Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition

Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from SARS-CoV-2, based on reported 3D structures and glycomics data for the protein produced in HEK293 cells. We also analyze structures for glycoforms representing those present in the nascent glycoproteins (prior to e...

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Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; p. 14991
Main Authors:	Grant, Oliver C., Montgomery, David, Ito, Keigo, Woods, Robert J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.09.2020 Nature Publishing Group
Subjects:	631/114/2411 631/250 ACE2 Adaptive Immunity Amino Acid Sequence Angiotensin-Converting Enzyme 2 Antibodies, Neutralizing - immunology Antigen-Antibody Complex Betacoronavirus - immunology Betacoronavirus - isolation & purification Betacoronavirus - metabolism Binding Sites Cadmium Coronavirus Infections - immunology Coronavirus Infections - pathology Coronavirus Infections - virology COVID-19 Fourier analysis Glycoproteins Glycosylation HEK293 Cells HLA Antigens - metabolism Humanities and Social Sciences Humans Immune response Immunity, Innate Molecular Dynamics Simulation multidisciplinary Nanotechnology Pandemics Peptides Peptidyl-Dipeptidase A - chemistry Peptidyl-Dipeptidase A - metabolism Physicochemical properties Pneumonia, Viral - immunology Pneumonia, Viral - pathology Pneumonia, Viral - virology Polysaccharides - chemistry Protein Binding Protein Structure, Tertiary SARS-CoV-2 Scanning electron microscopy Science Science (multidisciplinary) Sensors Sequence Alignment Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism Transmission electron microscopy X-ray diffraction
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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