Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart

Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fastin...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular diabetology Vol. 18; no. 1; pp. 145 - 16
Main Authors: Markus, Marcello Ricardo Paulista, Rospleszcz, Susanne, Ittermann, Till, Baumeister, Sebastian Edgar, Schipf, Sabine, Siewert-Markus, Ulrike, Lorbeer, Roberto, Storz, Corinna, Ptushkina, Violetta, Peters, Annette, Meisinger, Christa, Bamberg, Fabian, Nauck, Matthias, Bahls, Martin, Völzke, Henry, Felix, Stephan Burkhard, Bülow, Robin, Rathmann, Wolfgang, Dörr, Marcus
Format: Journal Article
Language:English
Published: London BioMed Central 04.11.2019
BMC
Subjects:
Adult
Aged
Aged, 80 and over
Angiology
Arterial stiffness
Biomarkers - blood
Blood Glucose - analysis
Cardiology
Concentric remodeling
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Female
Germany - epidemiology
Humans
Insulin - blood
Insulin Resistance
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Original Investigation
Prediabetes
Prediabetic State - blood
Prediabetic State - diagnosis
Prediabetic State - epidemiology
Risk Assessment
Risk Factors
Vascular Stiffness
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - epidemiology
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left
Ventricular Remodeling
Young Adult
Germany
Insulin resistance
Arterial stiffness
Prediabetes
Concentric remodeling
Diabetes mellitus
ISSN:1475-2840, 1475-2840
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes. Methods Cross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models. Results In total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m 2.7 (1.80 to 0.57; p < 0.001) lower left ventricular end-diastolic volume index, a 0.042 mm/m 2.7 (0.014 to 0.070) higher left ventricular wall-thickness index, a 0.12 mmHg m 2.7 /ml (0.06 to 0.17; p < 0.001) greater arterial stiffness index and a 0.037 g/ml (0.018 to 0.056; p < 0.001) higher left ventricular concentricity. Conclusions Our findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart.
AbstractList Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes. Methods Cross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models. Results In total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m 2.7 (1.80 to 0.57; p < 0.001) lower left ventricular end-diastolic volume index, a 0.042 mm/m 2.7 (0.014 to 0.070) higher left ventricular wall-thickness index, a 0.12 mmHg m 2.7 /ml (0.06 to 0.17; p < 0.001) greater arterial stiffness index and a 0.037 g/ml (0.018 to 0.056; p < 0.001) higher left ventricular concentricity. Conclusions Our findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart.
Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes.BACKGROUNDMortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes.Cross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models.METHODSCross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models.In total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m2.7 (1.80 to 0.57; p < 0.001) lower left ventricular end-diastolic volume index, a 0.042 mm/m2.7 (0.014 to 0.070) higher left ventricular wall-thickness index, a 0.12 mmHg m2.7/ml (0.06 to 0.17; p < 0.001) greater arterial stiffness index and a 0.037 g/ml (0.018 to 0.056; p < 0.001) higher left ventricular concentricity.RESULTSIn total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m2.7 (1.80 to 0.57; p < 0.001) lower left ventricular end-diastolic volume index, a 0.042 mm/m2.7 (0.014 to 0.070) higher left ventricular wall-thickness index, a 0.12 mmHg m2.7/ml (0.06 to 0.17; p < 0.001) greater arterial stiffness index and a 0.037 g/ml (0.018 to 0.056; p < 0.001) higher left ventricular concentricity.Our findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart.CONCLUSIONSOur findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart.
Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes. Cross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models. In total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m (1.80 to 0.57; p < 0.001) lower left ventricular end-diastolic volume index, a 0.042 mm/m (0.014 to 0.070) higher left ventricular wall-thickness index, a 0.12 mmHg m /ml (0.06 to 0.17; p < 0.001) greater arterial stiffness index and a 0.037 g/ml (0.018 to 0.056; p < 0.001) higher left ventricular concentricity. Our findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart.
Abstract Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes. Methods Cross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models. Results In total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m2.7 (1.80 to 0.57; p < 0.001) lower left ventricular end-diastolic volume index, a 0.042 mm/m2.7 (0.014 to 0.070) higher left ventricular wall-thickness index, a 0.12 mmHg m2.7/ml (0.06 to 0.17; p < 0.001) greater arterial stiffness index and a 0.037 g/ml (0.018 to 0.056; p < 0.001) higher left ventricular concentricity. Conclusions Our findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart.
