Genetic characterization and molecular epidemiological analysis of novel enterovirus EV-B80 in China

Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed t...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Emerging microbes & infections Ročník 7; číslo 1; s. 1 - 12
Hlavní autoři: Han, Zhenzhi, Zhang, Yong, Huang, Keqiang, Cui, Hui, Hong, Mei, Tang, Haishu, Song, Yang, Yang, Qian, Zhu, Shuangli, Yan, Dongmei, Xu, Wenbo
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Taylor & Francis 28.11.2018
Taylor & Francis Ltd
Nature Publishing Group UK
Taylor & Francis Group
Témata:
Antibodies, Viral - blood
Child, Preschool
China - epidemiology
Enterovirus - genetics
Enterovirus - isolation & purification
Enterovirus Infections - blood
Enterovirus Infections - epidemiology
Epidemiology
Evolution, Molecular
Feces - virology
Genome, Viral
Geography
Humans
Infant
Infant, Newborn
Phylogenetics
Phylogeny
Recombination, Genetic
RNA, Viral - genetics
Sequence Analysis, DNA
Seroepidemiologic Studies
Serogroup
China
ISSN:2222-1751, 2222-1751
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8-79% nucleotide identity and 94-94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A-C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology.
AbstractList Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8–79% nucleotide identity and 94–94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A–C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology.
Abstract Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8–79% nucleotide identity and 94–94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A–C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology.
Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8-79% nucleotide identity and 94-94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A-C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology.Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8-79% nucleotide identity and 94-94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A-C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology.
Author Cui, Hui
Yang, Qian
Yan, Dongmei
Hong, Mei
Tang, Haishu
Huang, Keqiang
Han, Zhenzhi
Xu, Wenbo
Song, Yang
Zhu, Shuangli
Zhang, Yong
Author_xml – sequence: 1
  givenname: Zhenzhi
  surname: Han
  fullname: Han, Zhenzhi
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 2
  givenname: Yong
  orcidid: 0000-0002-2692-5437
  surname: Zhang
  fullname: Zhang, Yong
  email: yongzhang75@sina.com
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 3
  givenname: Keqiang
  surname: Huang
  fullname: Huang, Keqiang
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 4
  givenname: Hui
  surname: Cui
  fullname: Cui, Hui
  organization: Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi CityXinjiang Uygur Autonomous Region
– sequence: 5
  givenname: Mei
  surname: Hong
  fullname: Hong, Mei
  organization: Tibet Center for Disease Control and Prevention, Lhasa CityTibet Autonomous Region
– sequence: 6
  givenname: Haishu
  surname: Tang
  fullname: Tang, Haishu
  organization: Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi CityXinjiang Uygur Autonomous Region
– sequence: 7
  givenname: Yang
  surname: Song
  fullname: Song, Yang
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 8
  givenname: Qian
  surname: Yang
  fullname: Yang, Qian
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 9
  givenname: Shuangli
  surname: Zhu
  fullname: Zhu, Shuangli
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 10
  givenname: Dongmei
  surname: Yan
  fullname: Yan, Dongmei
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 11
  givenname: Wenbo
  surname: Xu
  fullname: Xu, Wenbo
  organization: Anhui University of Science and Technology
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30482903$$D View this record in MEDLINE/PubMed
BookMark eNp9kl1rFDEUhgep2Fr7A7yRAW-8GU0mmSQDItSl1kLBG_U2nM3HbpZMsiYzK-uvN9tppS3YwCEh530fzknOy-ooxGCq6jVG7zEi4kOmmLasQViU6FnTP6tO2rIazDt8dO98XJ3lvEFlccSK6UV1TBAVbY_ISaUvTTCjU7VaQwI1muT-wOhiqCHoeojeqMlDqs3WaTO46OPKKfAlC36fXa6jrUPcGV-bUMxx59KU64ufzWeBahfqxdoFeFU9t-CzObvdT6sfXy6-L742198urxbn143qOB0bjZHVvS5BQHEqGOosASilEia0JbbVbWe5YkCEQopSA8iKZdmssD3V5LS6mrk6wkZukxsg7WUEJ28uYlpJSKVZb-RSaeAdM6B0TylXS6QwQtQa0QmEMCmsTzNrOy0Ho1VpL4F_AH2YCW4tV3EnWdsJ3nYF8O4WkOKvyeRRDi4r4z0EE6csW0wEo4yRvkjfPpJu4pTKCxdVhxlinOPuSdWBhVgnDqw39-v-V_DdlxcBnwUqxZyTsVK58ebLSxvOS4zkYb7kPF-yzJc8zJc8oPEj5x38Kc_H2eOCjWmA3zF5LUfY-5hsgqBcluT_9r_jmeXs
