Structural insights into the mechanism of human soluble guanylate cyclase

Soluble guanylate cyclase (sGC) is the primary sensor of nitric oxide. It has a central role in nitric oxide signalling and has been implicated in many essential physiological processes and disease conditions. The binding of nitric oxide boosts the enzymatic activity of sGC. However, the mechanism b...

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Bibliographic Details
Published in:	Nature (London) Vol. 574; no. 7777; pp. 206 - 210
Main Authors:	Kang, Yunlu, Liu, Rui, Wu, Jing-Xiang, Chen, Lei
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.10.2019 Nature Publishing Group
Subjects:	101/28 631/443/1338/1872 631/45/607 631/535/1258/1259 631/80/86 692/699/75 82/16 82/29 82/80 82/83 Angina pectoris Animals Binding Catalysis Cryoelectron Microscopy Disease Disulfides - chemistry Disulfides - metabolism Domains Drosophila melanogaster Electron microscopy Enzymatic activity Enzyme Activation Guanylate cyclase Health aspects HEK293 Cells Heme - metabolism Humanities and Social Sciences Humans Hydrazines - pharmacology Kinases Mice Microscopy Models, Molecular Modules multidisciplinary Nitric oxide Nitric Oxide - metabolism Nitric Oxide Donors - metabolism Oxygen Oxygen - metabolism Physiological aspects Physiology Protein Domains Protein Multimerization Protein research Proteins Science Science (multidisciplinary) Sensors Soluble Guanylyl Cyclase - chemistry Soluble Guanylyl Cyclase - genetics Soluble Guanylyl Cyclase - metabolism Soluble Guanylyl Cyclase - ultrastructure Structure China
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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