Genetic characterization and molecular epidemiological analysis of novel enterovirus EV-B80 in China

Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed t...

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Vydané v:Emerging microbes & infections Ročník 7; číslo 1; s. 1 - 12
Hlavní autori: Han, Zhenzhi, Zhang, Yong, Huang, Keqiang, Cui, Hui, Hong, Mei, Tang, Haishu, Song, Yang, Yang, Qian, Zhu, Shuangli, Yan, Dongmei, Xu, Wenbo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Taylor & Francis 28.11.2018
Taylor & Francis Ltd
Nature Publishing Group UK
Taylor & Francis Group
Predmet:
Antibodies, Viral - blood
Child, Preschool
China - epidemiology
Enterovirus - genetics
Enterovirus - isolation & purification
Enterovirus Infections - blood
Enterovirus Infections - epidemiology
Epidemiology
Evolution, Molecular
Feces - virology
Genome, Viral
Geography
Humans
Infant
Infant, Newborn
Phylogenetics
Phylogeny
Recombination, Genetic
RNA, Viral - genetics
Sequence Analysis, DNA
Seroepidemiologic Studies
Serogroup
China
ISSN:2222-1751, 2222-1751
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Abstract Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8-79% nucleotide identity and 94-94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A-C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology.
AbstractList Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8–79% nucleotide identity and 94–94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A–C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology.
Abstract Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8–79% nucleotide identity and 94–94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A–C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology.
Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8-79% nucleotide identity and 94-94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A-C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology.Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8-79% nucleotide identity and 94-94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A-C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology.
Author Cui, Hui
Yang, Qian
Yan, Dongmei
Hong, Mei
Tang, Haishu
Huang, Keqiang
Han, Zhenzhi
Xu, Wenbo
Song, Yang
Zhu, Shuangli
Zhang, Yong
Author_xml – sequence: 1
  givenname: Zhenzhi
  surname: Han
  fullname: Han, Zhenzhi
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 2
  givenname: Yong
  orcidid: 0000-0002-2692-5437
  surname: Zhang
  fullname: Zhang, Yong
  email: yongzhang75@sina.com
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
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  givenname: Keqiang
  surname: Huang
  fullname: Huang, Keqiang
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
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  organization: Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi CityXinjiang Uygur Autonomous Region
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  organization: Tibet Center for Disease Control and Prevention, Lhasa CityTibet Autonomous Region
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  organization: Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi CityXinjiang Uygur Autonomous Region
– sequence: 7
  givenname: Yang
  surname: Song
  fullname: Song, Yang
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 8
  givenname: Qian
  surname: Yang
  fullname: Yang, Qian
  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 9
  givenname: Shuangli
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  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
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  givenname: Dongmei
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  organization: WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention
– sequence: 11
  givenname: Wenbo
  surname: Xu
  fullname: Xu, Wenbo
  organization: Anhui University of Science and Technology
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Snippet Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are...
Abstract Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of...
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StartPage 1
SubjectTerms Antibodies, Viral - blood
Child, Preschool
China - epidemiology
Enterovirus - genetics
Enterovirus - isolation & purification
Enterovirus Infections - blood
Enterovirus Infections - epidemiology
Epidemiology
Evolution, Molecular
Feces - virology
Genome, Viral
Geography
Humans
Infant
Infant, Newborn
Phylogenetics
Phylogeny
Recombination, Genetic
RNA, Viral - genetics
Sequence Analysis, DNA
Seroepidemiologic Studies
Serogroup
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Title Genetic characterization and molecular epidemiological analysis of novel enterovirus EV-B80 in China
URI https://www.tandfonline.com/doi/abs/10.1038/s41426-018-0196-9
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