CitedBy_id crossref_primary_10_1093_ve_vead080
crossref_primary_10_1038_s41598_020_63691_4
crossref_primary_10_3390_v16071013
crossref_primary_10_3390_v12090995
crossref_primary_10_1080_22221751_2020_1796527
crossref_primary_10_3389_fmicb_2020_01137
crossref_primary_10_3390_ani13152512
crossref_primary_10_3389_fcimb_2020_00475
crossref_primary_10_3389_fmicb_2022_988538
crossref_primary_10_1186_s12985_022_01821_2
crossref_primary_10_1093_ve_veaa084
crossref_primary_10_1002_jmv_29202
crossref_primary_10_3390_v15122323
crossref_primary_10_1128_spectrum_01711_23
crossref_primary_10_1007_s00705_024_06138_9
crossref_primary_10_1093_ve_veaa029
crossref_primary_10_1002_jmv_29503
crossref_primary_10_1002_jmv_28215
crossref_primary_10_1016_j_virusres_2021_198501
crossref_primary_10_1007_s12250_021_00412_9
crossref_primary_10_1186_s12985_021_01590_4
Cites_doi 10.1128/JCM.38.3.1170-1174.2000
10.1099/0022-1317-80-10-2535
10.1007/BF00163230
10.1371/journal.pone.0015300
10.1371/journal.pone.0055480
10.1016/j.jcv.2011.03.006
10.1016/j.jcv.2013.08.023
10.1099/vir.0.80475-0
10.1128/JCM.37.5.1288-1293.1999
10.1128/JVI.00706-15
10.1007/978-1-4939-3292-4_10
10.1038/srep18558
10.1128/jvi.65.7.3475-3480.1991
10.1038/srep17291
10.1016/j.jcv.2009.02.002
10.1038/srep43080
10.1128/JVI.02467-12
10.1371/journal.pone.0061650
10.1128/JVI.01721-12
10.1038/emi.2016.101
10.1016/j.virol.2009.03.012
10.1128/JCM.40.12.4439-4444.2002
10.1371/journal.ppat.1005266
10.1016/j.meegid.2010.06.019
10.1038/nmeth.2109
10.1128/genomeA.00015-12
10.1099/vir.0.18708-0
10.1007/s11540-015-9307-3
10.1128/JCM.02119-12
10.1016/j.cell.2018.02.025
10.3201/eid1802.111524
10.1128/JVI.78.2.855-867.2004
10.1371/journal.pone.0094579
10.1007/s00705-017-3358-5
10.3201/eid1811.120090
10.1007/s00705-016-2783-1
10.1093/molbev/msw054
10.1016/j.virusres.2014.01.002
10.1099/vir.0.81179-0
10.1128/JVI.80.1.483-493.2006
10.1016/j.virusres.2007.04.001
10.1038/srep06035
10.1128/JVI.73.3.1941-1948.1999
10.1016/j.jcv.2018.01.008
10.1089/aid.1995.11.1423
10.1128/JVI.77.15.8366-8377.2003
10.1093/bioinformatics/btu033
10.3201/eid1811.111457
10.1099/vir.0.80784-0
10.1099/jgv.0.000911
10.1371/journal.pone.0056341
10.1093/ve/vev003
10.1186/1743-422X-7-300
10.1002/jmv.23478
ContentType Journal Article
Copyright The Author(s) 2018 2018
2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2018. This work is licensed under the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2018
Copyright_xml – notice: The Author(s) 2018 2018
– notice: 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2018. This work is licensed under the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2018
DBID 0YH
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
M1P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
7X8
5PM
DOA
DOI 10.1038/s41426-018-0196-9
DatabaseName Taylor & Francis Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials - QC
ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database



MEDLINE
MEDLINE - Academic
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 0YH
  name: Taylor & Francis Open Access
  url: https://www.tandfonline.com
  sourceTypes: Publisher
– sequence: 4
  dbid: PIMPY
  name: Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Public Health
Geography
EISSN 2222-1751
EndPage 12
ExternalDocumentID oai_doaj_org_article_bcda756eacd9447cb0c1004fe8580013
PMC6258725
30482903
10_1038_s41426_018_0196_9
12049599
Genre Research Article
Journal Article
GeographicLocations China
GeographicLocations_xml – name: China
GrantInformation_xml – fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 81672070
– fundername: ;
– fundername: ;
  grantid: 81672070; 81672070
GroupedDBID 0YH
53G
5VS
7X7
88E
8FI
8FJ
AAHBH
ABUWG
ACGFS
ADBBV
ADRAZ
AENEX
AFKRA
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AQTUD
BAWUL
BENPR
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBS
ECGQY
EJD
EMOBN
FYUFA
GROUPED_DOAJ
HMCUK
HYE
KQ8
M1P
M48
M4Z
M~E
NAO
OK1
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
TDBHL
UKHRP
AAYXX
AFFHD
CITATION
3V.
