Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart

Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fastin...

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Veröffentlicht in:Cardiovascular diabetology Jg. 18; H. 1; S. 145 - 16
Hauptverfasser: Markus, Marcello Ricardo Paulista, Rospleszcz, Susanne, Ittermann, Till, Baumeister, Sebastian Edgar, Schipf, Sabine, Siewert-Markus, Ulrike, Lorbeer, Roberto, Storz, Corinna, Ptushkina, Violetta, Peters, Annette, Meisinger, Christa, Bamberg, Fabian, Nauck, Matthias, Bahls, Martin, Völzke, Henry, Felix, Stephan Burkhard, Bülow, Robin, Rathmann, Wolfgang, Dörr, Marcus
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 04.11.2019
BMC
Schlagworte:
Adult
Aged
Aged, 80 and over
Angiology
Arterial stiffness
Biomarkers - blood
Blood Glucose - analysis
Cardiology
Concentric remodeling
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Female
Germany - epidemiology
Humans
Insulin - blood
Insulin Resistance
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Original Investigation
Prediabetes
Prediabetic State - blood
Prediabetic State - diagnosis
Prediabetic State - epidemiology
Risk Assessment
Risk Factors
Vascular Stiffness
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - epidemiology
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left
Ventricular Remodeling
Young Adult
Germany
Insulin resistance
Arterial stiffness
Prediabetes
Concentric remodeling
Diabetes mellitus
ISSN:1475-2840, 1475-2840
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Zusammenfassung:Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes. Methods Cross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models. Results In total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m 2.7 (1.80 to 0.57; p < 0.001) lower left ventricular end-diastolic volume index, a 0.042 mm/m 2.7 (0.014 to 0.070) higher left ventricular wall-thickness index, a 0.12 mmHg m 2.7 /ml (0.06 to 0.17; p < 0.001) greater arterial stiffness index and a 0.037 g/ml (0.018 to 0.056; p < 0.001) higher left ventricular concentricity. Conclusions Our findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart.
Bibliographie:ObjectType-Article-1
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ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-019-0948-4