Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, we identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, and find focal amplifications in the GCA cohort are associated with the chromothripsis proce...

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Veröffentlicht in:	Nature communications Jg. 12; H. 1; S. 6489 - 14
Hauptverfasser:	Zhao, Xue-Ke, Xing, Pengwei, Song, Xin, Zhao, Miao, Zhao, Linxuan, Dang, Yonglong, Lei, Ling-Ling, Xu, Rui-Hua, Han, Wen-Li, Wang, Pan-Pan, Yang, Miao-Miao, Hu, Jing-Feng, Zhong, Kan, Zhou, Fu-You, Han, Xue-Na, Meng, Chao-Long, Ji, Jia-Jia, Chen, Xingqi, Wang, Li-Dong
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 11.11.2021 Nature Publishing Group Nature Portfolio
Schlagworte:	45 45/23 45/43 631/208/69 692/4017 692/53/2423 692/699/1503/1504/1829 Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Cancer Chromosomal Instability - genetics Chromosomal Instability - physiology Chromothripsis Correlation Damage accumulation Deoxyribonucleic acid DNA DNA damage DNA Methylation - genetics ErbB-2 protein Humanities and Social Sciences Humans Immunohistochemistry Medical prognosis multidisciplinary Patients Prognosis Science Science (multidisciplinary) Stomach Neoplasms - genetics Stomach Neoplasms - pathology Survival
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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