Are intrinsic neural timescales related to sensory processing? Evidence from abnormal behavioral states

•EEG resting-state shows a hierarchy of intrinsic neural timescales.•Sensory deficits as in disorders and alterations of consciousness lead to prolonged intrinsic neural timescales.•Clinical conditions with motor deficits do not show changes in intrinsic neural timescales. The brain exhibits a compl...

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Vydáno v:NeuroImage (Orlando, Fla.) Ročník 226; s. 117579
Hlavní autoři: Zilio, Federico, Gomez-Pilar, Javier, Cao, Shumei, Zhang, Jun, Zang, Di, Qi, Zengxin, Tan, Jiaxing, Hiromi, Tanigawa, Wu, Xuehai, Fogel, Stuart, Huang, Zirui, Hohmann, Matthias R., Fomina, Tatiana, Synofzik, Matthis, Grosse-Wentrup, Moritz, Owen, Adrian M., Northoff, Georg
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.02.2021
Elsevier Limited
Elsevier
Témata:
Adult
Aged
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - physiopathology
Anesthesia
Anesthesia, General
Anesthetics, General
Auto-correlation window
Behavior
Brain
Brain - physiology
Brain - physiopathology
Case-Control Studies
Consciousness
EEG
Electroencephalography
Female
Humans
Information processing
Intrinsic neural timescales
Investigations
Ketamine
Male
Middle Aged
Perception - physiology
Persistent Vegetative State - physiopathology
Power
Sensory integration
Sensory perception
Sevoflurane
Sleep
Sleep - physiology
Sleep and wakefulness
Spatio-Temporal Analysis
Time Factors
Unresponsive wakefulness syndrome
Young Adult
Anesthesia
Amyotrophic lateral sclerosis
Unresponsive wakefulness syndrome
Intrinsic neural timescales
Auto-correlation window
ISSN:1053-8119, 1095-9572, 1095-9572
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Shrnutí:•EEG resting-state shows a hierarchy of intrinsic neural timescales.•Sensory deficits as in disorders and alterations of consciousness lead to prolonged intrinsic neural timescales.•Clinical conditions with motor deficits do not show changes in intrinsic neural timescales. The brain exhibits a complex temporal structure which translates into a hierarchy of distinct neural timescales. An open question is how these intrinsic timescales are related to sensory or motor information processing and whether these dynamics have common patterns in different behavioral states. We address these questions by investigating the brain's intrinsic timescales in healthy controls, motor (amyotrophic lateral sclerosis, locked-in syndrome), sensory (anesthesia, unresponsive wakefulness syndrome), and progressive reduction of sensory processing (from awake states over N1, N2, N3). We employed a combination of measures from EEG resting-state data: auto-correlation window (ACW), power spectral density (PSD), and power-law exponent (PLE). Prolonged neural timescales accompanied by a shift towards slower frequencies were observed in the conditions with sensory deficits, but not in conditions with motor deficits. Our results establish that the spontaneous activity's intrinsic neural timescale is related to the neural capacity that specifically supports sensory rather than motor information processing in the healthy brain. [Display omitted]
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2020.117579