The GLP-1 analog liraglutide attenuates acute liver injury in mice
Acute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of the glucagon-like peptide-1 analog liraglutide against carbon tetrachloride (CCl4)-induced hepatotoxicity. Male Swiss mice were subjected to two...
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| Published in: | Annals of hepatology Vol. 18; no. 6; pp. 918 - 928 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Mexico
Elsevier España, S.L.U
01.11.2019
Elsevier |
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| ISSN: | 1665-2681, 2659-5982 |
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| Abstract | Acute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of the glucagon-like peptide-1 analog liraglutide against carbon tetrachloride (CCl4)-induced hepatotoxicity.
Male Swiss mice were subjected to two protocols. The first protocol (Pretreatment) consisted of intraperitoneal (i.p.) treatment with liraglutide (0.057 and 0.118mgkg−1) or vehicle (distilled water) once daily for 7 days. On days 6 and 7, the animals were challenged with 2% CCl4 (5mgkg−1, i.p.). The second protocol (Late treatment) began with an injection of 5% CCl4 (5mgkg−1, i.p.) and subsequent treatment with liraglutide (0.057mgkg−1) or vehicle (distilled water) for 1 day. In both protocols, 24h after the last administration, blood and bile were collected from anesthetized animals, followed by euthanasia and liver collection. Plasma and bile underwent biochemical analyses, and histological, oxidative stress, and metabolic parameters were evaluated in the liver.
Both liraglutide treatment protocols attenuated hepatotoxicity that was induced by CCl4, decreasing plasma levels of hepatic enzymes, stimulating the hepatic antioxidant system, and decreasing centrilobular necrosis, hepatic glycogen, and lipid accumulation. CCl4 tended to reduce bile lipid excretion, but liraglutide did not influence this parameter.
The present results demonstrated the hepatoprotective and therapeutic effects of liraglutide, which may be attributable to a decrease in liver oxidative stress and the preservation of metabolism. Liraglutide may have potential as a complementary therapy for acute liver injury. |
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| AbstractList | Acute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of the glucagon-like peptide-1 analog liraglutide against carbon tetrachloride (CCl4)-induced hepatotoxicity.
Male Swiss mice were subjected to two protocols. The first protocol (Pretreatment) consisted of intraperitoneal (i.p.) treatment with liraglutide (0.057 and 0.118mgkg−1) or vehicle (distilled water) once daily for 7 days. On days 6 and 7, the animals were challenged with 2% CCl4 (5mgkg−1, i.p.). The second protocol (Late treatment) began with an injection of 5% CCl4 (5mgkg−1, i.p.) and subsequent treatment with liraglutide (0.057mgkg−1) or vehicle (distilled water) for 1 day. In both protocols, 24h after the last administration, blood and bile were collected from anesthetized animals, followed by euthanasia and liver collection. Plasma and bile underwent biochemical analyses, and histological, oxidative stress, and metabolic parameters were evaluated in the liver.
Both liraglutide treatment protocols attenuated hepatotoxicity that was induced by CCl4, decreasing plasma levels of hepatic enzymes, stimulating the hepatic antioxidant system, and decreasing centrilobular necrosis, hepatic glycogen, and lipid accumulation. CCl4 tended to reduce bile lipid excretion, but liraglutide did not influence this parameter.
The present results demonstrated the hepatoprotective and therapeutic effects of liraglutide, which may be attributable to a decrease in liver oxidative stress and the preservation of metabolism. Liraglutide may have potential as a complementary therapy for acute liver injury. Acute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of the glucagon-like peptide-1 analog liraglutide against carbon tetrachloride (CCl4)-induced hepatotoxicity.INTRODUCTION AND OBJECTIVESAcute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of the glucagon-like peptide-1 analog liraglutide against carbon tetrachloride (CCl4)-induced hepatotoxicity.Male Swiss mice were subjected to two protocols. The first protocol (Pretreatment) consisted of intraperitoneal (i.p.) treatment with liraglutide (0.057 and 0.118mgkg-1) or vehicle (distilled water) once daily for 7 days. On days 6 and 7, the animals were challenged with 2% CCl4 (5mgkg-1, i.p.). The second protocol (Late treatment) began with an injection of 5% CCl4 (5mgkg-1, i.p.) and subsequent treatment with liraglutide (0.057mgkg-1) or vehicle (distilled water) for 1 day. In both protocols, 24h after the last administration, blood and bile were collected from anesthetized animals, followed by euthanasia and liver collection. Plasma and bile underwent biochemical analyses, and histological, oxidative stress, and metabolic