Structural insights into the mechanism of human soluble guanylate cyclase

Soluble guanylate cyclase (sGC) is the primary sensor of nitric oxide. It has a central role in nitric oxide signalling and has been implicated in many essential physiological processes and disease conditions. The binding of nitric oxide boosts the enzymatic activity of sGC. However, the mechanism b...

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Vydané v:	Nature (London) Ročník 574; číslo 7777; s. 206 - 210
Hlavní autori:	Kang, Yunlu, Liu, Rui, Wu, Jing-Xiang, Chen, Lei
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.10.2019 Nature Publishing Group
Predmet:	101/28 631/443/1338/1872 631/45/607 631/535/1258/1259 631/80/86 692/699/75 82/16 82/29 82/80 82/83 Angina pectoris Animals Binding Catalysis Cryoelectron Microscopy Disease Disulfides - chemistry Disulfides - metabolism Domains Drosophila melanogaster Electron microscopy Enzymatic activity Enzyme Activation Guanylate cyclase Health aspects HEK293 Cells Heme - metabolism Humanities and Social Sciences Humans Hydrazines - pharmacology Kinases Mice Microscopy Models, Molecular Modules multidisciplinary Nitric oxide Nitric Oxide - metabolism Nitric Oxide Donors - metabolism Oxygen Oxygen - metabolism Physiological aspects Physiology Protein Domains Protein Multimerization Protein research Proteins Science Science (multidisciplinary) Sensors Soluble Guanylyl Cyclase - chemistry Soluble Guanylyl Cyclase - genetics Soluble Guanylyl Cyclase - metabolism Soluble Guanylyl Cyclase - ultrastructure Structure China
ISSN:	0028-0836, 1476-4687, 1476-4687
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