Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis

Hippocampal volume increase in response to aerobic exercise has been consistently observed in animal models. However, the evidence from human studies is equivocal. We undertook a systematic review to identify all controlled trials examining the effect of aerobic exercise on the hippocampal volumes i...

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Vydané v:	NeuroImage (Orlando, Fla.) Ročník 166; s. 230 - 238
Hlavní autori:	Firth, Joseph, Stubbs, Brendon, Vancampfort, Davy, Schuch, Felipe, Lagopoulos, Jim, Rosenbaum, Simon, Ward, Philip B.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 01.02.2018 Elsevier Limited
Predmet:	Brain-derived neurotrophic factor Exercise Exercise - physiology Hippocampus Hippocampus - anatomy & histology Humans Meta-analysis Neurodegeneration Neurogenesis Physical activity Physical fitness Plasticity Resistance Rodents Systematic review Resistance Physical activity Neurodegeneration Neurogenesis Hippocampus Plasticity
ISSN:	1053-8119, 1095-9572, 1095-9572
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Abstract	Hippocampal volume increase in response to aerobic exercise has been consistently observed in animal models. However, the evidence from human studies is equivocal. We undertook a systematic review to identify all controlled trials examining the effect of aerobic exercise on the hippocampal volumes in humans, and applied meta-analytic techniques to determine if aerobic exercise resulted in volumetric increases. We also sought to establish how volume changes differed in relation to unilateral measures of left/right hippocampal volume, and across the lifespan. A systematic search identified 4398 articles, of which 14 were eligible for inclusion in the primary analysis. A random-effects meta-analysis showed no significant effect of aerobic exercise on total hippocampal volume across the 737 participants. However, aerobic exercise had significant positive effects on left hippocampal volume in comparison to control conditions. Post-hoc analyses indicated effects were driven through exercise preventing the volumetric decreases which occur over time. These results provide meta-analytic evidence for exercise-induced volumetric retention in the left hippocampus. Aerobic exercise interventions may be useful for preventing age-related hippocampal deterioration and maintaining neuronal health.
AbstractList	Hippocampal volume increase in response to aerobic exercise has been consistently observed in animal models. However, the evidence from human studies is equivocal. We undertook a systematic review to identify all controlled trials examining the effect of aerobic exercise on the hippocampal volumes in humans, and applied meta-analytic techniques to determine if aerobic exercise resulted in volumetric increases. We also sought to establish how volume changes differed in relation to unilateral measures of left/right hippocampal volume, and across the lifespan. A systematic search identified 4398 articles, of which 14 were eligible for inclusion in the primary analysis. A random-effects meta-analysis showed no significant effect of aerobic exercise on total hippocampal volume across the 737 participants. However, aerobic exercise had significant positive effects on left hippocampal volume in comparison to control conditions. Post-hoc analyses indicated effects were driven through exercise preventing the volumetric decreases which occur over time. These results provide meta-analytic evidence for exercise-induced volumetric retention in the left hippocampus. Aerobic exercise interventions may be useful for preventing age-related hippocampal deterioration and maintaining neuronal health. Hippocampal volume increase in response to aerobic exercise has been consistently observed in animal models. However, the evidence from human studies is equivocal. We undertook a systematic review to identify all controlled trials examining the effect of aerobic exercise on the hippocampal volumes in humans, and applied meta-analytic techniques to determine if aerobic exercise resulted in volumetric increases. We also sought to establish how volume changes differed in relation to unilateral measures of left/right hippocampal volume, and across the lifespan. A systematic search identified 4398 articles, of which 14 were eligible for inclusion in the primary analysis. A random-effects meta-analysis showed no significant effect of aerobic exercise on total hippocampal volume across the 737 participants. However, aerobic exercise had significant positive effects on left hippocampal volume in comparison to control conditions. Post-hoc analyses indicated effects were driven through exercise preventing the volumetric decreases which occur over time. These results provide meta-analytic evidence for exercise-induced volumetric retention in the left hippocampus. Aerobic exercise interventions may be useful for preventing age-related hippocampal deterioration and maintaining neuronal health.Hippocampal volume increase in response to aerobic exercise has been consistently observed in animal models. However, the evidence from human studies is equivocal. We undertook a systematic review to identify all controlled trials examining the effect of aerobic exercise on the hippocampal volumes in humans, and applied meta-analytic techniques to determine if aerobic exercise resulted in volumetric increases. We also sought to establish how volume changes differed in relation to unilateral measures of left/right hippocampal volume, and across the lifespan. A systematic search identified 4398 articles, of which 14 were eligible for inclusion in the primary analysis. A random-effects meta-analysis showed no significant effect of aerobic exercise on total hippocampal volume across the 737 participants. However, aerobic exercise had significant positive effects on left hippocampal volume in comparison to control conditions. Post-hoc analyses indicated effects were driven through exercise preventing the volumetric decreases which occur over time. These results provide meta-analytic evidence for exercise-induced volumetric retention in the left hippocampus. Aerobic exercise interventions may be useful for preventing age-related hippocampal deterioration and maintaining neuronal health.
Author	Lagopoulos, Jim Firth, Joseph Rosenbaum, Simon Stubbs, Brendon Vancampfort, Davy Ward, Philip B. Schuch, Felipe
Author_xml	– sequence: 1 givenname: Joseph surname: Firth fullname: Firth, Joseph email: j.firth@westernsydney.edu.au organization: NICM, School of Science and Health, University of Western Sydney, Australia – sequence: 2 givenname: Brendon surname: Stubbs fullname: Stubbs, Brendon organization: Physiotherapy Department, South London and Maudsley NHS Foundation Trust, UK – sequence: 3 givenname: Davy surname: Vancampfort fullname: Vancampfort, Davy organization: KU Leuven Department of Rehabilitation Sciences, Leuven, Belgium – sequence: 4 givenname: Felipe surname: Schuch fullname: Schuch, Felipe organization: Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil – sequence: 5 givenname: Jim surname: Lagopoulos fullname: Lagopoulos, Jim organization: Sunshine Coast Mind and Neuroscience, Thompson Institute, University of the Sunshine Coast, Australia – sequence: 6 givenname: Simon surname: Rosenbaum fullname: Rosenbaum, Simon organization: School of Psychiatry, UNSW, Sydney, Australia – sequence: 7 givenname: Philip B. surname: Ward fullname: Ward, Philip B. organization: School of Psychiatry, UNSW, Sydney, Australia
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29113943$$D View this record in MEDLINE/PubMed
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Keywords	Resistance Physical activity Neurodegeneration Neurogenesis Hippocampus Plasticity
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SubjectTerms	Brain-derived neurotrophic factor Exercise Exercise - physiology Hippocampus Hippocampus - anatomy & histology Humans Meta-analysis Neurodegeneration Neurogenesis Physical activity Physical fitness Plasticity Resistance Rodents Systematic review
Title	Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis
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