AJTQC
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
AZQEC
DWQXO
K9.
PKEHL
PQEST
PQUKI
7X8
PUEGO
5PM
ID FETCH-LOGICAL-c574t-d10fd9dfd93ac748605f3aa482368df3f2d25f7c6a38c0c44ea0f8b4eaf8f94d3
IEDL.DBID 0YH
ISICitedReferencesCount 26
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000452311600006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2222-1751
IngestDate Fri Oct 03 12:42:55 EDT 2025
Tue Nov 04 01:57:29 EST 2025
Thu Oct 02 10:53:00 EDT 2025
Tue Oct 07 06:54:01 EDT 2025
Tue Oct 07 06:51:46 EDT 2025
Thu Jan 02 23:05:44 EST 2025
Sat Nov 29 05:33:01 EST 2025
Tue Nov 18 20:53:24 EST 2025
Mon Oct 20 23:45:40 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License open-access: https://creativecommons.org/licenses/by/4.0/: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c574t-d10fd9dfd93ac748605f3aa482368df3f2d25f7c6a38c0c44ea0f8b4eaf8f94d3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-2692-5437
OpenAccessLink https://www.tandfonline.com/doi/abs/10.1038/s41426-018-0196-9
PMID 30482903
PQID 2138606589
PQPubID 2041957
PageCount 12
ParticipantIDs crossref_citationtrail_10_1038_s41426_018_0196_9
informaworld_taylorfrancis_310_1038_s41426_018_0196_9
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6258725
doaj_primary_oai_doaj_org_article_bcda756eacd9447cb0c1004fe8580013
pubmed_primary_30482903
proquest_journals_2516067715
crossref_primary_10_1038_s41426_018_0196_9
proquest_miscellaneous_2138646639
proquest_journals_2138606589
PublicationCentury 2000
PublicationDate 2018-11-28
PublicationDateYYYYMMDD 2018-11-28
PublicationDate_xml – month: 11
  year: 2018
  text: 2018-11-28
  day: 28
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: London
PublicationTitle Emerging microbes & infections
PublicationTitleAlternate Emerg Microbes Infect
PublicationYear 2018
Publisher Taylor & Francis
Taylor & Francis Ltd
Nature Publishing Group UK
Taylor & Francis Group
Publisher_xml – name: Taylor & Francis
– name: Taylor & Francis Ltd
– name: Nature Publishing Group UK
– name: Taylor & Francis Group
References e_1_3_5_2_50_1
e_1_3_5_2_31_1
e_1_3_5_2_52_1
e_1_3_5_2_10_1
e_1_3_5_2_33_1
e_1_3_5_2_54_1
e_1_3_5_2_12_1
e_1_3_5_2_35_1
e_1_3_5_2_3_1
e_1_3_5_2_1_1
e_1_3_5_2_7_1
e_1_3_5_2_5_1
e_1_3_5_2_26_1
e_1_3_5_2_47_1
e_1_3_5_2_28_1
e_1_3_5_2_49_1
e_1_3_5_2_20_1
e_1_3_5_2_41_1
e_1_3_5_2_22_1
e_1_3_5_2_43_1
e_1_3_5_2_24_1
e_1_3_5_2_45_1
e_1_3_5_2_9_1
e_1_3_5_2_15_1
e_1_3_5_2_36_1
e_1_3_5_2_17_1
e_1_3_5_2_38_1
e_1_3_5_2_19_1
e_1_3_5_2_51_1
e_1_3_5_2_30_1
e_1_3_5_2_53_1
e_1_3_5_2_32_1
e_1_3_5_2_55_1
e_1_3_5_2_11_1
e_1_3_5_2_34_1
e_1_3_5_2_13_1
e_1_3_5_2_4_1
