Placental expression of VEGF family mRNA in adverse pregnancy outcomes

The pregnancy complications preeclampsia, gestational hypertension, small for gestational age infants (SGA) and pre-term birth (PTB) affect approximately 21% of all pregnancies. The Vascular Endothelial Growth Factor family (VEGF) is implicated in the pathogenesis of these complications. We aimed to...

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Vydáno v:Placenta (Eastbourne) Ročník 33; číslo 6; s. 467 - 472
Hlavní autoři: Andraweera, P.H., Dekker, G.A., Laurence, J.A., Roberts, C.T.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Kidlington Elsevier Ltd 01.06.2012
Elsevier
Témata:
Adult
Biological and medical sciences
Case-Control Studies
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Humans
Hypertension, Pregnancy-Induced - metabolism
Infant, Newborn
Infant, Small for Gestational Age
Internal Medicine
mRNA
Obstetrics and Gynecology
Placenta
Placenta - metabolism
Placenta - pathology
Placenta Growth Factor
Pre-Eclampsia - metabolism
Pre-term birth
Preeclampsia
Pregnancy
Pregnancy Outcome
Pregnancy Proteins - genetics
Premature Birth - metabolism
RNA, Messenger - metabolism
SGA
Vascular Endothelial Growth Factor A - biosynthesis
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor A - metabolism
Vascular Endothelial Growth Factor Receptor-1 - genetics
Vascular Endothelial Growth Factor Receptor-2 - genetics
VEGF family
Pre-term birth
VEGF family
mRNA
Placenta
SGA
Preeclampsia
Pregnancy
Vertebrata
Vascular endothelium growth factor
Mammalia
Prognosis
Fetal membrane
Gene expression
ISSN:0143-4004, 1532-3102, 1532-3102
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Shrnutí:The pregnancy complications preeclampsia, gestational hypertension, small for gestational age infants (SGA) and pre-term birth (PTB) affect approximately 21% of all pregnancies. The Vascular Endothelial Growth Factor family (VEGF) is implicated in the pathogenesis of these complications. We aimed to evaluate the placental mRNA expression of VEGFA, PGF, FLT1 and KDR in pregnancies complicated by preeclampsia, gestational hypertension, SGA infants and pre-term birth. Placentae were collected at delivery from women with pregnancies complicated by preeclampsia (n = 18), gestational hypertension (n = 15), normotensive SGA infants (n = 13), late spontaneous pre-term birth (n = 10) and uncomplicated pregnancy (n = 30). RNA was extracted and VEGFA, PGF, FLT1 and KDR expression were quantified using qRT-PCR. Kruskal Wallis test was used to compare placental mRNA expression in the adverse pregnancy outcome groups compared to uncomplicated term pregnancy. Compared to placental mRNA from uncomplicated pregnancies, VEGFA (p = 0.006), PGF (p < 0.001), KDR (p < 0.001) and FLT1 (p = 0.02) mRNA were reduced in preeclamptic placentae; VEGFA (p < 0.001), PGF (p = 0.01) and KDR (p = 0.008) mRNA were reduced in placentae from pregnancies complicated by gestational hypertension; VEGFA (p = 0.03) mRNA was reduced in normotensive SGA pregnancies; VEGFA (p = 0.008), PGF (p = 0.01), KDR (p = 0.04) and FLT1 (p = 0.02) mRNA were reduced in placentae from late PTB. VEGF family of angiogenic growth factor mRNA expression in the placenta is reduced in gestational hypertensive disorders, SGA and in pre-term birth.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0143-4004
1532-3102
1532-3102
DOI:10.1016/j.placenta.2012.02.013