The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci

UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3’UTRs of mRNAs that are directed for NMD in the cytoplasm. Here we offer evidence, obtained from Drosophila, that UPF1 constantly moves between...

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Published in:eLife Vol. 8
Main Authors: Singh, Anand K, Choudhury, Subhendu Roy, De, Sandip, Zhang, Jie, Kissane, Stephen, Dwivedi, Vibha, Ramanathan, Preethi, Petric, Marija, Orsini, Luisa, Hebenstreit, Daniel, Brogna, Saverio
Format: Journal Article
Language:English
Published: England eLife Science Publications, Ltd 25.03.2019
eLife Sciences Publications Ltd
eLife Sciences Publications, Ltd
Subjects:
Animals
Cell division
Chromosomes
Chromosomes and Gene Expression
Cytoplasm
DNA helicase
Drosophila
Drosophila Proteins - metabolism
Gene expression
Genes
Genomes
Genomics
Insects
Messenger RNA
mRNA export
mRNA turnover
NMD
Nonsense-mediated mRNA decay
Observations
Peptides
Physiological aspects
Polytene
Polytene chromosomes
Proteins
Quantitative trait loci
RNA
RNA helicase
RNA helicases
RNA Helicases - metabolism
RNA, Messenger - metabolism
Salivary gland
Scripts
splicing
Transcription
Transcription (Genetics)
Transcription, Genetic
United States
United States > US
mRNA export
polytene chromosomes
NMD
RNA helicases
Transcription
chromosomes
splicing
D. melanogaster
gene expression
ISSN:2050-084X, 2050-084X
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Abstract UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3’UTRs of mRNAs that are directed for NMD in the cytoplasm. Here we offer evidence, obtained from Drosophila, that UPF1 constantly moves between the nucleus and cytoplasm by a mechanism that requires its RNA helicase activity. UPF1 is associated, genome-wide, with nascent RNAs at most of the active Pol II transcription sites and at some Pol III-transcribed genes, as demonstrated microscopically on the polytene chromosomes of salivary glands and by ChIP-seq analysis in S2 cells. Intron recognition seems to interfere with association and translocation of UPF1 on nascent pre-mRNAs, and cells depleted of UPF1 show defects in the release of mRNAs from transcription sites and their export from the nucleus.
AbstractList UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3’UTRs of mRNAs that are directed for NMD in the cytoplasm. Here we offer evidence, obtained from Drosophila, that UPF1 constantly moves between the nucleus and cytoplasm by a mechanism that requires its RNA helicase activity. UPF1 is associated, genome-wide, with nascent RNAs at most of the active Pol II transcription sites and at some Pol III-transcribed genes, as demonstrated microscopically on the polytene chromosomes of salivary glands and by ChIP-seq analysis in S2 cells. Intron recognition seems to interfere with association and translocation of UPF1 on nascent pre-mRNAs, and cells depleted of UPF1 show defects in the release of mRNAs from transcription sites and their export from the nucleus.
UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3'UTRs of mRNAs that are directed for NMD in the cytoplasm. Here we offer evidence, obtained from Drosophila, that UPF1 constantly moves between the nucleus and cytoplasm by a mechanism that requires its RNA helicase activity. UPF1 is associated, genome-wide, with nascent RNAs at most of the active Pol II transcription sites and at some Pol III-transcribed genes, as demonstrated microscopically on the polytene chromosomes of salivary glands and by ChIP-seq analysis in S2 cells. Intron recognition seems to interfere with association and translocation of UPF1 on nascent pre-mRNAs, and cells depleted of UPF1 show defects in the release of mRNAs from transcription sites and their export from the nucleus.UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3'UTRs of mRNAs that are directed for NMD in the cytoplasm. Here we offer evidence, obtained from Drosophila, that UPF1 constantly moves between the nucleus and cytoplasm by a mechanism that requires its RNA helicase activity. UPF1 is associated, genome-wide, with nascent RNAs at most of the active Pol II transcription sites and at some Pol III-transcribed genes, as demonstrated microscopically on the polytene chromosomes of salivary glands and by ChIP-seq analysis in S2 cells. Intron recognition seems to interfere with association and translocation of UPF1 on nascent pre-mRNAs, and cells depleted of UPF1 show defects in the release of mRNAs from transcription sites and their export from the nucleus.
UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the 3'UTRs of mRNAs that are directed for NMD in the cytoplasm. Here we offer evidence, obtained from , that UPF1 constantly moves between the nucleus and cytoplasm by a mechanism that requires its RNA helicase activity. UPF1 is associated, genome-wide, with nascent RNAs at most of the active Pol II transcription sites and at some Pol III-transcribed genes, as demonstrated microscopically on the polytene chromosomes of salivary glands and by ChIP-seq analysis in S2 cells. Intron recognition seems to interfere with association and translocation of UPF1 on nascent pre-mRNAs, and cells depleted of UPF1 show defects in the release of mRNAs from transcription sites and their export from the nucleus.
Audience Academic
Author Brogna, Saverio
Choudhury, Subhendu Roy
De, Sandip
Dwivedi, Vibha
Petric, Marija
Singh, Anand K
Orsini, Luisa
Zhang, Jie
Hebenstreit, Daniel
Kissane, Stephen
Ramanathan, Preethi
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  organization: School of Biosciences, University of Birmingham, Birmingham, United Kingdom
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  surname: Zhang
  fullname: Zhang, Jie
  organization: Life Sciences, University of Warwick, Coventry, United Kingdom
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  surname: Kissane
  fullname: Kissane, Stephen
  organization: School of Biosciences, University of Birmingham, Birmingham, United Kingdom
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  organization: School of Biosciences, University of Birmingham, Birmingham, United Kingdom
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30907728$$D View this record in MEDLINE/PubMed
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Keywords mRNA export
polytene chromosomes
NMD
RNA helicases
Transcription
chromosomes
splicing
D. melanogaster
gene expression
Language English
License http://creativecommons.org/licenses/by/4.0
2019, Singh et al.
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SSID ssj0000748819
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Snippet UPF1 is an RNA helicase that is required for nonsense-mediated mRNA decay (NMD) in eukaryotes, and the predominant view is that UPF1 mainly operates on the...
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SubjectTerms Animals
Cell division
Chromosomes
Chromosomes and Gene Expression
Cytoplasm
DNA helicase
Drosophila
Drosophila Proteins - metabolism
Gene expression
Genes
Genomes
Genomics
Insects
Messenger RNA
mRNA export
mRNA turnover
NMD
Nonsense-mediated mRNA decay
Observations
Peptides
Physiological aspects
Polytene
Polytene chromosomes
Proteins
Quantitative trait loci
RNA
RNA helicase
RNA helicases
RNA Helicases - metabolism
RNA, Messenger - metabolism
Salivary gland
Scripts
splicing
Transcription
Transcription (Genetics)
Transcription, Genetic
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Title The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci
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