Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1

CDX1 is a transcription factor that plays a key role in intestinal development and differentiation. However, the downstream targets of CDX1 are less well defined than those of its close homologue, CDX2. We report here the identification of downstream targets of CDX1 using microarray gene-expression...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 106; číslo 6; s. 1936
Hlavní autoři:	Chan, Carol W M, Wong, Newton A, Liu, Ying, Bicknell, David, Turley, Helen, Hollins, Laura, Miller, Crispin J, Wilding, Jennifer L, Bodmer, Walter F
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 10.02.2009
Témata:	Binding Sites Cell Line, Tumor Colorectal Neoplasms - etiology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Gastrointestinal Tract Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes, Homeobox - physiology Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humans Keratin-20 - genetics Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic
ISSN:	1091-6490, 1091-6490
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