Developmental trajectories of body mass index from childhood into late adolescence and subsequent late adolescence–young adulthood cardiometabolic risk markers

Background Reports on body mass index (BMI) trajectories from childhood into late adolescence, their determinants, and subsequent cardiometabolic risk markers, particularly among European populations have been few. Moreover, sex-specific investigation is necessary considering the sex difference in B...

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Veröffentlicht in:	Cardiovascular diabetology Jg. 18; H. 1; S. 9 - 14
Hauptverfasser:	Oluwagbemigun, Kolade, Buyken, Anette E., Alexy, Ute, Schmid, Matthias, Herder, Christian, Nöthlings, Ute
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 19.01.2019 BMC
Schlagworte:	Adolescent Adolescent Development Adult Age Factors Angiology Biomarkers - blood Blood Pressure Body Mass Index Body Weight Cardiology Cardiometabolic risk markers Child Child Development Child, Preschool Diabetes Diastolic blood pressure Female Germany - epidemiology Humans Interleukin-18 - blood Interleukin-6 - blood Latent (class) growth models Lipids - blood Longitudinal Studies Male Maternal Nutritional Physiological Phenomena Maternal prepregnancy body mass index Medicine Medicine & Public Health Metabolic Syndrome - blood Metabolic Syndrome - diagnosis Metabolic Syndrome - epidemiology Metabolic Syndrome - physiopathology Original Investigation Pediatric Obesity - diagnosis Pediatric Obesity - epidemiology Pediatric Obesity - physiopathology Prevalence Prognosis Risk Factors Sex Factors Time Factors Trajectory Young Adult Germany Body mass index Cardiometabolic risk markers Diastolic blood pressure IL-18 Maternal prepregnancy body mass index Latent (class) growth models Trajectory High-density lipoprotein cholesterol IL-6
ISSN:	1475-2840, 1475-2840
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Zusammenfassung:	Background Reports on body mass index (BMI) trajectories from childhood into late adolescence, their determinants, and subsequent cardiometabolic risk markers, particularly among European populations have been few. Moreover, sex-specific investigation is necessary considering the sex difference in BMI, and the sex-specific association between BMI and some cardiometabolic risk markers. Methods Using a sample from the DOrtmund Nutritional and Anthropometric Longitudinally Designed study, we explored sex-specific trajectories of the BMI standard deviation score (SDS) from 4 to 18 years of age in 354 males and 335 females by latent (class) growth models. The determinants of trajectory were assessed by logistic regression. We identified cardiometabolic risk markers that were highly associated with BMI SDS trajectory by random forest regression, and finally we used generalized linear models to investigate differences in the identified cardiometabolic risk markers between pairs of trajectories. Results We observed four: ‘low-normal weight’, ‘mid-normal weight’, ‘high-normal weight’, and ‘overweight’, and three: ‘‘low-normal weight’, ‘mid-normal weight’, and ‘high-normal weight’ trajectories in males and females, respectively. Higher maternal prepregnancy BMI was associated with the ‘overweight’ trajectory, and with ‘high-normal weight’ trajectory in both sexes. In addition, employed mothers and first-born status were associated with ‘high-normal weight’ trajectory in females. BMI SDS trajectory was associated with high-density lipoprotein-cholesterol and interleukin-18 (IL-18) in males, and diastolic blood pressure and interleukin-6 (IL-6) in females. However, only males following the ‘overweight’ trajectory had significantly higher IL-18 when compared to their ‘low-normal weight’ counterpart. Conclusions We identified sex-specific distinct trajectories of BMI SDS from childhood into late adolescence, higher maternal prepregnancy BMI as a common determinant of the ‘high-normal weight’ and ‘overweight’ trajectories, and ‘overweight’ trajectory being associated with elevated IL-18 in late adolescence–young adulthood. This study emphasizes the role of maternal prepregnancy BMI in overweight, and highlights IL-18 as a cardiometabolic signature of overweight across life.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1475-2840 1475-2840
DOI:	10.1186/s12933-019-0813-5