Feedback inhibition underlies new computational functions of cerebellar interneurons

The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in th...

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Veröffentlicht in:eLife Jg. 11
Hauptverfasser: Halverson, Hunter E, Kim, Jinsook, Khilkevich, Andrei, Mauk, Michael D, Augustine, George J
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England eLife Science Publications, Ltd 08.12.2022
eLife Sciences Publications Ltd
eLife Sciences Publications, Ltd
Schlagworte:
Analysis
Biological research
Biology, Experimental
Brain slice preparation
cerebellar learning
Cerebellum
Cerebellum - physiology
Computational neuroscience
disinhibition
Eyelid
Eyelids
Feedback
feedback circuit
Feedback inhibition
Genetics
Information processing
Information storage
Interneurons
Interneurons - physiology
Mathematical models
molecular layer interneurons
Neural recording
Neurons
Neuroscience
Optics
Purkinje cells
Purkinje Cells - physiology
Transgenic animals
United Kingdom
molecular layer interneurons
mouse
neuroscience
feedback circuit
rabbit
cerebellar learning
disinhibition
ISSN:2050-084X, 2050-084X
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Abstract The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in the inner third of the molecular layer. This inhibition is non-reciprocal, short-range (less than 200 μm) and is based on convergence of one to two Purkinje cells onto MLIs. During learning-related eyelid movements in vivo, the activity of a subset of MLIs progressively increases as Purkinje cell activity decreases, with Purkinje cells usually leading the MLIs. Computer simulations indicate that these relationships are best explained by the feedback circuit from Purkinje cells to MLIs and that this feedback circuit plays a central role in making cerebellar learning efficient.
AbstractList The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in the inner third of the molecular layer. This inhibition is non-reciprocal, short-range (less than 200 μm) and is based on convergence of one to two Purkinje cells onto MLIs. During learning-related eyelid movements in vivo, the activity of a subset of MLIs progressively increases as Purkinje cell activity decreases, with Purkinje cells usually leading the MLIs. Computer simulations indicate that these relationships are best explained by the feedback circuit from Purkinje cells to MLIs and that this feedback circuit plays a central role in making cerebellar learning efficient.The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in the inner third of the molecular layer. This inhibition is non-reciprocal, short-range (less than 200 μm) and is based on convergence of one to two Purkinje cells onto MLIs. During learning-related eyelid movements in vivo, the activity of a subset of MLIs progressively increases as Purkinje cell activity decreases, with Purkinje cells usually leading the MLIs. Computer simulations indicate that these relationships are best explained by the feedback circuit from Purkinje cells to MLIs and that this feedback circuit plays a central role in making cerebellar learning efficient.
The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in the inner third of the molecular layer. This inhibition is non-reciprocal, short-range (less than 200 μm) and is based on convergence of one to two Purkinje cells onto MLIs. During learning-related eyelid movements in vivo, the activity of a subset of MLIs progressively increases as Purkinje cell activity decreases, with Purkinje cells usually leading the MLIs. Computer simulations indicate that these relationships are best explained by the feedback circuit from Purkinje cells to MLIs and that this feedback circuit plays a central role in making cerebellar learning efficient.
The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in the inner third of the molecular layer. This inhibition is non-reciprocal, short-range (less than 200 [mu]m) and is based on convergence of one to two Purkinje cells onto MLIs. During learning-related eyelid movements in vivo, the activity of a subset of MLIs progressively increases as Purkinje cell activity decreases, with Purkinje cells usually leading the MLIs. Computer simulations indicate that these relationships are best explained by the feedback circuit from Purkinje cells to MLIs and that this feedback circuit plays a central role in making cerebellar learning efficient.
Audience Academic
Author Kim, Jinsook
Mauk, Michael D
Khilkevich, Andrei
Augustine, George J
Halverson, Hunter E
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  surname: Halverson
  fullname: Halverson, Hunter E
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  surname: Kim
  fullname: Kim, Jinsook
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  givenname: Andrei
  surname: Khilkevich
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  fullname: Mauk, Michael D
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  givenname: George J
  orcidid: 0000-0001-7408-7485
  surname: Augustine
  fullname: Augustine, George J
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36480240$$D View this record in MEDLINE/PubMed
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Keywords molecular layer interneurons
mouse
neuroscience
feedback circuit
rabbit
cerebellar learning
disinhibition
Language English
License 2022, Halverson, Kim et al.
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Snippet The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics,...
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SourceType Open Website
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SubjectTerms Analysis
Biological research
Biology, Experimental
Brain slice preparation
cerebellar learning
Cerebellum
Cerebellum - physiology
Computational neuroscience
disinhibition
Eyelid
Eyelids
Feedback
feedback circuit
Feedback inhibition
Genetics
Information processing
Information storage
Interneurons
Interneurons - physiology
Mathematical models
molecular layer interneurons
Neural recording
Neurons
Neuroscience
Optics
Purkinje cells
Purkinje Cells - physiology
Transgenic animals
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Title Feedback inhibition underlies new computational functions of cerebellar interneurons
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