ArticleNumber 145
Author Markus, Marcello Ricardo Paulista
Rospleszcz, Susanne
Völzke, Henry
Storz, Corinna
Dörr, Marcus
Ptushkina, Violetta
Peters, Annette
Ittermann, Till
Rathmann, Wolfgang
Lorbeer, Roberto
Meisinger, Christa
Schipf, Sabine
Baumeister, Sebastian Edgar
Siewert-Markus, Ulrike
Bamberg, Fabian
Bahls, Martin
Bülow, Robin
Felix, Stephan Burkhard
Nauck, Matthias
Author_xml – sequence: 1
  givenname: Marcello Ricardo Paulista
  orcidid: 0000-0002-6234-4955
  surname: Markus
  fullname: Markus, Marcello Ricardo Paulista
  email: marcello.markus@uni-greifswald.de
  organization: Department of Internal Medicine B, University Medicine Greifswald, German Center for Diabetes Research (DZD), Partner Site Greifswald, German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald
– sequence: 2
  givenname: Susanne
  surname: Rospleszcz
  fullname: Rospleszcz, Susanne
  organization: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
– sequence: 3
  givenname: Till
  surname: Ittermann
  fullname: Ittermann, Till
  organization: German Center for Diabetes Research (DZD), Partner Site Greifswald, German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald
– sequence: 4
  givenname: Sebastian Edgar
  surname: Baumeister
  fullname: Baumeister, Sebastian Edgar
  organization: Chair of Epidemiology, Ludwig-Maximilians-Universität München at UNIKA-T Augsburg, Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
– sequence: 5
  givenname: Sabine
  surname: Schipf
  fullname: Schipf, Sabine
  organization: German Center for Diabetes Research (DZD), Partner Site Greifswald, Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald
– sequence: 6
  givenname: Ulrike
  surname: Siewert-Markus
  fullname: Siewert-Markus, Ulrike
  organization: Institute for Medical Psychology, University Medicine Greifswald
– sequence: 7
  givenname: Roberto
  surname: Lorbeer
  fullname: Lorbeer, Roberto
  organization: Department of Radiology, Ludwig-Maximilians-University Hospital
– sequence: 8
  givenname: Corinna
  surname: Storz
  fullname: Storz, Corinna
  organization: Department of Diagnostic and Interventional Radiology, University of Tuebingen
– sequence: 9
  givenname: Violetta
  surname: Ptushkina
  fullname: Ptushkina, Violetta
  organization: Institute for Biometrics and Epidemiology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, German Center for Diabetes Research (DZD)
– sequence: 10
  givenname: Annette
  surname: Peters
  fullname: Peters, Annette
  organization: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, German Center for Diabetes Research (DZD)
– sequence: 11
  givenname: Christa
  surname: Meisinger
  fullname: Meisinger, Christa
  organization: Chair of Epidemiology, Ludwig-Maximilians-Universität München at UNIKA-T Augsburg, Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
– sequence: 12
  givenname: Fabian
  surname: Bamberg
  fullname: Bamberg, Fabian
  organization: Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg
– sequence: 13
  givenname: Matthias
  surname: Nauck
  fullname: Nauck, Matthias
  organization: German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
– sequence: 14
  givenname: Martin
  surname: Bahls
  fullname: Bahls, Martin
  organization: Department of Internal Medicine B, University Medicine Greifswald, German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald
– sequence: 15
  givenname: Henry
  surname: Völzke
  fullname: Völzke, Henry
  organization: German Center for Diabetes Research (DZD), Partner Site Greifswald, German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald
– sequence: 16
  givenname: Stephan Burkhard
  surname: Felix
  fullname: Felix, Stephan Burkhard
  organization: Department of Internal Medicine B, University Medicine Greifswald, German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald
– sequence: 17
  givenname: Robin
  surname: Bülow
  fullname: Bülow, Robin
  organization: German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald
– sequence: 18
  givenname: Wolfgang
  surname: Rathmann
  fullname: Rathmann, Wolfgang
  organization: Institute for Biometrics and Epidemiology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, German Center for Diabetes Research (DZD)
– sequence: 19
  givenname: Marcus
  surname: Dörr
  fullname: Dörr, Marcus
  organization: Department of Internal Medicine B, University Medicine Greifswald, German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31684945$$D View this record in MEDLINE/PubMed
BookMark eNp9UjtvFDEQXqEgkhz8ABq0Jc2C348GCUUQIkWigdpy7PGdTz472LtB_Ht8dwlKKFLNaPw9xprvfDjJJcMwvMXoA8ZKfGyYaEonhPWENFMTezGcYSb5RBRDJ4_60-G8tS1CWCqBXw2nFAvFNONnw-YyLa40GG32Y8xtSTGPCe4gtdHWPm6tuGhn8OPvOG_6bIYabRrbHEPI0NqB6Up2kOca3VhhVzx0mfVYwjhvYNxAZ70eXgabGry5r6vh59cvPy6-TdffL68uPl9Pjks-TwQCDcpiyX3w4IXXSAlBnZIsSH_DBaMOeaWFD9ISSiUgiQFAC4YVd5iuhqujri92a25r3Nn6xxQbzWFQ6tr0baJLYJQG7pklCvWCNddMayq55kSBCL1fDZ-OWrfLzQ784Yc2PRF9-pLjxqzLnRGKdDrrAu_vBWr5tUCbzS42BynZDGVphlBMiMKa8A5999jrn8nDqTpAHgGultYqBOPibOdY9tYxGYzMPhTmGArTQ2H2oTD7LfB_zAfx5zjkyGkdm9dQzbYsNffLPUP6C2lQylE
CitedBy_id crossref_primary_10_1016_j_eprac_2021_03_004
crossref_primary_10_1038_s41440_023_01507_4
crossref_primary_10_1186_s12933_020_01091_8
crossref_primary_10_1152_ajpheart_00826_2024
crossref_primary_10_1371_journal_pone_0308994
crossref_primary_10_1097_HJH_0000000000002677
crossref_primary_10_1186_s12933_024_02310_2
crossref_primary_10_1186_s12933_021_01321_7
crossref_primary_10_3389_fcvm_2022_1072191
crossref_primary_10_1186_s12933_023_02037_6
crossref_primary_10_1186_s12879_025_10649_4
crossref_primary_10_1016_j_jdiacomp_2020_107771
crossref_primary_10_1186_s12872_023_03406_5
crossref_primary_10_1016_j_preghy_2021_07_246
crossref_primary_10_1186_s12933_020_01086_5
crossref_primary_10_1016_j_bbrc_2023_09_089
crossref_primary_10_3389_fcvm_2022_1019233
crossref_primary_10_1038_s41598_024_52342_7
crossref_primary_10_1097_HJH_0000000000003433
crossref_primary_10_1186_s12933_020_01120_6
crossref_primary_10_1186_s12933_020_01124_2
crossref_primary_10_1186_s12933_023_01819_2
crossref_primary_10_3389_fcvm_2022_862252
crossref_primary_10_38109_2075_082X_2025_2_31_36
crossref_primary_10_38109_2075_082X_2024_4_111_119
crossref_primary_10_2478_enr_2021_0024
crossref_primary_10_1007_s00394_024_03510_y
crossref_primary_10_1093_eurjpc_zwaf523
crossref_primary_10_1111_all_15226
crossref_primary_10_1186_s12933_022_01540_6
crossref_primary_10_1186_s12933_020_01057_w
crossref_primary_10_56294_hl2025616
crossref_primary_10_1186_s12933_020_01194_2
crossref_primary_10_3389_fendo_2021_761397
crossref_primary_10_1186_s12933_020_01203_4
crossref_primary_10_1038_s41598_025_86746_w
crossref_primary_10_1097_HJH_0000000000003784
crossref_primary_10_3389_fcvm_2021_735637
crossref_primary_10_2147_IDR_S347089
crossref_primary_10_3390_ijms242317094
crossref_primary_10_3389_fmolb_2021_651215
crossref_primary_10_3390_microorganisms8040547
crossref_primary_10_1016_j_diabres_2023_110923
crossref_primary_10_1186_s12933_021_01262_1
crossref_primary_10_3389_fcvm_2025_1476815
crossref_primary_10_1016_j_jacl_2025_05_005
crossref_primary_10_3390_jcm13164957
crossref_primary_10_1186_s12944_024_02390_9
crossref_primary_10_3389_fcvm_2023_1275710
crossref_primary_10_3390_healthcare10010033
crossref_primary_10_1097_HJH_0000000000003227
crossref_primary_10_1186_s12933_021_01383_7
crossref_primary_10_3389_fcvm_2022_948402
crossref_primary_10_3390_antiox11122499
crossref_primary_10_1093_eurjpc_zwac087
crossref_primary_10_1093_eurjpc_zwad131
crossref_primary_10_1186_s12933_020_01210_5
crossref_primary_10_1186_s12933_023_02079_w
crossref_primary_10_1038_s41440_023_01192_3
