A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma

We previously used a pulse-based in vitro assay to unveil targetable signalling pathways associated with innate cisplatin resistance in lung adenocarcinoma (Hastings et al., 2020). Here, we advanced this model system and identified a non-genetic mechanism of resistance that drives recovery and regro...

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Veröffentlicht in:	eLife Jg. 10
Hauptverfasser:	Gonzalez Rajal, Alvaro, Marzec, Kamila A, McCloy, Rachael A, Nobis, Max, Chin, Venessa, Hastings, Jordan F, Lai, Kaitao, Kennerson, Marina, Hughes, William E, Vaghjiani, Vijesh, Timpson, Paul, Cain, Jason E, Watkins, D Neil, Croucher, David R, Burgess, Andrew
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Science Publications, Ltd 13.05.2021 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Schlagworte:	53BP1 Adenocarcinoma Biosensors BRCA1 Cancer Biology Cancer therapies Carboplatin Cell Biology Cell cycle Cisplatin Cyclin-dependent kinases Deoxyribonucleic acid DNA DNA damage DNA repair Flow cytometry G2 phase Kinases Lung cancer mitosis Ovaries PARP1 Poly(ADP-ribose) polymerase Research Advance S phase Senescence Signal transduction Testicular cancer Fiji human cancer biology cell biology
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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