e_1_3_5_2_2_1
e_1_3_5_2_8_1
e_1_3_5_2_6_1
e_1_3_5_2_25_1
e_1_3_5_2_48_1
e_1_3_5_2_27_1
e_1_3_5_2_29_1
e_1_3_5_2_40_1
e_1_3_5_2_42_1
e_1_3_5_2_21_1
e_1_3_5_2_44_1
e_1_3_5_2_23_1
e_1_3_5_2_46_1
e_1_3_5_2_14_1
e_1_3_5_2_37_1
e_1_3_5_2_16_1
e_1_3_5_2_39_1
e_1_3_5_2_18_1
References_xml – ident: e_1_3_5_2_12_1
  doi: 10.1128/JCM.38.3.1170-1174.2000
– ident: e_1_3_5_2_31_1
  doi: 10.1099/0022-1317-80-10-2535
– ident: e_1_3_5_2_54_1
  doi: 10.1007/BF00163230
– ident: e_1_3_5_2_55_1
  doi: 10.1371/journal.pone.0015300
– ident: e_1_3_5_2_23_1
  doi: 10.1371/journal.pone.0055480
– ident: e_1_3_5_2_21_1
  doi: 10.1016/j.jcv.2011.03.006
– ident: e_1_3_5_2_17_1
  doi: 10.1016/j.jcv.2013.08.023
– ident: e_1_3_5_2_6_1
  doi: 10.1099/vir.0.80475-0
– ident: e_1_3_5_2_11_1
  doi: 10.1128/JCM.37.5.1288-1293.1999
– ident: e_1_3_5_2_30_1
  doi: 10.1128/JVI.00706-15
– ident: e_1_3_5_2_45_1
  doi: 10.1007/978-1-4939-3292-4_10
– ident: e_1_3_5_2_33_1
  doi: 10.1038/srep18558
– ident: e_1_3_5_2_9_1
  doi: 10.1128/jvi.65.7.3475-3480.1991
– ident: e_1_3_5_2_27_1
  doi: 10.1038/srep17291
– ident: e_1_3_5_2_40_1
  doi: 10.1016/j.jcv.2009.02.002
– ident: e_1_3_5_2_24_1
  doi: 10.1038/srep43080
– ident: e_1_3_5_2_20_1
  doi: 10.1128/JVI.02467-12
– ident: e_1_3_5_2_35_1
  doi: 10.1371/journal.pone.0061650
– ident: e_1_3_5_2_38_1
  doi: 10.1128/JVI.01721-12
– ident: e_1_3_5_2_36_1
  doi: 10.1038/emi.2016.101
– ident: e_1_3_5_2_3_1
  doi: 10.1016/j.virol.2009.03.012
– ident: e_1_3_5_2_16_1
  doi: 10.1128/JCM.40.12.4439-4444.2002
– ident: e_1_3_5_2_4_1
  doi: 10.1371/journal.ppat.1005266
– ident: e_1_3_5_2_37_1
  doi: 10.1016/j.meegid.2010.06.019
– ident: e_1_3_5_2_50_1
  doi: 10.1038/nmeth.2109
– ident: e_1_3_5_2_22_1
  doi: 10.1128/genomeA.00015-12
– ident: e_1_3_5_2_42_1
  doi: 10.1099/vir.0.18708-0
– ident: e_1_3_5_2_48_1
– ident: e_1_3_5_2_49_1
  doi: 10.1007/s11540-015-9307-3
– ident: e_1_3_5_2_26_1
  doi: 10.1128/JCM.02119-12
– ident: e_1_3_5_2_44_1
  doi: 10.1016/j.cell.2018.02.025
– ident: e_1_3_5_2_19_1
  doi: 10.3201/eid1802.111524
– ident: e_1_3_5_2_25_1
  doi: 10.1128/JVI.78.2.855-867.2004
– ident: e_1_3_5_2_29_1
  doi: 10.1371/journal.pone.0094579
– ident: e_1_3_5_2_1_1
  doi: 10.1007/s00705-017-3358-5
– ident: e_1_3_5_2_14_1
  doi: 10.3201/eid1811.120090
– ident: e_1_3_5_2_15_1
  doi: 10.1007/s00705-016-2783-1
– ident: e_1_3_5_2_47_1
  doi: 10.1093/molbev/msw054
– ident: e_1_3_5_2_7_1
  doi: 10.1016/j.virusres.2014.01.002
– ident: e_1_3_5_2_13_1
  doi: 10.1099/vir.0.81179-0
– ident: e_1_3_5_2_28_1
  doi: 10.1128/JVI.80.1.483-493.2006
– ident: e_1_3_5_2_5_1
  doi: 10.1016/j.virusres.2007.04.001