crossref_primary_10_1186_s12944_024_02358_9
crossref_primary_10_1186_s40001_025_02690_5
crossref_primary_10_3390_ijerph191610368
crossref_primary_10_1113_JP287928
crossref_primary_10_1186_s12933_021_01330_6
crossref_primary_10_1002_hsr2_70157
crossref_primary_10_1186_s12933_022_01563_z
crossref_primary_10_1186_s12933_023_02113_x
crossref_primary_10_1016_j_clnesp_2025_06_028
crossref_primary_10_3389_fendo_2022_851338
crossref_primary_10_1186_s12933_020_01102_8
crossref_primary_10_1186_s12885_023_11102_y
crossref_primary_10_3390_ijms24086910
crossref_primary_10_1016_j_ahj_2022_02_014
crossref_primary_10_3390_biom11111680
crossref_primary_10_1186_s12933_023_01739_1
crossref_primary_10_1186_s12933_023_02041_w
Cites_doi 10.1089/met.2018.0090
10.1016/j.clnu.2004.06.004
10.1371/journal.pone.0113154
10.2337/db16-0630
10.1161/01.CIR.101.19.2271
10.1161/CIRCRESAHA.117.311586
10.1186/s12872-018-0900-7
10.1016/j.numecd.2017.10.007
10.1055/s-2005-858235
10.1016/j.jacc.2013.01.053
10.1007/s00330-018-5345-y
10.1186/s12933-017-0646-z
10.1161/CIRCIMAGING.109.911438
10.1159/000161078
10.7326/0003-4819-150-9-200905050-00006
10.1016/j.hlc.2017.05.142
10.1186/s12933-017-0514-x
10.1161/CIRCULATIONAHA.108.829176
10.1053/j.gastro.2007.10.024
10.1530/EJE-15-0631
10.2337/dc17-S005
10.1161/ATVBAHA.114.304831
10.1148/radiol.2302030042
10.1016/j.csda.2005.07.015
10.1186/s12933-018-0750-8
10.1002/dmrr.1239
10.1016/j.jacc.2006.03.072
10.1007/BF01324255
10.1161/CIRCULATIONAHA.106.634949
10.1093/ajh/hpw036
10.1186/s12944-018-0914-2
10.1093/ije/dyp394
10.1002/sim.1728
10.1111/sms.13057
10.1161/01.HYP.31.5.1077
10.2105/AJPH.85.5.726
10.1016/j.ghir.2011.02.001
10.1186/s12933-017-0545-3
ContentType Journal Article
Copyright The Author(s) 2019
Copyright_xml – notice: The Author(s) 2019
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOA
DOI 10.1186/s12933-019-0948-4
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1475-2840
EndPage 16
ExternalDocumentID oai_doaj_org_article_89e5d4a2805d419594993759528e6f99
PMC6829934
31684945
10_1186_s12933_019_0948_4
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Germany
GeographicLocations_xml – name: Germany
GroupedDBID ---
0R~
29B
2WC
53G
5GY
5VS
6J9
7X7
88E
8FI
8FJ
AAFWJ
AAJSJ
AASML
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
AHYZX
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
DU5
E3Z
EAD
EAP
EAS
EBD
EBLON
EBS
EJD
EMB
EMK
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HMCUK
HYE
IAO
IHR
INH
INR
ITC
KQ8
M1P
M48
M~E
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQQKQ
PROAC
PSQYO
PUEGO
RBZ
RNS
ROL
RPM
RSV
SMD
SOJ
SV3
TR2
TUS
UKHRP
W2D
WOQ
WOW
XSB
AAYXX
AFFHD
CITATION
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
ID FETCH-LOGICAL-c575t-2ef3f8a175dfded6d908663c874f7db5643c0d896df7a2337e071eee964185c13
IEDL.DBID DOA
ISICitedReferencesCount 75
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000494785900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1475-2840
IngestDate Fri Oct 03 12:44:15 EDT 2025
Tue Nov 04 01:57:48 EST 2025
Thu Sep 04 19:17:27 EDT 2025
Thu Apr 03 07:02:32 EDT 2025
Sat Nov 29 06:27:39 EST 2025
Tue Nov 18 21:32:19 EST 2025
Sat Sep 06 07:24:46 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Insulin resistance
Arterial stiffness
Prediabetes
Concentric remodeling
Diabetes mellitus
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c575t-2ef3f8a175dfded6d908663c874f7db5643c0d896df7a2337e071eee964185c13
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-6234-4955
OpenAccessLink https://doaj.org/article/89e5d4a2805d419594993759528e6f99
PMID 31684945
PQID 2312281925
PQPubID 23479
PageCount 16
ParticipantIDs doaj_primary_oai_doaj_org_article_89e5d4a2805d419594993759528e6f99
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6829934
proquest_miscellaneous_2312281925