parameters were evaluated in the liver.MATERIALS AND METHODSMale Swiss mice were subjected to two protocols. The first protocol (Pretreatment) consisted of intraperitoneal (i.p.) treatment with liraglutide (0.057 and 0.118mgkg-1) or vehicle (distilled water) once daily for 7 days. On days 6 and 7, the animals were challenged with 2% CCl4 (5mgkg-1, i.p.). The second protocol (Late treatment) began with an injection of 5% CCl4 (5mgkg-1, i.p.) and subsequent treatment with liraglutide (0.057mgkg-1) or vehicle (distilled water) for 1 day. In both protocols, 24h after the last administration, blood and bile were collected from anesthetized animals, followed by euthanasia and liver collection. Plasma and bile underwent biochemical analyses, and histological, oxidative stress, and metabolic parameters were evaluated in the liver.Both liraglutide treatment protocols attenuated hepatotoxicity that was induced by CCl4, decreasing plasma levels of hepatic enzymes, stimulating the hepatic antioxidant system, and decreasing centrilobular necrosis, hepatic glycogen, and lipid accumulation. CCl4 tended to reduce bile lipid excretion, but liraglutide did not influence this parameter.RESULTSBoth liraglutide treatment protocols attenuated hepatotoxicity that was induced by CCl4, decreasing plasma levels of hepatic enzymes, stimulating the hepatic antioxidant system, and decreasing centrilobular necrosis, hepatic glycogen, and lipid accumulation. CCl4 tended to reduce bile lipid excretion, but liraglutide did not influence this parameter.The present results demonstrated the hepatoprotective and therapeutic effects of liraglutide, which may be attributable to a decrease in liver oxidative stress and the preservation of metabolism. Liraglutide may have potential as a complementary therapy for acute liver injury.CONCLUSIONSThe present results demonstrated the hepatoprotective and therapeutic effects of liraglutide, which may be attributable to a decrease in liver oxidative stress and the preservation of metabolism. Liraglutide may have potential as a complementary therapy for acute liver injury. AbstractIntroduction and objectivesAcute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of the glucagon-like peptide-1 analog liraglutide against carbon tetrachloride (CCl 4)-induced hepatotoxicity. Materials and methodsMale Swiss mice were subjected to two protocols. The first protocol (Pretreatment) consisted of intraperitoneal (i.p.) treatment with liraglutide (0.057 and 0.118 mg kg −1) or vehicle (distilled water) once daily for 7 days. On days 6 and 7, the animals were challenged with 2% CCl 4 (5 mg kg −1, i.p.). The second protocol (Late treatment) began with an injection of 5% CCl 4 (5 mg kg −1, i.p.) and subsequent treatment with liraglutide (0.057 mg kg −1) or vehicle (distilled water) for 1 day. In both protocols, 24 h after the last administration, blood and bile were collected from anesthetized animals, followed by euthanasia and liver collection. Plasma and bile underwent biochemical analyses, and histological, oxidative stress, and metabolic parameters were evaluated in the liver. ResultsBoth liraglutide treatment protocols attenuated hepatotoxicity that was induced by CCl 4, decreasing plasma levels of hepatic enzymes, stimulating the hepatic antioxidant system, and decreasing centrilobular necrosis, hepatic glycogen, and lipid accumulation. CCl 4 tended to reduce bile lipid excretion, but liraglutide did not influence this parameter. ConclusionsThe present results demonstrated the hepatoprotective and therapeutic effects of liraglutide, which may be attributable to a decrease in liver oxidative stress and the preservation of metabolism. Liraglutide may have potential as a complementary therapy for acute liver injury. Acute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of the glucagon-like peptide-1 analog liraglutide against carbon tetrachloride (CCl )-induced hepatotoxicity. Male Swiss mice were subjected to two protocols. The first protocol (Pretreatment) consisted of intraperitoneal (i.p.) treatment with liraglutide (0.057 and 0.118mgkg ) or vehicle (distilled water) once daily for 7 days. On days 6 and 7, the animals were challenged with 2% CCl (5mgkg , i.p.). The second protocol (Late treatment) began with an injection of 5% CCl (5mgkg , i.p.) and subsequent treatment with liraglutide (0.057mgkg ) or vehicle (distilled water) for 1 day. In both protocols, 24h after the last administration, blood and bile were collected from anesthetized animals, followed by euthanasia and liver collection. Plasma and bile underwent biochemical analyses, and histological, oxidative stress, and metabolic parameters were evaluated in the liver. Both liraglutide treatment protocols attenuated hepatotoxicity that was induced by CCl , decreasing plasma levels of hepatic enzymes, stimulating the hepatic antioxidant system, and decreasing centrilobular necrosis, hepatic glycogen, and lipid accumulation. CCl