Single molecule microscopy reveals key physical features of repair foci in living cells

In response to double strand breaks (DSB), repair proteins accumulate at damaged sites, forming membrane-less sub-compartments or foci. Here we explored the physical nature of these foci, using single molecule microscopy in living cells. Rad52, the functional homolog of BRCA2 in yeast, accumulates a...

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Vydáno v:	eLife Ročník 10
Hlavní autoři:	Miné-Hattab, Judith, Heltberg, Mathias, Villemeur, Marie, Guedj, Chloé, Mora, Thierry, Walczak, Aleksandra M, Dahan, Maxime, Taddei, Angela
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England eLife Sciences Publications Ltd 05.02.2021 eLife Sciences Publication eLife Sciences Publications, Ltd
Témata:	BRCA2 protein Cell cycle Chromatin DNA Damage DNA repair Life Sciences liquid-liquid phase separation Microscopy nuclear sub-compartments Physics of Living Systems Population Proteins Rad52 DNA Repair and Recombination Protein - chemistry Rad52 protein Replication Protein A - chemistry Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae Proteins - chemistry Single Molecule Imaging single molecule microscopy single particle tracking Yeast nuclear sub-compartments liquid-liquid phase separation single particle tracking single molecule microscopy DNA repair physics of living systems S. cerevisiae
ISSN:	2050-084X, 2050-084X
On-line přístup:	Získat plný text
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