pubmed_primary_31684945
crossref_citationtrail_10_1186_s12933_019_0948_4
crossref_primary_10_1186_s12933_019_0948_4
springer_journals_10_1186_s12933_019_0948_4
PublicationCentury 2000
PublicationDate 2019-11-04
PublicationDateYYYYMMDD 2019-11-04
PublicationDate_xml – month: 11
  year: 2019
  text: 2019-11-04
  day: 04
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Cardiovascular diabetology
PublicationTitleAbbrev Cardiovasc Diabetol
PublicationTitleAlternate Cardiovasc Diabetol
PublicationYear 2019
Publisher BioMed Central
BMC
Publisher_xml – name: BioMed Central
– name: BMC
References SR Heckbert (948_CR4) 2006; 48
R Holle (948_CR10) 2005; 67
I Lambrinoudaki (948_CR33) 2018; 27
T Sakura (948_CR36) 2017; 16
UG Kyle (948_CR25) 2004; 23
American Diabetes A (948_CR13) 2017; 40
KU Juergens (948_CR17) 2004; 230
MRP Markus (948_CR11) 2017; 27
W Maziak (948_CR21) 2002; 6
M Zhang (948_CR34) 2017; 16
T Tamayo (948_CR3) 2014; 9
MR Markus (948_CR22) 2015; 35
AR Khoshdel (948_CR32) 2019; 17
G Jia (948_CR2) 2018; 122
AR Aroor (948_CR38) 2018; 17
V Spallone (948_CR40) 2011; 27
M Kusztal (948_CR26) 2008; 26
RB Devereux (948_CR20) 2000; 101
WHO/ISH-Guidelines-Subcommittee (948_CR28) 1999; 17
AS Levey (948_CR30) 2009; 150
RV Shah (948_CR5) 2013; 61
U John (948_CR8) 2001; 46
SE Baumeister (948_CR24) 2011; 21
R Roubenoff (948_CR39) 1995; 85
R Bulow (948_CR14) 2018; 28
948_CR23
F Bamberg (948_CR15) 2017; 66
V Lambadiari (948_CR37) 2018; 17
I Vinik Aaron (948_CR41) 2007; 115
C Huth (948_CR12) 2015; 173
G de Simone (948_CR19) 1998; 31
W Sauerbrei (948_CR31) 2006; 50
LR Loehr (948_CR7) 2016; 29
A Kohler (948_CR27) 2018; 28
S Rospleszcz (948_CR16) 2018; 18
JW Hogan (948_CR18) 2004; 23
H Volzke (948_CR9) 2011; 40
SE Baumeister (948_CR29) 2008; 134
R Preis Sarah (948_CR1) 2009; 119
KB Won (948_CR35) 2018; 17
RS Velagaleti (948_CR6) 2010; 3
References_xml – volume: 17
  start-page: 90
  issue: 2
  year: 2019
  ident: 948_CR32
  publication-title: Metab Syndr Relat Disord
  doi: 10.1089/met.2018.0090
– volume: 23
  start-page: 1226
  issue: 5
  year: 2004
  ident: 948_CR25
  publication-title: Clin Nutr
  doi: 10.1016/j.clnu.2004.06.004
– volume: 9
  start-page: e113154
  issue: 11
  year: 2014
  ident: 948_CR3
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0113154
– volume: 66
  start-page: 158
  issue: 1
  year: 2017
  ident: 948_CR15
  publication-title: Diabetes
  doi: 10.2337/db16-0630
– volume: 101
  start-page: 2271
  issue: 19
  year: 2000
  ident: 948_CR20
  publication-title: Circulation
  doi: 10.1161/01.CIR.101.19.2271
– volume: 122
  start-page: 624
  issue: 4
  year: 2018
  ident: 948_CR2
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.117.311586
– volume: 18
  start-page: 162
  issue: 1
  year: 2018
  ident: 948_CR16
  publication-title: BMC Cardiovasc Disord
  doi: 10.1186/s12872-018-0900-7
– volume: 27
  start-page: 1114
  issue: 12
  year: 2017
  ident: 948_CR11
  publication-title: Nutr Metab Cardiovasc Dis
  doi: 10.1016/j.numecd.2017.10.007
– volume: 67
  start-page: S19
  issue: Suppl 1
  year: 2005
  ident: 948_CR10
  publication-title: Gesundheitswesen
  doi: 10.1055/s-2005-858235
– volume: 61
  start-page: 1698
  issue: 16
  year: 2013
  ident: 948_CR5
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2013.01.053
– volume: 28
  start-page: 3996
  issue: 9
  year: 2018
  ident: 948_CR14
  publication-title: Eur Radiol
  doi: 10.1007/s00330-018-5345-y
– volume: 17
  start-page: 8
  issue: 1
  year: 2018
  ident: 948_CR37
  publication-title: Cardiovasc Diabetol
  doi: 10.1186/s12933-017-0646-z
– volume: 3
  start-page: 257
  issue: 3
  year: 2010
  ident: 948_CR6
  publication-title: Circ Cardiovasc Imaging
  doi: 10.1161/CIRCIMAGING.109.911438
– ident: 948_CR23
– volume: 26
  start-page: 498
  issue: 6
  year: 2008
  ident: 948_CR26