tended to reduce bile lipid excretion, but liraglutide did not influence this parameter. The present results demonstrated the hepatoprotective and therapeutic effects of liraglutide, which may be attributable to a decrease in liver oxidative stress and the preservation of metabolism. Liraglutide may have potential as a complementary therapy for acute liver injury. Introduction and objectives: Acute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of the glucagon-like peptide-1 analog liraglutide against carbon tetrachloride (CCl4)-induced hepatotoxicity. Materials and methods: Male Swiss mice were subjected to two protocols. The first protocol (Pretreatment) consisted of intraperitoneal (i.p.) treatment with liraglutide (0.057 and 0.118 mg kg−1) or vehicle (distilled water) once daily for 7 days. On days 6 and 7, the animals were challenged with 2% CCl4 (5 mg kg−1, i.p.). The second protocol (Late treatment) began with an injection of 5% CCl4 (5 mg kg−1, i.p.) and subsequent treatment with liraglutide (0.057 mg kg−1) or vehicle (distilled water) for 1 day. In both protocols, 24 h after the last administration, blood and bile were collected from anesthetized animals, followed by euthanasia and liver collection. Plasma and bile underwent biochemical analyses, and histological, oxidative stress, and metabolic parameters were evaluated in the liver. Results: Both liraglutide treatment protocols attenuated hepatotoxicity that was induced by CCl4, decreasing plasma levels of hepatic enzymes, stimulating the hepatic antioxidant system, and decreasing centrilobular necrosis, hepatic glycogen, and lipid accumulation. CCl4 tended to reduce bile lipid excretion, but liraglutide did not influence this parameter. Conclusions: The present results demonstrated the hepatoprotective and therapeutic effects of liraglutide, which may be attributable to a decrease in liver oxidative stress and the preservation of metabolism. Liraglutide may have potential as a complementary therapy for acute liver injury. |
| Author | Galindo, Claudia M. Milani, Letícia Corso, Claudia Rita Acco, Alexandra Adami, Eliana Rezende Stipp, Maria Carolina Beltrame, Olair Carlos Turin de Oliveira, Natalia Mulinari |
| Author_xml | – sequence: 1 givenname: Letícia surname: Milani fullname: Milani, Letícia organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 2 givenname: Claudia M. surname: Galindo fullname: Galindo, Claudia M. organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 3 givenname: Natalia Mulinari surname: Turin de Oliveira fullname: Turin de Oliveira, Natalia Mulinari organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 4 givenname: Claudia Rita surname: Corso fullname: Corso, Claudia Rita organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 5 givenname: Eliana Rezende surname: Adami fullname: Adami, Eliana Rezende organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 6 givenname: Maria Carolina surname: Stipp fullname: Stipp, Maria Carolina organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 7 givenname: Olair Carlos surname: Beltrame fullname: Beltrame, Olair Carlos organization: Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 8 givenname: Alexandra surname: Acco fullname: Acco, Alexandra email: aleacco@ufpr.br organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31151874$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3390/ijms161226225 10.1016/0003-2697(68)90092-4 10.1007/s00210-016-1330-7 10.1016/bs.acc.2014.11.001 10.3892/ijmm.2013.1453 10.1016/j.bbrc.2017.03.010 10.1016/S0302-4598(98)00072-5 10.1016/j.bbrc.2016.05.086 10.1016/0006-2952(66)90162-6 10.1016/0163-7258(89)90050-8 10.1111/jnc.12469 10.1016/j.jhep.2010.11.006 10.1007/s00216-012-6661-8 10.1006/faat.1993.1120 10.3892/etm.2016.3627 10.1016/S0021-9258(19)42083-8 10.1016/j.jpba.2003.12.019 10.1016/S0021-9258(18)64849-5 10.1016/S1499-3872(13)60092-2 10.1016/j.etap.2013.08.015 10.1016/j.foodchem.2003.09.020 10.1016/j.jchromb.2018.05.020 10.1016/j.yexmp.2018.06.001 10.2165/11635890-000000000-00000 10.1016/j.biopha.2017.06.080 10.1002/hep.1840010511 10.1016/j.toxrep.2015.05.012 10.1016/j.biopha.2017.11.085 10.1016/0014-5793(94)00699-7 10.3164/jcbn.10-35 10.1016/j.freeradbiomed.2013.02.008 10.1016/j.ejphar.2016.02.068 10.1248/bpb.b14-00505 10.1016/S0076-6879(84)05016-3 10.1016/j.diabres.2017.09.006 10.1007/BF02536169 10.1016/0003-2697(76)90527-3 |
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| Keywords | Drug induced liver injury Incretin Oxidative stress Hepatotoxicity CCl4 CCl 4 CCl |