– ident: e_1_3_5_2_39_1
  doi: 10.1038/srep06035
– ident: e_1_3_5_2_8_1
  doi: 10.1128/JVI.73.3.1941-1948.1999
– ident: e_1_3_5_2_43_1
  doi: 10.1016/j.jcv.2018.01.008
– ident: e_1_3_5_2_53_1
  doi: 10.1089/aid.1995.11.1423
– ident: e_1_3_5_2_46_1
  doi: 10.1128/JVI.77.15.8366-8377.2003
– ident: e_1_3_5_2_51_1
  doi: 10.1093/bioinformatics/btu033
– ident: e_1_3_5_2_34_1
  doi: 10.3201/eid1811.111457
– ident: e_1_3_5_2_41_1
  doi: 10.1099/vir.0.80784-0
– ident: e_1_3_5_2_2_1
  doi: 10.1099/jgv.0.000911
– ident: e_1_3_5_2_10_1
  doi: 10.1371/journal.pone.0056341
– ident: e_1_3_5_2_52_1
  doi: 10.1093/ve/vev003
– ident: e_1_3_5_2_32_1
  doi: 10.1186/1743-422X-7-300
– ident: e_1_3_5_2_18_1
  doi: 10.1002/jmv.23478
SSID ssj0000706414
Score 2.2679307
Snippet Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are...
Abstract Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
informaworld
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1
SubjectTerms Antibodies, Viral - blood
Child, Preschool
China - epidemiology
Enterovirus - genetics
Enterovirus - isolation & purification
Enterovirus Infections - blood
Enterovirus Infections - epidemiology
Epidemiology
Evolution, Molecular
Feces - virology
Genome, Viral
Geography
Humans
Infant
Infant, Newborn
Phylogenetics
Phylogeny
Recombination, Genetic
RNA, Viral - genetics
Sequence Analysis, DNA
Seroepidemiologic Studies
Serogroup
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQ1QMSQi3PpQUZiROS1cSP2D5S1IpTxQFQb5bjh1ipZNE--vuZsbNht4Jy4RBFjh3HmRnb49f3EfIOuiRug80MfFvOJA898zm3zPS-V51NnnehkE3oqytzfW0_71B94Z6wCg9cBXfWh-i16qB9iFZKHfomIMhZTkYZ9F-w9W203RlMlTZYQ1fbyu0ypjBnKwhyHDzj3i3bMbvXERW8_jtopX_yOe9undzpiy6PyOPRiaQfauGPyYM0PCGP6gwcrQeLnpKIiNKQgIYJk7keuaR-iPTHlhaXpt8csagwiK0wJXSR6bC4TTcUYTtx5mG5WdGLb-zcNHQ-0MK8_Yx8vbz48vETGzkVWFBarllsmxxthEv4oJGBSmXhvUTecxOzyDxylXXovDChCVIm32TTwy2bbGUUz8nBsBjSS0Jjp73K2Zi-MVIJ5cF7FKoXwaaIwRlptgJ2YQQcR96LG1cWvoVxVScOdOJQJ87OyPvplZ8VbeO-xOeotSkhAmWXB2A-bjQf9y_zmRG1q3O3LvMkuZKaOHHPx0-3xuHGWr9yvBUgUPDp_hKt2g4B-1o1I2-naKjOuEbjh7TYjFlIcAMhixfV1KYfFNDacttAmfWeEe5JYD9mmH8vkOEwyjWaq1f_Q2Qn5CHHatS2jJtTcrBebtJrchhu1_PV8k2ph78Apy43hQ
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELagcEBCvKFbCjISJySrid8-obZqxaniAGhvluMHrNQmZbPb319PXu1W1V56iKLETuJkxjOTsf19CH3NLokabxLJsS0lnPqKuJRKoitXCWmio9J3ZBPq7EzP5-bnkHBrh2mVo03sDHVoPOTID2jJtAR_ab5f_ifAGgWjqwOFxmP0BGizQc_VXE05lqzOkpd8HMxk-qDNhxR-oWEGl5HEbLijDrX_DmbpfZHn3QmUtzzS6cuHvssr9GKIRfFhrzyv0aNYv0HP-0Qe7tcnvUUBgKlzBewnaOd-5SZ2dcAXI7sujjdUsyD3XNqjneAm4bq5iucY0D8hgbFct_jkDznSBV7UuCPwfod-n578Ov5BBmoG4oXiKxLKIgUT8sacV0BkJRJzjgN9ug6JJRqoSMpLx7QvPOfRFUlXeZd0Mjyw92inbuq4i3CQyomUtK4KzQUTLgehTFTMmxjgcIaKUULWD7jlQJ9xbrvxc6ZtL1SbhWpBqNbM0LfpkssetGNb5SMQ-1QR8La7E83yrx26r618cErI7KWC4Vz5qvAAtZeiFhqi6BkSt5XGrrp0S-q5USzb8vD9UUPsYDxae6Me9xeLUgLuXylm6MtUnK0CDPW4Ojbr4RY8R5P5Fh96XZ1ekGWjTU2R26w2tHjjC2yW1It_HfJ4_lnWioq97a3-iJ5R6GFlSajeRzur5Tp-Qk_91WrRLj93XfQa40ZFPA
