Transforming insect population control with precision guided sterile males with demonstration in flies

The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enabl...

Full description

Saved in:

Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 84 - 12
Main Authors:	Kandul, Nikolay P., Liu, Junru, Sanchez C., Hector M., Wu, Sean L., Marshall, John M., Akbari, Omar S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.01.2019 Nature Publishing Group Nature Portfolio
Subjects:	38/23 38/44 38/70 45/23 45/29 45/41 45/77 631/208/4041/3196 631/61/338/552 64/24 Animals Biotechnology CRISPR CRISPR-Cas Systems - genetics Disease control Drosophila - genetics Drosophila - physiology Efficiency Eggs Female Females Fertility Fruit flies Gene Editing - methods Genome, Insect - genetics Genomes Humanities and Social Sciences Infertility Insect control Insect Vectors - genetics Insect Vectors - physiology Insects Life Sciences Male Male sterility Males Mathematical analysis Mathematical models Models, Biological multidisciplinary Pest control Pest Control, Biological - methods Pests Population Population control Population Control - methods RNA, Guide, CRISPR-Cas Systems - genetics Science Science (multidisciplinary) Sexing Sexual Behavior, Animal Stability Sterilization Sterilized organisms Vectors Vectors (mathematics) X chromosomes
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilitating the release of eggs into the environment ensuring only sterile adult males emerge. Importantly, for field applications, the release of eggs will eliminate burdens of manually sexing and sterilizing males, thereby reducing overall effort and increasing scalability. Here, to demonstrate efficacy, we systematically engineer multiple pgSIT systems in Drosophila which consistently give rise to 100% sterile males. Importantly, we demonstrate that pgSIT-generated sterile males are fit and competitive. Using mathematical models, we predict pgSIT will induce substantially greater population suppression than can be achieved by currently-available self-limiting suppression technologies. Taken together, pgSIT offers to potentially transform our ability to control insect agricultural pests and disease vectors. Sterile Insect Technique (SIT) is used to suppress wild populations. Here the authors integrate CRISPR-based technology and SIT to develop a precision guided SIT (pgSIT), and demonstrate its proof-of-principle by generating 100% sterile males.
AbstractList	The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilitating the release of eggs into the environment ensuring only sterile adult males emerge. Importantly, for field applications, the release of eggs will eliminate burdens of manually sexing and sterilizing males, thereby reducing overall effort and increasing scalability. Here, to demonstrate efficacy, we systematically engineer multiple pgSIT systems in Drosophila which consistently give rise to 100% sterile males. Importantly, we demonstrate that pgSIT-generated sterile males are fit and competitive. Using mathematical models, we predict pgSIT will induce substantially greater population suppression than can be achieved by currently-available self-limiting suppression technologies. Taken together, pgSIT offers to potentially transform our ability to control insect agricultural pests and disease vectors. Sterile Insect Technique (SIT) is used to suppress wild populations. Here the authors integrate CRISPR-based technology and SIT to develop a precision guided SIT (pgSIT), and demonstrate its proof-of-principle by generating 100% sterile males. Sterile Insect Technique (SIT) is used to suppress wild populations. Here the authors integrate CRISPR-based technology and SIT to develop a precision guided SIT (pgSIT), and demonstrate its proof-of-principle by generating 100% sterile males. The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilitating the release of eggs into the environment ensuring only sterile adult males emerge. Importantly, for field applications, the release of eggs will eliminate burdens of manually sexing and sterilizing males, thereby reducing overall effort and increasing scalability. Here, to demonstrate efficacy, we systematically engineer multiple pgSIT systems in Drosophila which consistently give rise to 100% sterile males. Importantly, we demonstrate that pgSIT-generated sterile males are fit and competitive. Using mathematical models, we predict pgSIT will induce substantially greater population suppression than can be achieved by currently-available self-limiting suppression technologies. Taken together, pgSIT offers to potentially transform our ability to control insect agricultural pests and disease vectors.The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilitating the release of eggs into the environment ensuring only sterile adult males emerge. Importantly, for field applications, the release of eggs will eliminate burdens of manually sexing and sterilizing males, thereby reducing overall effort and increasing scalability. Here, to demonstrate efficacy, we systematically engineer multiple pgSIT systems in Drosophila which consistently give rise to 100% sterile males. Importantly, we demonstrate that pgSIT-generated sterile males are fit and competitive. Using mathematical models, we predict pgSIT will induce substantially greater population suppression than can be achieved by currently-available self-limiting suppression technologies. Taken together, pgSIT offers to potentially transform our ability to control insect agricultural pests and disease vectors. The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilitating the release of eggs into the environment ensuring only sterile adult males emerge. Importantly, for field applications, the release of eggs will eliminate burdens of manually sexing and sterilizing males, thereby reducing overall effort and increasing scalability. Here, to demonstrate efficacy, we systematically engineer multiple pgSIT systems in Drosophila which consistently give rise to 100% sterile males. Importantly, we demonstrate that pgSIT-generated sterile males are fit and competitive. Using mathematical models, we predict pgSIT will induce substantially greater population suppression than can be achieved by currently-available self-limiting suppression technologies. Taken together, pgSIT offers to potentially transform our ability to control insect agricultural pests and disease vectors. The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilitating the release of eggs into the environment ensuring only sterile adult males emerge. Importantly, for field applications, the release of eggs will eliminate burdens of manually sexing and sterilizing males, thereby reducing overall effort and increasing scalability. Here, to demonstrate efficacy, we systematically engineer multiple pgSIT systems in Drosophila which consistently give rise to 100% sterile males. Importantly, we demonstrate that pgSIT-generated sterile males are fit and competitive. Using mathematical models, we predict pgSIT will induce substantially greater population suppression than can be achieved by currently-available self-limiting suppression technologies. Taken together, pgSIT offers to potentially transform our ability to control insect agricultural pests and disease vectors. Sterile Insect Technique (SIT) is used to suppress wild populations. Here the authors integrate CRISPR-based technology and SIT to develop a precision guided SIT (pgSIT), and demonstrate its proof-of-principle by generating 100% sterile males. The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilitating the release of eggs into the environment ensuring only sterile adult males emerge. Importantly, for field applications, the release of eggs will eliminate burdens of manually sexing and sterilizing males, thereby reducing overall effort and increasing scalability. Here, to demonstrate efficacy, we systematically engineer multiple pgSIT systems in Drosophila which consistently give rise to 100% sterile males. Importantly, we demonstrate that pgSIT-generated sterile males are fit and competitive. Using mathematical models, we predict pgSIT will induce substantially greater population suppression than can be achieved by currently-available self-limiting suppression technologies. Taken together, pgSIT offers to potentially transform our ability to control insect agricultural pests and disease vectors.
ArticleNumber	84
Author	Akbari, Omar S. Wu, Sean L. Marshall, John M. Sanchez C., Hector M. Liu, Junru Kandul, Nikolay P.