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| References | Lee, Marahatta, Bhandary, Kim, Chae (bib0430) 2016; 777 Weinstein, Dishmon, Helmberg (bib0450) 1966; 15 Bresciani, Cruz, González-Gallego (bib0385) 2015; 68 Gao, Zeng, Zhang, Zhou, Guan, Deng (bib0260) 2015; 38 Gutmann, Wahlefeld (bib0325) 1974 Abdelsameea, Abbas, Raouf (bib0340) 2017; 390 Olaywi, Bhatia, Anand, Singhal (bib0345) 2013; 12 He, Sha, Sun, Zhang, Dong (bib0435) 2016; 476 Jayesh, Helen, Vysakh, Binil, Latha (bib0355) 2017; 93 Czok, Lamprecht (bib0330) 1974 Valverde, Morales, Clemente, López-Delgado, Delgado, Perea (bib0420) 1994; 349 Holscher (bib0255) 2012; 2 Sedlak, Lindsay (bib0285) 1968; 25 Soni, Mehendale (bib0395) 1993; 21 Recknagel, Glende Junior, Dolak, Waller (bib0250) 1989; 43 Bradford (bib0310) 1976; 72 Folch, Lees, Stanley (bib0335) 1957; 226 Coen, Ruepp, Lindon, Nicholson, Pognan, Lenz (bib0400) 2004; 35 Guo, Li, Yang, Li, Wei, Lin (bib0265) 2018; 17 Dong, Gu, Wei, Si, Liu (bib0410) 2018; 1091 Ritesh, Suganya, Dileepkumar, Rajashekar, Shivanandappa (bib0245) 2015; 2 Rubenstein, Rubinstein (bib0445) 1964; 42 Niture, Khatri, Jaiswal (bib0270) 2014; 66 Petit, Cercueil, Loffroy, Denimal, Bouillet, Fourmont (bib0440) 2018; 102 Lu, Zhang, Tang, Zheng, Fan, Zhu (bib0235) 2016; 12 Aebi (bib0305) 1984; 105 Wang, Hou, Huang, Guo, Zhou (bib0350) 2017; 486 Jiang, Woollard, Wolff (bib0290) 1991; 26 Kepler, Decker (bib0320) 1974; vol. 4 Begriche, Massart, Robin, Borgne-Sanchez, Fromenty (bib0405) 2011; 54 Chen, Lyu, Yang, Ji, Yuan, Chen (bib0415) 2013; 32 Chen, Wu, Chen (bib0315) 2004; 86 Alam, Safhi, Anwer, Siddiqui, Khan, Moni (bib0360) 2018; 105 Aralbaeva, Mamataeva, Zhaparkulova, Utegalieva, Khanin, Danilenko (bib0240) 2017; 96 Cao, Waldon, Teffera, Roberts, Wells, Langley (bib0380) 2013; 405 Knodell, Ishak, Black, Chen, Craig, Kaplowitz (bib0280) 1981; 1 Sharma, Jalewa, Hölscher (bib0370) 2014; 128 Habig, Pabst, Jakoby (bib0295) 1974; 249 Pachaly, Brito (bib0275) 2001 Gao, Yuan, Zhao, Gao (bib0300) 1998; 45 Mubarak, Mahmoud, Shoukry, Merzeban, Sayed, Rashed (bib0365) 2018 Chen, Shi, Xu, Lin, Shao, Wu (bib0375) 2017; 137 Ingawalea, Mandlikb, Naik (bib0230) 2004; 37 Andrade, Moura, Santos, Araújo, Santos, Goulart (bib0390) 2015; 16 Yashi, Igarashi, Kiyose (bib0425) 2010; 47 Dong (10.1016/j.aohep.2019.04.011_bib0410) 2018; 1091 Yashi (10.1016/j.aohep.2019.04.011_bib0425) 2010; 47 Abdelsameea (10.1016/j.aohep.2019.04.011_bib0340) 2017; 390 Weinstein (10.1016/j.aohep.2019.04.011_bib0450) 1966; 15 Olaywi (10.1016/j.aohep.2019.04.011_bib0345) 2013; 12 Ingawalea (10.1016/j.aohep.2019.04.011_bib0230) 2004; 37 He (10.1016/j.aohep.2019.04.011_bib0435) 2016; 476 Niture (10.1016/j.aohep.2019.04.011_bib0270) 2014; 66 Chen (10.1016/j.aohep.2019.04.011_bib0415) 2013; 32 Gao (10.1016/j.aohep.2019.04.011_bib0260) 2015; 38 Habig (10.1016/j.aohep.2019.04.011_bib0295) 1974; 249 Wang (10.1016/j.aohep.2019.04.011_bib0350) 2017; 486 Chen (10.1016/j.aohep.2019.04.011_bib0375) 2017; 137 Guo (10.1016/j.aohep.2019.04.011_bib0265) 2018; 17 Knodell (10.1016/j.aohep.2019.04.011_bib0280) 1981; 1 Lu (10.1016/j.aohep.2019.04.011_bib0235) 2016; 12 Sedlak (10.1016/j.aohep.2019.04.011_bib0285) 1968; 25 Aebi (10.1016/j.aohep.2019.04.011_bib0305) 1984; 105 Bradford (10.1016/j.aohep.2019.04.011_bib0310) 1976; 72 Sharma (10.1016/j.aohep.2019.04.011_bib0370) 2014; 128 Coen (10.1016/j.aohep.2019.04.011_bib0400) 2004; 35 Begriche (10.1016/j.aohep.2019.04.011_bib0405) 2011; 54 Holscher (10.1016/j.aohep.2019.04.011_bib0255) 2012; 2 Pachaly (10.1016/j.aohep.2019.04.011_bib0275) 2001 Gutmann (10.1016/j.aohep.2019.04.011_bib0325) 1974 Bresciani (10.1016/j.aohep.2019.04.011_bib0385) 2015; 68 Ritesh (10.1016/j.aohep.2019.04.011_bib0245) 2015; 2 Soni (10.1016/j.aohep.2019.04.011_bib0395) 1993; 21 Recknagel (10.1016/j.aohep.2019.04.011_bib0250) 1989; 43 Alam (10.1016/j.aohep.2019.04.011_bib0360) 2018; 105 Folch (10.1016/j.aohep.2019.04.011_bib0335) 1957; 226 Mubarak (10.1016/j.aohep.2019.04.011_bib0365) 2018 Lee (10.1016/j.aohep.2019.04.011_bib0430) 2016; 777 Jiang (10.1016/j.aohep.2019.04.011_bib0290) 1991; 26 Rubenstein (10.1016/j.aohep.2019.04.011_bib0445) 1964; 42 Petit (10.1016/j.aohep.2019.04.011_bib0440) 2018; 102 Kepler (10.1016/j.aohep.2019.04.011_bib0320) 1974; vol. 4 Cao (10.1016/j.aohep.2019.04.011_bib0380) 2013; 405 Andrade (10.1016/j.aohep.2019.04.011_bib0390) 2015; 16 Aralbaeva (10.1016/j.aohep.2019.04.011_bib0240) 2017; 96 Gao (10.1016/j.aohep.2019.04.011_bib0300) 1998; 45 Jayesh (10.1016/j.aohep.2019.04.011_bib0355) 2017; 93 Valverde (10.1016/j.aohep.2019.04.011_bib0420) 1994; 349 Chen (10.1016/j.aohep.2019.04.011_bib0315) 2004; 86 Czok (10.1016/j.aohep.2019.04.011_bib0330) 1974 |
