Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model
Background Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standard 1:1 ratio on transfusion requirements, correction of TIC, and organ damage in...
Uložené v:
| Vydané v: | Intensive care medicine experimental Ročník 7; číslo Suppl 1; s. 42 - 12 |
|---|---|
| Hlavní autori: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Cham
Springer International Publishing
25.07.2019
Springer Nature B.V SpringerOpen |
| Predmet: | |
| ISSN: | 2197-425X, 2197-425X |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Background
Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standard 1:1 ratio on transfusion requirements, correction of TIC, and organ damage in a rat multiple trauma transfusion model.
Methods
Mechanically ventilated male Sprague Dawley rats were traumatized by crush injury to the small intestine and liver and a fracture of the femur, followed by exsanguination until a mean arterial pressure (MAP) of 40 mmHg. Animals were randomly assigned to receive resuscitation in a high PLT dose (PLT to plasma to RBC in a ratio of 2:1:1) or a standard PLT dose (ratio of 1:1:1) until a MAP of 60 mmHg was reached (
n
= 8 per group). Blood samples were taken for biochemical and thromboelastometry (ROTEM) assessment. Organs were harvested for histopathology.Outcome measures were transfusion requirements needed to reach a pretargeted MAP, as well as ROTEM correction and organ failure.
Results
Trauma resulted in coagulopathy as assessed by deranged ROTEM results. Mortality rate was 19%, with all deaths occurring in the standard dose group. The severity of hypovolemic shock as assessed by lactate and base excess was not different in both groups. The volume of transfusion needed to reach the MAP target was lower in the high PLT dose group compared to the standard dose, albeit not statistically significant (
p
= 0.054). Transfusion with a high PLT dose resulted in significant stronger clot firmness compared to the standard dose at all time points following trauma, while platelet counts were similar. Organ failure as assessed by biochemical analysis and histopathology was not different between groups, nor were there any thromboembolic events recorded.
Conclusions
Resuscitation with a high (2:1) PLT-to-RBC ratio was more effective compared to standard (1:1) PLT-to-RBC ratio in treating TIC, with a trend towards reduced transfusion volumes. Also, high PLT dose did not aggravate organ damage. Transfusion strategies using higher PLT dose regiments might be a feasible treatment option in hemorrhaging trauma patients for the correction of TIC. |
|---|---|
| AbstractList | Background
Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standard 1:1 ratio on transfusion requirements, correction of TIC, and organ damage in a rat multiple trauma transfusion model.
Methods
Mechanically ventilated male Sprague Dawley rats were traumatized by crush injury to the small intestine and liver and a fracture of the femur, followed by exsanguination until a mean arterial pressure (MAP) of 40 mmHg. Animals were randomly assigned to receive resuscitation in a high PLT dose (PLT to plasma to RBC in a ratio of 2:1:1) or a standard PLT dose (ratio of 1:1:1) until a MAP of 60 mmHg was reached (
n
= 8 per group). Blood samples were taken for biochemical and thromboelastometry (ROTEM) assessment. Organs were harvested for histopathology.Outcome measures were transfusion requirements needed to reach a pretargeted MAP, as well as ROTEM correction and organ failure.
Results
Trauma resulted in coagulopathy as assessed by deranged ROTEM results. Mortality rate was 19%, with all deaths occurring in the standard dose group. The severity of hypovolemic shock as assessed by lactate and base excess was not different in both groups. The volume of transfusion needed to reach the MAP target was lower in the high PLT dose group compared to the standard dose, albeit not statistically significant (
p
= 0.054). Transfusion with a high PLT dose resulted in significant stronger clot firmness compared to the standard dose at all time points following trauma, while platelet counts were similar. Organ failure as assessed by biochemical analysis and histopathology was not different between groups, nor were there any thromboembolic events recorded.
Conclusions
Resuscitation with a high (2:1) PLT-to-RBC ratio was more effective compared to standard (1:1) PLT-to-RBC ratio in treating TIC, with a trend towards reduced transfusion volumes. Also, high PLT dose did not aggravate organ damage. Transfusion strategies using higher PLT dose regiments might be a feasible treatment option in hemorrhaging trauma patients for the correction of TIC. BackgroundPlatelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standard 1:1 ratio on transfusion requirements, correction of TIC, and organ damage in a rat multiple trauma transfusion model.MethodsMechanically ventilated male Sprague Dawley rats were traumatized by crush injury to the small intestine and liver and a fracture of the femur, followed by exsanguination until a mean arterial pressure (MAP) of 40 mmHg. Animals were randomly assigned to receive resuscitation in a high PLT dose (PLT to plasma to RBC in a ratio of 2:1:1) or a standard PLT dose (ratio of 1:1:1) until a MAP of 60 mmHg was reached (n = 8 per group). Blood samples were taken for biochemical and thromboelastometry (ROTEM) assessment. Organs were harvested for histopathology.Outcome measures were transfusion requirements needed to reach a pretargeted MAP, as well as ROTEM correction and organ failure.ResultsTrauma resulted in coagulopathy as assessed by deranged ROTEM results. Mortality rate was 19%, with all deaths occurring in the standard dose group. The severity of hypovolemic shock as assessed by lactate and base excess was not different in both groups. The volume of transfusion needed to reach the MAP target was lower in the high PLT dose group compared to the standard dose, albeit not statistically significant (p = 0.054). Transfusion with a high PLT dose resulted in significant stronger clot firmness compared to the standard dose at all time points following trauma, while platelet counts were similar. Organ failure as assessed by biochemical analysis and histopathology was not different between groups, nor were there any thromboembolic events recorded.ConclusionsResuscitation with a high (2:1) PLT-to-RBC ratio was more effective compared to standard (1:1) PLT-to-RBC ratio in treating TIC, with a trend towards reduced transfusion volumes. Also, high PLT dose did not aggravate organ damage. Transfusion strategies using higher PLT dose regiments might be a feasible treatment option in hemorrhaging trauma patients for the correction of TIC. Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standard 1:1 ratio on transfusion requirements, correction of TIC, and organ damage in a rat multiple trauma transfusion model. Mechanically ventilated male Sprague Dawley rats were traumatized by crush injury to the small intestine and liver and a fracture of the femur, followed by exsanguination until a mean arterial pressure (MAP) of 40 mmHg. Animals were randomly assigned to receive resuscitation in a high PLT dose (PLT to plasma to RBC in a ratio of 2:1:1) or a standard PLT dose (ratio of 1:1:1) until a MAP of 60 mmHg was reached (n = 8 per group). Blood samples were taken for biochemical and thromboelastometry (ROTEM) assessment. Organs were harvested for histopathology.Outcome measures were transfusion requirements needed to reach a pretargeted MAP, as well as ROTEM correction and organ failure. Trauma resulted in coagulopathy as assessed by deranged ROTEM results. Mortality rate was 19%, with all deaths occurring in the standard dose group. The severity of hypovolemic shock as assessed by lactate and base excess was not different in both groups. The volume of transfusion needed to reach the MAP target was lower in the high PLT dose group compared to the standard dose, albeit not statistically significant (p = 0.054). Transfusion with a high PLT dose resulted in significant stronger clot firmness compared to the standard dose at all time points following trauma, while platelet counts were similar. Organ failure as assessed by biochemical analysis and histopathology was not different between groups, nor were there any thromboembolic events recorded. Resuscitation with a high (2:1) PLT-to-RBC ratio was more effective compared to standard (1:1) PLT-to-RBC ratio in treating TIC, with a trend towards reduced transfusion volumes. Also, high PLT dose did not aggravate organ damage. Transfusion strategies using higher PLT dose regiments might be a feasible treatment option in hemorrhaging trauma patients for the correction of TIC. Abstract Background Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standard 1:1 ratio on transfusion requirements, correction of TIC, and organ damage in a rat multiple trauma transfusion model. Methods Mechanically ventilated male Sprague Dawley rats were traumatized by crush injury to the small intestine and liver and a fracture of the femur, followed by exsanguination until a mean arterial pressure (MAP) of 40 mmHg. Animals were randomly assigned to receive resuscitation in a high PLT dose (PLT to plasma to RBC in a ratio of 2:1:1) or a standard PLT dose (ratio of 1:1:1) until a MAP of 60 mmHg was reached (n = 8 per group). Blood samples were taken for biochemical and thromboelastometry (ROTEM) assessment. Organs were harvested for histopathology.Outcome measures were transfusion requirements needed to reach a pretargeted MAP, as well as ROTEM correction and organ failure. Results Trauma resulted in coagulopathy as assessed by deranged ROTEM results. Mortality rate was 19%, with all deaths occurring in the standard dose group. The severity of hypovolemic shock as assessed by lactate and base excess was not different in both groups. The volume of transfusion needed to reach the MAP target was lower in the high PLT dose group compared to the standard dose, albeit not statistically significant (p = 0.054). Transfusion with a high PLT dose resulted in significant stronger clot firmness compared to the standard dose at all time points following trauma, while platelet counts were similar. Organ failure as assessed by biochemical analysis and histopathology was not different between groups, nor were there any thromboembolic events recorded. Conclusions Resuscitation with a high (2:1) PLT-to-RBC ratio was more effective compared to standard (1:1) PLT-to-RBC ratio in treating TIC, with a trend towards reduced transfusion volumes. Also, high PLT dose did not aggravate organ damage. Transfusion strategies using higher PLT dose regiments might be a feasible treatment option in hemorrhaging trauma patients for the correction of TIC. Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standard 1:1 ratio on transfusion requirements, correction of TIC, and organ damage in a rat multiple trauma transfusion model.BACKGROUNDPlatelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standard 1:1 ratio on transfusion requirements, correction of TIC, and organ damage in a rat multiple trauma transfusion model.Mechanically ventilated male Sprague Dawley rats were traumatized by crush injury to the small intestine and liver and a fracture of the femur, followed by exsanguination until a mean arterial pressure (MAP) of 40 mmHg. Animals were randomly assigned to receive resuscitation in a high PLT dose (PLT to plasma to RBC in a ratio of 2:1:1) or a standard PLT dose (ratio of 1:1:1) until a MAP of 60 mmHg was reached (n = 8 per group). Blood samples were taken for biochemical and thromboelastometry (ROTEM) assessment. Organs were harvested for histopathology.Outcome measures were transfusion requirements needed to reach a pretargeted MAP, as well as ROTEM correction and organ failure.METHODSMechanically ventilated male Sprague Dawley rats were traumatized by crush injury to the small intestine and liver and a fracture of the femur, followed by exsanguination until a mean arterial pressure (MAP) of 40 mmHg. Animals were randomly assigned to receive resuscitation in a high PLT dose (PLT to plasma to RBC in a ratio of 2:1:1) or a standard PLT dose (ratio of 1:1:1) until a MAP of 60 mmHg was reached (n = 8 per group). Blood samples were taken for biochemical and thromboelastometry (ROTEM) assessment. Organs were harvested for histopathology.Outcome measures were transfusion requirements needed to reach a pretargeted MAP, as well as ROTEM correction and organ failure.Trauma resulted in coagulopathy as assessed by deranged ROTEM results. Mortality rate was 19%, with all deaths occurring in the standard dose group. The severity of hypovolemic shock as assessed by lactate and base excess was not different in both groups. The volume of transfusion needed to reach the MAP target was lower in the high PLT dose group compared to the standard dose, albeit not statistically significant (p = 0.054). Transfusion with a high PLT dose resulted in significant stronger clot firmness compared to the standard dose at all time points following trauma, while platelet counts were