A Natural-Product Switch for a Dynamic Protein Interface

Small ligands are a powerful way to control the function of protein complexes via dynamic binding interfaces. The classic example is found in gene transcription where small ligands regulate nuclear receptor binding to coactivator proteins via the dynamic activation function 2 (AF2) interface. Curren...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 53; no. 25; pp. 6443 - 6448
Main Authors:	Scheepstra, Marcel, Nieto, Lidia, Hirsch, Anna K. H., Fuchs, Sascha, Leysen, Seppe, Lam, Chan Vinh, in het Panhuis, Leslie, van Boeckel, Constant A. A., Wienk, Hans, Boelens, Rolf, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 16.06.2014 WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Binding Binding Sites Biological Products - chemistry Biphenyl Compounds - chemistry Chemical synthesis Chemistry Chemistry, Multidisciplinary Crystallography Crystallography, X-Ray drug discovery Dynamics Inhibitors Interfaces Ligands Lignans - chemistry Magnetic resonance spectroscopy Mathematical models Models, Biological Natural products NMR NMR spectroscopy Nuclear magnetic resonance nuclear receptors Physical Sciences protein-protein interactions Proteins Receptors Receptors, Cytoplasmic and Nuclear - chemistry retinoid X receptor Retinoid X receptors Retinoid X Receptors - chemistry Science & Technology Screening Transcription retinoid X receptor ANDROGEN RECEPTOR NUCLEAR MODULATORS COACTIVATOR BINDING ESTROGEN-RECEPTOR protein-protein interactions nuclear receptors natural products drug discovery SMALL-MOLECULE INHIBITORS BIOLOGICAL EVALUATION RETINOID-X-RECEPTOR THYROID-HORMONE RECEPTOR
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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