| References_xml | – volume: 777 start-page: 104 year: 2016 end-page: 112 ident: bib0430 article-title: 4-Phenylbutyric acid regulates CCl publication-title: Eur J Pharmacol – volume: 25 start-page: 1192 year: 1968 end-page: 1205 ident: bib0285 article-title: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent publication-title: Anal Biochem – volume: 390 start-page: 311 year: 2017 end-page: 319 ident: bib0340 article-title: Liraglutide attenuates partial warm ischemia–reperfusion injury in rat livers publication-title: Naunyn Schmiedebergs Arch Pharmacol – volume: 68 start-page: 87 year: 2015 end-page: 130 ident: bib0385 article-title: Manganese superoxide dismutase and oxidative stress modulation publication-title: Adv Clin Chem – volume: 105 start-page: 81 year: 2018 end-page: 88 ident: bib0360 article-title: Therapeutic potential of Vanillylacetone against CCl publication-title: Exp Mol Pathol – start-page: 1446 year: 1974 end-page: 1448 ident: bib0330 article-title: Pyruvate, phosphoenolpyruvate and publication-title: Methods of enzymatic analysis – volume: 86 start-page: 479 year: 2004 end-page: 484 ident: bib0315 article-title: The influence of different treatments on the free radical scavenging activity of burdock and variations of its active components publication-title: Food Chem – volume: 349 start-page: 313 year: 1994 end-page: 316 ident: bib0420 article-title: Glucagon-like peptide 1: a potent glycogenic hormone publication-title: FEBS Lett – volume: 45 start-page: 41 year: 1998 end-page: 45 ident: bib0300 article-title: Mechanism of pyrogallol autoxidation and determination of superoxide dismutase enzyme activity publication-title: Bioelectrochem Bioenergy – volume: 12 start-page: 584 year: 2013 end-page: 588 ident: bib0345 article-title: Novel anti-diabetic agents in non-alcoholic fatty liver disease: a mini-review publication-title: Hepatobiliary Pancreat Dis Int – volume: 42 start-page: 1263 year: 1964 end-page: 1273 ident: bib0445 article-title: The effect of carbon tetrachloride on hepatic lipid metabolism publication-title: Can J Biochem Cell Biol – volume: 102 start-page: 407 year: 2018 end-page: 415 ident: bib0440 article-title: Effect of liraglutide therapy on liver fat content in patients with inadequately controlled type 2 diabetes: the Lira-NAFLD Study publication-title: J Clin Endocrinol Metab – volume: 38 start-page: 694 year: 2015 end-page: 702 ident: bib0260 article-title: The glucagon-like peptide-1 analogue liraglutide inhibits oxidative stress and inflammatory response in the liver of rats with diet-induced non-alcoholic fatty liver disease publication-title: Biol Pharm Bull – volume: 47 start-page: 148 year: 2010 end-page: 154 ident: bib0425 article-title: Protective effects of vitamin E analogs against carbon tetrachloride-induced fatty liver in rats publication-title: J Clin Biochem Nutr – start-page: 1 year: 2018 end-page: 9 ident: bib0365 article-title: Protective effects of melatonin and glucagon-like peptide-1 receptor agonist (liraglutide) on gastric ischaemia-reperfusion injury in high-fat/sucrose-fed rats publication-title: Clin Exp Pharmacol Physiol – volume: 35 start-page: 93 year: 2004 end-page: 105 ident: bib0400 article-title: Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse publication-title: J Pharm Biomed Anal – volume: 17 start-page: 8316 year: 2018 end-page: 8324 ident: bib0265 article-title: Liraglutide reduces hepatic glucolipotoxicity-induced liver cell apoptosis through NRF2 signaling in Zucker diabetic fatty rats publication-title: Mol Med Rep – volume: 12 start-page: 2606 year: 2016 end-page: 2616 ident: bib0235 article-title: Clinical characteristics of drug-induced liver injury and related risk factors publication-title: Exp Ther Med – start-page: 1464 year: 1974 end-page: 1472 ident: bib0325 article-title: -(+)-lactate: determination with lactate dehydrogenase and NAD publication-title: Methods of enzymatic analysis – volume: 21 start-page: 442 year: 1993 end-page: 450 ident: bib0395 article-title: Hepatic failure leads to lethality of chlordecone-amplified hepatotoxicity of carbon tetrachloride publication-title: Fundam Appl Toxicol – volume: 43 start-page: 139 year: 1989 end-page: 154 ident: bib0250 article-title: Mechanisms of carbon tetrachloride toxicity publication-title: Pharmacol Ther – volume: 66 start-page: 36 year: 2014 end-page: 44 ident: bib0270 article-title: Regulation of Nrf2: an update publication-title: Free Radic Biol Med – start-page: 475 year: 2001 end-page: 481 ident: bib0275 article-title: Interspecific allometric scaling publication-title: Biology, medicine, and surgery of South American wild animals – volume: 405 start-page: 2635 year: 2013 end-page: 2642 ident: bib0380 article-title: Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): a potential index to screen drug-induced hepatic oxidative stress in rats and mice publication-title: Anal Bioanal Chem – volume: 137 start-page: 173 year: 2017 end-page: 182 ident: bib0375 article-title: Liraglutide ameliorates early renal injury by the activation of renal FoxO1 in a type 2 diabetic kidney disease rat model publication-title: Diabetes Res Clin Pract – volume: 15 start-page: 851 year: 1966 end-page: 871 ident: bib0450 article-title: Hepatic lipid metabolism in carbon tetrachloride poisoning publication-title: Biochem Pharmacol – volume: 37 start-page: 118 year: 2004 end-page: 133 ident: bib0230 article-title: Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion publication-title: Environ Toxicol Pharmacol – volume: 128 start-page: 459 year: 2014 end-page: 471 ident: bib0370 