similar. Organ failure as assessed by biochemical analysis and histopathology was not different between groups, nor were there any thromboembolic events recorded.RESULTSTrauma resulted in coagulopathy as assessed by deranged ROTEM results. Mortality rate was 19%, with all deaths occurring in the standard dose group. The severity of hypovolemic shock as assessed by lactate and base excess was not different in both groups. The volume of transfusion needed to reach the MAP target was lower in the high PLT dose group compared to the standard dose, albeit not statistically significant (p = 0.054). Transfusion with a high PLT dose resulted in significant stronger clot firmness compared to the standard dose at all time points following trauma, while platelet counts were similar. Organ failure as assessed by biochemical analysis and histopathology was not different between groups, nor were there any thromboembolic events recorded.Resuscitation with a high (2:1) PLT-to-RBC ratio was more effective compared to standard (1:1) PLT-to-RBC ratio in treating TIC, with a trend towards reduced transfusion volumes. Also, high PLT dose did not aggravate organ damage. Transfusion strategies using higher PLT dose regiments might be a feasible treatment option in hemorrhaging trauma patients for the correction of TIC.CONCLUSIONSResuscitation with a high (2:1) PLT-to-RBC ratio was more effective compared to standard (1:1) PLT-to-RBC ratio in treating TIC, with a trend towards reduced transfusion volumes. Also, high PLT dose did not aggravate organ damage. Transfusion strategies using higher PLT dose regiments might be a feasible treatment option in hemorrhaging trauma patients for the correction of TIC. |
| ArticleNumber | 42 |
| Author | Hollmann, Markus W. Wirtz, Mathijs R. Kleinveld, Derek J. B. Roelofs, Joris J. T. H. Juffermans, Nicole P. Maas, M. Adrie W. van den Brink, Daan P. Goslings, J. Carel |
| Author_xml | – sequence: 1 givenname: Derek J. B. surname: Kleinveld fullname: Kleinveld, Derek J. B. organization: Department of Intensive Care Medicine, Amsterdam UMC, Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, Department of Trauma Surgery, Amsterdam UMC – sequence: 2 givenname: Mathijs R. surname: Wirtz fullname: Wirtz, Mathijs R. organization: Department of Intensive Care Medicine, Amsterdam UMC, Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, Department of Trauma Surgery, Amsterdam UMC – sequence: 3 givenname: Daan P. surname: van den Brink fullname: van den Brink, Daan P. organization: Department of Intensive Care Medicine, Amsterdam UMC – sequence: 4 givenname: M. Adrie W. surname: Maas fullname: Maas, M. Adrie W. organization: Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC – sequence: 5 givenname: Joris J. T. H. surname: Roelofs fullname: Roelofs, Joris J. T. H. organization: Department of Pathology, Amsterdam UMC – sequence: 6 givenname: J. Carel surname: Goslings fullname: Goslings, J. Carel organization: Department of Trauma Surgery, Onze Lieve Vrouwe Gasthuis – sequence: 7 givenname: Markus W. surname: Hollmann fullname: Hollmann, Markus W. organization: Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, Department of Anesthesiology, Amsterdam UMC – sequence: 8 givenname: Nicole P. orcidid: 0000-0002-3039-6574 surname: Juffermans fullname: Juffermans, Nicole P. email: n.p.juffermans@amc.nl, n.p.juffermans@amc.uva.nl organization: Department of Intensive Care Medicine, Amsterdam UMC, Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31346913$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks1u1DAUhSNUREvpA7BBltiwCfg_CQukMuKnUiUkRCV2luPcZFx57MF2KvWBeE8cZhjaSrBy7HvOd6_j87Q68sFDVT0n-DUhrXyTOJZM1Jh0Naac1uJRdUJJ19Sciu9Hd76Pq7OUrjHGBAsmO_ykOmaEcdkRdlL9vEqAwog0WttpjbZOZ3CQ6xzqr-9XKOpsw1KnbwmyCW1CBATjCCbbG0DWIxNiXHZ-QjnqeaNr64fZwFAqeppd2Oq8vkV5rX1pcuCRhbc_QZvZZbt1sCcsi0_jnGzwpeMA7ln1eNQuwdl-Pa2uPn74tvpcX375dLE6v6yNaESu-4F3o2wpa7WWfQ-NGZqei75raadl2wvGW0aINJox1oycgWFSSMEJEXoovtPqYscdgr5W22g3Ot6qoK36fRDipHTM1jhQQrSjbjojDTccj0z3gkosmh5zoJq2hfVux9rO_QYGA75cy92D3q94u1ZTuFFSilYyWQCv9oAYfsyQstrYZMA57SHMSVEqRcMl6ViRvnwgvQ5z9OVXLSrGCaUNL6oXdyc6jPInDUVAdgITQ0oRxoOEYLWETu1Cp0ro1BI6JYqneeAxNi-vvFzKuv866c6ZShc_Qfw79L9NvwAiyOq_ |
| CitedBy_id | crossref_primary_10_1111_trf_15937 crossref_primary_10_1007_s10495_023_01894_6 crossref_primary_10_1016_j_bja_2021_01_032 crossref_primary_10_1111_trf_16455 crossref_primary_10_1182_bloodadvances_2021004404 crossref_primary_10_1016_j_injury_2024_112021 |
| Cites_doi | 10.1097/TA.0000000000000147 10.1097/SHK.0b013e31826dbd23 10.1371/journal.pmed.1002352 10.1016/j.tracli.2018.03.006 10.32098/mltj.01.2014.02 10.1016/S0140-6736(04)16415-5 10.1001/jama.2015.12 10.1097/SLA.0b013e318185a9ad 10.1097/TA.0000000000001017 10.1177/0363546510387517 10.1016/j.smim.2018.02.011 10.1016/j.thromres.2016.03.007 10.1111/trf.15039 10.1097/TA.0b013e318256deab 10.1182/blood-2009-10-248732 10.1172/JCI81660 10.1097/SHK.0000000000000265 10.1016/j.blre.2017.08.003 10.1007/s00068-018-0953-4 10.4103/2229-5151.195448 10.1097/00005373-198602000-00014 10.1002/bjs.10052 10.1016/j.jss.2017.05.027 10.1097/TA.0b013e318227edbb 10.1186/s13054-015-0823-y 10.1002/bjs.10905 10.1097/SHK.0000000000000652 10.1111/trf.14236 10.2174/1381612811209023267 10.1097/ALN.0b013e3181de6f25 10.1016/j.resuscitation.2008.12.003 10.1088/0143-0815/5/3/007 10.1097/TA.0b013e31825889ba 10.1097/TA.0000000000000691 10.1097/01.TA.0000075338.21177.EF 10.1097/SHK.0000000000000875 10.1186/s12959-017-0154-0 |
| ContentType | Journal Article |
| Copyright | The Author(s). 2019 Intensive Care Medicine Experimental is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s). 2019 – notice: Intensive Care Medicine Experimental is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION NPM 3V. 7RV 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. KB0 M0S NAPCQ PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.1186/s40635-019-0242-5 |
| DatabaseName | Springer Nature OA Free Journals CrossRef PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central (subscription) ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Health & Medical Collection (Alumni Edition) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2197-425X |
| EndPage | 12 |
| ExternalDocumentID | oai_doaj_org_article_558fa79c6c4c40f3ab526057b04e2a28 PMC6658636 31346913 10_1186_s40635_019_0242_5 |
| Genre | Journal Article |