Author_xml	– sequence: 1 givenname: Nikolay P. surname: Kandul fullname: Kandul, Nikolay P. organization: Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego – sequence: 2 givenname: Junru surname: Liu fullname: Liu, Junru organization: Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego – sequence: 3 givenname: Hector M. orcidid: 0000-0001-7378-8853 surname: Sanchez C. fullname: Sanchez C., Hector M. organization: Division of Biostatistics and Epidemiology, School of Public Health, University of California – sequence: 4 givenname: Sean L. surname: Wu fullname: Wu, Sean L. organization: Division of Biostatistics and Epidemiology, School of Public Health, University of California – sequence: 5 givenname: John M. surname: Marshall fullname: Marshall, John M. organization: Division of Biostatistics and Epidemiology, School of Public Health, University of California – sequence: 6 givenname: Omar S. orcidid: 0000-0002-6853-9884 surname: Akbari fullname: Akbari, Omar S. email: oakbari@ucsd.edu organization: Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, Tata Institute for Genetics and Society, University of California, San Diego
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30622266$$D View this record in MEDLINE/PubMed https://hal.science/cirad-02341975$$DView record in HAL
BookMark	eNp9Us1u1DAQjlARLaUvwAFF4oKEAv6NnQtSVQGttBKXcrYcZ5L1yrEXOynibXiWPlm9m1LaPXQuHo2_n9HMvC6OfPBQFG8x-oQRlZ8Tw6wWFcKyQqKpWSVeFCcEMVxhQejRo_y4OEtpg3LQBkvGXhXHFNWEkLo-KYbrqH3qQxytH0rrE5ip3Ibt7PRkgy9N8FMMrvxtp3W5jWBs2pWH2XbQlWmCaB2Uo3aQFkwHY_Bpigvd-tu_vbOQ3hQve-0SnN2_p8XPb1-vLy6r1Y_vVxfnq8pwUU8VM5T3pidtI3nbMUpMg3pOhDA19JLoRvdcciYog66TRgusdcNzDgS0zuzT4mrR7YLeqG20o45_VNBW7QshDkrHyRoHCrWNaQWSPUPAGqxb0kqMJSG0BkFbmbW-LFrbuR2hM5BHod0T0ac_3q7VEG5UTQnHlGeBj4vA-oB2eb5SxkbdKUQow43gNzijP9zbxfBrhjSp0SYDzmkPYU6K4JrXXOTI0PcH0E2Yo8-D3aNQFtzbv3vc_0MH_7afAWQBmBhSitA_QDBSuytTy5WpfGVqf2Vq5y0PSMZO-23nGVj3PJUu1JR9_ADxf9vPsO4Akf3o0g
CitedBy_id	crossref_primary_10_1007_s00018_025_05722_9 crossref_primary_10_1534_g3_119_400544 crossref_primary_10_1186_s13071_025_06905_w crossref_primary_10_1089_genbio_2023_0022 crossref_primary_10_1002_ps_70073 crossref_primary_10_1038_s41684_020_0617_y crossref_primary_10_1038_s41467_023_42183_9 crossref_primary_10_1038_s41598_024_54498_8 crossref_primary_10_3390_insects14030255 crossref_primary_10_1186_s12864_024_10597_4 crossref_primary_10_3390_su13105653 crossref_primary_10_1007_s41348_024_01036_3 crossref_primary_10_1111_2041_210X_13318 crossref_primary_10_1080_17441692_2020_1779328 crossref_primary_10_1016_j_ibmb_2021_103565 crossref_primary_10_3389_fbioe_2022_821428 crossref_primary_10_1089_genbio_2022_0019 crossref_primary_10_1002_ps_5634 crossref_primary_10_1016_j_aspen_2022_102031 crossref_primary_10_1111_imb_12717 crossref_primary_10_1007_s40003_024_00731_9 crossref_primary_10_1016_j_cropro_2020_105492 crossref_primary_10_1111_1744_7917_70161 crossref_primary_10_1534_g3_119_401006 crossref_primary_10_1089_crispr_2021_0077 crossref_primary_10_1111_1744_7917_70038 crossref_primary_10_1073_pnas_2411587121 crossref_primary_10_1093_g3journal_jkae239 crossref_primary_10_1093_aesa_saae021 crossref_primary_10_1073_pnas_2107413118 crossref_primary_10_1111_eea_13155 crossref_primary_10_3390_ijms22136724 crossref_primary_10_1038_s41467_023_41834_1 crossref_primary_10_1186_s12915_020_0759_9 crossref_primary_10_1186_s13068_021_02007_8 crossref_primary_10_3389_fevo_2022_884159 crossref_primary_10_7554_eLife_90199 crossref_primary_10_1016_j_jia_2024_07_021 crossref_primary_10_1016_j_cois_2021_02_003 crossref_primary_10_1007_s00122_022_04060_9 crossref_primary_10_1002_ps_8634 crossref_primary_10_1186_s12874_020_01146_0 crossref_primary_10_1093_g3journal_jkad024 crossref_primary_10_1111_1744_7917_70031 crossref_primary_10_1007_s10709_023_00189_7 crossref_primary_10_7554_eLife_51701 crossref_primary_10_3390_insects16020137 crossref_primary_10_1016_j_sciaf_2025_e02888 crossref_primary_10_1038_s41467_024_54863_1 crossref_primary_10_1371_journal_pone_0295335 crossref_primary_10_1016_j_jia_2022_11_003 crossref_primary_10_1126_science_aax1318 crossref_primary_10_7554_eLife_65939 crossref_primary_10_1089_crispr_2021_0129 crossref_primary_10_1016_j_ibmb_2021_103705 crossref_primary_10_1073_pnas_2011648117 crossref_primary_10_1111_1744_7917_12974 crossref_primary_10_1016_j_envsci_2020_02_016 crossref_primary_10_1038_s41598_025_88598_w crossref_primary_10_1073_pnas_2312456121 crossref_primary_10_1146_annurev_genet_031623_105059 crossref_primary_10_3389_fbioe_2022_867851 crossref_primary_10_1002_arch_70053 crossref_primary_10_1016_j_jinsphys_2023_104598 crossref_primary_10_1016_j_pt_2019_06_001 crossref_primary_10_1093_g3journal_jkaf116 crossref_primary_10_1093_g3journal_jkae025 crossref_primary_10_3157_021_132_0402 crossref_primary_10_1016_j_aspen_2023_102105 crossref_primary_10_1111_imb_12982 crossref_primary_10_1186_s12915_025_02201_2 crossref_primary_10_7554_eLife_71230 crossref_primary_10_1093_molbev_msaf048 crossref_primary_10_2989_20702620_2020_1813651 crossref_primary_10_1002_arch_22059 crossref_primary_10_1007_s10340_023_01736_z crossref_primary_10_1002_arch_70043 crossref_primary_10_1371_journal_pgen_1011226 crossref_primary_10_1016_j_tree_2024_11_011 crossref_primary_10_1038_s42003_024_06848_5 crossref_primary_10_1186_s12915_024_01823_2 crossref_primary_10_1016_j_cryobiol_2021_02_001 crossref_primary_10_1089_genbio_2023_0041 crossref_primary_10_1038_s42003_024_06961_5 crossref_primary_10_1016_j_ijbiomac_2025_146574 crossref_primary_10_1111_1744_7917_70089 crossref_primary_10_1038_s41467_019_11616_9 crossref_primary_10_1002_ps_8022 crossref_primary_10_1073_pnas_2412149122 crossref_primary_10_1089_crispr_2020_0018 crossref_primary_10_7554_eLife_90199_3 crossref_primary_10_1016_j_ibmb_2024_104189 crossref_primary_10_3390_biom14091074 crossref_primary_10_1002_arch_22024 crossref_primary_10_1089_crispr_2021_0028 crossref_primary_10_1534_g3_119_400985 crossref_primary_10_1038_s41467_024_50992_9 crossref_primary_10_1186_s12983_025_00566_2 crossref_primary_10_15252_embr_201948269 crossref_primary_10_3389_fbioe_2022_848707 crossref_primary_10_1073_pnas_2414207122 crossref_primary_10_3389_fbioe_2022_900785 crossref_primary_10_3389_fbioe_2022_856981 crossref_primary_10_1101_gr_265157_120 crossref_primary_10_1079_planthealthcases_2023_0001 crossref_primary_10_3157_021_132_0104 