Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway

Although cancer-associated fibroblast (CAF) heterogeneity is well-established, the impact of chemotherapy on CAF populations remains poorly understood. Here we address this question in high-grade serous ovarian cancer (HGSOC), in which we previously identified 4 CAF populations. While the global con...

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Veröffentlicht in:	Nature communications Jg. 15; H. 1; S. 1312 - 27
Hauptverfasser:	Licaj, Monika, Mhaidly, Rana, Kieffer, Yann, Croizer, Hugo, Bonneau, Claire, Meng, Arnaud, Djerroudi, Lounes, Mujangi-Ebeka, Kevin, Hocine, Hocine R., Bourachot, Brigitte, Magagna, Ilaria, Leclere, Renaud, Guyonnet, Lea, Bohec, Mylene, Guérin, Coralie, Baulande, Sylvain, Kamal, Maud, Le Tourneau, Christophe, Lecuru, Fabrice, Becette, Véronique, Rouzier, Roman, Vincent-Salomon, Anne, Gentric, Geraldine, Mechta-Grigoriou, Fatima
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 12.02.2024 Nature Publishing Group Nature Portfolio
Schlagworte:	13 13/31 13/51 13/89 38 49 49/91 631/67/1517/1709 631/67/2329 692/4028/67/327 Cancer Cancer therapies CD8 antigen Chemoresistance Chemotherapy Clusters Cytotoxicity Extracellular matrix Fibroblasts Heterogeneity Humanities and Social Sciences Immunity Immunohistochemistry Life Sciences Lymphocytes Lymphocytes T multidisciplinary Ovarian cancer Populations Science Science (multidisciplinary) Signal transduction Spatial analysis Stroma Toxicity Transcriptomics Tumors Yes-associated protein
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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