| GroupedDBID | -A0 0R~ 3V. 53G 5VS 7RV 7X7 8FI 8FJ AAFWJ AAJSJ AAKKN ABDBF ABEEZ ABUWG ACACY ACGFS ACUHS ACULB ADBBV ADFRT ADINQ ADRAZ AFGXO AFKRA AHBYD AHMBA AHYZX ALIPV ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS ASPBG AVWKF BAPOH BAWUL BCNDV BENPR BFQNJ BKEYQ BPHCQ BVXVI C24 C6C CCPQU DIK EBLON EBS FYUFA GROUPED_DOAJ HMCUK HYE IAO IHR ITC KQ8 M48 M~E NAPCQ OK1 PGMZT PIMPY PQQKQ PROAC RBZ RPM RSV SOJ UKHRP AASML AAYXX AFPKN CITATION NPM 7XB 8FK AZQEC DWQXO K9. PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQUKI PRINS 7X8 5PM |
| ID | FETCH-LOGICAL-c575t-bd49f68238aa6bbe7cd7b45b9829a68b53483116ca3337f43ec365654115ad823 |
| IEDL.DBID | 7X7 |
| ISICitedReferencesCount | 8 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000477601600011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2197-425X |
| IngestDate | Tue Oct 14 19:08:30 EDT 2025 Tue Nov 04 02:04:07 EST 2025 Sun Nov 09 11:39:04 EST 2025 Tue Oct 14 14:10:35 EDT 2025 Wed Feb 19 02:05:29 EST 2025 Tue Nov 18 21:49:17 EST 2025 Sat Nov 29 05:19:14 EST 2025 Fri Feb 21 02:34:21 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | Suppl 1 |
| Keywords | Transfusion Platelets Trauma Experimental Coagulopathy |
| Language | English |
| License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c575t-bd49f68238aa6bbe7cd7b45b9829a68b53483116ca3337f43ec365654115ad823 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-3039-6574 |
| OpenAccessLink | https://www.proquest.com/docview/2263412274?pq-origsite=%requestingapplication% |
| PMID | 31346913 |
| PQID | 2263412274 |
| PQPubID | 2034745 |
| PageCount | 12 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_558fa79c6c4c40f3ab526057b04e2a28 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6658636 proquest_miscellaneous_2265746193 proquest_journals_2263412274 pubmed_primary_31346913 crossref_primary_10_1186_s40635_019_0242_5 crossref_citationtrail_10_1186_s40635_019_0242_5 springer_journals_10_1186_s40635_019_0242_5 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-07-25 |
| PublicationDateYYYYMMDD | 2019-07-25 |
| PublicationDate_xml | – month: 07 year: 2019 text: 2019-07-25 day: 25 |
| PublicationDecade | 2010 |
| PublicationPlace | Cham |
| PublicationPlace_xml | – name: Cham – name: Germany – name: Heidelberg |
| PublicationTitle | Intensive care medicine experimental |
| PublicationTitleAbbrev | ICMx |
| PublicationTitleAlternate | Intensive Care Med Exp |
| PublicationYear | 2019 |
| Publisher | Springer International Publishing Springer Nature B.V SpringerOpen |
| Publisher_xml | – name: Springer International Publishing – name: Springer Nature B.V – name: SpringerOpen |
| References | TraversoLWLeeWPLangfordMJFluid resuscitation after an otherwise fatal hemorrhage: I. Crystalloid solutionsJ Trauma19862621681751:STN:280:DyaL287hsFentw%3D%3D308060210.1097/00005373-198602000-00014 RamseyMTFabianTCShahanCPSharpeJPMabrySEWeinbergJAA prospective study of platelet function in trauma patientsJ Trauma Acute Care Surg20168057267321:CAS:528:DC%2BC28Xmsl2qurs%3D2689508810.1097/TA.0000000000001017discussion 32-3 WirtzMathijs R.JurgensJordyZuurbierCoert J.RoelofsJoris J.T.H.SpinellaPhilip C.MuszynskiJennifer A.Carel GoslingsJ.JuffermansNicole P.Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusionTransfusion20185911341453046102510.1111/trf.15039 EndoAShiraishiAFushimiKMurataKOtomoYOutcomes of patients receiving a massive transfusion for major traumaBr J Surg201810514261:STN:280:DC%2BB3c%2FnsVOltA%3D%3D2999951810.1002/bjs.10905 VogelSBodensteinRChenQFeilSFeilRRheinlaenderJPlatelet-derived HMGB1 is a critical mediator of thrombosisJ Clin Investig201512512463846542655168110.1172/JCI81660 ChenQVogelSLoughranPZuckerbraunBSBilliarTNealMDPlatelet derived HMGB1 regulates thrombosis and organ injury following traumaShock.2015432410.1097/SHK.0000000000000265 WuXSchwachaMGDubickMACapAPDarlingtonDNTrauma-related acute lung injury develops rapidly irrespective of resuscitation strategy in the ratShock.2016463S1081142717215010.1097/SHK.0000000000000652 HolcombJBWadeCEMichalekJEChisholmGBZarzabalLASchreiberMAIncreased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. [Erratum appears in Ann Surg. 2011 Feb;253(2):392]Ann Surg2008248344745818791365 AnderssonUYangHHarrisHHigh-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cellsSemin Immunol201838401:CAS:528:DC%2BC1cXkt1Knt7c%3D2953041010.1016/j.smim.2018.02.011 TuinmanPRSchultzMJJuffermansNPCoagulopathy as a therapeutic target for TRALI: rationale and possible sites of actionCurr Pharm Des20121822326732721:CAS:528:DC%2BC38XhtVGls7nO2262126910.2174/1381612811209023267 HolcombJBTilleyBCBaraniukSFoxEEWadeCEPodbielskiJMTransfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trialJAMA.201531354714821:CAS:528:DC%2BC2MXisVClsbs%3D25647203437474410.1001/jama.2015.12 HagemoJSChristiaansSCStanworthSJBrohiKJohanssonPIGoslingsJCDetection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation studyCrit Care2015199725888032437441110.1186/s13054-015-0823-y Kasotakis G, Starr N, Nelson E, Sarkar B, Burke PA, Remick DG et al (2018) Platelet transfusion increases risk for acute respiratory distress syndrome in non-massively transfused blunt trauma patients. Eur J Trauma Emerg Surg AyalaAWangPBaZFPerrinMMErtelWChaudryIHDifferential alterations in plasma IL-6 and TNF levels after trauma and hemorrhageAm J Phys19912601 Pt 2R167R1711:CAS:528:DyaK3MXht1SjtLs%3D TariketSSutCHamzeh-CognasseHLaradiSGarraudOCognasseFPlatelet and TRALI: from blood component to organismTransfus Clin Biol2018252041:STN:280:DC%2BC1MjgtlKquw%3D%3D2963196310.1016/j.tracli.2018.03.006 CabreraCPMansonJShepherdJMTorranceHDWatsonDLonghiMPSignatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: a prospective cohort studyPLoS Med2017147e100235228715416551340010.1371/journal.pmed.1002352 Dohan EhrenfestDMAndiaIZumsteinMAZhangCQPintoNRBieleckiTClassification of platelet concentrates (platelet-rich plasma-PRP, platelet-rich fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectivesMuscles Ligaments Tendons J2014413924932440404964710.32098/mltj.01.2014.02 CastilloTNPouliotMAKimHJDragooJLComparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systemsAm J Sports Med20113922662712105142810.1177/0363546510387517 MacLeodJBALynnMMcKenneyMGCohnSMMurthaMEarly coagulopathy predicts mortality in traumaJ Trauma200355139441285587910.1097/01.TA.0000075338.21177.EF Naumann DN, Hazeldine J, Davies DJ, Bishop J, Midwinter MJ, Belli A et al (2017) Endotheliopathy of trauma is an on-scene phenomenon, and is associated with multiple organ dysfunction syndrome: a prospective observational study. PLoS One 12(12):e0189870. SauaiaAMooreEEJohnsonJLChinTLBanerjeeASperryJLTemporal trends of postinjury multiple- organ failure: still resource intensive, morbid, and lethalJ Trauma Acute Care