  priority: 102
  providerName: ProQuest
Title Genetic characterization and molecular epidemiological analysis of novel enterovirus EV-B80 in China
URI https://www.tandfonline.com/doi/abs/10.1038/s41426-018-0196-9
https://www.ncbi.nlm.nih.gov/pubmed/30482903
https://www.proquest.com/docview/2138606589
https://www.proquest.com/docview/2516067715
https://www.proquest.com/docview/2138646639
https://pubmed.ncbi.nlm.nih.gov/PMC6258725
https://doaj.org/article/bcda756eacd9447cb0c1004fe8580013
Volume 7
WOSCitedRecordID wos000452311600006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2222-1751
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000706414
  issn: 2222-1751
  databaseCode: DOA
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2222-1751
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000706414
  issn: 2222-1751
  databaseCode: M~E
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2222-1751
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000706414
  issn: 2222-1751
  databaseCode: 7X7
  dateStart: 20120701
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 2222-1751
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000706414
  issn: 2222-1751
  databaseCode: BENPR
  dateStart: 20120701
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 2222-1751
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000706414
  issn: 2222-1751
  databaseCode: PIMPY
  dateStart: 20120701
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVAWR
  databaseName: Taylor & Francis Open Access
  customDbUrl:
  eissn: 2222-1751
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000706414
  issn: 2222-1751
  databaseCode: 0YH
  dateStart: 20140101
  isFulltext: true
  titleUrlDefault: https://www.tandfonline.com
  providerName: Taylor & Francis
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Nb9MwFLdg44CE-P4ojMpInJAsEn_E9pGiTuNAVSFA3cly7HhUGilq2v39PNtpWKexAxySKLGdxM_Pfh-2fw-htyCSqHY6ENBtKeHU1cSGUBJV21pUurG0cinYhJzN1GKh5_3anK5fVhlt6JCBItJYHTu3rbt-i7h63_ES5AoYwXEZlq6Ivo0OKZgl0fYqTk8GFwtwcwVZd3OZ15Xck0YJtP8KZOl1iufV9ZOXBNLxg_-sykN0v9dE8YfMOo_QraZ9jO5lNx7Ou5OeIB9hqSEDdgOwc963ieGT-Ocuti5u_gSaja0OqRnrBK8CblcXzTmO2J_RfbHednj6nUxUgZctTuG7n6Jvx9OvH09IH5iBOCH5hviyCF57OJh1MoaxEoFZy2PwdOUDC9RTEaSrLFOucJw3tgiqhktQQXPPnqGDdtU2LxD2lbQiBKXqQnHBhAUVlImaOd34eDtCxa6BjOtRy2PwjHOTZs-ZMpmEBkhoIgmNHqF3Q5FfGbLjpsyT2OpDxoi2nR6s1mem77ymdt5KUYGM8ppz6erCRaC90Cihog49QuIyz5hNcraEHBnFsBs-frRjLtMPHZ2hJQOCgmL4l2RRVhH1rxQj9GZIhjEhTvTYtllt-1dw0CXhFc8zqw4VZDBkU13AP8s9Jt6jwH5Ku_yRcMfBVFaSipf_WNtX6C6NjF6WhKojdLBZb5vX6I672Cy79Th1XTjLhUxnNUaHk-ls_mWc3CRwN__0eX76G20kS_A
