Patterns of leukemia incidence in the United States by subtype and demographic characteristics, 1997-2002

Objective Efforts to prevent leukemia have been hampered by an inability to identify significant risk factors. Exploring incidence patterns of leukemia subtypes by sex and race/ethnic group may generate new etiologic hypotheses and identify high-risk groups for further study. Methods Data from the N...

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Bibliographic Details
Published in:Cancer causes & control Vol. 19; no. 4; pp. 379 - 390
Main Authors: Yamamoto, Jennifer F, Goodman, Marc T
Format: Journal Article
Language:English
Published: Dordrecht Dordrecht : Springer Netherlands 01.05.2008
Springer
Springer Netherlands
Springer Nature B.V
Subjects:
African Americans - ethnology
Age Factors
Age groups
Apis
Application programming interfaces
Asian Americans - ethnology
Asian people
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Childhood
Chronic myeloid leukemia
Disease
Epidemiology
Ethnicity
Female
Health risk assessment
Hematology
Hispanic Americans
Hispanic Americans - ethnology
Hispanics
Human T-lymphotropic virus 1
Humans
Incidence
Leukemia
Leukemia - classification
Leukemia - ethnology
Leukemia - etiology
Lymphoma
Male
Medical research
Myeloid leukemia
Oncology
Original Paper
Population
Public Health
Registries - statistics & numerical data
Risk Factors
Sex Factors
Surveillance
Trends
United States - epidemiology
United States
United States > US
Alaska
Hispanic ethnicity
Subtype
Epidemiology
Leukemia
Race
Incidence
ISSN:0957-5243, 1573-7225
Online Access:Get full text
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Summary:Objective Efforts to prevent leukemia have been hampered by an inability to identify significant risk factors. Exploring incidence patterns of leukemia subtypes by sex and race/ethnic group may generate new etiologic hypotheses and identify high-risk groups for further study. Methods Data from the North American Association of Central Cancer Registries for 1997-2002 were used to assess patterns of leukemia incidence by subtype, sex, age, race and ethnicity. Results A total of 144,559 leukemia cases were identified, including 66,067 (46%) acute and 71,860 (50%) chronic leukemias. The highest rates of acute myeloid leukemia with and without maturation were observed in Asian-Pacific Islanders (API). Hispanics had a higher incidence of acute lymphocytic leukemia, particularly in childhood, and promyelocytic leukemia than did non-Hispanics. African-Americans had the highest rates of HTLV-1 positive adult T-cell leukemia/lymphoma. A sharp increase in the incidence of chronic myeloid leukemia was observed for both APIs and Hispanics, 85 years and older. Conclusion Known risk factors are unlikely to explain the observed disparities in leukemia incidence. Further studies of differences in environmental and genetic risk factors in these populations by specific leukemia subtype may provide clues to the etiologies of these malignancies.
Bibliography:http://dx.doi.org/10.1007/s10552-007-9097-2
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ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-007-9097-2