Surg201476358259224553523411608810.1097/TA.0000000000000147 CruzMVLukerJNCarneyBCBrummel-ZiedinsKEBravoMCOrfeoTReference ranges for rotational thromboelastometry in male Sprague Dawley ratsThromb J2017153129299031574709210.1186/s12959-017-0154-0 LeeCCLeeRPSubeqYMLeeCJChenTMHsuBGFluvastatin attenuates severe hemorrhagic shock-induced organ damage in ratsResuscitation.20098033723781:CAS:528:DC%2BD1MXhvFKjsb8%3D1915016610.1016/j.resuscitation.2008.12.003 VlaarAPHofstraJJKulikWvan LentheHNieuwlandRSchultzMJSupernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion modelBlood.20101168136013681:CAS:528:DC%2BC3cXhtFersbfO2047928610.1182/blood-2009-10-248732 MorsingKSHPetersALvan BuulJDVlaarAPJThe role of endothelium in the onset of antibody-mediated TRALIBlood Rev2018321171:CAS:528:DC%2BC2sXhtlKmsrvK2882376310.1016/j.blre.2017.08.003 StettlerGRMooreEEMooreHBLawsonPJFragosoMNunnsGRThrombelastography indicates limitations of animal models of trauma-induced coagulopathyJ Surg Res201721720721228583756560336910.1016/j.jss.2017.05.027 MaegeleMSpinellaPCSchochlHThe acute coagulopathy of trauma: mechanisms and tools for risk stratificationShock.20123854504582304219210.1097/SHK.0b013e31826dbd23 TrowbridgeEAMartinJFSlaterDNKishkYTWarrenCWHarleyPJThe origin of platelet count and volumeClin Phys Physiol Meas1984531451701:STN:280:DyaL2M%2FisFyhsg%3D%3D648872210.1088/0143-0815/5/3/007 LetsonHLDobsonGPDifferential contributions of platelets and fibrinogen to early coagulopathy in a rat model of hemorrhagic shockThromb Res201614158651:CAS:528:DC%2BC28XktVCks7g%3D2697071410.1016/j.thromres.2016.03.007 BrownJBCohenMJMineiJPMaierRVWestMABilliarTRDebunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusionJ Trauma Acute Care Surg20127323583642284694010.1097/TA.0b013e31825889badiscussion 64 KutcherMERedickBJMcCreeryRCCraneIMGreenbergMDCacholaLMCharacterization of platelet dysfunction after traumaJ Trauma Acute Care Surg201273113191:CAS:528:DC%2BC38Xpsl2qtr8%3D22743367338738710.1097/TA.0b013e318256deab VlaarAPHofstraJJLeviMKulikWNieuwlandRToolATSupernatant of aged erythrocytes causes lung inflammation and coagulopathy in a “two-hit” in vivo syngeneic transfusion modelAnesthesiology.20101131921032050849310.1097/ALN.0b013e3181de6f25 DarlingtonDWuXCapAPPolytrauma and hemorrhage affects platelet function in ratsTransfusion.20145420A21A StraatMTuipAKleiTRLBeugerBMRoelofsJvan BruggenREndotoxemia results in trapping of transfused red blood cells in lungs with associated lung injuryShock.20174844844892891521810.1097/SHK.0000000000000875 GoodmanMDMakleyATHansemanDJPrittsTARobinsonBRAll the bang without the bucks: defining essential point-of-care testing for traumatic coagulopathyJ Trauma Acute Care Surg20157911171241:CAS:528:DC%2BC2MXhtValu7zI26091324555826410.1097/TA.0000000000000691discussion 24 LiYXiangMYuanYXiaoGZhangJJiangYHemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2Am J Phys Regul Integr Comp Phys20092976R1670R16801:CAS:528:DC%2BD1MXhsFOltLfF JuffermansNPVlaarAPPossible TRALI is a real entityTransfusion.20175710253925412869132110.1111/trf.14236 HolcombJBZarzabalLAMichalekJEKozarRASpinellaPCPerkinsJGIncreased platelet: RBC ratios are associated with improved survival after massive transfusionJ Trauma2011712 Suppl 3S318S3282181409910.1097/TA.0b013e318227edbb MooreFAMcKinleyBAMooreEEThe next generation in shock resuscitationLancet.20043639425198819961519426010.1016/S0140-6736(04)16415-5 StanworthSJDavenportRCurryNSeeneyFEaglestoneSEdwardsAMortality from trauma haemorrhage and opportunities for improvement in transfusion practiceBr J Surg201610343573651:STN:280:DC%2BC28nnt12ntg%3D%3D2684172010.1002/bjs.10052 PeraltaRVijayAEl-MenyarAConsunjiRAfifiIMahmoodIEarly high ratio platelet transfusion in trauma resuscitation and its outcomesInt J Crit Illn Inj Sci20166418819328149824522576210.4103/2229-5151.195448 HL Letson (242_CR24) 2016; 141 JBA MacLeod (242_CR4) 2003; 55 M Maegele (242_CR8) 2012; 38 LW Traverso (242_CR9) 1986; 26 EA Trowbridge (242_CR40) 1984; 5 KSH Morsing (242_CR31) 2018; 32 R Peralta (242_CR35) 2016; 6 MT Ramsey (242_CR14) 2016; 80 X Wu (242_CR22) 2016; 46 Y Li (242_CR39) 2009; 297 PR Tuinman (242_CR36) 2012; 18 AP Vlaar (242_CR20) 2010; 113 JS Hagemo (242_CR26) 2015; 19 242_CR34 ME Kutcher (242_CR15) 2012; 73 CC Lee (242_CR28) 2009; 80 JB Holcomb (242_CR13) 2008; 248 Mathijs R. Wirtz (242_CR21) 2018; 59 MV Cruz (242_CR25) 2017; 15 M Straat (242_CR27) 2017; 48 JB Holcomb (242_CR12) 2011; 71 U Andersson (242_CR18) 2018; 38 FA Moore (242_CR10) 2004; 363 JB Holcomb (242_CR11) 2015; 313 TN Castillo (242_CR30) 2011; 39 NP Juffermans (242_CR32) 2017; 57 A Sauaia (242_CR5) 2014; 76 CP Cabrera (242_CR2) 2017; 14 JB Brown (242_CR6) 2012; 73 AP Vlaar (242_CR19) 2010; 116 GR Stettler (242_CR41) 2017; 217 242_CR1 A Endo (242_CR16) 2018; 105 DM Dohan Ehrenfest (242_CR29) 2014; 4 D Darlington (242_CR23) 2014; 54 S Vogel (242_CR38) 2015; 125 Q Chen (242_CR17) 2015; 43 A Ayala (242_CR37) 1991; 260 SJ Stanworth (242_CR3) 2016; 103 MD Goodman (242_CR7) 2015; 79 S Tariket (242_CR33) 2018; 25 |
| References_xml | – reference: RamseyMTFabianTCShahanCPSharpeJPMabrySEWeinbergJAA prospective study of platelet function in trauma patientsJ Trauma Acute Care Surg20168057267321:CAS:528:DC%2BC28Xmsl2qurs%3D2689508810.1097/TA.0000000000001017discussion 32-3 – reference: StraatMTuipAKleiTRLBeugerBMRoelofsJvan BruggenREndotoxemia results in trapping of transfused red blood cells in lungs with associated lung injuryShock.20174844844892891521810.1097/SHK.0000000000000875 – reference: AyalaAWangPBaZFPerrinMMErtelWChaudryIHDifferential alterations in plasma IL-6 and TNF levels after trauma and hemorrhageAm J Phys19912601 Pt 2R167R1711:CAS:528:DyaK3MXht1SjtLs%3D – reference: VlaarAPHofstraJJKulikWvan LentheHNieuwlandRSchultzMJSupernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion modelBlood.20101168136013681:CAS:528:DC%2BC3cXhtFersbfO2047928610.1182/blood-2009-10-248732 – reference: MacLeodJBALynnMMcKenneyMGCohnSMMurthaMEarly coagulopathy predicts mortality in traumaJ Trauma200355139441285587910.1097/01.TA.0000075338.21177.EF – reference: MaegeleMSpinellaPCSchochlHThe acute coagulopathy of trauma: mechanisms and tools for risk stratificationShock.20123854504582304219210.1097/SHK.0b013e31826dbd23 – reference: KutcherMERedickBJMcCreeryRCCraneIMGreenbergMDCacholaLMCharacterization of platelet dysfunction after traumaJ Trauma Acute Care Surg201273113191:CAS:528:DC%2BC38Xpsl2qtr8%3D22743367338738710.1097/TA.0b013e318256deab – reference: LiYXiangMYuanYXiaoGZhangJJiangYHemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2Am