linkProvider Taylor & Francis
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1JbxMxGLVKQQIJsS-BAkaCC5LVGS9j-4AQhVatWiIOBeVmPPYYIpWZkkmK-FP8RvzN1qaqcuuBQzSa2HFmed_i7T2EXsWQRLXTgcTclhJOXU5sCClRuc1FpgtLM9eITcjxWE0m-vMa-tvvhYFllb1PbBy1rxyMkW_SlKkM4qV-d_yLgGoUzK72EhotLPaLP79jl61-u_cxvt_XlO5sH37YJZ2qAHFC8jnxaRK89vHDrJOgwSQCs5aD8rfygQXqqQjSZZYplzjOC5sElcdDUEFzz2K7V9DV6McldPbkRA5jOtF8Mp7yfvKUqc06nlLossOKMZ0RvRT-GpWAcxypF2W65xdsnomAO7f_t2d3B93qcm38vjWOu2itKO-hm-1AJW73X91HHoi3YwXsBurqdmcqtqXHP3v1YFycSukCrmNpy-aCq4DL6qQ4wsBuCgM0s0WNt7-SLZXgaYkbgfIH6Mul3OhDtF5WZfEYYZ9JK0JQKk8UF0zYmGQzkTOnCw-nI5T0iDCu42UHeZAj06wPYMq0IDIRRAZAZPQIvRl-ctySkqyqvAUwGyoCn3jzRTX7bjr3ZHLnrRRZjMJecy5dnjigEgyFEgp6CSMkzoLUzJvhpNBqvxi24s83ekSazjnW5hSOFxeLNANew1SM0MuhOHo9mMqyZVEtuiZ4zJZjE49a2xhukMWgRHUSr1kuWc3SE1guKac_Gmb1jAolqXiy-qpfoOu7h58OzMHeeP8pukHButOUULWB1uezRfEMXXMn82k9e964B4y-XbZN_QMN9KTk
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELagIISEeD8WChiJE1JE4kdsHyl0VQRa9QConCzHD1ipZKvNbn8_M3E2dKvSAxyiKLFjx-OxZ_z6PkJeg0lixptUgG_LCsF8U7iUqkI3rpG1iY7VviebULOZPjoyh8PenG7YVolj6JSBIvq-Ghv3SUjDEXH9thMV2BUYBOM2LFMX5iq5JrUySGBQfj8Yp1hAm2uIulnLvOjLLWvUg_afgyy9yPE8v3_yjEGa3vnPotwltwdPlL7LqnOPXIntfXIrT-PRfDrpAQkISw0RqB-BnfO5TQpZ0l8bbl0a_xDNYq1DaMY6oYtE28VpPKaI_YnTF8t1R_e_FXu6pPOW9vTdD8nX6f6X9wfFQMxQeKnEqghVmYIJcHHnFdJYycSdE0ierkPiiQUmk_K149qXXojoyqQbuCWdjAj8EdlpF218QmiolZMpad2UWkguHbigXDbcmxjwcULKTQVZP6CWI3nGse1Xz7m2WYQWRGhRhNZMyJvxk5MM2XFZ5D2s9TEiom33LxbLH3ZovLbxwSlZg40KRgjlm9Ij0F6KWmr0oSdEntUZu-onW1JmRrH8ksx3N8plh66js6ziIFBwDP8SLKsaUf8qOSGvxmDoE3Chx7VxsR6SEOBLQhKPs6qOBeTQZTNTwj-rLSXeksB2SDv_2eOOw1BZKyaf_mNpX5Ibhx-m9vPH2adn5CZDna-qguldsrNaruNzct2frubd8kXfin8DEWpIfQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+characterization+and+molecular+epidemiological+analysis+of+novel+enterovirus+EV-B80+in+China&rft.jtitle=Emerging+microbes+%26+infections&rft.au=Han%2C+Zhenzhi&rft.au=Zhang%2C+Yong&rft.au=Huang%2C+Keqiang&rft.au=Cui%2C+Hui&rft.date=2018-11-28&rft.issn=2222-1751&rft.eissn=2222-1751&rft.volume=7&rft.issue=1&rft.spage=1&rft.epage=12&rft_id=info:doi/10.1038%2Fs41426-018-0196-9&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41426_018_0196_9
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2222-1751&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2222-1751&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2222-1751&client=summon