article-title: Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress publication-title: J Neurochem – volume: 1091 start-page: 29 year: 2018 end-page: 35 ident: bib0410 article-title: Determination of liraglutide in rat plasma by a selective liquid chromatography-tandem mass spectrometry method: application to a pharmacokinetics study publication-title: J Chromatogr B Biomed Sci Appl – volume: 486 start-page: 116 year: 2017 end-page: 123 ident: bib0350 article-title: Exenatide improves liver mitochondrial dysfunction and insulin resistance by reducing oxidative stress in high fat diet-induced obese mice publication-title: Biochem Biophys Res Commun – volume: 72 start-page: 248 year: 1976 end-page: 254 ident: bib0310 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal Biochem – volume: 1 start-page: 431 year: 1981 end-page: 435 ident: bib0280 article-title: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis publication-title: Hepatology – volume: 54 start-page: 773 year: 2011 end-page: 794 ident: bib0405 article-title: Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver publication-title: J Hepatol – volume: 32 start-page: 892 year: 2013 end-page: 900 ident: bib0415 article-title: Liraglutide ameliorates glycometabolism and insulin resistance through the upregulation of GLUT4 in diabetic KKAy mice publication-title: Int J Mol Med – volume: 226 start-page: 497 year: 1957 end-page: 509 ident: bib0335 article-title: A simple method for the isolation and purification of total lipides from animal tissues publication-title: J Biol Chem – volume: 105 start-page: 121 year: 1984 end-page: 126 ident: bib0305 article-title: Catalase in vitro publication-title: Methods Enzymol – volume: 2 start-page: 891 year: 2015 end-page: 895 ident: bib0245 article-title: A single acute hepatotoxic dose of CCl publication-title: Toxicol Rep – volume: 26 start-page: 853 year: 1991 end-page: 856 ident: bib0290 article-title: Lipid hydroperoxide measurement by oxidation of Fe publication-title: Lipids – volume: 249 start-page: 7130 year: 1974 end-page: 7139 ident: bib0295 article-title: Glutathione S-transferases: the first enzymatic step in mercapturic acid formation publication-title: J Biol Chem – volume: 93 start-page: 327 year: 2017 end-page: 333 ident: bib0355 article-title: (Gaertn.) Roxb. fruit mitigates CCl publication-title: Biomed Pharmacother – volume: 96 start-page: 1283 year: 2017 end-page: 1291 ident: bib0240 article-title: A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity publication-title: Biomed Pharmacother – volume: 2 start-page: 871 year: 2012 end-page: 882 ident: bib0255 article-title: Potential role of Glucagon-Like Peptide-1 (GLP-1) in neuroprotection publication-title: CNS Drugs – volume: vol. 4 start-page: 1126 year: 1974 end-page: 1131 ident: bib0320 article-title: Glycogen: determination with amyloglucosidase publication-title: Methods of Enzymatic Analysis – volume: 476 start-page: 196 year: 2016 end-page: 203 ident: bib0435 article-title: GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway publication-title: Biochem Biophys Res Commun – volume: 16 start-page: 30269 year: 2015 end-page: 30308 ident: bib0390 article-title: Oxidative stress and inflammation in hepatic diseases: therapeutic possibilities of N-acetylcysteine publication-title: Int J Mol Sci – volume: 16 start-page: 30269 year: 2015 ident: 10.1016/j.aohep.2019.04.011_bib0390 article-title: Oxidative stress and inflammation in hepatic diseases: therapeutic possibilities of N-acetylcysteine publication-title: Int J Mol Sci doi: 10.3390/ijms161226225 – volume: 25 start-page: 1192 year: 1968 ident: 10.1016/j.aohep.2019.04.011_bib0285 article-title: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent publication-title: Anal Biochem doi: 10.1016/0003-2697(68)90092-4 – volume: 390 start-page: 311 year: 2017 ident: 10.1016/j.aohep.2019.04.011_bib0340 article-title: Liraglutide attenuates partial warm ischemia–reperfusion injury in rat livers publication-title: Naunyn Schmiedebergs Arch Pharmacol doi: 10.1007/s00210-016-1330-7 – volume: 68 start-page: 87 year: 2015 ident: 10.1016/j.aohep.2019.04.011_bib0385 article-title: Manganese superoxide dismutase and oxidative stress modulation publication-title: Adv Clin Chem doi: 10.1016/bs.acc.2014.11.001 – volume: 32 start-page: 892 year: 2013 ident: 10.1016/j.aohep.2019.04.011_bib0415 article-title: Liraglutide ameliorates glycometabolism and insulin resistance through the upregulation of GLUT4 in diabetic KKAy mice publication-title: Int J Mol Med doi: 10.3892/ijmm.2013.1453 – start-page: 1 year: 2018 ident: 10.1016/j.aohep.2019.04.011_bib0365 article-title: Protective effects of melatonin and glucagon-like peptide-1 receptor agonist (liraglutide) on gastric ischaemia-reperfusion injury in high-fat/sucrose-fed rats publication-title: Clin Exp Pharmacol Physiol – volume: 486 start-page: 116 year: 2017 ident: 10.1016/j.aohep.2019.04.011_bib0350 article-title: Exenatide improves