J Phys Regul Integr Comp Phys20092976R1670R16801:CAS:528:DC%2BD1MXhsFOltLfF – reference: DarlingtonDWuXCapAPPolytrauma and hemorrhage affects platelet function in ratsTransfusion.20145420A21A – reference: PeraltaRVijayAEl-MenyarAConsunjiRAfifiIMahmoodIEarly high ratio platelet transfusion in trauma resuscitation and its outcomesInt J Crit Illn Inj Sci20166418819328149824522576210.4103/2229-5151.195448 – reference: TrowbridgeEAMartinJFSlaterDNKishkYTWarrenCWHarleyPJThe origin of platelet count and volumeClin Phys Physiol Meas1984531451701:STN:280:DyaL2M%2FisFyhsg%3D%3D648872210.1088/0143-0815/5/3/007 – reference: HagemoJSChristiaansSCStanworthSJBrohiKJohanssonPIGoslingsJCDetection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation studyCrit Care2015199725888032437441110.1186/s13054-015-0823-y – reference: Kasotakis G, Starr N, Nelson E, Sarkar B, Burke PA, Remick DG et al (2018) Platelet transfusion increases risk for acute respiratory distress syndrome in non-massively transfused blunt trauma patients. Eur J Trauma Emerg Surg – reference: VogelSBodensteinRChenQFeilSFeilRRheinlaenderJPlatelet-derived HMGB1 is a critical mediator of thrombosisJ Clin Investig201512512463846542655168110.1172/JCI81660 – reference: JuffermansNPVlaarAPPossible TRALI is a real entityTransfusion.20175710253925412869132110.1111/trf.14236 – reference: SauaiaAMooreEEJohnsonJLChinTLBanerjeeASperryJLTemporal trends of postinjury multiple- organ failure: still resource intensive, morbid, and lethalJ Trauma Acute Care Surg201476358259224553523411608810.1097/TA.0000000000000147 – reference: AnderssonUYangHHarrisHHigh-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cellsSemin Immunol201838401:CAS:528:DC%2BC1cXkt1Knt7c%3D2953041010.1016/j.smim.2018.02.011 – reference: Dohan EhrenfestDMAndiaIZumsteinMAZhangCQPintoNRBieleckiTClassification of platelet concentrates (platelet-rich plasma-PRP, platelet-rich fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectivesMuscles Ligaments Tendons J2014413924932440404964710.32098/mltj.01.2014.02 – reference: CabreraCPMansonJShepherdJMTorranceHDWatsonDLonghiMPSignatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: a prospective cohort studyPLoS Med2017147e100235228715416551340010.1371/journal.pmed.1002352 – reference: WirtzMathijs R.JurgensJordyZuurbierCoert J.RoelofsJoris J.T.H.SpinellaPhilip C.MuszynskiJennifer A.Carel GoslingsJ.JuffermansNicole P.Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusionTransfusion20185911341453046102510.1111/trf.15039 – reference: HolcombJBTilleyBCBaraniukSFoxEEWadeCEPodbielskiJMTransfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trialJAMA.201531354714821:CAS:528:DC%2BC2MXisVClsbs%3D25647203437474410.1001/jama.2015.12 – reference: WuXSchwachaMGDubickMACapAPDarlingtonDNTrauma-related acute lung injury develops rapidly irrespective of resuscitation strategy in the ratShock.2016463S1081142717215010.1097/SHK.0000000000000652 – reference: GoodmanMDMakleyATHansemanDJPrittsTARobinsonBRAll the bang without the bucks: defining essential point-of-care testing for traumatic coagulopathyJ Trauma Acute Care Surg20157911171241:CAS:528:DC%2BC2MXhtValu7zI26091324555826410.1097/TA.0000000000000691discussion 24 – reference: BrownJBCohenMJMineiJPMaierRVWestMABilliarTRDebunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusionJ Trauma Acute Care Surg20127323583642284694010.1097/TA.0b013e31825889badiscussion 64 – reference: HolcombJBZarzabalLAMichalekJEKozarRASpinellaPCPerkinsJGIncreased platelet: RBC ratios are associated with improved survival after massive transfusionJ Trauma2011712 Suppl 3S318S3282181409910.1097/TA.0b013e318227edbb – reference: LeeCCLeeRPSubeqYMLeeCJChenTMHsuBGFluvastatin attenuates severe hemorrhagic shock-induced organ damage in ratsResuscitation.20098033723781:CAS:528:DC%2BD1MXhvFKjsb8%3D1915016610.1016/j.resuscitation.2008.12.003 – reference: StanworthSJDavenportRCurryNSeeneyFEaglestoneSEdwardsAMortality from trauma haemorrhage and opportunities for improvement in transfusion practiceBr J Surg201610343573651:STN:280:DC%2BC28nnt12ntg%3D%3D2684172010.1002/bjs.10052 – reference: TariketSSutCHamzeh-CognasseHLaradiSGarraudOCognasseFPlatelet and TRALI: from blood component to organismTransfus Clin Biol2018252041:STN:280:DC%2BC1MjgtlKquw%3D%3D2963196310.1016/j.tracli.2018.03.006 – reference: LetsonHLDobsonGPDifferential contributions of platelets and fibrinogen to early coagulopathy in a rat model of hemorrhagic shockThromb Res201614158651:CAS:528:DC%2BC28XktVCks7g%3D2697071410.1016/j.thromres.2016.03.007 – reference: StettlerGRMooreEEMooreHBLawsonPJFragosoMNunnsGRThrombelastography indicates limitations of animal models of trauma-induced coagulopathyJ Surg Res201721720721228583756560336910.1016/j.jss.2017.05.027 – reference: TraversoLWLeeWPLangfordMJFluid resuscitation after an otherwise fatal hemorrhage: I. Crystalloid solutionsJ Trauma19862621681751:STN:280:DyaL287hsFentw%3D%3D308060210.1097/00005373-198602000-00014 – reference: TuinmanPRSchultzMJJuffermansNPCoagulopathy as a therapeutic target for TRALI: rationale and possible sites of actionCurr Pharm Des20121822326732721:CAS:528:DC%2BC38XhtVGls7nO2262126910.2174/1381612811209023267 – reference: HolcombJBWadeCEMichalekJEChisholmGBZarzabalLASchreiberMAIncreased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. [Erratum appears in Ann Surg. 2011 Feb;253(2):392]Ann Surg2008248344745818791365 – reference: Naumann DN, Hazeldine J, Davies DJ, Bishop J, Midwinter MJ, Belli A et al (2017) Endotheliopathy of trauma is an on-scene phenomenon, and is associated with multiple organ dysfunction syndrome: a prospective observational study. PLoS One 12(12):e0189870. – reference: MooreFAMcKinleyBAMooreEEThe next generation in shock resuscitationLancet.20043639425198819961519426010.1016/S0140-6736(04)16415-5 – reference: ChenQVogelSLoughranPZuckerbraunBSBilliarTNealMDPlatelet derived HMGB1 regulates thrombosis and organ injury following traumaShock.2015432410.1097/SHK.0000000000000265 – reference: CruzMVLukerJNCarneyBCBrummel-ZiedinsKEBravoMCOrfeoTReference ranges for rotational thromboelastometry in male Sprague Dawley ratsThromb J2017153129299031574709210.1186/s12959-017-0154-0 – reference: EndoAShiraishiAFushimiKMurataKOtomoYOutcomes of patients receiving a massive transfusion for major traumaBr J Surg201810514261:STN:280:DC%2BB3c%2FnsVOltA%3D%3D2999951810.1002/bjs.10905 – reference: MorsingKSHPetersALvan BuulJDVlaarAPJThe role of endothelium in the onset of antibody-mediated TRALIBlood Rev2018321171:CAS:528:DC%2BC2sXhtlKmsrvK2882376310.1016/j.blre.2017.08.003 – reference: CastilloTNPouliotMAKimHJDragooJLComparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systemsAm J Sports Med20113922662712105142810.1177/0363546510387517 – reference: VlaarAPHofstraJJLeviMKulikWNieuwlandRToolATSupernatant of aged erythrocytes causes lung inflammation and coagulopathy in a “two-hit” in vivo syngeneic transfusion modelAnesthesiology.20101131921032050849310.1097/ALN.0b013e3181de6f25 – volume: 54 start-page: 20A year: 2014 ident: 242_CR23 publication-title: Transfusion. – volume: 76 start-page: 582 issue: 3 year: 2014 ident: 242_CR5 publication-title: J Trauma Acute Care Surg doi: 10.1097/TA.0000000000000147 – volume: 38 start-page: 450 issue: 5 year: 2012 ident: 242_CR8 publication-title: Shock. doi: 10.1097/SHK.0b013e31826dbd23 – volume: 14 start-page: e1002352 issue: 7 year: 2017 ident: 242_CR2 publication-title: PLoS Med doi: 10.1371/journal.pmed.1002352 – volume: 25 start-page: 204 year: 2018 ident: 242_CR33 publication-title: Transfus Clin Biol doi: 10.1016/j.tracli.2018.03.006 – volume: 4 start-page: 3 issue: 1 year: 2014 ident: 242_CR29 publication-title: Muscles Ligaments Tendons J doi: 10.32098/mltj.01.2014.02 – volume: 363 start-page: 1988 issue: 9425 year: 2004 ident: 242_CR10 publication-title: Lancet. doi: 10.1016/S0140-6736(04)16415-5 – volume: 313 start-page: 471 issue: 5 year: 2015 ident: 242_CR11 publication-title: JAMA. doi: 10.1001/jama.2015.12 – volume: 248 start-page: 447 issue: 3 year: 2008 ident: 242_CR13 publication-title: Ann Surg doi: 10.1097/SLA.0b013e318185a9ad – volume: 80 start-page: 726 issue: 5 year: 2016 ident: 242_CR14 publication-title: J Trauma Acute Care Surg doi: 10.1097/TA.0000000000001017 – volume: 39 start-page: 266 issue: 2 year: 2011 ident: 242_CR30 publication-title: Am J Sports Med doi: 10.1177/0363546510387517 – volume: 38 start-page: 40 year: 2018 ident: 242_CR18 publication-title: Semin Immunol doi: 10.1016/j.smim.2018.02.011 – volume: 141 start-page: 58 year: 2016 ident: 242_CR24 publication-title: Thromb Res doi: 10.1016/j.thromres.2016.03.007 – volume: 59 start-page: 134 issue: 1 year: 2018 ident: 242_CR21 publication-title: Transfusion doi: 10.1111/trf.15039 – volume: 297 start-page: R1670 issue: 6 year: 2009 ident: 242_CR39 publication-title: Am J Phys Regul Integr Comp Phys – volume: 73 start-page: 13 issue: 1 year: 2012 ident: 242_CR15 publication-title: J Trauma Acute Care Surg doi: 10.1097/TA.0b013e318256deab – volume: 116 start-page: 1360 issue: 8 year: 2010 ident: 242_CR19 publication-title: Blood. doi: 10.1182/blood-2009-10-248732 – volume: 125 start-page: 4638 issue: 12 year: 2015 ident: 242_CR38 publication-title: J Clin Investig doi: 10.1172/JCI81660 – volume: 43 start-page: 24 year: 2015 ident: 242_CR17 publication-title: Shock. doi: 10.1097/SHK.0000000000000265 – volume: 32 start-page: 1 issue: 1 year: 2018 ident: 242_CR31 publication-title: Blood Rev doi: 10.1016/j.blre.2017.08.003 – ident: 242_CR34 doi: 10.1007/s00068-018-0953-4 – volume: 6 start-page: 188 issue: 4 year: 2016 ident: 242_CR35 publication-title: Int J Crit Illn Inj Sci doi: 10.4103/2229-5151.195448 – volume: 26 start-page: 168 issue: 2 year: 1986 ident: 242_CR9 publication-title: J Trauma doi: 10.1097/00005373-198602000-00014 – volume: 103 start-page: 357 issue: 4 year: 2016 ident: 242_CR3 publication-title: Br J Surg doi: 10.1002/bjs.10052 – volume: 217 start-page: 207 year: 2017 ident: 242_CR41 publication-title: J Surg Res doi: 10.1016/j.jss.2017.05.027 – volume: 71 start-page: S318 issue: 2 Suppl 3 year: 2011 ident: 242_CR12 publication-title: J Trauma doi: 10.1097/TA.0b013e318227edbb – volume: 19 start-page: 97 year: 2015 ident: 242_CR26 publication-title: Crit Care doi: 10.1186/s13054-015-0823-y – volume: 105 start-page: 1426 year: 2018 ident: 242_CR16 publication-title: Br J Surg doi: 10.1002/bjs.10905 – volume: 46 start-page: 108 issue: 3S year: 2016 ident: 242_CR22 publication-title: Shock. doi: 10.1097/SHK.0000000000000652 – volume: 57 start-page: 2539 issue: 10 year: 2017 ident: 242_CR32 publication-title: Transfusion. doi: 10.1111/trf.14236 – volume: 18 start-page: 3267 issue: 22 year: 2012 ident: 242_CR36 publication-title: Curr Pharm Des doi: 10.2174/1381612811209023267 – volume: 113 start-page: 92 issue: 1 year: 2010 ident: 242_CR20 publication-title: Anesthesiology. doi: 10.1097/ALN.0b013e3181de6f25 – volume: 80 start-page: 372 issue: 3 year: 2009 ident: 242_CR28 publication-title: Resuscitation. doi: 10.1016/j.resuscitation.2008.12.003 – volume: 5 start-page: 145 issue: 3 year: 1984 ident: 242_CR40 publication-title: Clin Phys Physiol Meas doi: 10.1088/0143-0815/5/3/007 – volume: 260 start-page: R167 issue: 1 Pt 2 year: 1991 ident: 242_CR37 publication-title: Am J Phys – volume: 73 start-page: 358 issue: 2 year: 2012 ident: 242_CR6 publication-title: J Trauma Acute Care Surg doi: 10.1097/TA.0b013e31825889ba – volume: 79 start-page: 117 issue: 1 year: 2015 ident: 242_CR7 publication-title: J Trauma Acute Care Surg doi: 10.1097/TA.0000000000000691 – volume: 55 start-page: 39 issue: 1 year: 2003 ident: 242_CR4 publication-title: J Trauma doi: 10.1097/01.TA.0000075338.21177.EF – volume: 48 start-page: 484 issue: 4 year: 2017 ident: 242_CR27 publication-title: Shock. doi: 10.1097/SHK.0000000000000875 – volume: 15 start-page: 31 year: 2017 ident: 242_CR25 publication-title: Thromb J doi: 10.1186/s12959-017-0154-0 – ident: 242_CR1 |
| SSID | ssj0001053690 |
| Score | 2.1379106 |
| Snippet | Background
Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs)... Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1... BackgroundPlatelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing platelets (PLTs)... Abstract Background Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC). Our aim was to examine the impact of transfusing... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 42 |
