IFNγ causes mitochondrial dysfunction and oxidative stress in myositis

Idiopathic inflammatory myopathies (IIMs) are severe autoimmune diseases with poorly understood pathogenesis and unmet medical needs. Here, we examine the role of interferon γ (IFNγ) using NOD female mice deficient in the inducible T cell co-stimulator ( Icos ), which have previously been shown to d...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 5403 - 18
Main Authors:	Abad, Catalina, Pinal-Fernandez, Iago, Guillou, Clement, Bourdenet, Gwladys, Drouot, Laurent, Cosette, Pascal, Giannini, Margherita, Debrut, Lea, Jean, Laetitia, Bernard, Sophie, Genty, Damien, Zoubairi, Rachid, Remy-Jouet, Isabelle, Geny, Bernard, Boitard, Christian, Mammen, Andrew, Meyer, Alain, Boyer, Olivier
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26.06.2024 Nature Publishing Group Nature Portfolio
Subjects:	13 13/51 14/1 14/105 14/28 14/63 38/77 49/88 631/250/249/1313 631/250/256/2515 631/250/38 64/60 82/79 Abnormalities Acetylcysteine Adaptive immunology Animals Autoimmune diseases Biochemistry, Molecular Biology Disease Models, Animal Drug delivery Female Genomics Health services Human health and pathology Humanities and Social Sciences Humans Immunology Innate immunity Interferon-gamma - metabolism Life Sciences Lymphocytes Lymphocytes T Metabolism Mice Mice, Inbred NOD Mice, Knockout Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria, Muscle - metabolism Mitochondria, Muscle - pathology multidisciplinary Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Myoblasts Myoblasts - metabolism Myositis Myositis - genetics Myositis - metabolism Myositis - pathology Oxidative Stress Pathogenesis Proteomics Reactive oxygen species Reactive Oxygen Species - metabolism Science Science (multidisciplinary) Spatial analysis Stimulators Transcriptomics Ultrastructure γ-Interferon
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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