liver mitochondrial dysfunction and insulin resistance by reducing oxidative stress in high fat diet-induced obese mice publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2017.03.010 – volume: 45 start-page: 41 year: 1998 ident: 10.1016/j.aohep.2019.04.011_bib0300 article-title: Mechanism of pyrogallol autoxidation and determination of superoxide dismutase enzyme activity publication-title: Bioelectrochem Bioenergy doi: 10.1016/S0302-4598(98)00072-5 – volume: 476 start-page: 196 year: 2016 ident: 10.1016/j.aohep.2019.04.011_bib0435 article-title: GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2016.05.086 – volume: 102 start-page: 407 year: 2018 ident: 10.1016/j.aohep.2019.04.011_bib0440 article-title: Effect of liraglutide therapy on liver fat content in patients with inadequately controlled type 2 diabetes: the Lira-NAFLD Study publication-title: J Clin Endocrinol Metab – volume: 15 start-page: 851 year: 1966 ident: 10.1016/j.aohep.2019.04.011_bib0450 article-title: Hepatic lipid metabolism in carbon tetrachloride poisoning publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(66)90162-6 – volume: 17 start-page: 8316 year: 2018 ident: 10.1016/j.aohep.2019.04.011_bib0265 article-title: Liraglutide reduces hepatic glucolipotoxicity-induced liver cell apoptosis through NRF2 signaling in Zucker diabetic fatty rats publication-title: Mol Med Rep – volume: 42 start-page: 1263 year: 1964 ident: 10.1016/j.aohep.2019.04.011_bib0445 article-title: The effect of carbon tetrachloride on hepatic lipid metabolism publication-title: Can J Biochem Cell Biol – volume: 43 start-page: 139 year: 1989 ident: 10.1016/j.aohep.2019.04.011_bib0250 article-title: Mechanisms of carbon tetrachloride toxicity publication-title: Pharmacol Ther doi: 10.1016/0163-7258(89)90050-8 – volume: 128 start-page: 459 year: 2014 ident: 10.1016/j.aohep.2019.04.011_bib0370 article-title: Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress publication-title: J Neurochem doi: 10.1111/jnc.12469 – volume: 54 start-page: 773 year: 2011 ident: 10.1016/j.aohep.2019.04.011_bib0405 article-title: Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver publication-title: J Hepatol doi: 10.1016/j.jhep.2010.11.006 – volume: 405 start-page: 2635 year: 2013 ident: 10.1016/j.aohep.2019.04.011_bib0380 article-title: Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): a potential index to screen drug-induced hepatic oxidative stress in rats and mice publication-title: Anal Bioanal Chem doi: 10.1007/s00216-012-6661-8 – volume: 21 start-page: 442 year: 1993 ident: 10.1016/j.aohep.2019.04.011_bib0395 article-title: Hepatic failure leads to lethality of chlordecone-amplified hepatotoxicity of carbon tetrachloride publication-title: Fundam Appl Toxicol doi: 10.1006/faat.1993.1120 – volume: 12 start-page: 2606 year: 2016 ident: 10.1016/j.aohep.2019.04.011_bib0235 article-title: Clinical characteristics of drug-induced liver injury and related risk factors publication-title: Exp Ther Med doi: 10.3892/etm.2016.3627 – volume: vol. 4 start-page: 1126 year: 1974 ident: 10.1016/j.aohep.2019.04.011_bib0320 article-title: Glycogen: determination with amyloglucosidase – start-page: 1464 year: 1974 ident: 10.1016/j.aohep.2019.04.011_bib0325 article-title: L-(+)-lactate: determination with lactate dehydrogenase and NAD – volume: 249 start-page: 7130 year: 1974 ident: 10.1016/j.aohep.2019.04.011_bib0295 article-title: Glutathione S-transferases: the first enzymatic step in mercapturic acid formation publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)42083-8 – volume: 35 start-page: 93 year: 2004 ident: 10.1016/j.aohep.2019.04.011_bib0400 article-title: Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse publication-title: J Pharm Biomed Anal doi: 10.1016/j.jpba.2003.12.019 – volume: 226 start-page: 497 year: 1957 ident: 10.1016/j.aohep.2019.04.011_bib0335 article-title: A simple method for the isolation and purification of total lipides from animal tissues publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)64849-5 – volume: 12 start-page: 584 year: 2013 ident: 10.1016/j.aohep.2019.04.011_bib0345 article-title: Novel anti-diabetic agents in non-alcoholic fatty liver disease: a mini-review publication-title: Hepatobiliary Pancreat Dis Int doi: 10.1016/S1499-3872(13)60092-2 – volume: 37 start-page: 118 year: 2004 ident: 10.1016/j.aohep.2019.04.011_bib0230 article-title: Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion publication-title: Environ Toxicol Pharmacol doi: 10.1016/j.etap.2013.08.015 – volume: 86 start-page: 479 year: 2004 ident: 10.1016/j.aohep.2019.04.011_bib0315 article-title: The influence of different treatments on the free radical scavenging activity of burdock and variations of its active components publication-title: Food Chem doi: 10.1016/j.foodchem.2003.09.020 – volume: 1091 start-page: 29 year: 2018 ident: 10.1016/j.aohep.2019.04.011_bib0410 article-title: Determination of liraglutide in rat