| SubjectTerms | Blood platelets Blood transfusions Coagulation Coagulopathy Critical Care Medicine Experimental Hemorrhage Histopathology Intensive Intensive care Medicine Medicine & Public Health Platelets Rodents Transfusion Trauma |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Ni9UwEA-yiHgRv62uEsGTErZpPpp4cxcXLy4iLuytJGmiD57tsn0V_IP8P51J--o-Py9e-qCTpkNmpvObZN4MIc-cFl77pBlgacUkbxMzsWzB4iMXKUkfjcvNJuqTE3N2Zt9davWFOWFTeeBp4Q6UMsnVNugggyyTcF4hBK99KWPlqvw337K2l4KpvLsCugVx33yMyY0-GMBzCcxTswzdElM7jijX6_8dyPw1V_KnA9Psh45vkhszgKSvJsZvkSuxu02uvZ2PyO-Qb6dDpH2ijmIlYnq-BjAJsmGbnr0_PKJZ4EivXnK6Gijm2dIpqQO-e3TV0YD9OgJmQ1NgZfzsGITtoAAtUNzHcd1jE-OvFLfc4SXLfBznm-_QbZriPAP-ADwecWeO5t47d8np8esPR2_Y3IuBBQB0G-ZbaZM24OCd097HOrS1l8pbU1mnjVdCGsG5Dk4IUScpYhAAFZUExOlaeO4e2ev6Lj4g1BouaqNDAD2QScNFtEKUztqA9eZdQcqtYJowFyrHfhnrJgcsRjeTLBuQZYOybFRBni-PnE9VOv42-BClvQzEAtv5BqhdM6td8y-1K8j-Vlea2eqHBqAsgIIKAv2CPF3IYK94COO62I95jKolhK2iIPcn1Vo4EVxIbTlQ6h2l22F1l9KtPuWa4BqQpBa6IC-26vmDrT-uxMP_sRKPyPUqWxVW_Ngne5uLMT4mV8OXzWq4eJLN8juXgDmy priority: 102 providerName: Directory of Open Access Journals – databaseName: SpringerLink Open Access Journals dbid: C24 link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3di9QwEA96ivjit171lAg-KcFt89HEN2_x8MVDxIN7K0mangtre2y3wv1B_p_OpGll9RT0pYVOks2mv0l-k0xnCHlhFXfKNYoBl5ZM5HXDdFjUoPEh500jXNA2Jpsoj4_16an5mL7j7idv9-lIMs7UUa21et3D0sPR0cwwXFeYvEquyVwb9ONbpk8c4sYKwApMvnSCeWnNnTUohuq_jF_-7ib5y1lpXIKObv9X5--QW4lx0rcjRO6SK6G9R258SGfq98n3kz7QrqGWYuhier4G9gkvk2079ulwSSNCUF68yemqp-iYS0cvEJgo6aqlHhN8eHSfpvAHhq-WgZ0PiKlBYs-GdYdZjy8o7tHDj8zt5dheekInv8bUAt6ATw-4lUdjsp4H5OTo3efle5aSNzAPDHDLXC1MozQwAmuVc6H0demEdEYXxirtJBea57nylnNeNoIHz4FbSgEU1dZQ7yHZa7s27BNqdM5LrbwH4IhGwYXXnC-sMR4D1NuMLKbXWfkU2RwTbKyraOFoVY3DX8HwVzj8lczIy7nK-RjW42-FDxEjc0GMyB0fdJuzKil4JaVubGm88sKLRcOtk2gqlm4hQmELnZGDCWFVmib6CrgvsIiiKEVGns9iUHA8tbFt6IZYRpYC7FyekUcjIOee8JwLZXKQlDtQ3enqrqRdfYlBxBVQT8VVRl5NgP3ZrT-OxON_Kv2E3Cwi4jEWyAHZ226G8JRc99-2q37zLGrtDzLyPO0 priority: 102 providerName: Springer Nature |
| Title | Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model |
| URI | https://link.springer.com/article/10.1186/s40635-019-0242-5 https://www.ncbi.nlm.nih.gov/pubmed/31346913 https://www.proquest.com/docview/2263412274 https://www.proquest.com/docview/2265746193 https://pubmed.ncbi.nlm.nih.gov/PMC6658636 https://doaj.org/article/558fa79c6c4c40f3ab526057b04e2a28 |
| Volume | 7 |
| WOSCitedRecordID | wos000477601600011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMedCentral customDbUrl: eissn: 2197-425X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001053690 issn: 2197-425X databaseCode: RBZ dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2197-425X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001053690 issn: 2197-425X databaseCode: DOA dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2197-425X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001053690 issn: 2197-425X databaseCode: M~E dateStart: 20130101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2197-425X dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0001053690 issn: 2197-425X databaseCode: 7X7 dateStart: 20190101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 2197-425X dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0001053690 issn: 2197-425X databaseCode: 7RV dateStart: 20190101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central (New) (NC LIVE) customDbUrl: eissn: 2197-425X dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0001053690 issn: 2197-425X databaseCode: BENPR dateStart: 20190101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2197-425X dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0001053690 issn: 2197-425X databaseCode: PIMPY dateStart: 20190101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLink Open Access Journals customDbUrl: eissn: 2197-425X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001053690 issn: 2197-425X databaseCode: C24 dateStart: 20131201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwELZgFyEuvB-BpTISJ5C1TezYDhdEq13BYauqYtFyimzHWSqVpDQtEj-I_8mM67Yqj71wSRXbce3kG_ub8WiGkJdGcittLRlw6ZyJtKqZ9v0KJN6nvK6F9dqEZBNqNNIXF8U4Gty66Fa5WRPDQl21Dm3kx0ATYMHNQIl6O__GMGsUnq7GFBrXySGmzUacqwu1s7EAwkD7i4eZqZbHHexfHL3VCoabE8v3tqMQtf9vVPNPj8nfjk3DbnR653_ncZfcjjyUvlsD5x655pv75OZZPGl_QH6ed562NTUUAxrT-Qw4KXxitmzZZDCkATdYn71J6bSj6K5L174hsHzSaUMdpv1w6FRNYS6rr4aB9g84qqDGXK5mLeZC_kHRcg9_su0vxf5iCd14O8Ye8AdY9goNfDSk8HlIzk9PPg7fs5jSgTnghUtmK1HUUgNPMEZa65WrlBW5LXRWGKltzoXmaSqd4ZyrWnDvODDOXABxNRU894gcNG3jnxBa6JQrLZ0DOIlawoVXnPdNUTgMW28S0t982dLFeOeYdmNWBr1Hy3INhhLAUCIYyjwhr7aPzNfBPq5qPEC4bBtinO5Q0C4uyyj2ZZ7r2qjCSSec6Nfc2BwVSGX7wmcm0wk52qCkjItHV-4gkpAX22oQezzLMY1vV6FNrgRovzwhj9fY3I6Ep1zIIoUatYfavaHu1zTTLyG0uARCKrlMyOsNvnfD-uebeHr1JJ6RW1kQOAwJckQOlouVf05uuO_LabfogcROPvWC3Iar7pHDwcloPIG7YSZ6wUgCZeMPZ-PPvwCtGk7Z |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLamDgEv3C-BAUaCF5C1JHYcBwkhNphWba0qtEnjyTiOMyqVpDQtaD-IV34j5-TSqlz2tgdeGinHdVznOzef03MIeWYkT2WaSwa2dMREkOVMOT8DjncBz3OROmXqZhPxcKhOTpLRBvnZ_RcG0yo7mVgL6qy0eEa-DWYCCNwQnKg3068Mu0ZhdLVrodHA4sCdfQeXrXrdfwfv93kY7r0_2t1nbVcBZsE0mbM0E0kuFagqY2SauthmcSqiNFFhYqRKIy4UDwJpDec8zgV3loPREwmwnUymsNABiPxNgWDvkc1RfzD6uDrVAUyDv9mGTwMltyvQmBzz4xKG6pBFawqw7hPwN-P2zxzN3wK1tf7bu_6_7dwNcq21tOnbhjVukg1X3CKXB20uwW3y47hytMypoViymU4nYHUDiNm8ZB92dmnNGUgPXwV0XFFMSKZN9gsoCDouqMXGJhbTxins3eKLYeMiA07JgGJOF5MSuz2fUYxNwEOW8wU4X3uHdvmc7Qx4AT9igUeYtG5SdIccX8gm3SW9oizcfUITFfBYSWuBYUQu4YNnnPsmSSwW5jce8TskadtWdMfGIhNde3ZK6gZ8GsCnEXw68siL5VemTTmT8wbvIDyXA7ESeX2jnJ3qVrDpKFK5iRMrrbDCz7lJI3SR49QXLjSh8shWh0rdisdKryDpkadLMgg2jFaZwpWLekwUC_DvuUfuNbywXAkPuJBJAJR4jUvWlrpOKcaf6-LpEkxuyaVHXnb8tFrWP3fiwfk_4gm5sn80ONSH_eHBQ3I1rJkdC6Bskd58tnCPyCX7bT6uZo9beUHJp4tmtF_6nqSU |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lj9MwELZWXbTiwvsRWMBIcAFZTWLHcZAQYnepqJatKsRKyynYjrNUKklpWtD-IP4Ev46ZPFqVx972wKWRMq7jOvPNwzOdIeSJltxIk0sGtnTERJDlTDk_A8S7gOe5ME7putlEPBqpk5NkvEV-dv-FwbTKTibWgjorLZ6R98FMAIEbghPVz9u0iPHB4NXsK8MOUhhp7dppNCxy6M6-g_tWvRwewLt-GoaDNx_237K2wwCzYKYsmMlEkksFaktraYyLbRYbEZlEhYmWykRcKB4E0mrOeZwL7iwHAygSYEfpTGHRAxD_22CSi7BHtsfDo_HH9QkP8Df4nm0oNVCyX4H25JgrlzBUjSzaUIZ1z4C_Gbp_5mv-FrStdeHg6v-8i9fIldYCp68byFwnW664QXaO2hyDm-THceVomVNNsZQznU3BGgfmZouSvd_bpzVikB6-COikopioTJusGFAcdFJQiw1PLKaTU9jH5RfNJkUGCMqAok-X0xK7QJ9RjFnAQ1bzBThfe4d2eZ7tDHgB_2KJR5u0bl50ixxfyCbdJr2iLNxdQhMV8FhJawFIIpfwwTPOfZ0kFgv2a4_4HVeltq30jg1Hpmnt8SmZNoyYAiOmyIhp5JFnq6_MmjIn5w3eQ1ZdDcQK5fWNcn6atgIvjSKV6zix0gor_JxrE6HrHBtfuFCHyiO7HYemrdis0jV7euTxigwCD6NYunDlsh4TxQL8fu6ROw0uVivhARcyCYASbyBmY6mblGLyuS6qLsEUl1x65HmHrfWy_rkT987_EY_IDqArfTccHd4nl8Ma91gXZZf0FvOle0Au2W-LSTV_2IoOSj5dNM5-AbkarVQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Use+of+a+high+platelet-to-RBC+ratio+of+2%3A1+is+more+effective+in+correcting+trauma-induced+coagulopathy+than+a+ratio+of+1%3A1+in+a+rat+multiple+trauma+transfusion+model&rft.jtitle=Intensive+care+medicine+experimental&rft.au=Kleinveld%2C+Derek+J+B&rft.au=Wirtz%2C+Mathijs+R&rft.au=Daan+P+van+den+Brink&rft.au=Maas%2C+M+Adrie+W&rft.date=2019-07-25&rft.pub=Springer+Nature+B.V&rft.eissn=2197-425X&rft.volume=7&rft.issue=1&rft.spage=1&rft.epage=12&rft_id=info:doi/10.1186%2Fs40635-019-0242-5&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2197-425X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2197-425X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2197-425X&client=summon |