  publication-title: Blood Purif
  doi: 10.1159/000161078
– volume: 150
  start-page: 604
  issue: 9
  year: 2009
  ident: 948_CR30
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-150-9-200905050-00006
– volume: 27
  start-page: 716
  issue: 6
  year: 2018
  ident: 948_CR33
  publication-title: Heart Lung Circ
  doi: 10.1016/j.hlc.2017.05.142
– volume: 17
  start-page: 151
  issue: 2
  year: 1999
  ident: 948_CR28
  publication-title: J Hypertens
– volume: 16
  start-page: 30
  issue: 1
  year: 2017
  ident: 948_CR34
  publication-title: Cardiovasc Diabetol
  doi: 10.1186/s12933-017-0514-x
– volume: 119
  start-page: 1728
  issue: 13
  year: 2009
  ident: 948_CR1
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.108.829176
– volume: 134
  start-page: 85
  issue: 1
  year: 2008
  ident: 948_CR29
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2007.10.024
– volume: 173
  start-page: 643
  issue: 5
  year: 2015
  ident: 948_CR12
  publication-title: Eur J Endocrinol
  doi: 10.1530/EJE-15-0631
– volume: 40
  start-page: S11
  issue: Suppl 1
  year: 2017
  ident: 948_CR13
  publication-title: Diabetes Care
  doi: 10.2337/dc17-S005
– volume: 35
  start-page: 1265
  issue: 5
  year: 2015
  ident: 948_CR22
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/ATVBAHA.114.304831
– volume: 230
  start-page: 403
  issue: 2
  year: 2004
  ident: 948_CR17
  publication-title: Radiology
  doi: 10.1148/radiol.2302030042
– volume: 50
  start-page: 3464
  issue: 12
  year: 2006
  ident: 948_CR31
  publication-title: Comput Stat Data Anal
  doi: 10.1016/j.csda.2005.07.015
– volume: 17
  start-page: 108
  issue: 1
  year: 2018
  ident: 948_CR38
  publication-title: Cardiovasc Diabetol
  doi: 10.1186/s12933-018-0750-8
– volume: 27
  start-page: 639
  issue: 7
  year: 2011
  ident: 948_CR40
  publication-title: Diabetes Metab Res Rev
  doi: 10.1002/dmrr.1239
– volume: 48
  start-page: 2285
  issue: 11
  year: 2006
  ident: 948_CR4
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2006.03.072
– volume: 46
  start-page: 186
  issue: 3
  year: 2001
  ident: 948_CR8
  publication-title: Soz Praventivmed
  doi: 10.1007/BF01324255
– volume: 115
  start-page: 387
  issue: 3
  year: 2007
  ident: 948_CR41
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.634949
– volume: 29
  start-page: 1038
  issue: 9
  year: 2016
  ident: 948_CR7
  publication-title: Am J Hypertens
  doi: 10.1093/ajh/hpw036
– volume: 17
  start-page: 268
  issue: 1
  year: 2018
  ident: 948_CR35
  publication-title: Lipids Health Dis
  doi: 10.1186/s12944-018-0914-2
– volume: 40
  start-page: 294
  issue: 2
  year: 2011
  ident: 948_CR9
  publication-title: Int J Epidemiol
  doi: 10.1093/ije/dyp394
– volume: 6
  start-page: 824
  issue: 9
  year: 2002
  ident: 948_CR21
  publication-title: Int J Tuberc Lung Dis
– volume: 23
  start-page: 1455
  issue: 9
  year: 2004
  ident: 948_CR18
  publication-title: Stat Med
  doi: 10.1002/sim.1728
– volume: 28
  start-page: 1628
  issue: 6
  year: 2018
  ident: 948_CR27
  publication-title: Scand J Med Sci Sports
  doi: 10.1111/sms.13057
– volume: 31
  start-page: 1077
  issue: 5
  year: 1998
  ident: 948_CR19
  publication-title: Hypertension
  doi: 10.1161/01.HYP.31.5.1077
– volume: 85
  start-page: 726
  issue: 5
  year: 1995
  ident: 948_CR39
  publication-title: Am J Public Health
  doi: 10.2105/AJPH.85.5.726
– volume: 21
  start-page: 89
  issue: 2
  year: 2011
  ident: 948_CR24
  publication-title: Growth Horm IGF Res
  doi: 10.1016/j.ghir.2011.02.001
– volume: 16
  start-page: 62
  issue: 1
  year: 2017
  ident: 948_CR36
  publication-title: Cardiovasc Diabetol
  doi: 10.1186/s12933-017-0545-3
SSID ssj0017861
Score 2.4958243
Snippet Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It...
Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated...
