Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

Active targeting and specific drug delivery to parenchymal liver cells is a promising strategy to treat various liver disorders. Here, we modified synthetic lipid-based nanoparticles with targeting peptides derived from the hepatitis B virus large envelope protein (HBVpreS) to specifically target th...

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Veröffentlicht in:	eLife Jg. 8
Hauptverfasser:	Witzigmann, Dominik, Uhl, Philipp, Sieber, Sandro, Kaufman, Christina, Einfalt, Tomaz, Schöneweis, Katrin, Grossen, Philip, Buck, Jonas, Ni, Yi, Schenk, Susanne H, Hussner, Janine, Meyer zu Schwabedissen, Henriette E, Québatte, Gabriela, Mier, Walter, Urban, Stephan, Huwyler, Jörg
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Science Publications, Ltd 23.07.2019 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Schlagworte:	Animals Biochemistry and Chemical Biology Drug Carriers - administration & dosage Drug delivery Drug delivery systems Drug Delivery Systems - methods Drug dosages Fluorescence Fluorescence microscopy Hepatitis Hepatitis B Hepatitis B Surface Antigens - administration & dosage Hepatitis B virus hepatocyte targeting Hepatocytes Internalization Ligands Lipids liposomes Liposomes - administration & dosage Liver Liver - diagnostic imaging Liver diseases Microbiology and Infectious Disease Microscopy Myrcludex B nanocarriers Nanoparticles NTCP Optimization Organic Anion Transporters, Sodium-Dependent - administration & dosage Organic Anion Transporters, Sodium-Dependent - pharmacokinetics Peptides Pharmaceutical sciences Pharmacokinetics Physicochemical properties Polypeptides Production processes Proteins Radionuclide Imaging Scintigraphy Sodium Statistical analysis Symporters - administration & dosage Symporters - pharmacokinetics Technology application Variance analysis Veins & arteries Viral envelope proteins Zebrafish United States Heidelberg Germany Basel Switzerland Switzerland Germany hepatocyte targeting rat liposomes hepatitis B virus nanocarriers microbiology mouse chemical biology Myrcludex B infectious disease NTCP biochemistry zebrafish
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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