plasma by a selective liquid chromatography-tandem mass spectrometry method: application to a pharmacokinetics study publication-title: J Chromatogr B Biomed Sci Appl doi: 10.1016/j.jchromb.2018.05.020 – volume: 105 start-page: 81 year: 2018 ident: 10.1016/j.aohep.2019.04.011_bib0360 article-title: Therapeutic potential of Vanillylacetone against CCl4 induced hepatotoxicity by suppressing the serum marker, oxidative stress, inflammatory cytokines and apoptosis in Swiss albino mice publication-title: Exp Mol Pathol doi: 10.1016/j.yexmp.2018.06.001 – volume: 2 start-page: 871 year: 2012 ident: 10.1016/j.aohep.2019.04.011_bib0255 article-title: Potential role of Glucagon-Like Peptide-1 (GLP-1) in neuroprotection publication-title: CNS Drugs doi: 10.2165/11635890-000000000-00000 – volume: 93 start-page: 327 year: 2017 ident: 10.1016/j.aohep.2019.04.011_bib0355 article-title: Terminalia bellirica (Gaertn.) Roxb. fruit mitigates CCl4 induced oxidative stress and hepatotoxicity in rats publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2017.06.080 – start-page: 1446 year: 1974 ident: 10.1016/j.aohep.2019.04.011_bib0330 article-title: Pyruvate, phosphoenolpyruvate and d-glycerate-2-phosphate – volume: 1 start-page: 431 year: 1981 ident: 10.1016/j.aohep.2019.04.011_bib0280 article-title: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis publication-title: Hepatology doi: 10.1002/hep.1840010511 – volume: 2 start-page: 891 year: 2015 ident: 10.1016/j.aohep.2019.04.011_bib0245 article-title: A single acute hepatotoxic dose of CCl4 causes oxidative stress in the rat brain publication-title: Toxicol Rep doi: 10.1016/j.toxrep.2015.05.012 – volume: 96 start-page: 1283 year: 2017 ident: 10.1016/j.aohep.2019.04.011_bib0240 article-title: A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2017.11.085 – volume: 349 start-page: 313 year: 1994 ident: 10.1016/j.aohep.2019.04.011_bib0420 article-title: Glucagon-like peptide 1: a potent glycogenic hormone publication-title: FEBS Lett doi: 10.1016/0014-5793(94)00699-7 – volume: 47 start-page: 148 year: 2010 ident: 10.1016/j.aohep.2019.04.011_bib0425 article-title: Protective effects of vitamin E analogs against carbon tetrachloride-induced fatty liver in rats publication-title: J Clin Biochem Nutr doi: 10.3164/jcbn.10-35 – volume: 66 start-page: 36 year: 2014 ident: 10.1016/j.aohep.2019.04.011_bib0270 article-title: Regulation of Nrf2: an update publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2013.02.008 – start-page: 475 year: 2001 ident: 10.1016/j.aohep.2019.04.011_bib0275 article-title: Interspecific allometric scaling – volume: 777 start-page: 104 year: 2016 ident: 10.1016/j.aohep.2019.04.011_bib0430 article-title: 4-Phenylbutyric acid regulates CCl4-induced acute hepatic dyslipidemia in a mouse model: a mechanism-based PK/PD study publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2016.02.068 – volume: 38 start-page: 694 year: 2015 ident: 10.1016/j.aohep.2019.04.011_bib0260 article-title: The glucagon-like peptide-1 analogue liraglutide inhibits oxidative stress and inflammatory response in the liver of rats with diet-induced non-alcoholic fatty liver disease publication-title: Biol Pharm Bull doi: 10.1248/bpb.b14-00505 – volume: 105 start-page: 121 year: 1984 ident: 10.1016/j.aohep.2019.04.011_bib0305 article-title: Catalase in vitro publication-title: Methods Enzymol doi: 10.1016/S0076-6879(84)05016-3 – volume: 137 start-page: 173 year: 2017 ident: 10.1016/j.aohep.2019.04.011_bib0375 article-title: Liraglutide ameliorates early renal injury by the activation of renal FoxO1 in a type 2 diabetic kidney disease rat model publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2017.09.006 – volume: 26 start-page: 853 year: 1991 ident: 10.1016/j.aohep.2019.04.011_bib0290 article-title: Lipid hydroperoxide measurement by oxidation of Fe2+ in the presence of xylenol orange. Comparison with the TBA Assay and an Iodometric Method publication-title: Lipids doi: 10.1007/BF02536169 – volume: 72 start-page: 248 year: 1976 ident: 10.1016/j.aohep.2019.04.011_bib0310 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal Biochem doi: 10.1016/0003-2697(76)90527-3 |
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| Snippet | Acute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective and curative potential of the... AbstractIntroduction and objectivesAcute liver injury is a current health problem with few effective treatments. The present study investigated the... Introduction and objectives: Acute liver injury is a current health problem with few effective treatments. The present study investigated the hepatoprotective... |
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| SubjectTerms | CCl4 Drug induced liver injury Gastroenterology and Hepatology Hepatotoxicity Incretin Oxidative stress |
| Title | The GLP-1 analog liraglutide attenuates acute liver injury in mice |
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