Genetic risk factors underlying white matter hyperintensities and cortical atrophy

White matter hyperintensities index structural abnormalities in the cerebral white matter, including axonal damage. The latter may promote atrophy of the cerebral cortex, a key feature of dementia. Here, we report a study of 51,065 individuals from 10 cohorts demonstrating that higher white matter h...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 9517 - 11
Main Authors:	Patel, Yash, Shin, Jean, Sliz, Eeva, Tang, Ariana, Mishra, Aniket, Xia, Rui, Hofer, Edith, Rajula, Hema Sekhar Reddy, Wang, Ruiqi, Beyer, Frauke, Horn, Katrin, Riedl, Max, Yu, Jing, Völzke, Henry, Bülow, Robin, Völker, Uwe, Frenzel, Stefan, Wittfeld, Katharina, Van der Auwera, Sandra, Mosley, Thomas H., Bouteloup, Vincent, Lambert, Jean-Charles, Chêne, Geneviève, Dufouil, Carole, Tzourio, Christophe, Mangin, Jean-François, Gottesman, Rebecca F., Fornage, Myriam, Schmidt, Reinhold, Yang, Qiong, Witte, Veronica, Scholz, Markus, Loeffler, Markus, Roshchupkin, Gennady V., Ikram, M. Arfan, Grabe, Hans J., Seshadri, Sudha, Debette, Stephanie, Paus, Tomas, Pausova, Zdenka
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.11.2024 Nature Publishing Group Nature Portfolio
Subjects:	45 45/43 631/114/2114 631/378/2583 692/617/375/1370 692/617/375/364 Abnormalities Aged Aged, 80 and over Astrocytes Atrophy Atrophy - genetics Axonal transport Axons Biological activity Biomarkers Cerebral cortex Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Cognitive ability Cohort Studies Cytoskeleton Dementia Dementia - genetics Dementia - pathology Dementia disorders Female Genes Genetic Predisposition to Disease Genetics Genome-Wide Association Study Humanities and Social Sciences Humans Life Sciences Magnetic Resonance Imaging Male Middle Aged multidisciplinary Neurodegeneration Oligodendrocytes Polygenic inheritance Polymorphism, Single Nucleotide Risk Factors Santé publique et épidémiologie Science Science (multidisciplinary) Substantia alba Thickness Vascular dementia White Matter - diagnostic imaging White Matter - pathology
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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