crossref_primary_10_1038_s41467_021_25421_w crossref_primary_10_1038_s41598_020_69259_6 crossref_primary_10_1186_s40249_024_01242_z crossref_primary_10_1038_s41467_021_27333_1 crossref_primary_10_1371_journal_pntd_0008971 crossref_primary_10_3390_pathogens14030285 crossref_primary_10_1016_j_gene_2024_148925 crossref_primary_10_3389_finsc_2025_1618382 crossref_primary_10_1089_crispr_2021_0032 crossref_primary_10_1007_s11248_021_00262_x crossref_primary_10_1371_journal_pgph_0004903 crossref_primary_10_1093_jme_tjab030 crossref_primary_10_1002_arch_22035 crossref_primary_10_1038_s41467_022_34739_y crossref_primary_10_1038_s41467_024_55391_8 crossref_primary_10_1016_j_pt_2022_05_012 crossref_primary_10_1002_ps_5602 crossref_primary_10_1007_s11248_024_00406_9 crossref_primary_10_1016_j_ecoenv_2022_114028 crossref_primary_10_1038_s41467_019_11617_8 crossref_primary_10_1038_s41587_022_01325_y crossref_primary_10_3390_ijms25094623 crossref_primary_10_3390_insects16040345 crossref_primary_10_1111_imb_12778 crossref_primary_10_1073_pnas_2105075118 crossref_primary_10_1016_j_ijbiomac_2024_135413 crossref_primary_10_1038_s41467_021_24654_z crossref_primary_10_1002_arch_22121 crossref_primary_10_3389_finsc_2023_1198252 crossref_primary_10_1186_s13071_022_05522_1 crossref_primary_10_1080_10937404_2020_1776655 crossref_primary_10_3390_insects12090799 crossref_primary_10_1186_s12870_024_05852_5 crossref_primary_10_1016_j_ibmb_2025_104257 crossref_primary_10_1038_s41598_021_97443_9 crossref_primary_10_1007_s10592_019_01165_5 crossref_primary_10_1016_j_tibtech_2024_09_005 crossref_primary_10_1038_s41467_021_23531_z crossref_primary_10_1140_epjp_s13360_025_06125_2 crossref_primary_10_1016_j_pt_2023_11_001 crossref_primary_10_1007_s11105_021_01286_7 crossref_primary_10_1038_s41467_023_44399_1 crossref_primary_10_1016_j_jtbi_2023_111654 crossref_primary_10_1093_aesa_saab041 crossref_primary_10_1038_s41467_021_23239_0 crossref_primary_10_1016_j_ibmb_2024_104085 crossref_primary_10_1038_s42003_023_05030_7
Cites_doi	10.1093/jee/48.4.459 10.1016/0092-8674(88)90384-4 10.1371/journal.pone.0135194 10.1126/science.282.5390.943 10.1016/S1095-6433(98)00013-0 10.1038/nmeth.1318 10.1038/nrg.2015.34 10.1371/journal.pntd.0003864 10.1038/nbt1152 10.1073/pnas.1000251107 10.1016/j.actatropica.2013.08.015 10.1002/bies.201500102 10.1038/nbt.3926 10.1186/1471-2148-11-41 10.1126/science.1057987 10.1038/154607a0 10.1016/j.nbt.2016.06.828 10.1038/nbt.2019 10.1111/j.1748-5967.2007.00102.x 10.1086/416718 10.1038/nbt.4245 10.1603/ME13223 10.1242/jeb.01819 10.1126/science.aaa5945 10.1111/j.1365-2583.2006.00701.x 10.1002/(SICI)1097-0258(19960715)15:13<1387::AID-SIM268>3.0.CO;2-R 10.1073/pnas.1713825115 10.1371/journal.pone.0121126 10.1371/journal.pgen.1000291 10.1534/g3.113.006742 10.1186/1471-2121-10-8 10.4161/spmg.24376 10.1073/pnas.1521077112 10.1016/S0925-4773(01)00654-2 10.1126/science.aac7932 10.1038/s41598-017-02744-7 10.1016/j.ibmb.2004.03.025 10.1016/S0092-8674(00)80319-0 10.1016/S0960-9822(98)70091-0 10.1186/s13071-017-2235-0 10.1016/0003-3472(62)90066-0 10.1016/j.molcel.2015.02.032 10.1016/j.cub.2005.01.034 10.1534/genetics.166.4.1761 10.1007/s11538-006-9067-y 10.4161/spmg.21775 10.1126/science.287.5462.2474 10.1038/nbt.3439 10.1093/nar/gkw398 10.1534/genetics.116.197285 10.1016/j.cub.2013.02.059 10.1016/0092-8674(89)90633-8 10.1126/science.1057991 10.1016/0092-8674(87)90332-1 10.1126/science.122.3163.287 10.1016/0092-8674(91)90157-T 10.1016/0092-8674(80)90481-X 10.1073/pnas.1110717108 10.1534/g3.116.034884 10.1101/362558 10.1101/421537 10.1101/156778 10.1007/1-4020-4051-2 10.1101/350488 10.1079/9781780644516.0083 10.1101/081620 10.18637/jss.v036.i02
ContentType	Journal Article
Copyright	The Author(s) 2019 This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml	– notice: The Author(s) 2019 – notice: This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Distributed under a Creative Commons Attribution 4.0 International License
DBID	C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 1XC 5PM DOA
DOI	10.1038/s41467-018-07964-7
DatabaseName	SpringerOpen CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic Hyper Article en Ligne (HAL) PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE CrossRef Publicly Available Content Database
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2041-1723
EndPage	12
ExternalDocumentID	oai_doaj_org_article_0b9cb708f40e491ab2b81182236e73b8 PMC6325135 oai:HAL:cirad-02341975v1 30622266 10_1038_s41467_018_07964_7
Genre	Research Support, Non-U.S. Gov't Evaluation Study Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NIAID NIH HHS grantid: R21 AI123937 – fundername: NIH HHS grantid: 5K22AI113060 – fundername: NIAID NIH HHS grantid: K22 AI113060 – fundername: NIH HHS grantid: 1R21AI123937
GroupedDBID	--- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX AFFHD CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 SOI 7X8 PUEGO 1XC 4.4 BAPOH CAG COF EJD LGEZI LOTEE NADUK NXXTH 5PM
ID	FETCH-LOGICAL-c576t-4c35fcf2b985bd432c90f5277c6ef82a9af5854734edd8ca71aa95edde2eaa4c3
IEDL.DBID	DOA
ISICitedReferencesCount	174
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000455102900023&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2041-1723
IngestDate	Fri Oct 03 12:37:23 EDT 2025 Tue Nov 04 01:55:45 EST 2025 Tue Oct 14 20:33:00 EDT 2025 Fri Sep 05 07:13:53 EDT 2025 Sat Nov 29 14:56:06 EST 2025 Mon Jul 21 05:33:57 EDT 2025 Tue Nov 18 21:08:04 EST 2025 Sat Nov 29 03:37:58 EST 2025 Fri Feb 21 02:38:52 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c576t-4c35fcf2b985bd432c90f5277c6ef82a9af5854734edd8ca71aa95edde2eaa4c3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 PMCID: PMC6325135
ORCID	0000-0002-6853-9884 0000-0001-7378-8853 0000-0002-1913-416X
OpenAccessLink	https://doaj.org/article/0b9cb708f40e491ab2b81182236e73b8
PMID	30622266
PQID	2165097535
PQPubID	546298
PageCount	12
ParticipantIDs	doaj_primary_oai_doaj_org_article_0b9cb708f40e491ab2b81182236e73b8 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6325135 hal_primary_oai_HAL_cirad_02341975v1 proquest_miscellaneous_2165657777 proquest_journals_2165097535 pubmed_primary_30622266 crossref_primary_10_1038_s41467_018_07964_7 crossref_citationtrail_10_1038_s41467_018_07964_7 springer_journals_10_1038_s41467_018_07964_7
PublicationCentury	2000
PublicationDate	2019-01-08
PublicationDateYYYYMMDD	2019-01-08
