Towards a representative reference for MRI-based human axon radius assessment using light microscopy

•A pipeline for automated estimation of ensemble mean axon radii at MRI voxel scale•Incorporation of 4 human white matter brain tissue samples for training and testing•Accurate mapping of the MRI-visible radius in the presence of staining heterogeneity•Includes 2 to 4 orders of magnitude more axons...

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Bibliographic Details
Published in:	NeuroImage (Orlando, Fla.) Vol. 249; p. 118906
Main Authors:	Mordhorst, Laurin, Morozova, Maria, Papazoglou, Sebastian, Fricke, Björn, Oeschger, Jan Malte, Tabarin, Thibault, Rusch, Henriette, Jäger, Carsten, Geyer, Stefan, Weiskopf, Nikolaus, Morawski, Markus, Mohammadi, Siawoosh
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.04.2022 Elsevier Limited Elsevier
Subjects:	Aged Aged, 80 and over Anatomy Axon radii distribution Axons Axons - ultrastructure Brain Brain architecture Corpus callosum Cross microscopy Deep Learning Estimates Female Histology Humans Light microscopy Magnetic Resonance Imaging Male Microscopy Microscopy - methods Middle Aged MRI-based axon radius Nervous system Neuroanatomy Neuroimaging - methods Segmentation Variation White Matter - diagnostic imaging White Matter - ultrastructure Deep learning MRI-based axon radius Neuroanatomy Cross microscopy Axon radii distribution
ISSN:	1053-8119, 1095-9572, 1095-9572
Online Access:	Get full text
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