Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis

Background Sepsis is an increasingly significant challenge throughout the world as one of the major causes of patient morbidity and mortality. Central to the host immunologic response to sepsis is the increase in circulating myeloid-derived suppressor cells (MDSCs), which have been demonstrated to b...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 23; no. 1; pp. 355 - 16
Main Authors:	Hollen, McKenzie K., Stortz, Julie A., Darden, Dijoia, Dirain, Marvin L., Nacionales, Dina C., Hawkins, Russell B., Cox, Michael C., Lopez, Maria-Cecilia, Rincon, Jaimar C., Ungaro, Ricardo, Wang, Zhongkai, Wu, Quran, Brumback, Babette, Gauthier, Marie-Pierre L., Kladde, Michael, Leeuwenburgh, Christiaan, Segal, Mark, Bihorac, Azra, Brakenridge, Scott, Moore, Frederick A., Baker, Henry V., Mohr, Alicia M., Moldawer, Lyle L., Efron, Philip A.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 13.11.2019 BioMed Central Ltd BMC
Subjects:	Aged Critical Care Medicine Emergency Medicine Epigenesis, Genetic - genetics Epigenesis, Genetic - physiology Epigenetic inheritance Epigenetics Female Health aspects Hospital patients Human Humans Immunotherapy Infection Intensive Intensive Care Units - organization & administration Intensive Care Units - statistics & numerical data Male Medicine Medicine & Public Health MicroRNA MicroRNAs - immunology MicroRNAs - metabolism Middle Aged miRNA Mortality Myeloid-derived suppressor cells Myeloid-Derived Suppressor Cells - immunology Myeloid-Derived Suppressor Cells - metabolism Sepsis Sepsis - complications Sepsis - physiopathology Surgery T cells Time Factors Human Immunosuppression Myeloid-derived suppressor cells Surgery Epigenetics Sepsis miRNA
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X
Online Access:	Get full text
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