PublicationDate_xml	– month: 01 year: 2019 text: 2019-01-08 day: 08
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Nature communications
PublicationTitleAbbrev	Nat Commun
PublicationTitleAlternate	Nat Commun
PublicationYear	2019
Publisher	Nature Publishing Group UK Nature Publishing Group Nature Portfolio
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio
References	Labun, Montague, Gagnon, Thyme, Valen (CR61) 2016; 44 Alphey (CR23) 2016; 33 Hales, Fuller (CR30) 1997; 90 Gantz, Bier (CR2) 2015; 348 Gantz (CR4) 2015; 112 Slee, Bownes (CR25) 1990; 65 Akbari (CR56) 2013; 3 CR38 Sano, Nakamura, Kobayashi (CR33) 2002; 112 CR36 Knipling (CR13) 1955; 48 Salvemini (CR52) 2011; 11 Scali, Catteruccia, Li, Crisanti (CR53) 2005; 208 Lin, Seroude, Benzer (CR41) 1998; 282 Adelman (CR7) 2017; 35 CR3 Zhang, Zheng, Xi, Bourtzis, Gilles (CR47) 2015; 10 Akbari (CR63) 2013; 23 CR9 Vanderplank (CR16) 1944; 154 Kemphues, Raff, Raff, Kaufman (CR29) 1980; 21 CR43 Hammond (CR5) 2016; 34 Bushland, Lindquist, Knipling (CR14) 1955; 122 Smith, Walter, Hice, O’Brochta, Atkinson (CR55) 2007; 16 Zhang, Lees, Xi, Gilles, Bourtzis (CR48) 2015; 10 Sun (CR67) 1996; 15 Diniz, de Albuquerque, Oliva, de Melo-Santos, Ayres (CR42) 2017; 10 Yamada, Parker, Oliva, Balestrino, Gilles (CR49) 2014; 51 Wilkinson (CR24) 1998; 119 Gilles, Schetelig, Scolari, Marec, Capurro, Franz, Bourtzis (CR59) 2014; 132 Bell, Horabin, Schedl, Cline (CR26) 1991; 65 Tatar (CR39) 2001; 292 Thomas (CR20) 2000; 287 CR17 Panagiotis, Bourtzis (CR19) 2007; 37 CR15 Champer, Buchman, Akbari (CR11) 2016; 17 Nagoshi, McKeown, Burtis, Belote, Baker (CR37) 1988; 53 CR58 CR57 Doren, Van Doren, Williamson, Lehmann (CR34) 1998; 8 Deredec, Godfray, Burt (CR66) 2011; 108 Burtis, Baker (CR28) 1989; 56 Gibson (CR62) 2009; 6 Carvalho (CR44) 2015; 9 Pomiankowski (CR68) 2004; 166 Boggs, Gregor, Idriss, Belote, McKeown (CR27) 1987; 50 Kyrou, Hammond, Galizi, Kranjc, Burt, Beaghton, Nolan, Crisanti (CR50) 2018; 36 Harris (CR46) 2011; 29 Akbari (CR8) 2015; 349 Otero, Solari, Schweigmann (CR45) 2006; 68 Fu (CR21) 2010; 107 Sternberg, Doudna (CR1) 2015; 58 Gantz, Bier (CR6) 2016; 38 Windbichler, Papathanos, Crisanti (CR22) 2008; 4 KaramiNejadRanjbar (CR51) 2018; 115 Unckless, Clark, Messer (CR10) 2017; 205 Catteruccia, Benton, Crisanti (CR54) 2005; 23 Manning (CR69) 1962; 10 Peng (CR64) 2005; 15 Marshall, Buchman, Sánchez, H. M., Akbari (CR12) 2017; 7 Lim, Tarayrah, Chen (CR32) 2012; 2 Sinkins (CR18) 2004; 34 Kanippayoor, Alpern, Moehring (CR31) 2013; 3 CR65 Clancy (CR40) 2001; 292 Akbari, Oliver, Eyer, Pai (CR35) 2009; 10 CR60 I Panagiotis (7964_CR19) 2007; 37 KG Hales (7964_CR30) 1997; 90 SH Sternberg (7964_CR1) 2015; 58 DD Thomas (7964_CR20) 2000; 287 OS Akbari (7964_CR35) 2009; 10 7964_CR43 R Slee (7964_CR25) 1990; 65 H Yamada (7964_CR49) 2014; 51 DJ Clancy (7964_CR40) 2001; 292 FL Vanderplank (7964_CR16) 1944; 154 OS Akbari (7964_CR8) 2015; 349 G Fu (7964_CR21) 2010; 107 JM Marshall (7964_CR12) 2017; 7 A Manning (7964_CR69) 1962; 10 TL Wilkinson (7964_CR24) 1998; 119 J Champer (7964_CR11) 2016; 17 DFA Diniz (7964_CR42) 2017; 10 AF Harris (7964_CR46) 2011; 29 J Peng (7964_CR64) 2005; 15 RT Boggs (7964_CR27) 1987; 50 M Tatar (7964_CR39) 2001; 292 RN Nagoshi (7964_CR37) 1988; 53 VM Gantz (7964_CR2) 2015; 348 7964_CR36 L Alphey (7964_CR23) 2016; 33 RC Bushland (7964_CR14) 1955; 122 7964_CR38 Kyros Kyrou (7964_CR50) 2018; 36 M Otero (7964_CR45) 2006; 68 RC Smith (7964_CR55) 2007; 16 SP Sinkins (7964_CR18) 2004; 34 C Scali (7964_CR53) 2005; 208 A Deredec (7964_CR66) 2011; 108 MV Doren (7964_CR34) 1998; 8 KJ Kemphues (7964_CR29) 1980; 21 F Catteruccia (7964_CR54) 2005; 23 A Hammond (7964_CR5) 2016; 34 Z Adelman (7964_CR7) 2017; 35 YJ Lin (7964_CR41) 1998; 282 LR Bell (7964_CR26) 1991; 65 DO Carvalho (7964_CR44) 2015; 9 RL Kanippayoor (7964_CR31) 2013; 3 VM Gantz (7964_CR6) 2016; 38 H Sano (7964_CR33) 2002; 112 D Zhang (7964_CR47) 2015; 10 OS Akbari (7964_CR63) 2013; 23 7964_CR65 J Sun (7964_CR67) 1996; 15 N Windbichler (7964_CR22) 2008; 4 C Lim (7964_CR32) 2012; 2 7964_CR60 7964_CR3 EF Knipling (7964_CR13) 1955; 48 7964_CR9 A Pomiankowski (7964_CR68) 2004; 166 OS Akbari (7964_CR56) 2013; 3 KC Burtis (7964_CR28) 1989; 56 M KaramiNejadRanjbar (7964_CR51) 2018; 115 Jeremie R.L. Gilles (7964_CR59) 2014; 132 RL Unckless (7964_CR10) 2017; 205 D Zhang (7964_CR48) 2015; 10 7964_CR17 DG Gibson (7964_CR62) 2009; 6 7964_CR58 7964_CR57 VM Gantz (7964_CR4) 2015; 112 7964_CR15 M Salvemini (7964_CR52) 2011; 11 K Labun (7964_CR61) 2016; 44 31477702 - Nat Commun. 2019 Sep 2;10(1):3955 31477713 - Nat Commun. 2019 Sep 2;10(1):3954
References_xml	– volume: 48 start-page: 459 year: 1955 end-page: 462 ident: CR13 article-title: Possibilities of insect control or eradication through the use of sexually sterile males1 publication-title: J. Econ. Entomol. doi: 10.1093/jee/48.4.459 – volume: 53 start-page: 229 year: 1988 end-page: 236 ident: CR37 article-title: The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster publication-title: Cell doi: 10.1016/0092-8674(88)90384-4 – volume: 10 start-page: e0135194 year: 2015 ident: CR48 article-title: Combining the sterile insect technique with Wolbachia-based approaches: II- A safer approach to Aedes albopictus population suppression programmes, designed to minimize the consequences of inadvertent female release publication-title: PLoS. One. doi: 10.1371/journal.pone.0135194 – volume: 282 start-page: 943 year: 1998 end-page: 946 ident: CR41 article-title: Extended life-span and stress resistance in the Drosophila mutant methuselah publication-title: Science doi: 10.1126/science.282.5390.943 – volume: 119 start-page: 871 year: 1998 end-page: 881 ident: CR24 article-title: The elimination of intracellular microorganisms from insects: an analysis of antibiotic-treatment in the pea aphid (Acyrthosiphon pisum) publication-title: Comp. Biochem. Physiol. A. Mol. Integr. Physiol. doi: 10.1016/S1095-6433(98)00013-0 – volume: 6 start-page: 343 year: 2009 end-page: 345 ident: CR62 article-title: Enzymatic assembly of DNA molecules up to several hundred kilobases publication-title: Nat. Methods doi: 10.1038/nmeth.1318 – volume: 17 start-page: 146 year: 2016 end-page: 159 ident: CR11 article-title: Cheating evolution: engineering gene drives to manipulate the fate of wild populations publication-title: Nat. Rev. Genet. doi: 10.1038/nrg.2015.34 – volume: 9 start-page: e0003864 year: 2015 ident: CR44 article-title: Suppression of a field population of Aedes aegypti in Brazil by sustained release of transgenic male mosquitoes publication-title: PLoS. Negl. Trop. Dis. doi: 10.1371/journal.pntd.0003864 – ident: CR58 – volume: 23 start-page: 1414 year: 2005 end-page: 1417 ident: CR54 article-title: An Anopheles transgenic sexing strain for vector control publication-title: Nat. Biotechnol. doi: 10.1038/nbt1152 – volume: 107 start-page: 4550 year: 2010 end-page: 4554 ident: CR21 article-title: Female-specific flightless phenotype for mosquito control publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1000251107 – volume: 132 start-page: S178 year: 2014 end-page: S187 ident: CR59 article-title: Towards mosquito sterile insect technique programmes: Exploring genetic, molecular, mechanical and behavioural methods of sex separation in mosquitoes publication-title: Acta Tropica doi: 10.1016/j.actatropica.2013.08.015 – volume: 38 start-page: 50 year: 2016 end-page: 63 ident: CR6 article-title: The dawn of active genetics publication-title: Bioessays doi: 10.1002/bies.201500102 – volume: 35 start-page: 716 year: 2017 end-page: 718 ident: CR7 article-title: Rules of the road for insect gene drive research and testing publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3926 – volume: 11 start-page: 41 year: 2011 ident: CR52 article-title: Genomic organization and splicing evolution of the doublesex gene, a Drosophila regulator of sexual differentiation, in the dengue and yellow fever mosquito Aedes aegypti publication-title: BMC Evol. Biol. doi: 10.1186/1471-2148-11-41 – volume: 292 start-page: 107 year: 2001 end-page: 110 ident: CR39 article-title: A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function publication-title: Science doi: 10.1126/science.1057987 – volume: 154 start-page: 607 year: 1944 end-page: 608 ident: CR16 article-title: Hybridization between Glossina species and suggested new method for control of certain species of Tsetse publication-title: Nature doi: 10.1038/154607a0 – volume: 33 start-page: S30 year: 2016 ident: CR23 article-title: Genetic control of mosquitoes publication-title: N. Biotechnol. doi: 10.1016/j.nbt.2016.06.828 – volume: 29 start-page: 1034 year: 2011 end-page: 1037 ident: CR46 article-title: Field performance of engineered male mosquitoes publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2019 – volume: 37 start-page: 125 year: 2007 end-page: 138 ident: CR19 article-title: Insect symbionts and applications: the paradigm of cytoplasmic incompatibility-inducing Wolbachia publication-title: Entomol. Res. doi: 10.1111/j.1748-5967.2007.00102.x – ident: CR15 – volume: 65 start-page: 175 year: 1990 end-page: 204 ident: CR25 article-title: Sex Determination in Drosophila melanogaster publication-title: Q. Rev. Biol. doi: 10.1086/416718 – ident: CR9 – ident: CR57 – volume: 36 start-page: 1062 issue: 11 year: 2018 end-page: 1066 ident: CR50 article-title: A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes publication-title: Nature Biotechnology doi: 10.1038/nbt.4245 – volume: 51 start-page: 811 year: 2014 end-page: 816 ident: CR49 article-title: X-ray-induced sterility in Aedes albopictus (Diptera: Culicidae) and male longevity following irradiation publication-title: J. Med. Entomol. doi: 10.1603/ME13223 – volume: 208 start-page: 3701 year: 2005 end-page: 3709 ident: CR53 article-title: Identification of sex-specific transcripts of the Anopheles gambiae doublesex gene publication-title: J. Exp. Biol. doi: 10.1242/jeb.01819 – ident: CR60 – ident: CR36 – volume: 348 start-page: 442 year: 2015 end-page: 444 ident: CR2 article-title: Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations publication-title: Science doi: 10.1126/science.aaa5945 – volume: 16 start-page: 61 year: 2007 end-page: 71 ident: CR55 article-title: Testis-specific expression of the beta2 tubulin promoter of Aedes aegypti and its application as a genetic sex-separation marker publication-title: Insect Mol. Biol. doi: 10.1111/j.1365-2583.2006.00701.x – volume: 15 start-page: 1387 year: 1996 end-page: 1395 ident: CR67 article-title: A non-parametric test for interval-censored failure time data with application to AIDS studies publication-title: Stat. Med. doi: 10.1002/(SICI)1097-0258(19960715)15:13<1387::AID-SIM268>3.0.CO;2-R – volume: 115 start-page: 6189 year: 2018 end-page: 6194 ident: CR51 article-title: Consequences of resistance evolution in a Cas9-based sex conversion-suppression gene drive for insect pest management publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1713825115 – ident: CR43 – volume: 10 start-page: e0121126 year: 2015 ident: CR47 article-title: Combining the sterile insect technique with the incompatible insect technique: I-impact of wolbachia infection on the fitness of triple- and double-infected strains of Aedes albopictus publication-title: PLoS. One. doi: 10.1371/journal.pone.0121126 – volume: 4 start-page: e1000291 year: 2008 ident: CR22 article-title: Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae publication-title: PLoS. Genet. doi: 10.1371/journal.pgen.1000291 – volume: 3 start-page: 1493 year: 2013 end-page: 1509 ident: CR56 article-title: The developmental transcriptome of the mosquito Aedes aegypti, an invasive species and major arbovirus vector publication-title: G3 doi: 10.1534/g3.113.006742 – volume: 10 year: 2009 ident: CR35 article-title: An Entry/Gateway® cloning system for general expression of genes with molecular tags in Drosophila melanogaster publication-title: Bmc. Cell. Biol. doi: 10.1186/1471-2121-10-8 – volume: 3 start-page: e24376 year: 2013 ident: CR31 article-title: Protamines and spermatogenesis in and: a comparative analysis publication-title: Spermatogenesis doi: 10.4161/spmg.24376 – volume: 112 start-page: E6736 year: 2015 end-page: E6743 ident: CR4 article-title: Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1521077112 – volume: 112 start-page: 129 year: 2002 end-page: 139 ident: CR33 article-title: Identification of a transcriptional regulatory region for germline-specific expression of vasa gene in Drosophila melanogaster publication-title: Mech. Dev. doi: 10.1016/S0925-4773(01)00654-2 – volume: 349 start-page: 927 year: 2015 end-page: 929 ident: CR8 article-title: Safeguarding gene drive experiments in the laboratory publication-title: Science doi: 10.1126/science.aac7932 – volume: 7 year: 2017 ident: CR12 article-title: Overcoming evolved resistance to population-suppressing homing-based gene drives publication-title: Sci. Rep. doi: 10.1038/s41598-017-02744-7 – volume: 34 start-page: 723 year: 2004 end-page: 729 ident: CR18 article-title: Wolbachia and cytoplasmic incompatibility in mosquitoes publication-title: Insect Biochem. Mol. Biol. doi: 10.1016/j.ibmb.2004.03.025 – volume: 90 start-page: 121 year: 1997 end-page: 129 ident: CR30 article-title: Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase publication-title: Cell doi: 10.1016/S0092-8674(00)80319-0 – volume: 8 start-page: 243 year: 1998 end-page: 246 ident: CR34 article-title: Regulation of zygotic gene expression in Drosophila primordial germ cells publication-title: Curr. Biol. doi: 10.1016/S0960-9822(98)70091-0 – volume: 10 start-page: 310 year: 2017 ident: CR42 article-title: Diapause and quiescence: dormancy mechanisms that contribute to the geographical expansion of mosquitoes and their evolutionary success publication-title: Parasit. Vectors doi: 10.1186/s13071-017-2235-0 – volume: 10 start-page: 384 year: 1962 end-page: 385 ident: CR69 article-title: The control of sexual receptivity in female Drosophila publication-title: Anim. Behav. doi: 10.1016/0003-3472(62)90066-0 – volume: 58 start-page: 568 year: 2015 end-page: 574 ident: CR1 article-title: Expanding the biologist’s toolkit with CRISPR-Cas9 publication-title: Mol. Cell doi: 10.1016/j.molcel.2015.02.032 – volume: 15 start-page: 207 year: 2005 end-page: 213 ident: CR64 article-title: Gradual release of sperm bound sex-peptide controls female postmating behavior in Drosophila publication-title: Curr. Biol. doi: 10.1016/j.cub.2005.01.034 – volume: 166 start-page: 1761 year: 2004 end-page: 1773 ident: CR68 article-title: The evolution of the Drosophila sex-determination pathway publication-title: Genetics doi: 10.1534/genetics.166.4.1761 – volume: 68 start-page: 1945 year: 2006 end-page: 1974 ident: CR45 article-title: A stochastic population dynamics model for Aedes aegypti: formulation and application to a city with temperate climate publication-title: Bull. Math. Biol. doi: 10.1007/s11538-006-9067-y – volume: 2 start-page: 158 year: 2012 end-page: 166 ident: CR32 article-title: Transcriptional regulation during Drosophila spermatogenesis publication-title: Spermatogenesis doi: 10.4161/spmg.21775 – ident: CR65 – volume: 287 start-page: 2474 year: 2000 end-page: 2476 ident: CR20 article-title: Insect population control using a dominant, repressible, lethal genetic system publication-title: Science doi: 10.1126/science.287.5462.2474 – ident: CR3 – volume: 34 start-page: 78 year: 2016 end-page: 83 ident: CR5 article-title: A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3439 – ident: CR38 – volume: 44 start-page: W272 year: 2016 end-page: W276 ident: CR61 article-title: CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw398 – ident: CR17 – volume: 205 start-page: 827 year: 2017 end-page: 841 ident: CR10 article-title: Evolution of resistance against CRISPR/Cas9 gene drive publication-title: Genetics doi: 10.1534/genetics.116.197285 – volume: 23 start-page: 671 year: 2013 end-page: 677 ident: CR63 article-title: A synthetic gene drive system for local, reversible modification and suppression of insect populations publication-title: Curr. Biol. doi: 10.1016/j.cub.2013.02.059 – volume: 56 start-page: 997 year: 1989 end-page: 1010 ident: CR28 article-title: Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides publication-title: Cell doi: 10.1016/0092-8674(89)90633-8 – volume: 292 start-page: 104 year: 2001 end-page: 106 ident: CR40 article-title: Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein publication-title: Science doi: 10.1126/science.1057991 – volume: 50 start-page: 739 year: 1987 end-page: 747 ident: CR27 article-title: Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene publication-title: Cell doi: 10.1016/0092-8674(87)90332-1 – volume: 122 start-page: 287 year: 1955 end-page: 288 ident: CR14 article-title: Eradication of screw-worms through release of sterilized males publication-title: Science doi: 10.1126/science.122.3163.287 – volume: 65 start-page: 229 year: 1991 end-page: 239 ident: CR26 article-title: Positive autoregulation of Sex-lethal by alternative splicing maintains the female determined state in Drosophila publication-title: Cell doi: 10.1016/0092-8674(91)90157-T – volume: 21 start-page: 445 year: 1980 end-page: 451 ident: CR29 article-title: Mutation in a testis-specific β-tubulin in Drosophila: Analysis of its effects on meiosis and map location of the gene publication-title: Cell doi: 10.1016/0092-8674(80)90481-X – volume: 108 start-page: E874 year: 2011 end-page: E880 ident: CR66 article-title: Requirements for effective malaria control with homing endonuclease genes publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1110717108 – volume: 53 start-page: 229 year: 1988 ident: 7964_CR37 publication-title: Cell doi: 10.1016/0092-8674(88)90384-4 – volume: 36 start-page: 1062 issue: 11 year: 2018 ident: 7964_CR50 publication-title: Nature Biotechnology doi: 10.1038/nbt.4245 – volume: 90 start-page: 121 year: 1997 ident: 7964_CR30 publication-title: Cell doi: 10.1016/S0092-8674(00)80319-0 – ident: 7964_CR38 doi: 10.1534/g3.116.034884 – volume: 348 start-page: 442 year: 2015 ident: 7964_CR2 publication-title: Science doi: 10.1126/science.aaa5945 – volume: 3 start-page: e24376 year: 2013 ident: 7964_CR31 publication-title: Spermatogenesis doi: 10.4161/spmg.24376 – volume: 15 start-page: 1387 year: 1996 ident: 7964_CR67 publication-title: Stat. Med. doi: 10.1002/(SICI)1097-0258(19960715)15:13<1387::AID-SIM268>3.0.CO;2-R – volume: 7 year: 2017 ident: 7964_CR12 publication-title: Sci. Rep. doi: 10.1038/s41598-017-02744-7 – volume: 119 start-page: 871 year: 1998 ident: 7964_CR24 publication-title: Comp. Biochem. Physiol. A. Mol. Integr. Physiol. doi: 10.1016/S1095-6433(98)00013-0 – ident: 7964_CR9 – volume: 65 start-page: 175 year: 1990 ident: 7964_CR25 publication-title: Q. Rev. Biol. doi: 10.1086/416718 – volume: 208 start-page: 3701 year: 2005 ident: 7964_CR53 publication-title: J. Exp. Biol. doi: 10.1242/jeb.01819 – ident: 7964_CR3 doi: 10.1101/362558 – volume: 17 start-page: 146 year: 2016 ident: 7964_CR11 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg.2015.34 – ident: 7964_CR60 doi: 10.1101/421537 – volume: 10 start-page: e0121126 year: 2015 ident: 7964_CR47 publication-title: PLoS. One. doi: 10.1371/journal.pone.0121126 – ident: 7964_CR36 doi: 10.1101/156778 – ident: 7964_CR17 doi: 10.1007/1-4020-4051-2 – volume: 6 start-page: 343 year: 2009 ident: 7964_CR62 publication-title: Nat. Methods doi: 10.1038/nmeth.1318 – volume: 23 start-page: 1414 year: 2005 ident: 7964_CR54 publication-title: Nat. Biotechnol. doi: 10.1038/nbt1152 – volume: 205 start-page: 827 year: 2017 ident: 7964_CR10 publication-title: Genetics doi: 10.1534/genetics.116.197285 – volume: 10 year: 2009 ident: 7964_CR35 publication-title: Bmc. Cell. Biol. doi: 10.1186/1471-2121-10-8 – volume: 11 start-page: 41 year: 2011 ident: 7964_CR52 publication-title: BMC Evol. Biol. doi: 10.1186/1471-2148-11-41 – volume: 35 start-page: 716 year: 2017 ident: 7964_CR7 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3926 – volume: 10 start-page: e0135194 year: 2015 ident: 7964_CR48 publication-title: PLoS. One. doi: 10.1371/journal.pone.0135194 – volume: 349 start-page: 927 year: 2015 ident: 7964_CR8 publication-title: Science doi: 10.1126/science.aac7932 – ident: 7964_CR15 – volume: 282 start-page: 943 year: 1998 ident: 7964_CR41 publication-title: Science doi: 10.1126/science.282.5390.943 – volume: 65 start-page: 229 year: 1991 ident: 7964_CR26 publication-title: Cell doi: 10.1016/0092-8674(91)90157-T – volume: 29 start-page: 1034 year: 2011 ident: 7964_CR46 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2019 – volume: 4 start-page: e1000291 year: 2008 ident: 7964_CR22 publication-title: PLoS. Genet. doi: 10.1371/journal.pgen.1000291 – volume: 9 start-page: e0003864 year: 2015 ident: 7964_CR44 publication-title: PLoS. Negl. Trop. Dis. doi: 10.1371/journal.pntd.0003864 – volume: 44 start-page: W272 year: 2016 ident: 7964_CR61 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw398 – ident: 7964_CR43 doi: 10.1101/350488 – volume: 122 start-page: 287 year: 1955 ident: 7964_CR14 publication-title: Science doi: 10.1126/science.122.3163.287 – volume: 112 start-page: E6736 year: 2015 ident: 7964_CR4 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1521077112 – volume: 115 start-page: 6189 year: 2018 ident: 7964_CR51 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1713825115 – volume: 48 start-page: 459 year: 1955 ident: 7964_CR13 publication-title: J. Econ. Entomol. doi: 10.1093/jee/48.4.459 – volume: 56 start-page: 997 year: 1989 ident: 7964_CR28 publication-title: Cell doi: 10.1016/0092-8674(89)90633-8 – ident: 7964_CR58 doi: 10.1079/9781780644516.0083 – volume: 287 start-page: 2474 year: 2000 ident: 7964_CR20 publication-title: Science doi: 10.1126/science.287.5462.2474 – volume: 292 start-page: 107 year: 2001 ident: 7964_CR39 publication-title: Science doi: 10.1126/science.1057987 – volume: 58 start-page: 568 year: 2015 ident: 7964_CR1 publication-title: Mol. Cell doi: 10.1016/j.molcel.2015.02.032 – ident: 7964_CR57 doi: 10.1101/081620 – volume: 154 start-page: 607 year: 1944 ident: 7964_CR16 publication-title: Nature doi: 10.1038/154607a0 – volume: 50 start-page: 739 year: 1987 ident: 7964_CR27 publication-title: Cell doi: 10.1016/0092-8674(87)90332-1 – volume: 37 start-page: 125 year: 2007 ident: 7964_CR19 publication-title: Entomol. Res. doi: 10.1111/j.1748-5967.2007.00102.x – volume: 34 start-page: 723 year: 2004 ident: 7964_CR18 publication-title: Insect Biochem. Mol. Biol. doi: 10.1016/j.ibmb.2004.03.025 – volume: 3 start-page: 1493 year: 2013 ident: 7964_CR56 publication-title: G3 doi: 10.1534/g3.113.006742 – volume: 68 start-page: 1945 year: 2006 ident: 7964_CR45 publication-title: Bull. Math. Biol. doi: 10.1007/s11538-006-9067-y – volume: 112 start-page: 129 year: 2002 ident: 7964_CR33 publication-title: Mech. Dev. doi: 10.1016/S0925-4773(01)00654-2 – volume: 10 start-page: 384 year: 1962 ident: 7964_CR69 publication-title: Anim. Behav. doi: 10.1016/0003-3472(62)90066-0 – volume: 21 start-page: 445 year: 1980 ident: 7964_CR29 publication-title: Cell doi: 10.1016/0092-8674(80)90481-X – volume: 16 start-page: 61 year: 2007 ident: 7964_CR55 publication-title: Insect Mol. Biol. doi: 10.1111/j.1365-2583.2006.00701.x – volume: 2 start-page: 158 year: 2012 ident: 7964_CR32 publication-title: Spermatogenesis doi: 10.4161/spmg.21775 – volume: 51 start-page: 811 year: 2014 ident: 7964_CR49 publication-title: J. Med. Entomol. doi: 10.1603/ME13223 – volume: 132 start-page: S178 year: 2014 ident: 7964_CR59 publication-title: Acta Tropica doi: 10.1016/j.actatropica.2013.08.015 – volume: 166 start-page: 1761 year: 2004 ident: 7964_CR68 publication-title: Genetics doi: 10.1534/genetics.166.4.1761 – volume: 15 start-page: 207 year: 2005 ident: 7964_CR64 publication-title: Curr. Biol. doi: 10.1016/j.cub.2005.01.034 – volume: 8 start-page: 243 year: 1998 ident: 7964_CR34 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(98)70091-0 – volume: 34 start-page: 78 year: 2016 ident: 7964_CR5 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3439 – volume: 33 start-page: S30 year: 2016 ident: 7964_CR23 publication-title: N. Biotechnol. doi: 10.1016/j.nbt.2016.06.828 – volume: 292 start-page: 104 year: 2001 ident: 7964_CR40 publication-title: Science doi: 10.1126/science.1057991 – volume: 107 start-page: 4550 year: 2010 ident: 7964_CR21 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1000251107 – volume: 23 start-page: 671 year: 2013 ident: 7964_CR63 publication-title: Curr. Biol. doi: 10.1016/j.cub.2013.02.059 – ident: 7964_CR65 doi: 10.18637/jss.v036.i02 – volume: 108 start-page: E874 year: 2011 ident: 7964_CR66 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1110717108 – volume: 10 start-page: 310 year: 2017 ident: 7964_CR42 publication-title: Parasit. Vectors doi: 10.1186/s13071-017-2235-0 – volume: 38 start-page: 50 year: 2016 ident: 7964_CR6 publication-title: Bioessays doi: 10.1002/bies.201500102 – reference: 31477702 - Nat Commun. 2019 Sep 2;10(1):3955 – reference: 31477713 - Nat Commun. 2019 Sep 2;10(1):3954
SSID	ssj0000391844
Score	2.6293223
Snippet	The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel... Sterile Insect Technique (SIT) is used to suppress wild populations. Here the authors integrate CRISPR-based technology and SIT to develop a precision guided...