Abstract Background Mortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 145
SubjectTerms Adult
Aged
Aged, 80 and over
Angiology
Arterial stiffness
Biomarkers - blood
Blood Glucose - analysis
Cardiology
Concentric remodeling
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Female
Germany - epidemiology
Humans
Insulin - blood
Insulin Resistance
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Original Investigation
Prediabetes
Prediabetic State - blood
Prediabetic State - diagnosis
Prediabetic State - epidemiology
Risk Assessment
Risk Factors
Vascular Stiffness
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - epidemiology
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left
Ventricular Remodeling
Young Adult
SummonAdditionalLinks – databaseName: SpringerLink
  dbid: RSV
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Ja90wEBZZSsile5uXLqjQU4uJLcmydExLkx7aULqE3ISsJQkEv2C_5Pd3RpYfvDYNNCeDLGF5NCN90oy-IeRtK5WXLddFG2VZCNWKwkpnCx55QLdfiIms-vhLc3SkTk70t3yPe5ii3SeXZJqpk1kruTfgyoSxPxjig6dg62QTVjuF1vj9x_HSddAoWWX35Y3NVhagxNN_E7j8O0byD0dpWn8OHtyp5w_J_Qw36f6oH4_IWugek62v2aH-hJwdjiHr1Hae5rh0eoGBRAO1PRTn0Que4oktTRGgoLIUZoYYcZpMLR1efuyQ7J_2ISXXgf7ReaQALynmzF48Jb8OPv38-LnIyRcKBwhuUbAQeVQW0IWPPnjpNWx-JHeqEbHxbQ1IxpVeaeljYxnnTQCwEkLQEulwXMWfkY1u3oUdQsvWVSBHAHqqEqGqLCs901K1CtBLFHxGymlEjMvM5Jgg48KkHYqSZpSgAQkalKARM_Ju2eRypOW4rfIHHOZlRWTUTgXz_tRkAzVKh9oLy1QJD2TcEYjcal0zFWTUekbeTEpiwALRrWK7ML8aDCBkhu5IVs_I81Fplp_CtGBCC3jTrKjTSl9W33TnZ4nlWypAChw6_35SKpOnl-Hfv7r7X7VfkG2GWomn5OIl2Vj0V-EVueeuF-dD_zqZ1W97oB71
  priority: 102
  providerName: Springer Nature
Title Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart
URI https://link.springer.com/article/10.1186/s12933-019-0948-4
https://www.ncbi.nlm.nih.gov/pubmed/31684945
https://www.proquest.com/docview/2312281925
https://pubmed.ncbi.nlm.nih.gov/PMC6829934
https://doaj.org/article/89e5d4a2805d419594993759528e6f99
Volume 18
WOSCitedRecordID wos000494785900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVADU
  databaseName: BioMedCentral
  customDbUrl:
  eissn: 1475-2840
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017861
  issn: 1475-2840
  databaseCode: RBZ
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://www.biomedcentral.com/search/
  providerName: BioMedCentral
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1475-2840
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017861
  issn: 1475-2840
  databaseCode: DOA
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 1475-2840
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017861
  issn: 1475-2840
  databaseCode: M~E
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1475-2840
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017861
  issn: 1475-2840
  databaseCode: 7X7
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1475-2840
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017861
  issn: 1475-2840
  databaseCode: BENPR
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 1475-2840
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017861
  issn: 1475-2840
  databaseCode: PIMPY
  dateStart: 20090101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVAVX
  databaseName: SpringerLINK
  customDbUrl:
  eissn: 1475-2840
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017861
  issn: 1475-2840
  databaseCode: RSV
  dateStart: 20021201
  isFulltext: true
  titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22
  providerName: Springer Nature
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagIMQF8WZ5rIzECRQ1sR0_jhS1gERXqwLVcrIcP9RKVRZttvx-ZhzviuV54ZIotqM4nnHms2fyDSEvOqmD7LipuiTrSuhOVE56V_HEI7r9Yspk1acf1GymFwsz_yHVF8aEjfTA48DtaxPbIBzTNZyQCUWgRW1Ny3SUyeRf9wD1bBZTxX-gtGyKD7PRcn9Aq4ZxQxgehDtoO1Yok_X_DmH-Gij5k7c0G6Gj2-RWQY_09djrO-RK7O-SG8fFP36PnL0dI9Cp6wMtYeb0AuOCBupWUFyEEQPFDViaAzpBAylM9JTwq5fv9PgvY4_c_XQVc64c6A1dJgpokWIK7PV98vno8NObd1XJpVB5AGTrisXEk3YAFkIKMchgYC0juddKJBW6FoCJr4M2MiTlGOcqAvaIMRqJ7Da-4Q_IXr_s4yNC6843MCKA23QjYtM4VgdmpO40gJEk-ITUm7G1vhCNY76LC5sXHFraURwWxGFRHFZMyMvtLV9Hlo2_NT5AgW0bIkF2LgC1sUVt7L_UZkKeb8RtYUKhl8T1cXk5WAC8DL2LrJ2Qh6P4t4_CLF_CCKhRO4qx05fdmv78LJN2Sw2Gn0PnX21UyJavxfDnV338P171CbnJUPNxL1w8JXvr1WV8Rq77b-vzYTUlV9VC5aOekmsHh7P5yTTPJbiavz-ef4Grk4-n3wFqlR-y
linkProvider Directory of Open Access Journals
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9UgFCc6jfrit_P6iYlPmmYtUAqPapwz3t0YncveCOXDLVl6l_bOv99zKL3J1WmiT00opBQO8IPz43cIedlK5WXLddFGWRZCtaKw0tmCRx7Q7RdiEqs-nDeLhTo60p_zPe5hYrtPLsk0U6dhreTOgCsTcn-Q4oOnYJfJFQELFvL4vnw9XLsOGiWr7L68sNjGApR0-i8Cl79zJH9xlKb1Z_fWf9X8NrmZ4SZ9M9rHHXIpdHfJtf3sUL9Hjj-MlHVqO08zL52eIpFooLaH5Nx7wVM8saWJAQomS2FmiBGnyVTS4eXHDsX-aR9ScB2oH11GCvCSYszs1X3ybff9wbu9IgdfKBwguFXBQuRRWUAXPvrgpdew-ZHcqUbExrc1IBlXeqWlj41lnDcBwEoIQUuUw3EVf0C2umUXHhJatq6CdgSgpyoRqsqy0jMtVasAvUTBZ6ScesS4rEyOATJOTdqhKGnGFjTQggZb0IgZebUucjbKcvwt81vs5nVGVNROCcv-u8kD1Cgdai8sUyU8UHFHIHKrdc1UkFHrGXkxGYmBEYhuFduF5flgACEzdEeyeka2R6NZfwrDggkt4E2zYU4bddl8050cJ5VvqQApcKj868moTJ5ehj__6qN_yv2cXN872J-b-cfFp8fkBkMLxRNz8YRsrfrz8JRcdT9WJ0P_LA2xn_K-Idk
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELagoKoX3qVbXkbiBIqaxI5jH9vCAqKsKgFVb5bjB61UZask5fcz4zgrLRQkxCmSH4o9HtufPeNvCHnVCOlEw1TWBJFnXDY8M8KajAXm0eznQySrPjmqFwt5eqqOU5zTfvJ2n0yS45sGZGlqh71LF8YpLsVej7sU-gGhuw_eiN0ktzjGDMLj-peTlRmhlqJIpsxrq61tRpGz_zqg-bu_5C9G07gXze_-dy_ukTsJhtL9UW_ukxu-fUA2PydD-0Ny9n50ZaemdTT5q9MLdDDqqekgOY2qdxRvcmn0DAVVprBihIDLZ6xp8VFki0EAaOdj0B1oK10GCrCTYizt4RH5Nn_39fBDloIyZBaQ3ZCVPrAgDaAOF5x3wikQu2BW1jzUrqkA4djcSSVcqE3JWO0BxHjvlUCaHFuwbbLRLlu_Q2je2AJkCgBQFtwXhSlzVyohGwmoJnA2I_k0OtomxnIMnHGh48lFCj1KUIMENUpQ8xl5vapyOdJ1_K3wAQ75qiAybceEZfddp4mrpfKV46aUOXyQiYcjoqtUVUovglIz8nJSGA0zE80tpvXLq14Dci7RTFlWM_J4VKDVrzBcGFcccuo11Vpry3pOe34W2b-FBATBoPFvJgXTadnp_9zV3X8q_YJsHr-d66OPi09PyFaJCooX6fwp2Ri6K_-M3LY_hvO-ex5n20_qgiq9
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Glucose+and+insulin+levels+are+associated+with+arterial+stiffness+and+concentric+remodeling+of+the+heart&rft.jtitle=Cardiovascular+diabetology&rft.au=Marcello+Ricardo+Paulista+Markus&rft.au=Susanne+Rospleszcz&rft.au=Till+Ittermann&rft.au=Sebastian+Edgar+Baumeister&rft.date=2019-11-04&rft.pub=BMC&rft.eissn=1475-2840&rft.volume=18&rft.issue=1&rft.spage=1&rft.epage=16&rft_id=info:doi/10.1186%2Fs12933-019-0948-4&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_89e5d4a2805d419594993759528e6f99
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1475-2840&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1475-2840&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1475-2840&client=summon