Endothelin signalling mediates experience-dependent myelination in the CNS

Experience and changes in neuronal activity can alter CNS myelination, but the signalling pathways responsible remain poorly understood. Here we define a pathway in which endothelin, signalling through the G protein-coupled receptor endothelin receptor B and PKC epsilon, regulates the number of myel...

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Bibliographic Details
Published in:	eLife Vol. 8
Main Authors:	Swire, Matthew, Kotelevtsev, Yuri, Webb, David J, Lyons, David A, ffrench-Constant, Charles
Format:	Journal Article
Language:	English
Published:	England eLife Science Publications, Ltd 28.10.2019 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Subjects:	Animals Cellular signal transduction Containers Deoxyribonucleic acid DNA Endothelin Endothelins Endothelins - metabolism G proteins Hypotheses Kinases Medical research Membrane proteins Mice Myelin Sheath - metabolism Myelination Neural circuitry Neurons Neuroscience Neurosciences Novels Observations Oligodendrocytes Oligodendroglia - metabolism Phenotypes Physiological aspects Prefrontal cortex Prefrontal Cortex - physiology Protein kinase C Protein Kinase C-epsilon - metabolism Receptor, Endothelin B - metabolism Signal Transduction Social interactions Social isolation Software Zebrafish United States United Kingdom > UK endothelin mouse rat neuroscience myelination oligodendrocytes zebrafish
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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