SourceID	doaj pubmedcentral hal proquest pubmed crossref springer
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	84
SubjectTerms	38/23 38/44 38/70 45/23 45/29 45/41 45/77 631/208/4041/3196 631/61/338/552 64/24 Animals Biotechnology CRISPR CRISPR-Cas Systems - genetics Disease control Drosophila - genetics Drosophila - physiology Efficiency Eggs Female Females Fertility Fruit flies Gene Editing - methods Genome, Insect - genetics Genomes Humanities and Social Sciences Infertility Insect control Insect Vectors - genetics Insect Vectors - physiology Insects Life Sciences Male Male sterility Males Mathematical analysis Mathematical models Models, Biological multidisciplinary Pest control Pest Control, Biological - methods Pests Population Population control Population Control - methods RNA, Guide, CRISPR-Cas Systems - genetics Science Science (multidisciplinary) Sexing Sexual Behavior, Animal Stability Sterilization Sterilized organisms Vectors Vectors (mathematics) X chromosomes
SummonAdditionalLinks	– databaseName: Advanced Technologies & Aerospace Database dbid: P5Z link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaggMSF9yNQkJF6g6hO4sT2CRVE1UNV9VBQxcXys12pzS7JbiX-PWPHSRUqemFPq40T2zufx5_HzjcI7ThmCyN0nRNDSU6p17l2VuSeKcCXoqWPoj4_DtnRET89Fccp4NanY5WjT4yO2i5NiJHvlkXQegNyXX9e_cpD1qiwu5pSaNxF94JKQhiYx_XPKcYS1M85peldGVLx3Z5Gz0AKnpPwEmbOZvNRlO2HWeY8HIq8yThvHpz8a_c0Tkr7j_-3O0_Qo0RH8d6An6fojmufoQdDgsrfz5E_GXktVI8XbQ_uEa-mnF84HXTHIZqLV13K14PPNgvrLA4aDOB08CVMQv1QxrrLQEgH2MEDsQcO3L9A3_e_nXw9yFNmhtzA-mSdU1PV3vhSC15rS6vSCOLrkjHTOM9LJZSHZQhlFXXWcqNYoZSo4bsrnVJw90u01S5b9xph552jZaHrhjuqCq04UcZSRzS1lTBFhorRPtIk2fKQPeNCxu3zisvBphJsKqNNJcvQx-me1SDacWvpL8HsU8kguB1_WHZnMo1fSbQwmhHuKXFUFEqXmoe1WVk1jlWaZ2gHQDN7xsHeIbS4U1YCL6IFGPsKerM9wkEmZ9HLayxk6MN0GYZ52LtRrVtuhjJNzeCToVcDCKfKYNUHLK9pMsRm8Jy1Zn6lXZxHKfGmAn4b6v00Avm6Wf_-x97c3ou36CHQShEDVXwbba27jXuH7pur9aLv3sch-gdD1kWV priority: 102 providerName: ProQuest
Title	Transforming insect population control with precision guided sterile males with demonstration in flies
URI	https://link.springer.com/article/10.1038/s41467-018-07964-7 https://www.ncbi.nlm.nih.gov/pubmed/30622266 https://www.proquest.com/docview/2165097535 https://www.proquest.com/docview/2165657777 https://hal.science/cirad-02341975 https://pubmed.ncbi.nlm.nih.gov/PMC6325135 https://doaj.org/article/0b9cb708f40e491ab2b81182236e73b8
Volume	10
WOSCitedRecordID	wos000455102900023&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M7P dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: 7X7 dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest advanced technologies & aerospace journals customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: P5Z dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: BENPR dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: PIMPY dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELaggMQF8U-grILUG0S1Eye2jy1qVaSyilBBCxfLv-1KNF1tdivxNjwLT8bYyYaGCriQQxTFduJ4xvY38fgbhHYcs8QIXWbYUJxR6nWmnRWZZwr0S9HcR1KfT8dsOuWzmaivhPoKPmEdPXDXcLtYC6MZ5p5iRwVROtc8gOK8qBwrdNzmC6jnijEVx-BCgOlC-10yuOC7LY1jAiY8w2H7ZcZGM1Ek7If55Sy4Q17HmtddJn9bN43T0eF9dK_HkeleV_8H6IZrHqI7XWTJb4_Q6ckGkELpdN60MK6liyFYV9p7qKfhN2y6WPaBdtLT9dw6mwbyBBgt0nOYPdouj3XnAUl2-gIP_PHdA3ptH6OPhwcnb4-yPqZCZsCyWGXUFKU3PteCl9rSIjcC-zJnzFTO81wJ5cGAoKygzlpuFCNKiRKuXe6UgtJP0FZz0bhnKHXeOZoTXVbcUUW04lgZSx3W1BbCkASRTftK0xOOh7gXX2Vc-C647GQiQSYyykSyBL0eyiw6uo2_5t4PYhtyBqrseAMUSPYKJP-lQAnaAaGPnnG0dww1XiorAdFQIlh5CV-zvdEK2XfzVuYkEBCCxVcm6NWQDB00rLqoxl2suzxVyeBI0NNOiYaXgb0G-KyqEsRG6jWqzTilmZ9FEvCqAGQa3vtmo4i_qvXnFnv-P1rsBboLsFHEH1F8G22tlmv3Et02l6t5u5ygm2zG4plP0K39g2n9YRI75yT41dZwrssvkFK_e19__gnmhz8C
linkProvider	Directory of Open Access Journals
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGAMEL90tggJHGE0RzHCd2HhAal6nTSsVDQX0zvm6VWFqadmh_it_IcW5TmdjbHuhT1TiOnX7n82f7-ByEth23iSl0FhPDSMyY17F2tog9V4Avxaivg_p8G_LRSEwmxZcN9Ls7CxPcKjtOrInazkxYI9-hSYj1BuI6ezf_GYesUWF3tUuh0cDiwJ3-gilb9Xb_I_y_ryjd-zT-MIjbrAKxAW29jJlJM2881YXItGUpNQXxGeXc5M4LqgrlQUIznjJnrTCKJ0oVGXx31CkFd0O9V9BV4HEeXMj4hPdrOiHaumCsPZtDUrFTsZqJSCJiEg59xnxt_KvTBMCodhScMM8r3POOmn_t1taD4N7t_-313UG3WrmNdxv7uIs2XHkPXW8ScJ7eR37c6XboLp6WFdA_nvc5zXDryI_DajWeL9p8RPhwNbXO4hBjAkgVH8MgWzVlrDsOgrsxK6gQe9D41QP09VI6-RBtlrPSPUbYeecYTXSWC8dUopUgyljmiGY2LUwSoaTDgzRtWPaQHeSHrN0DUiEbDEnAkKwxJHmEXvf3zJugJBeWfh9g1pcMAcXrH2aLQ9nykyS6MJoT4RlxrEiUplqEuSdNc8dTLSK0DSBdq2OwO4QWL5SVoPtYAuA6gd5sdfCTLRlW8gx7EXrZXwYaC3tTqnSzVVMmzzh8IvSoAX3_MJjVgorN8wjxNXNYa836lXJ6VIdKz1PQ7-G5bzrDOWvWv9_Yk4t78QLdGIw_D-Vwf3TwFN0ECV3Ui3JiC20uFyv3DF0zJ8tptXhe0wNG3y_boP4Agj-lrw
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LbxMxELZKeYgL78dCASOVE6zi9XrX3gNChVK1ahTlUFDFxfjZRqKbkE2K-tf4dYz3VYWK3nogpyjr9dqbb2a-scczCG06bhNT6CwmhpGYMa9j7WwRe64AX4pRXyf1-Trko5E4PCzGa-h3dxYmhFV2OrFW1HZqwhr5gCYh1xuQ62zg27CI8fbOh9nPOFSQCjutXTmNBiL77uwXuG_V-71t-K_fULrz-eDTbtxWGIgN8OxFzEyaeeOpLkSmLUupKYjPKOcmd15QVSgPdJrxlDlrhVE8UarI4LujTim4G_q9hq5z8DGD4zfOvvXrOyHzumCsPadDUjGoWK2VSCJiEg6AxnzFFtYlA8DCHYeAzIts92LQ5l87t7VB3Ln7P7_Ke-hOS8PxViM399GaKx-gm01hzrOHyB90fB6mjidlBWYBz_paZ7gN8MdhFRvP5m2dIny0nFhnccg9AcoWn4DxrZo21p0EIt6IG3SIPXD_6hH6ciWTfIzWy2npniLsvHOMJjrLhWMq0UoQZSxzRDObFiaJUNJhQ5o2XXuoGvJD1mEDqZANniTgSdZ4kjxCb_t7Zk2ykktbfwyQ61uGROP1D9P5kWz1liS6MJoT4RlxrEiUploEn5SmueOpFhHaBMCu9LG7NYQRz5WVwAdZAkA7hdlsdFCUrZKs5DkOI_S6vwzqLexZqdJNl02bPOPwidCTRgD6h4G3C-w2zyPEV0RjZTSrV8rJcZ1CPU-B14fnvuuE6HxY_35jzy6fxSt0C-RIDvdG-8_RbWDWRb1WJzbQ-mK-dC_QDXO6mFTzl7WmwOj7VcvTHxxSrqI
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Transforming+insect+population+control+with+precision+guided+sterile+males+with+demonstration+in%C2%A0flies&rft.jtitle=Nature+communications&rft.au=Kandul%2C+Nikolay+P.&rft.au=Liu%2C+Junru&rft.au=Sanchez+C.%2C+Hector+M.&rft.au=Wu%2C+Sean+L.&rft.date=2019-01-08&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=10&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-018-07964-7&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41467_018_07964_7
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon