-title: J. Org. Chem. doi: 10.1021/jo001695p – volume: 43 start-page: 645 year: 2006 ident: 79414_CR54 publication-title: J. Heterocyclic Chem. doi: 10.1002/jhet.5570430318 – volume: 408 start-page: 402 year: 2001 ident: 79414_CR51 publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 175 start-page: 184 year: 1988 ident: 79414_CR50 publication-title: Exp. Cell Res. doi: 10.1016/0014-4827(88)90265-0 – volume: 142 start-page: 557 year: 2012 ident: 79414_CR7 publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2012.05.051 – volume: 49 start-page: 1741 year: 1998 ident: 79414_CR26 publication-title: Phytochemistry doi: 10.1016/S0031-9422(98)00298-2 – volume: 124 start-page: 43 year: 2017 ident: 79414_CR28 publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2017.07.019 – volume: 3 start-page: 1 year: 2017 ident: 79414_CR8 publication-title: J. Biol. Active Prod. Nat. doi: 10.1080/22311866.2013.782757 – ident: 79414_CR24 – volume: 752 start-page: 10 year: 2013 ident: 79414_CR39 publication-title: Mutat. Res./Rev. Mutat. Res. doi: 10.1016/j.mrrev.2012.08.001 – volume: 35 start-page: 496 year: 2007 ident: 79414_CR37 publication-title: Toxicol Pathol. doi: 10.1080/01926230701320337 – year: 1997 ident: 79414_CR48 publication-title: Curr. Protoc. Immun. doi: 10.1002/0471142735.ima03bs21 – year: 2018 ident: 79414_CR3 publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19010263 – volume: 11 start-page: 5429 year: 2018 ident: 79414_CR42 publication-title: Onco Targets Ther. doi: 10.2147/OTT.S174498 – volume: 25 start-page: 235 year: 2001 ident: 79414_CR27 publication-title: Stud. Nat. Prod. Chem. doi: 10.1016/S1572-5995(01)80009-0 – volume: 35 start-page: 1 year: 2016 ident: 79414_CR9 publication-title: Cancer Invest. doi: 10.1080/07357907.2016.1247166 – volume: 28 start-page: 1393 year: 2018 ident: 79414_CR17 publication-title: J. Fluorsc. doi: 10.1007/s10895-018-2306-4 – volume: 9 start-page: 230 year: 2019 ident: 79414_CR41 publication-title: Nanomaterials doi: 10.3390/nano9020230 – volume: 55 start-page: 79 year: 2005 ident: 79414_CR19 publication-title: Cancer Chemother. Pharmacol. doi: 10.1007/s00280-004-0849-3 – volume: 22 start-page: 305 year: 2008 ident: 79414_CR38 publication-title: In vivo – volume: 504 start-page: 11 year: 2012 ident: 79414_CR40 publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2010.07.025 – volume: 55 start-page: 110 year: 2019 ident: 79414_CR45 publication-title: Medicina. doi: 10.3390/medicina55040110 – volume: 151 start-page: 493 year: 2014 ident: 79414_CR6 publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2013.10.062 – volume: 5 start-page: a008730 year: 2013 ident: 79414_CR22 publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a008730 – year: 2015 ident: 79414_CR11 publication-title: Gastroenterol. Res. Pract. doi: 10.1155/2015/142979 – volume: 7 start-page: 14114 year: 2017 ident: 79414_CR29 publication-title: RSC Adv. doi: 10.1039/C6RA27830B – volume: 45 start-page: 1469 year: 2018 ident: 79414_CR33 publication-title: Mol. Biol. Rep. doi: 10.1007/s11033-018-4258-9 – volume: 141 start-page: 803 year: 2012 ident: 79414_CR43 publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2012.03.014 – volume: 255 start-page: 203 year: 2017 ident: 79414_CR47 publication-title: Protoplasma doi: 10.1007/s00709-017-1137-5 – volume: 53 start-page: 319 year: 2014 ident: 79414_CR30 publication-title: Indian J. Chem. – volume: 6 start-page: 190 year: 2017 ident: 79414_CR35 publication-title: Integr. Med. Res. doi: 10.1016/j.imr.2017.03.004 – volume: 1 start-page: 2315 year: 2006 ident: 79414_CR49 publication-title: Nat. Protoc. doi: 10.1038/nprot.2006.339 – volume: 79 start-page: 629 year: 2016 ident: 79414_CR1 publication-title: J. Nat. Prod. doi: 10.1021/acs.jnatprod.5b01055 – volume: 12 start-page: 803 year: 2007 ident: 79414_CR20 publication-title: Apoptosis doi: 10.1007/s10495-007-0720-1 – volume: 10 start-page: 2365 year: 2014 ident: 79414_CR36 publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2014.2531 – volume: 32 start-page: 253 year: 2013 ident: 79414_CR10 publication-title: Ancient Sci. Life. doi: 10.4103/0257-7941.131989 – volume: 56 start-page: 43 year: 2004 ident: 79414_CR14 publication-title: Gard. Bull. Singapore – volume: 6 start-page: 799 year: 2015 ident: 79414_CR23 publication-title: Front. Plant Sci. doi: 10.3389/fpls.2015.00799 – volume: 23 start-page: 965 year: 2018 ident: 79414_CR44 publication-title: JBUON |
| SSID | ssj0000529419 |
| Score | 2.4573567 |
| Snippet | Zingiberaceae plants are well known for their use in ethnomedicine.
Curcuma mutabilis
Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from... Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from... Abstract Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 552 |
| SubjectTerms | 631/154 631/337 631/449 631/67 631/80 Acute toxicity Apoptosis Bioactive compounds Calcium (intracellular) Calcium (mitochondrial) Cancer Cell death Cell survival Chemotherapy Curcuma Cytotoxicity Diterpenes DNA fingerprinting DNA fragmentation Endemic plants Endemic species Erythrocytes Genomics Humanities and Social Sciences Lymphocytes Membrane potential Mitochondria multidisciplinary Peripheral blood Petroleum ether Phosphatidylserine Rhizomes Science Science (multidisciplinary) Transcription Tumor cell lines Western blotting Zingiberaceae |
| SummonAdditionalLinks | – databaseName: Science Database (ProQuest) dbid: M2P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaggMSlvGmgICNxg6ixnfXjhEpFAQmqHnj0FvmVdqVuEpIsEjd-OjNJdqvl0QvX2FHszOeZ8TwJec6y0ouZ1KkWjqe5jzq1IOZTUwoRdW5kHGy6Xz6ooyN9cmKOJ4NbN4VVrnjiwKhD7dFGvsdzpeD2navZq-Zbil2j0Ls6tdC4Sq6BZsMwpOsjP17bWNCLlTMz5cpkQu91IK8wpwzuTABElqd6Qx4NZfv_pmv-GTL5m990EEeHt_53I7fJ9qSI0v0ROXfIlVjdJTfG1pQ_7pGf-xVauQESLW3qHmOKYHZd0haD9BaRAlPHBCtqq0AtBSwFW0UaMKO5iVU9DxQzV-jBsvXLhaWLZT_U8u1ocw7EpGh5X8w97Wv6dSzWQN-e2b7DT7yvALT3yefDN58O3qVTt4bUz5TqU-uiYJYp6UDsO8WD8rrUVjhdZjzOjNCBW1TgnLEyKOOUdY6BAuqdKoOx4gHZquoq7hBagl7jhcx8BredyIV1pbXKqsil5TzwhLAVzQo_lTLHjhrnxeBSF7oY6VwAnYuBzoVOyIv1O81YyOPS2a8RCuuZWIR7eFC3p8V0pgsVQMzMnGAs2twwa-CuaoVSUcpc85AnZHeFgGLiDF1xQf6EPFsPw5lGRw0Qql6Oc0DPlBp2-nDE3XolQuRCSiMTojYQubHUzZFqfjbUDVc6w-4BCXm5wu7Fsv79Kx5dvovH5CbHMJ-MpYzvkq2-XcYn5Lr_3s-79ulwHn8B4q09UQ priority: 102 providerName: ProQuest |
| Title | Anticancer potential of rhizome extract and a labdane diterpenoid from Curcuma mutabilis plant endemic to Western Ghats of India |
| URI | https://link.springer.com/article/10.1038/s41598-020-79414-8 https://www.ncbi.nlm.nih.gov/pubmed/33436696 https://www.proquest.com/docview/2477093475 https://www.proquest.com/docview/2477515682 https://pubmed.ncbi.nlm.nih.gov/PMC7803788 https://doaj.org/article/7d1465b311ea491a9401a377e66482d4 |
| Volume | 11 |
| WOSCitedRecordID | wos000621919500015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M7P dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: 7X7 dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central (subscription) customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: BENPR dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: PIMPY dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database (ProQuest) customDbUrl: eissn: 2045-2322 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000529419 issn: 2045-2322 databaseCode: M2P dateStart: 20110101 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagBYkL4k1KWRmJG0SN7azHPrZVC5XoaoV4LKfIjh11pW6y2s0i9cZPZ-xkly7PC5c5JI7ieD5nZuyZz4S8ZFlViqFUqRKWp3npVWrQzKe6EsKrXEsf13Q_vYPRSE0menztqK-QE9bRA3cDdwAO5_LQCsa8yTUzGgMCIwC8lLniLjKBZqCvBVMdqzfXOdN9lUwm1MESLVWoJsNoCSHI8lRtWaJI2P87L_PXZMmfdkyjITq9R-72HiQ97Hp-n9zw9QNyuztT8uoh-XZYh-Vp1OWCzps2JANh66aii5BdN_MU_8ahMoqa2lFDEQTO1J66UIo893UzdTSUnNDj1aJczQydrdpIwruk80vUAg1L5rNpSduGfu5YFuibC9MuwyvOakTbI_Lx9OTD8du0P2YhLYcAbWqsF8wwkBbttQXuoFSVMsKqKuN-qIVy3ATPy2ojHWgLxlqGnmNpoXLaiMdkp25q_5TQCh2SUsiszDBM8VwYWxkDBjyXhnPHE8LWQ16UPQd5OArjsoh74UIVnZoKVFMR1VSohLzaPDPvGDj-2vooaHLTMrBnxwuIqaLHVPEvTCVkf42Dop_Sy4LnAJkWOQwT8mJzGydj2GFBRTWrrg06iFLhlz7pYLPpiRC5kFLLhMAWoLa6un2nnl5Ewm9QWaD9T8jrNfR-dOvPQ7H3P4biGbnDQxZPxlLG98lOu1j55-RW-bWdLhcDchMmEKUakN2jk9H4_SBORJTnfBwkoNwdn52Pv3wH5fU0xA |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jb9QwFLZKAZUL-xIoYCQ4QdTYztjOAaFSKB11GPVQaG_BW9qROsmQZEC98Yv4jTxnmWpYeuuBa-IktvO9zW9D6DmJMsMGXIaSaRrGxslQgZgPk4wxJ-OEu-ZM9_NIjMfy8DDZW0E_-1wYH1bZ88SGUdvC-DPyDRoLAdZ3LAZvZl9D3zXKe1f7FhotLHbd6Xcw2arXw3fwf19Quv1-f2sn7LoKhGYgRB0q7RhRRHAN4kkLaoWRmVRMyyyibpAwaanyioZOFLci0UJpTUBRMlpkNlEM3nsJXY59ZTEfKkj3Fmc63msWk6TLzYmY3KhAPvocNrDRAPgkDuWS_GvaBPxNt_0zRPM3P20j_rZv_G8bdxNd7xRtvNlSxi204vLb6GrbevP0DvqxmftTfIB8iWdF7WOmYHSR4dIHIU4dBqHlE8iwyi1WGGjFqtxh6zO2Zy4vJhb7zBy8NS_NfKrwdF43tYorPDsBsGLvWZhODK4LfNAWo8AfjlVd-U8McyDKu-jThSz_HlrNi9w9QDgDvc0wHpkIrDlHmdKZUkIJR7mi1NIAkR4jqelKtfuOISdpEzLAZNriKgVcpQ2uUhmgl4tnZm2hknNHv_XQW4z0RcabC0V5lHY8KxUWxOhAM0KcihOiErDFFRPCcR5LauMArfeISzvOV6VncAvQs8Vt4FneEQU_qpi3Y0CP5hJWer_F-WImjMWM84QHSCxRwNJUl-_kk-OmLrqQke-OEKBXPa2cTevfW_Hw_FU8RWs7-x9H6Wg43n2ErlEf0hSRkNB1tFqXc_cYXTHf6klVPml4AUZfLpqGfgHfgpuG |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jc9MwFNaUFBgu7EuggJiBE3hiSY4kHximtAQyLZkcWMrJaDPNTGMH24Hpjd_Fr-PJSzph6a0HrrZsS_L3Nr0NocckTA0bchlIpmkQGScDBWI-iFPGnIxi7uoz3Q_7YjKRBwfxdAP97HJhfFhlxxNrRm1z48_IBzQSAqzvSAwHaRsWMd0dvVh8DXwHKe9p7dppNBDZc8ffwXwrn4934V8_oXT06t3Om6DtMBCYoRBVoLRjRBHBNYgqLagVRqZSMS3TkLphzKSlyisdOlbcilgLpTUBpclokdpYMXjvObQJKnlEe2hzOn47_bQ64fE-tIjEbaZOyOSgBGnpM9rAYgMyIFEg16Rh3TTgb5runwGbv3lta2E4uvI_b-NVdLlVwfF2QzPX0IbLrqMLTVPO4xvox3bmz_eBGAq8yCsfTQWj8xQXPjxx7jAsxqeWYZVZrDBQkVWZw9bnci9cls8s9jk7eGdZmOVc4fmyqqsYl3hxBDDG3ucwnxlc5fhjU6YCvz5UVek_Mc6AXG-i92ey_Fuol-WZu4NwChqdYTw0Idh5jjKlU6WEEo5yRamlfUQ6vCSmLeLue4kcJXUwAZNJg7EEMJbUGEtkHz1dPbNoSpicOvqlh-FqpC8_Xl_Iiy9Jy80SYUHADjUjxKkoJioGK10xIRznkaQ26qOtDn1JyxPL5AR6ffRodRu4mXdRwY_Kl80Y0LC5hJXebjC_mgljEeM85n0k1qhhbarrd7LZYV0xXcjQ903oo2cd3ZxM699bcff0VTxEF4F0kv3xZO8eukR9rFNIAkK3UK8qlu4-Om--VbOyeNAyBow-nzUR_QK2saXP |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Anticancer+potential+of+rhizome+extract+and+a+labdane+diterpenoid+from+Curcuma+mutabilis+plant+endemic+to+Western+Ghats+of+India&rft.jtitle=Scientific+reports&rft.au=Soumya%2C+T.&rft.au=Lakshmipriya%2C+T.&rft.au=Klika%2C+Karel+D.&rft.au=Jayasree%2C+P.+R.&rft.date=2021-01-12&rft.issn=2045-2322&rft.eissn=2045-2322&rft.volume=11&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-020-79414-8&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41598_020_79414_8 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |