Longitudinal uric acid has nonlinear association with kidney failure and mortality in chronic kidney disease

We investigated the shape of the relationship between longitudinal uric acid (UA) and the hazard of kidney failure and death in chronic kidney disease (CKD) patients, and attempted to identify thresholds associated with increased hazards. We included CKD stage 3–5 patients from the CKD-REIN cohort w...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scientific reports Jg. 13; H. 1; S. 3952 - 11
Hauptverfasser: Prezelin-Reydit, Mathilde, Combe, Christian, Fouque, Denis, Frimat, Luc, Jacquelinet, Christian, Laville, Maurice, Massy, Ziad A., Lange, Céline, Ayav, Carole, Pecoits-Filho, Roberto, Liabeuf, Sophie, Stengel, Bénédicte, Harambat, Jérôme, Leffondré, Karen
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 09.03.2023
Nature Publishing Group
Nature Portfolio
Schlagworte:
692/4022
692/499
692/53
Aged
Death
Female
Health hazards
Human health and pathology
Humanities and Social Sciences
Humans
Kidney diseases
Kidney Failure, Chronic
Kidneys
Life Sciences
Male
Mortality
multidisciplinary
Proportional Hazards Models
Renal failure
Renal Insufficiency, Chronic - complications
Risk Factors
Science
Science (multidisciplinary)
Uric Acid
ISSN:2045-2322, 2045-2322
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract We investigated the shape of the relationship between longitudinal uric acid (UA) and the hazard of kidney failure and death in chronic kidney disease (CKD) patients, and attempted to identify thresholds associated with increased hazards. We included CKD stage 3–5 patients from the CKD-REIN cohort with one serum UA measurement at cohort entry. We used cause-specific multivariate Cox models including a spline function of current values of UA (cUA), estimated from a separate linear mixed model. We followed 2781 patients (66% men, median age, 69 years) for a median of 3.2 years with a median of five longitudinal UA measures per patient. The hazard of kidney failure increased with increasing cUA, with a plateau between 6 and 10 mg/dl and a sharp increase above 11 mg/dl. The hazard of death had a U-shape relationship with cUA, with a hazard twice higher for 3 or 11 mg/dl, compared to 5 mg/dl. In CKD patients, our results indicate that UA above 10 mg/dl is a strong risk marker for kidney failure and death and that low UA levels below 5 mg/dl are associated with death before kidney failure.
AbstractList We investigated the shape of the relationship between longitudinal uric acid (UA) and the hazard of kidney failure and death in chronic kidney disease (CKD) patients, and attempted to identify thresholds associated with increased hazards. We included CKD stage 3–5 patients from the CKD-REIN cohort with one serum UA measurement at cohort entry. We used cause-specific multivariate Cox models including a spline function of current values of UA (cUA), estimated from a separate linear mixed model. We followed 2781 patients (66% men, median age, 69 years) for a median of 3.2 years with a median of five longitudinal UA measures per patient. The hazard of kidney failure increased with increasing cUA, with a plateau between 6 and 10 mg/dl and a sharp increase above 11 mg/dl. The hazard of death had a U-shape relationship with cUA, with a hazard twice higher for 3 or 11 mg/dl, compared to 5 mg/dl. In CKD patients, our results indicate that UA above 10 mg/dl is a strong risk marker for kidney failure and death and that low UA levels below 5 mg/dl are associated with death before kidney failure.
Abstract We investigated the shape of the relationship between longitudinal uric acid (UA) and the hazard of kidney failure and death in chronic kidney disease (CKD) patients, and attempted to identify thresholds associated with increased hazards. We included CKD stage 3–5 patients from the CKD-REIN cohort with one serum UA measurement at cohort entry. We used cause-specific multivariate Cox models including a spline function of current values of UA (cUA), estimated from a separate linear mixed model. We followed 2781 patients (66% men, median age, 69 years) for a median of 3.2 years with a median of five longitudinal UA measures per patient. The hazard of kidney failure increased with increasing cUA, with a plateau between 6 and 10 mg/dl and a sharp increase above 11 mg/dl. The hazard of death had a U-shape relationship with cUA, with a hazard twice higher for 3 or 11 mg/dl, compared to 5 mg/dl. In CKD patients, our results indicate that UA above 10 mg/dl is a strong risk marker for kidney failure and death and that low UA levels below 5 mg/dl are associated with death before kidney failure.
We investigated the shape of the relationship between longitudinal uric acid (UA) and the hazard of kidney failure and death in chronic kidney disease (CKD) patients, and attempted to identify thresholds associated with increased hazards. We included CKD stage 3-5 patients from the CKD-REIN cohort with one serum UA measurement at cohort entry. We used cause-specific multivariate Cox models including a spline function of current values of UA (cUA), estimated from a separate linear mixed model. We followed 2781 patients (66% men, median age, 69 years) for a median of 3.2 years with a median of five longitudinal UA measures per patient. The hazard of kidney failure increased with increasing cUA, with a plateau between 6 and 10 mg/dl and a sharp increase above 11 mg/dl. The hazard of death had a U-shape relationship with cUA, with a hazard twice higher for 3 or 11 mg/dl, compared to 5 mg/dl. In CKD patients, our results indicate that UA above 10 mg/dl is a strong risk marker for kidney failure and death and that low UA levels below 5 mg/dl are associated with death before kidney failure.We investigated the shape of the relationship between longitudinal uric acid (UA) and the hazard of kidney failure and death in chronic kidney disease (CKD) patients, and attempted to identify thresholds associated with increased hazards. We included CKD stage 3-5 patients from the CKD-REIN cohort with one serum UA measurement at cohort entry. We used cause-specific multivariate Cox models including a spline function of current values of UA (cUA), estimated from a separate linear mixed model. We followed 2781 patients (66% men, median age, 69 years) for a median of 3.2 years with a median of five longitudinal UA measures per patient. The hazard of kidney failure increased with increasing cUA, with a plateau between 6 and 10 mg/dl and a sharp increase above 11 mg/dl. The hazard of death had a U-shape relationship with cUA, with a hazard twice higher for 3 or 11 mg/dl, compared to 5 mg/dl. In CKD patients, our results indicate that UA above 10 mg/dl is a strong risk marker for kidney failure and death and that low UA levels below 5 mg/dl are associated with death before kidney failure.
We investigated the shape of the relationship between longitudinal uric acid (UA) and the hazard of kidney failure and death in chronic kidney disease (CKD) patients, and attempted to identify thresholds associated with increased hazards. We included CKD stage 3–5 patients from the CKD-REIN cohort with one serum UA measurement at cohort entry. We used cause-specific multivariate Cox models including a spline function of current values of UA (cUA), estimated from a separate linear mixed model. We followed 2781 patients (66% men, median age, 69 years) for a median of 3.2 years with a median of five longitudinal UA measures per patient. The hazard of kidney failure increased with increasing cUA, with a plateau between 6 and 10 mg/dl and a sharp increase above 11 mg/dl. The hazard of death had a U-shape relationship with cUA, with a hazard twice higher for 3 or 11 mg/dl, compared to 5 mg/dl. In CKD patients, our results indicate that UA above 10 mg/dl is a strong risk marker for kidney failure and death and that low UA levels below 5 mg/dl are associated with death before kidney failure.
ArticleNumber 3952
Author Liabeuf, Sophie
Massy, Ziad A.
Jacquelinet, Christian
Laville, Maurice
Fouque, Denis
Stengel, Bénédicte
Pecoits-Filho, Roberto
Harambat, Jérôme
Lange, Céline
Combe, Christian
Frimat, Luc
Leffondré, Karen
Ayav, Carole
Prezelin-Reydit, Mathilde
Author_xml – sequence: 1
  givenname: Mathilde
  surname: Prezelin-Reydit
  fullname: Prezelin-Reydit, Mathilde
  email: mathilde.reydit@maisondurein-aurad.fr
  organization: INSERM, Bordeaux Population Health Research Center, UMR1219, Univ Bordeaux, Maison du REIN AURAD Aquitaine, INSERM, CIC1401-EC, Univ Bordeaux
– sequence: 2
  givenname: Christian
  surname: Combe
  fullname: Combe, Christian
  organization: Department of Nephrology Dialysis Transplantation, Centre Hospitalier Universitaire de Bordeaux, INSERM U1026, Univ Bordeaux
– sequence: 3
  givenname: Denis
  surname: Fouque
  fullname: Fouque, Denis
  organization: Nephrology Department, Centre Hospitalier Lyon Sud, Université de Lyon
– sequence: 4
  givenname: Luc
  surname: Frimat
  fullname: Frimat, Luc
  organization: Nephrology Department, Centre Hospitalier Régional Universitaire de Nancy, APEMAC, Lorraine University
– sequence: 5
  givenname: Christian
  surname: Jacquelinet
  fullname: Jacquelinet, Christian
  organization: Center for Research in Epidemiology and Population Health (CESP), Clinical Epidemiology Team, Paris-Saclay University, Paris-Sud University, Versailles Saint-Quentin-en-Yvelines University, Renal Epidemiology and Information Network Registry, Biomedicine Agency
– sequence: 6
  givenname: Maurice
  surname: Laville
  fullname: Laville, Maurice
  organization: Carmen INSERM U1060, Université Claude Bernard Lyon 1, AURAL
– sequence: 7
  givenname: Ziad A.
  surname: Massy
  fullname: Massy, Ziad A.
  organization: Center for Research in Epidemiology and Population Health (CESP), Clinical Epidemiology Team, Paris-Saclay University, Paris-Sud University, Versailles Saint-Quentin-en-Yvelines University, Division of Nephrology, Ambroise Paré University Hospital, Assistance publique - Hôpitaux de Paris
– sequence: 8
  givenname: Céline
  surname: Lange
  fullname: Lange, Céline
  organization: Center for Research in Epidemiology and Population Health (CESP), Clinical Epidemiology Team, Paris-Saclay University, Paris-Sud University, Versailles Saint-Quentin-en-Yvelines University
– sequence: 9
  givenname: Carole
  surname: Ayav
  fullname: Ayav, Carole
  organization: CHRU-Nancy, INSERM, Université de Lorraine, CIC, Epidémiologie Clinique
– sequence: 10
  givenname: Roberto
  surname: Pecoits-Filho
  fullname: Pecoits-Filho, Roberto
  organization: Arbor Research Collaborative for Health, School of Medicine, Pontificia Universidade Catolica do Parana
– sequence: 11
  givenname: Sophie
  surname: Liabeuf
  fullname: Liabeuf, Sophie
  organization: Center for Research in Epidemiology and Population Health (CESP), Clinical Epidemiology Team, Paris-Saclay University, Paris-Sud University, Versailles Saint-Quentin-en-Yvelines University, Department of Clinical Pharmacology, Centre Hospitalier Universitaire, Laboratoire MP3CV, EA7517, Université de Picardie Jules Verne
– sequence: 12
  givenname: Bénédicte
  surname: Stengel
  fullname: Stengel, Bénédicte
  organization: Center for Research in Epidemiology and Population Health (CESP), Clinical Epidemiology Team, Paris-Saclay University, Paris-Sud University, Versailles Saint-Quentin-en-Yvelines University
– sequence: 13
  givenname: Jérôme
  surname: Harambat
  fullname: Harambat, Jérôme
  organization: INSERM, Bordeaux Population Health Research Center, UMR1219, Univ Bordeaux, INSERM, CIC1401-EC, Univ Bordeaux, Pediatric Nephrology Unit, Pellegrin-Enfants Hospital, Centre Hospitalier Universitaire de Bordeaux, Centre de Référence Maladies rénales rares Sorare
– sequence: 14
  givenname: Karen
  surname: Leffondré
  fullname: Leffondré, Karen
  organization: INSERM, Bordeaux Population Health Research Center, UMR1219, Univ Bordeaux, INSERM, CIC1401-EC, Univ Bordeaux
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36894586$$D View this record in MEDLINE/PubMed
https://u-picardie.hal.science/hal-04032437$$DView record in HAL
BookMark eNp9ks1u1DAUhS1URMvQF2CBLLGBRcDxT2JvkKoKaKWR2MDaurGdGQ8Zu9hJq749nslQ2lk0myTOd87xdc5rdBJicAi9rcmnmjD5OfNaKFkRyipGFKFV-wKdUcJFRRmlJ4-eT9F5zhtSLkEVr9UrdMoaqbiQzRkaljGs_DhZH2DAU_IGg_EWryHjkjj44CBhyDkaD6OPAd_5cY1_exvcPe7BD1NyGILF25hGGPx4j33AZp1iKF4HzvrsILs36GUPQ3bnh_sC_fr29eflVbX88f368mJZGdHysepsCwBtKzsQhtnGkqa81obTXkkFQpZReuANsJqr3ommY5YIpnrRK1sGZgt0PfvaCBt9k_wW0r2O4PV-IaaVhjR6MzjdMlnCDJdWEO6kkJRaB9ARSvuOmK54fZm9bqZu66xxYUwwPDF9-iX4tV7FW62Ukg1risHH2WB9JLu6WOrdGuGEUc7a27qwHw5hKf6ZXB711mfjhgGCi1PWtJUNUbSpZUHfH6GbOKXyE_dUGUZQsqPePd79Q_6_AhSAzoBJMefk-gekJnpXND0XTZei6X3RypEtkDwSGT_u21FOwA_PS9kszSUnrFz6v-1nVH8BSUzn8w
CitedBy_id crossref_primary_10_1038_s41598_023_51010_6
crossref_primary_10_1093_ndt_gfad201
crossref_primary_10_3390_jcm13051360
crossref_primary_10_1089_met_2023_0238
crossref_primary_10_1007_s40620_024_02179_0
crossref_primary_10_1016_j_ekir_2025_02_024
Cites_doi 10.1161/JAHA.117.007523
10.1016/j.exger.2008.01.006
10.1053/j.ajkd.2017.08.017
10.1214/ss/1038425655
10.1007/s40620-020-00702-7
10.1002/art.40472
10.1080/0886022X.2020.1745234
10.1111/j.1523-1755.2005.00074.x
10.1093/ajh/hpaa044
10.1002/sim.3289
10.1159/000345509
10.2215/CJN.09420911
10.1007/s11606-008-0520-5
10.1056/NEJMoa1915833
10.1053/j.ajkd.2008.12.021
10.1056/NEJMoa1916624
10.1371/journal.pone.0145506
10.1371/journal.pone.0132927
10.1007/978-3-319-19425-7_2
10.1093/ndt/gfr561
10.1007/s00467-015-3299-8
10.1681/ASN.2020010028
10.1161/hy1101.092839
10.1053/j.ajkd.2020.05.006
10.1111/j.1541-0420.2007.00983.x
10.1152/physiol.00039.2004
10.1016/S0272-6386(99)70295-7
10.3389/fcvm.2021.641513
10.2215/CJN.10400915
10.1093/ndt/gfv225
10.1002/bimj.201100052
10.1056/NEJMra1700312
10.1111/dom.13274
10.1038/s41598-020-74747-w
10.1016/j.amjmed.2018.12.010
10.2307/2533670
10.1201/b12208
10.2215/CJN.05190420
10.1152/ajprenal.00283.2001
10.1093/ndt/gft500
10.1016/S0272-6386(04)00934-5
10.1186/1471-2369-15-91
10.1038/ki.1997.260
10.1093/ndt/gfx341
10.1007/s11255-021-02902-x
10.1093/ndt/gfu325
10.1093/ndt/gft388
10.1093/ndt/gfx297
10.1371/journal.pone.0170393
10.1016/j.ekir.2020.05.021
10.1159/000331453
ContentType Journal Article
Contributor Herpe, Yves-Edouard
Speyer, Elodie
de Pinho, Natalia Alencar
Lambert, Oriane
Pascal, Christophe
Metzger, Marie
Schanstra, Joost
Contributor_xml – sequence: 1
  givenname: Natalia Alencar
  surname: de Pinho
  fullname: de Pinho, Natalia Alencar
– sequence: 2
  givenname: Yves-Edouard
  surname: Herpe
  fullname: Herpe, Yves-Edouard
– sequence: 3
  givenname: Christophe
  surname: Pascal
  fullname: Pascal, Christophe
– sequence: 4
  givenname: Joost
  surname: Schanstra
  fullname: Schanstra, Joost
– sequence: 5
  givenname: Oriane
  surname: Lambert
  fullname: Lambert, Oriane
– sequence: 6
  givenname: Marie
  surname: Metzger
  fullname: Metzger, Marie
– sequence: 7
  givenname: Elodie
  surname: Speyer
  fullname: Speyer, Elodie
Copyright The Author(s) 2023
2023. The Author(s).
The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml – notice: The Author(s) 2023
– notice: 2023. The Author(s).
– notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Distributed under a Creative Commons Attribution 4.0 International License
CorporateAuthor CKD-REIN study group
CorporateAuthor_xml – name: CKD-REIN study group
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
Q9U
7X8
1XC
VOOES
5PM
DOA
DOI 10.1038/s41598-023-30902-7
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection (Proquest)
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Science Database (ProQuest)
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList


MEDLINE
MEDLINE - Academic
CrossRef

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 11
ExternalDocumentID oai_doaj_org_article_7387aac48d504e85822deaab022fb0cb
PMC9998636
oai:HAL:hal-04032437v1
36894586
10_1038_s41598_023_30902_7
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFFHD
AFPKN
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
K9.
PKEHL
PQEST
PQUKI
Q9U
7X8
PUEGO
1XC
EJD
IPNFZ
RIG
VOOES
5PM
ID FETCH-LOGICAL-c574t-bd7aaa778ba5c3d6d06aa71c42f989a58000fa46a3149fe56b3d0539f5f9d3223
IEDL.DBID DOA
ISICitedReferencesCount 7
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000955919300072&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2045-2322
IngestDate Tue Oct 14 19:05:44 EDT 2025
Tue Nov 04 02:07:36 EST 2025
Sat Oct 18 23:42:45 EDT 2025
Fri Sep 05 11:30:54 EDT 2025
Tue Oct 07 09:16:32 EDT 2025
Mon Jul 21 05:53:27 EDT 2025
Tue Nov 18 20:44:40 EST 2025
Sat Nov 29 06:33:41 EST 2025
Fri Feb 21 02:37:26 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2023. The Author(s).
Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c574t-bd7aaa778ba5c3d6d06aa71c42f989a58000fa46a3149fe56b3d0539f5f9d3223
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
PMCID: PMC9998636
ORCID 0000-0002-9707-7199
0000-0001-5771-5996
0000-0001-5384-9006
OpenAccessLink https://doaj.org/article/7387aac48d504e85822deaab022fb0cb
PMID 36894586
PQID 2785045208
PQPubID 2041939
PageCount 11
ParticipantIDs doaj_primary_oai_doaj_org_article_7387aac48d504e85822deaab022fb0cb
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9998636
hal_primary_oai_HAL_hal_04032437v1
proquest_miscellaneous_2786092618
proquest_journals_2785045208
pubmed_primary_36894586
crossref_primary_10_1038_s41598_023_30902_7
crossref_citationtrail_10_1038_s41598_023_30902_7
springer_journals_10_1038_s41598_023_30902_7
PublicationCentury 2000
PublicationDate 2023-03-09
PublicationDateYYYYMMDD 2023-03-09
PublicationDate_xml – month: 03
  year: 2023
  text: 2023-03-09
  day: 09
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2023
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References JohnsonRJKivlighnSDKimYGSugaSFogoABReappraisal of the pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal diseaseAm. J. Kidney Dis.19993322252341:STN:280:DyaK1M7ks1agug%3D%3D1002363310.1016/S0272-6386(99)70295-7
ZoccaliCMallamaciFUric acid in chronic kidney disease: The quest for causality continuesNephrol Dial Transpl.20183321931951:CAS:528:DC%2BC1MXps1Oht7w%3D10.1093/ndt/gfx341
Sanchez-LozadaLGRodriguez-IturbeBKelleyEENakagawaTMaderoMFeigDIUric acid and hypertension: An update with recommendationsAm. J. Hypertens.20203375835941:CAS:528:DC%2BB3cXisF2ntL7K32179896736816710.1093/ajh/hpaa044
Sturm G, Kollerits B, Neyer U, Ritz E, Kronenberg F, MMKD Study Group. Uric acid as a risk factor for progression of non-diabetic chronic kidney disease? The mild to Moderate Kidney Disease (MMKD) Study. Exp. Gerontol.43(4), 347–352 (2008).
NacakHvan DiepenMde GoeijMCRotmansJIDekkerFWUric acid: association with rate of renal function decline and time until start of dialysis in incident pre-dialysis patientsBMC Nephrol.20141519124939671407549910.1186/1471-2369-15-91
BadveSVPascoeEMTikuABoudvilleNBrownFGCassAEffects of allopurinol on the progression of chronic kidney diseaseN. Engl. J. Med.202038226250425131:CAS:528:DC%2BB3cXht12rtLvI3257981110.1056/NEJMoa1915833
LiMYeZCLiCMZhaoWBTangHLiuXLow serum uric acid levels increase the risk of all-cause death and cardiovascular death in hemodialysis patientsRen. Fail.20204213153221:CAS:528:DC%2BB3cXlvVygsrc%3D32223483717027710.1080/0886022X.2020.1745234
Modification of Diet in Renal Disease Study Group, Hunsicker LG, Adler S, Caggiula A, England BK, Greene T, et al. Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study. Kidney Int.51(6), 1908–1919 (1997).
SweetingMJThompsonSGJoint modelling of longitudinal and time-to-event data with application to predicting abdominal aortic aneurysm growth and ruptureBiom J201153575076328614842183412734433861226.6213010.1002/bimj.201100052
PaulRZaihraTInterval estimation of risk difference for data sampled from clustersStat. Med.200827214207422025265401840757410.1002/sim.3289
KoGJRheeCMKalantar-ZadehKJoshiSThe effects of high-protein diets on kidney health and longevityJ. Am. Soc. Nephrol.2020318166716791:CAS:528:DC%2BB3cXitF2rtLzJ32669325746090510.1681/ASN.2020010028
ChoSKChangYKimIRyuSU-shaped association between serum uric acid level and risk of mortalityArthritis Rheumatol.2018707112211321:CAS:528:DC%2BC1cXht1WrurvF2969471910.1002/art.40472
LeffondreKJagerKJBoucquemontJStelVSHeinzeGRepresentation of exposures in regression analysis and interpretation of regression coefficients: Basic concepts and pitfallsNephrol. Dial. Transpl.201429101806181410.1093/ndt/gft500
R Core Team (2019). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available from: https://www.R-project.org
Perez-GomezMVBartschLACastillo-RodriguezEFernandez-PradoRKanbayMOrtizAPotential dangers of serum urate-lowering therapyAm. J. Med.201913244574671:CAS:528:DC%2BC1MXisFWgu7o%3D3061183310.1016/j.amjmed.2018.12.010
StengelBCombeCJacquelinetCBrianconSFouqueDLavilleMThe French chronic kidney disease-renal epidemiology and information network (CKD-REIN) cohort studyNephrol Dial Transpl.20142981500150710.1093/ndt/gft388
ZawadaAMCarreroJJWolfMFeuersengerAStuardSGaulyASerum uric acid and mortality risk among hemodialysis patientsKidney Int. Rep.2020581196120632775819740356010.1016/j.ekir.2020.05.021
ChewLDGriffinJMPartinMRNoorbaloochiSGrillJPSnyderAValidation of screening questions for limited health literacy in a large VA outpatient populationJ. Gen. Intern. Med.200823556156618335281232416010.1007/s11606-008-0520-5
LeeCLTsaiSFAssociation between mortality and serum uric acid levels in non-diabetes-related chronic kidney disease: An analysis of the National Health and Nutrition Examination Survey, USA, 1999–2010Sci. Rep.2020101175852020NatSR..1017585L1:CAS:528:DC%2BB3cXitFCkt7nN33067501756853410.1038/s41598-020-74747-w
IsekiKIkemiyaYInoueTIsekiCKinjoKTakishitaSSignificance of hyperuricemia as a risk factor for developing ESRD in a screened cohortAm. J. Kidney Dis.20044446426501538401510.1016/S0272-6386(04)00934-5
DoriaAGaleckiATSpinoCPop-BusuiRCherneyDZLingvayISerum urate lowering with allopurinol and kidney function in type 1 diabetesN. Engl. J. Med.202038226249325031:CAS:528:DC%2BB3cXht12rtLrJ32579810737570810.1056/NEJMoa1916624
HarrellFEHarrellJFrankEGeneral aspects of fitting regression modelsRegression Modeling Strategies: With Applications to Linear Models, Logistic and Ordinal Regression, and Survival Analysis2015New YorkSpringer13441330.6200110.1007/978-3-319-19425-7_2
BeberashviliIErlichAAzarASinuaniIFeldmanLGorelikOLongitudinal study of serum uric acid, nutritional status, and mortality in maintenance hemodialysis patientsClin. J. Am. Soc. Nephrol.2016116101510231:CAS:528:DC%2BC2sXhsVSks7vN27026520489175310.2215/CJN.10400915
ChangWXAsakawaSToyokiDNemotoYMorimotoCTamuraYPredictors and the subsequent risk of end-stage renal disease—usefulness of 30% decline in estimated GFR over 2 yearsPLoS ONE2015107e013292726177463450340310.1371/journal.pone.0132927
BjornstadPMaahsDMRoncalCASnell-BergeonJKShahVNMilagresTRole of bicarbonate supplementation on urine uric acid crystals and diabetic tubulopathy in adults with type 1 diabetesDiabetes Obes. Metab.2018207177617801:CAS:528:DC%2BC1cXhtFKhtLjJ29498467634434910.1111/dom.13274
MaderoMSarnakMJWangXGreeneTBeckGJKusekJWUric acid and long-term outcomes in CKDAm. J. Kidney Dis.20095357968031:CAS:528:DC%2BD1MXlvFOjsrs%3D19303683269155310.1053/j.ajkd.2008.12.021
HedigerMAJohnsonRJMiyazakiHEndouHMolecular physiology of urate transportPhysiology20052021251331:CAS:528:DC%2BD2MXjs1Ontrk%3D1577230110.1152/physiol.00039.2004
MazzaliMHughesJKimYGJeffersonAKangDHGordonKLElevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanismHypertension2001385110111061:CAS:528:DC%2BD3MXovVOrsbg%3D1171150510.1161/hy1101.092839
BjornstadPRoncalCMilagresTPyleLLanaspaMABishopFKHyperfiltration and uricosuria in adolescents with type 1 diabetesPediatr. Nephrol. Berl. Ger.201631578779310.1007/s00467-015-3299-8
ShiYChenWJalalDLiZChenWMaoHClinical outcome of hyperuricemia in IgA nephropathy: A Retrospective Cohort Study and Randomized Controlled TrialKidney Blood Press Res.20123531531601:CAS:528:DC%2BC38XmtlOrtbg%3D2211619610.1159/000331453
IkizlerTABurrowesJDByham-GrayLDCampbellKLCarreroJJChanWKDOQI clinical practice guideline for nutrition in CKD: 2020 updateAm. J. Kidney Dis.2020763S1S1071:CAS:528:DC%2BB3cXhs1Gqs7bN3282975110.1053/j.ajkd.2020.05.006
UchidaSChangWXOtaTTamuraYShiraishiTKumagaiTTargeting uric acid and the inhibition of progression to end-stage renal disease—a propensity score analysisPLoS ONE20151012e014550626700005468934910.1371/journal.pone.0145506
Sánchez-LozadaLGLanaspaMACristóbal-GarcíaMGarcía-ArroyoFSotoVCruz-RoblesDUric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrationsNephron. Exp. Nephrol.20121213–4e71782323549310.1159/000345509
LiQWuCKuangWZhanXZhouJCorrelation analysis of low-level serum uric acid and cardiovascular events in patients on peritoneal dialysisInt. Urol. Nephrol.20215311239924081:CAS:528:DC%2BB3MXhsVCmtbnI34101100818602010.1007/s11255-021-02902-x
SrivastavaAKazeADMcMullanCJIsakovaTWaikarSSUric acid and the risks of kidney failure and death in individuals with CKDAm. J. Kidney Dis.20187133623701:CAS:528:DC%2BC2sXhsl2qt7%2FM2913294510.1053/j.ajkd.2017.08.017
ChenQWangZZhouJChenZLiYLiSEffect of urate-lowering therapy on cardiovascular and kidney outcomes: A systematic review and meta-analysisClin. J. Am. Soc. Nephrol.202015111576158633055192764624410.2215/CJN.05190420
TsaiCWChiuHTHuangHCTingIWYehHCKuoCCUric acid predicts adverse outcomes in chronic kidney disease: a novel insight from trajectory analysesNephrol. Dial Transpl.20183322312411:CAS:528:DC%2BC1MXps1OhsLc%3D10.1093/ndt/gfx297
BoninoBLeonciniGRussoEPontremoliRViazziFUric acid in CKD: Has the jury come to the verdict?J. Nephrol.20203347157241:CAS:528:DC%2BB3cXnvVCmtA%3D%3D3193316110.1007/s40620-020-00702-7
EilersPHCMarxBDFlexible smoothing with B-splines and penaltiesStat. Sci.1996118912114354850955.6256210.1214/ss/1038425655
Sánchez-LozadaLGTapiaESantamaríaJAvila-CasadoCSotoVNepomucenoTMild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney ratsKidney Int.20056712372471561024710.1111/j.1523-1755.2005.00074.x
SuttorpMMSiegerinkBJagerKJZoccaliCDekkerFWGraphical presentation of confounding in directed acyclic graphsNephrol. Dial. Transpl.20153091418142310.1093/ndt/gfu325
KDIGO. KDIGOClinical practice guideline for the evaluation and management of chronic kidney diseaseKidney Int. Suppl.2012201331150
Kalantar-ZadehKFouqueDNutritional management of chronic kidney diseaseN. Engl. J. Med.201737718176517761:CAS:528:DC%2BC2sXhvFChtbfN2909156110.1056/NEJMra1700312
RizopoulosDJoint Models for Longitudinal and Time-to-Event Data: With Applications in R20121New-YorkCRC Press1284.6203210.1201/b12208
NacakHvan DiepenMQureshiARCarreroJJStijnenTDekkerFWUric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with Stage III, IV and V chronic kidney diseaseNephrol. Dial. Transpl.201530122039204510.1093/ndt/gfv225
LiuWCHungCCChenSCYehSMLinMYChiuYWAssociation of hyperuricemia with renal outcomes, cardiovascular disease, and mortalityClin. J. Am. Soc. Nephrol.2012745415481:CAS:528:DC%2BC38XmvFaqsb8%3D2230073710.2215/CJN.09420911
GirerdXEvaluation de l’observance par l’interrogatoire au cours du suivi des hypertendus dans des consultations spécialiséesArch. Mal. Coeur. Vaiss.20019488398421:STN:280:DC%2BD3MrivFaitg%3D%3D11575214
MazzaliMKanellisJHanLFengLXiaYYChenQHyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-indepen
KDIGO. KDIGO (30902_CR16) 2012; 2013
Y Cang (30902_CR45) 2021; 8
A Doria (30902_CR53) 2020; 382
CW Tsai (30902_CR41) 2017; 12
B Stengel (30902_CR15) 2014; 29
TA Ikizler (30902_CR17) 2020; 76
LG Sánchez-Lozada (30902_CR37) 2005; 67
M Li (30902_CR47) 2020; 42
MM Suttorp (30902_CR24) 2015; 30
PHC Eilers (30902_CR30) 1996; 11
AM Zawada (30902_CR42) 2020; 5
M Madero (30902_CR3) 2009; 53
30902_CR2
30902_CR1
Q Chen (30902_CR51) 2020; 15
GJ Ko (30902_CR28) 2020; 31
RJ Johnson (30902_CR33) 1999; 33
LD Chew (30902_CR19) 2008; 23
A Srivastava (30902_CR10) 2018; 71
CL Lee (30902_CR44) 2020; 10
H Nacak (30902_CR5) 2015; 30
LG Sánchez-Lozada (30902_CR34) 2012; 121
U Dafni (30902_CR20) 1998; 54
K Kalantar-Zadeh (30902_CR27) 2017; 377
Y Shi (30902_CR11) 2012; 35
WC Tseng (30902_CR49) 2018; 7
K Iseki (30902_CR40) 2004; 44
MA Hediger (30902_CR26) 2005; 20
C Zoccali (30902_CR12) 2018; 33
H Nacak (30902_CR9) 2014; 15
MJ Sweeting (30902_CR21) 2011; 53
LG Sanchez-Lozada (30902_CR25) 2020; 33
N Altemtam (30902_CR8) 2012; 27
SV Badve (30902_CR52) 2020; 382
S Uchida (30902_CR7) 2015; 10
CW Tsai (30902_CR14) 2018; 33
I Beberashvili (30902_CR48) 2016; 11
MV Perez-Gomez (30902_CR54) 2019; 132
K Leffondre (30902_CR31) 2014; 29
M Mazzali (30902_CR35) 2001; 38
SK Cho (30902_CR43) 2018; 70
Q Li (30902_CR46) 2021; 53
WC Liu (30902_CR4) 2012; 7
P Bjornstad (30902_CR38) 2018; 20
R Paul (30902_CR29) 2008; 27
D Rizopoulos (30902_CR50) 2012
P Bjornstad (30902_CR39) 2016; 31
FE Harrell (30902_CR23) 2015
M Mazzali (30902_CR36) 2002; 282
X Girerd (30902_CR18) 2001; 94
30902_CR32
B Bonino (30902_CR13) 2020; 33
WX Chang (30902_CR6) 2015; 10
W Ye (30902_CR22) 2008; 64
References_xml – reference: HedigerMAJohnsonRJMiyazakiHEndouHMolecular physiology of urate transportPhysiology20052021251331:CAS:528:DC%2BD2MXjs1Ontrk%3D1577230110.1152/physiol.00039.2004
– reference: BjornstadPRoncalCMilagresTPyleLLanaspaMABishopFKHyperfiltration and uricosuria in adolescents with type 1 diabetesPediatr. Nephrol. Berl. Ger.201631578779310.1007/s00467-015-3299-8
– reference: SrivastavaAKazeADMcMullanCJIsakovaTWaikarSSUric acid and the risks of kidney failure and death in individuals with CKDAm. J. Kidney Dis.20187133623701:CAS:528:DC%2BC2sXhsl2qt7%2FM2913294510.1053/j.ajkd.2017.08.017
– reference: GirerdXEvaluation de l’observance par l’interrogatoire au cours du suivi des hypertendus dans des consultations spécialiséesArch. Mal. Coeur. Vaiss.20019488398421:STN:280:DC%2BD3MrivFaitg%3D%3D11575214
– reference: TsaiCWLinSYKuoCCHuangCCSerum uric acid and progression of kidney disease: A longitudinal analysis and mini-reviewPLoS ONE2017121e017039328107415524924510.1371/journal.pone.0170393
– reference: ZoccaliCMallamaciFUric acid in chronic kidney disease: The quest for causality continuesNephrol Dial Transpl.20183321931951:CAS:528:DC%2BC1MXps1Oht7w%3D10.1093/ndt/gfx341
– reference: NacakHvan DiepenMQureshiARCarreroJJStijnenTDekkerFWUric acid is not associated with decline in renal function or time to renal replacement therapy initiation in a referred cohort of patients with Stage III, IV and V chronic kidney diseaseNephrol. Dial. Transpl.201530122039204510.1093/ndt/gfv225
– reference: BoninoBLeonciniGRussoEPontremoliRViazziFUric acid in CKD: Has the jury come to the verdict?J. Nephrol.20203347157241:CAS:528:DC%2BB3cXnvVCmtA%3D%3D3193316110.1007/s40620-020-00702-7
– reference: BjornstadPMaahsDMRoncalCASnell-BergeonJKShahVNMilagresTRole of bicarbonate supplementation on urine uric acid crystals and diabetic tubulopathy in adults with type 1 diabetesDiabetes Obes. Metab.2018207177617801:CAS:528:DC%2BC1cXhtFKhtLjJ29498467634434910.1111/dom.13274
– reference: SuttorpMMSiegerinkBJagerKJZoccaliCDekkerFWGraphical presentation of confounding in directed acyclic graphsNephrol. Dial. Transpl.20153091418142310.1093/ndt/gfu325
– reference: MazzaliMHughesJKimYGJeffersonAKangDHGordonKLElevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanismHypertension2001385110111061:CAS:528:DC%2BD3MXovVOrsbg%3D1171150510.1161/hy1101.092839
– reference: LiMYeZCLiCMZhaoWBTangHLiuXLow serum uric acid levels increase the risk of all-cause death and cardiovascular death in hemodialysis patientsRen. Fail.20204213153221:CAS:528:DC%2BB3cXlvVygsrc%3D32223483717027710.1080/0886022X.2020.1745234
– reference: LeffondreKJagerKJBoucquemontJStelVSHeinzeGRepresentation of exposures in regression analysis and interpretation of regression coefficients: Basic concepts and pitfallsNephrol. Dial. Transpl.201429101806181410.1093/ndt/gft500
– reference: ZawadaAMCarreroJJWolfMFeuersengerAStuardSGaulyASerum uric acid and mortality risk among hemodialysis patientsKidney Int. Rep.2020581196120632775819740356010.1016/j.ekir.2020.05.021
– reference: AltemtamNRussellJEl NahasMA study of the natural history of diabetic kidney disease (DKD)Nephrol Dial Transpl.2012275184718541:CAS:528:DC%2BC38XmvVejuro%3D10.1093/ndt/gfr561
– reference: KDIGO. KDIGOClinical practice guideline for the evaluation and management of chronic kidney diseaseKidney Int. Suppl.2012201331150
– reference: ChenQWangZZhouJChenZLiYLiSEffect of urate-lowering therapy on cardiovascular and kidney outcomes: A systematic review and meta-analysisClin. J. Am. Soc. Nephrol.202015111576158633055192764624410.2215/CJN.05190420
– reference: Perez-GomezMVBartschLACastillo-RodriguezEFernandez-PradoRKanbayMOrtizAPotential dangers of serum urate-lowering therapyAm. J. Med.201913244574671:CAS:528:DC%2BC1MXisFWgu7o%3D3061183310.1016/j.amjmed.2018.12.010
– reference: YeWLinXTaylorJMGSemiparametric modeling of longitudinal measurements and time-to-event data—a two-stage regression calibration approachBiometrics2008644123812462522273182611601151.6209310.1111/j.1541-0420.2007.00983.x
– reference: IkizlerTABurrowesJDByham-GrayLDCampbellKLCarreroJJChanWKDOQI clinical practice guideline for nutrition in CKD: 2020 updateAm. J. Kidney Dis.2020763S1S1071:CAS:528:DC%2BB3cXhs1Gqs7bN3282975110.1053/j.ajkd.2020.05.006
– reference: ShiYChenWJalalDLiZChenWMaoHClinical outcome of hyperuricemia in IgA nephropathy: A Retrospective Cohort Study and Randomized Controlled TrialKidney Blood Press Res.20123531531601:CAS:528:DC%2BC38XmtlOrtbg%3D2211619610.1159/000331453
– reference: EilersPHCMarxBDFlexible smoothing with B-splines and penaltiesStat. Sci.1996118912114354850955.6256210.1214/ss/1038425655
– reference: Sturm G, Kollerits B, Neyer U, Ritz E, Kronenberg F, MMKD Study Group. Uric acid as a risk factor for progression of non-diabetic chronic kidney disease? The mild to Moderate Kidney Disease (MMKD) Study. Exp. Gerontol.43(4), 347–352 (2008).
– reference: HarrellFEHarrellJFrankEGeneral aspects of fitting regression modelsRegression Modeling Strategies: With Applications to Linear Models, Logistic and Ordinal Regression, and Survival Analysis2015New YorkSpringer13441330.6200110.1007/978-3-319-19425-7_2
– reference: MaderoMSarnakMJWangXGreeneTBeckGJKusekJWUric acid and long-term outcomes in CKDAm. J. Kidney Dis.20095357968031:CAS:528:DC%2BD1MXlvFOjsrs%3D19303683269155310.1053/j.ajkd.2008.12.021
– reference: DoriaAGaleckiATSpinoCPop-BusuiRCherneyDZLingvayISerum urate lowering with allopurinol and kidney function in type 1 diabetesN. Engl. J. Med.202038226249325031:CAS:528:DC%2BB3cXht12rtLrJ32579810737570810.1056/NEJMoa1916624
– reference: CangYXuSZhangJJuJChenZWangKSerum uric acid revealed a U-shaped relationship with all-cause mortality and cardiovascular mortality in high atherosclerosis risk patients: The ASSURE studyFront. Cardiovasc. Med.202186415131:CAS:528:DC%2BB3MXitFCltrbO34109223818055910.3389/fcvm.2021.641513
– reference: ChangWXAsakawaSToyokiDNemotoYMorimotoCTamuraYPredictors and the subsequent risk of end-stage renal disease—usefulness of 30% decline in estimated GFR over 2 yearsPLoS ONE2015107e013292726177463450340310.1371/journal.pone.0132927
– reference: R Core Team (2019). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available from: https://www.R-project.org/
– reference: Modification of Diet in Renal Disease Study Group, Hunsicker LG, Adler S, Caggiula A, England BK, Greene T, et al. Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study. Kidney Int.51(6), 1908–1919 (1997).
– reference: JohnsonRJKivlighnSDKimYGSugaSFogoABReappraisal of the pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal diseaseAm. J. Kidney Dis.19993322252341:STN:280:DyaK1M7ks1agug%3D%3D1002363310.1016/S0272-6386(99)70295-7
– reference: Sanchez-LozadaLGRodriguez-IturbeBKelleyEENakagawaTMaderoMFeigDIUric acid and hypertension: An update with recommendationsAm. J. Hypertens.20203375835941:CAS:528:DC%2BB3cXisF2ntL7K32179896736816710.1093/ajh/hpaa044
– reference: ChewLDGriffinJMPartinMRNoorbaloochiSGrillJPSnyderAValidation of screening questions for limited health literacy in a large VA outpatient populationJ. Gen. Intern. Med.200823556156618335281232416010.1007/s11606-008-0520-5
– reference: Kalantar-ZadehKFouqueDNutritional management of chronic kidney diseaseN. Engl. J. Med.201737718176517761:CAS:528:DC%2BC2sXhvFChtbfN2909156110.1056/NEJMra1700312
– reference: MazzaliMKanellisJHanLFengLXiaYYChenQHyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanismAm. J. Physiol. Renal. Physiol.20022826F9919971:CAS:528:DC%2BD38Xks12msrw%3D1199731510.1152/ajprenal.00283.2001
– reference: LeeCLTsaiSFAssociation between mortality and serum uric acid levels in non-diabetes-related chronic kidney disease: An analysis of the National Health and Nutrition Examination Survey, USA, 1999–2010Sci. Rep.2020101175852020NatSR..1017585L1:CAS:528:DC%2BB3cXitFCkt7nN33067501756853410.1038/s41598-020-74747-w
– reference: TsaiCWChiuHTHuangHCTingIWYehHCKuoCCUric acid predicts adverse outcomes in chronic kidney disease: a novel insight from trajectory analysesNephrol. Dial Transpl.20183322312411:CAS:528:DC%2BC1MXps1OhsLc%3D10.1093/ndt/gfx297
– reference: RizopoulosDJoint Models for Longitudinal and Time-to-Event Data: With Applications in R20121New-YorkCRC Press1284.6203210.1201/b12208
– reference: Sánchez-LozadaLGTapiaESantamaríaJAvila-CasadoCSotoVNepomucenoTMild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney ratsKidney Int.20056712372471561024710.1111/j.1523-1755.2005.00074.x
– reference: LiQWuCKuangWZhanXZhouJCorrelation analysis of low-level serum uric acid and cardiovascular events in patients on peritoneal dialysisInt. Urol. Nephrol.20215311239924081:CAS:528:DC%2BB3MXhsVCmtbnI34101100818602010.1007/s11255-021-02902-x
– reference: TsengWCChenYTOuSMShihCJTarngDCTaiwan Geriatric Kidney Disease (TGKD) Research GroupU-shaped association between serum uric acid levels with cardiovascular and all-cause mortality in the elderly: The role of malnourishmentJ. Am. Heart Assoc.201874e00752329440009585018910.1161/JAHA.117.007523
– reference: StengelBCombeCJacquelinetCBrianconSFouqueDLavilleMThe French chronic kidney disease-renal epidemiology and information network (CKD-REIN) cohort studyNephrol Dial Transpl.20142981500150710.1093/ndt/gft388
– reference: DafniUTsiatisAEvaluating surrogate markers of clinical outcome when measured with errorBiometrics1998544144514621:STN:280:DyaK1M%2FpvF2qtQ%3D%3D98835441058.6259710.2307/2533670
– reference: KoGJRheeCMKalantar-ZadehKJoshiSThe effects of high-protein diets on kidney health and longevityJ. Am. Soc. Nephrol.2020318166716791:CAS:528:DC%2BB3cXitF2rtLzJ32669325746090510.1681/ASN.2020010028
– reference: IsekiKIkemiyaYInoueTIsekiCKinjoKTakishitaSSignificance of hyperuricemia as a risk factor for developing ESRD in a screened cohortAm. J. Kidney Dis.20044446426501538401510.1016/S0272-6386(04)00934-5
– reference: NacakHvan DiepenMde GoeijMCRotmansJIDekkerFWUric acid: association with rate of renal function decline and time until start of dialysis in incident pre-dialysis patientsBMC Nephrol.20141519124939671407549910.1186/1471-2369-15-91
– reference: BadveSVPascoeEMTikuABoudvilleNBrownFGCassAEffects of allopurinol on the progression of chronic kidney diseaseN. Engl. J. Med.202038226250425131:CAS:528:DC%2BB3cXht12rtLvI3257981110.1056/NEJMoa1915833
– reference: SweetingMJThompsonSGJoint modelling of longitudinal and time-to-event data with application to predicting abdominal aortic aneurysm growth and ruptureBiom J201153575076328614842183412734433861226.6213010.1002/bimj.201100052
– reference: PaulRZaihraTInterval estimation of risk difference for data sampled from clustersStat. Med.200827214207422025265401840757410.1002/sim.3289
– reference: BeberashviliIErlichAAzarASinuaniIFeldmanLGorelikOLongitudinal study of serum uric acid, nutritional status, and mortality in maintenance hemodialysis patientsClin. J. Am. Soc. Nephrol.2016116101510231:CAS:528:DC%2BC2sXhsVSks7vN27026520489175310.2215/CJN.10400915
– reference: ChoSKChangYKimIRyuSU-shaped association between serum uric acid level and risk of mortalityArthritis Rheumatol.2018707112211321:CAS:528:DC%2BC1cXht1WrurvF2969471910.1002/art.40472
– reference: Sánchez-LozadaLGLanaspaMACristóbal-GarcíaMGarcía-ArroyoFSotoVCruz-RoblesDUric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrationsNephron. Exp. Nephrol.20121213–4e71782323549310.1159/000345509
– reference: LiuWCHungCCChenSCYehSMLinMYChiuYWAssociation of hyperuricemia with renal outcomes, cardiovascular disease, and mortalityClin. J. Am. Soc. Nephrol.2012745415481:CAS:528:DC%2BC38XmvFaqsb8%3D2230073710.2215/CJN.09420911
– reference: UchidaSChangWXOtaTTamuraYShiraishiTKumagaiTTargeting uric acid and the inhibition of progression to end-stage renal disease—a propensity score analysisPLoS ONE20151012e014550626700005468934910.1371/journal.pone.0145506
– volume: 7
  start-page: e007523
  issue: 4
  year: 2018
  ident: 30902_CR49
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.117.007523
– ident: 30902_CR2
  doi: 10.1016/j.exger.2008.01.006
– volume: 71
  start-page: 362
  issue: 3
  year: 2018
  ident: 30902_CR10
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2017.08.017
– volume: 11
  start-page: 89
  year: 1996
  ident: 30902_CR30
  publication-title: Stat. Sci.
  doi: 10.1214/ss/1038425655
– volume: 33
  start-page: 715
  issue: 4
  year: 2020
  ident: 30902_CR13
  publication-title: J. Nephrol.
  doi: 10.1007/s40620-020-00702-7
– volume: 70
  start-page: 1122
  issue: 7
  year: 2018
  ident: 30902_CR43
  publication-title: Arthritis Rheumatol.
  doi: 10.1002/art.40472
– volume: 42
  start-page: 315
  issue: 1
  year: 2020
  ident: 30902_CR47
  publication-title: Ren. Fail.
  doi: 10.1080/0886022X.2020.1745234
– volume: 67
  start-page: 237
  issue: 1
  year: 2005
  ident: 30902_CR37
  publication-title: Kidney Int.
  doi: 10.1111/j.1523-1755.2005.00074.x
– volume: 33
  start-page: 583
  issue: 7
  year: 2020
  ident: 30902_CR25
  publication-title: Am. J. Hypertens.
  doi: 10.1093/ajh/hpaa044
– volume: 27
  start-page: 4207
  issue: 21
  year: 2008
  ident: 30902_CR29
  publication-title: Stat. Med.
  doi: 10.1002/sim.3289
– volume: 121
  start-page: e71
  issue: 3–4
  year: 2012
  ident: 30902_CR34
  publication-title: Nephron. Exp. Nephrol.
  doi: 10.1159/000345509
– volume: 7
  start-page: 541
  issue: 4
  year: 2012
  ident: 30902_CR4
  publication-title: Clin. J. Am. Soc. Nephrol.
  doi: 10.2215/CJN.09420911
– volume: 94
  start-page: 839
  issue: 8
  year: 2001
  ident: 30902_CR18
  publication-title: Arch. Mal. Coeur. Vaiss.
– volume: 23
  start-page: 561
  issue: 5
  year: 2008
  ident: 30902_CR19
  publication-title: J. Gen. Intern. Med.
  doi: 10.1007/s11606-008-0520-5
– volume: 382
  start-page: 2504
  issue: 26
  year: 2020
  ident: 30902_CR52
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1915833
– volume: 53
  start-page: 796
  issue: 5
  year: 2009
  ident: 30902_CR3
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2008.12.021
– volume: 382
  start-page: 2493
  issue: 26
  year: 2020
  ident: 30902_CR53
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1916624
– ident: 30902_CR32
– volume: 10
  start-page: e0145506
  issue: 12
  year: 2015
  ident: 30902_CR7
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0145506
– volume: 10
  start-page: e0132927
  issue: 7
  year: 2015
  ident: 30902_CR6
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0132927
– start-page: 13
  volume-title: Regression Modeling Strategies: With Applications to Linear Models, Logistic and Ordinal Regression, and Survival Analysis
  year: 2015
  ident: 30902_CR23
  doi: 10.1007/978-3-319-19425-7_2
– volume: 27
  start-page: 1847
  issue: 5
  year: 2012
  ident: 30902_CR8
  publication-title: Nephrol Dial Transpl.
  doi: 10.1093/ndt/gfr561
– volume: 31
  start-page: 787
  issue: 5
  year: 2016
  ident: 30902_CR39
  publication-title: Pediatr. Nephrol. Berl. Ger.
  doi: 10.1007/s00467-015-3299-8
– volume: 31
  start-page: 1667
  issue: 8
  year: 2020
  ident: 30902_CR28
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2020010028
– volume: 38
  start-page: 1101
  issue: 5
  year: 2001
  ident: 30902_CR35
  publication-title: Hypertension
  doi: 10.1161/hy1101.092839
– volume: 76
  start-page: S1
  issue: 3
  year: 2020
  ident: 30902_CR17
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2020.05.006
– volume: 64
  start-page: 1238
  issue: 4
  year: 2008
  ident: 30902_CR22
  publication-title: Biometrics
  doi: 10.1111/j.1541-0420.2007.00983.x
– volume: 20
  start-page: 125
  issue: 2
  year: 2005
  ident: 30902_CR26
  publication-title: Physiology
  doi: 10.1152/physiol.00039.2004
– volume: 33
  start-page: 225
  issue: 2
  year: 1999
  ident: 30902_CR33
  publication-title: Am. J. Kidney Dis.
  doi: 10.1016/S0272-6386(99)70295-7
– volume: 8
  start-page: 641513
  year: 2021
  ident: 30902_CR45
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2021.641513
– volume: 11
  start-page: 1015
  issue: 6
  year: 2016
  ident: 30902_CR48
  publication-title: Clin. J. Am. Soc. Nephrol.
  doi: 10.2215/CJN.10400915
– volume: 30
  start-page: 2039
  issue: 12
  year: 2015
  ident: 30902_CR5
  publication-title: Nephrol. Dial. Transpl.
  doi: 10.1093/ndt/gfv225
– volume: 53
  start-page: 750
  issue: 5
  year: 2011
  ident: 30902_CR21
  publication-title: Biom J
  doi: 10.1002/bimj.201100052
– volume: 377
  start-page: 1765
  issue: 18
  year: 2017
  ident: 30902_CR27
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra1700312
– volume: 20
  start-page: 1776
  issue: 7
  year: 2018
  ident: 30902_CR38
  publication-title: Diabetes Obes. Metab.
  doi: 10.1111/dom.13274
– volume: 10
  start-page: 17585
  issue: 1
  year: 2020
  ident: 30902_CR44
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-74747-w
– volume: 132
  start-page: 457
  issue: 4
  year: 2019
  ident: 30902_CR54
  publication-title: Am. J. Med.
  doi: 10.1016/j.amjmed.2018.12.010
– volume: 54
  start-page: 1445
  issue: 4
  year: 1998
  ident: 30902_CR20
  publication-title: Biometrics
  doi: 10.2307/2533670
– volume: 2013
  start-page: 1
  issue: 3
  year: 2012
  ident: 30902_CR16
  publication-title: Kidney Int. Suppl.
– volume-title: Joint Models for Longitudinal and Time-to-Event Data: With Applications in R
  year: 2012
  ident: 30902_CR50
  doi: 10.1201/b12208
– volume: 15
  start-page: 1576
  issue: 11
  year: 2020
  ident: 30902_CR51
  publication-title: Clin. J. Am. Soc. Nephrol.
  doi: 10.2215/CJN.05190420
– volume: 282
  start-page: F991
  issue: 6
  year: 2002
  ident: 30902_CR36
  publication-title: Am. J. Physiol. Renal. Physiol.
  doi: 10.1152/ajprenal.00283.2001
– volume: 29
  start-page: 1806
  issue: 10
  year: 2014
  ident: 30902_CR31
  publication-title: Nephrol. Dial. Transpl.
  doi: 10.1093/ndt/gft500
– volume: 44
  start-page: 642
  issue: 4
  year: 2004
  ident: 30902_CR40
  publication-title: Am. J. Kidney Dis.
  doi: 10.1016/S0272-6386(04)00934-5
– volume: 15
  start-page: 91
  issue: 1
  year: 2014
  ident: 30902_CR9
  publication-title: BMC Nephrol.
  doi: 10.1186/1471-2369-15-91
– ident: 30902_CR1
  doi: 10.1038/ki.1997.260
– volume: 33
  start-page: 193
  issue: 2
  year: 2018
  ident: 30902_CR12
  publication-title: Nephrol Dial Transpl.
  doi: 10.1093/ndt/gfx341
– volume: 53
  start-page: 2399
  issue: 11
  year: 2021
  ident: 30902_CR46
  publication-title: Int. Urol. Nephrol.
  doi: 10.1007/s11255-021-02902-x
– volume: 30
  start-page: 1418
  issue: 9
  year: 2015
  ident: 30902_CR24
  publication-title: Nephrol. Dial. Transpl.
  doi: 10.1093/ndt/gfu325
– volume: 29
  start-page: 1500
  issue: 8
  year: 2014
  ident: 30902_CR15
  publication-title: Nephrol Dial Transpl.
  doi: 10.1093/ndt/gft388
– volume: 33
  start-page: 231
  issue: 2
  year: 2018
  ident: 30902_CR14
  publication-title: Nephrol. Dial Transpl.
  doi: 10.1093/ndt/gfx297
– volume: 12
  start-page: e0170393
  issue: 1
  year: 2017
  ident: 30902_CR41
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0170393
– volume: 5
  start-page: 1196
  issue: 8
  year: 2020
  ident: 30902_CR42
  publication-title: Kidney Int. Rep.
  doi: 10.1016/j.ekir.2020.05.021
– volume: 35
  start-page: 153
  issue: 3
  year: 2012
  ident: 30902_CR11
  publication-title: Kidney Blood Press Res.
  doi: 10.1159/000331453
SSID ssj0000529419
Score 2.4233263
Snippet We investigated the shape of the relationship between longitudinal uric acid (UA) and the hazard of kidney failure and death in chronic kidney disease (CKD)...
Abstract We investigated the shape of the relationship between longitudinal uric acid (UA) and the hazard of kidney failure and death in chronic kidney disease...
SourceID doaj
pubmedcentral
hal
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3952
SubjectTerms 692/4022
692/499
692/53
Aged
Death
Female
Health hazards
Human health and pathology
Humanities and Social Sciences
Humans
Kidney diseases
Kidney Failure, Chronic
Kidneys
Life Sciences
Male
Mortality
multidisciplinary
Proportional Hazards Models
Renal failure
Renal Insufficiency, Chronic - complications
Risk Factors
Science
Science (multidisciplinary)
Uric Acid
SummonAdditionalLinks – databaseName: Science Database (ProQuest)
  dbid: M2P
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaggMSF9yNQkEHcIGoSx4l9QgVR9VCqHkDqzfKTjSjZstmt1H_PjPNYhYpeOCYZb-ydGfuzZ_INIe-CZo47HtIsZCItK65TY7GGhuN16XPuy8zFYhP18bE4PZUnw4FbN6RVjnNinKjd0uIZ-V5RC47035n4eP47xapRGF0dSmjcJLcA2eSY0vW1OJnOWDCKVeZy-FYmY2Kvg_UKvykrWMowIzGtZ-tRpO2HVWaBSZFXEefVxMm_oqdxUTq4_7_DeUDuDXCU7vf285Dc8O0jcqcvUHn5mJwdLbGe0cZh7SyKBERU28bRhe5o25Ns6BXVWxVTPNelPxvX-ksadINJ71S3jv6KMB8gP21aantG3lFuCBI9Id8Pvnz7fJgO9RlSC4pcp8bVWuu6FkZzy1zlsgouc1sWQQqpOWDRLOiy0gy2YcHzyjAHPi8DD9LBRMKekh3oq39OqJG59ABlAG-UpfWFqTxzVvu8MKGApgnJRy0pO5CXYw2NMxWD6EyoXrMKNKuiZlWdkPdTm_OeuuNa6U-o_EkSabfjjeXqhxq8WNVMwJBtKRwozwsO6Mp5rQ0AoWAyaxLyFkxn9huH-0cK78FkyZD88SJPyO5oEmqYMDq1tYeEvJkeg6tj_Ea3frmJMlUmYcsLMs96Q5xexSohSy6qhNQzE531Zf6kbRaRThy2CKJi0PLDaMzbbv37_3px_ShekrsFehlm68ldsrNebfwrctterJtu9Tq66R_PIUUv
  priority: 102
  providerName: ProQuest
Title Longitudinal uric acid has nonlinear association with kidney failure and mortality in chronic kidney disease
URI https://link.springer.com/article/10.1038/s41598-023-30902-7
https://www.ncbi.nlm.nih.gov/pubmed/36894586
https://www.proquest.com/docview/2785045208
https://www.proquest.com/docview/2786092618
https://u-picardie.hal.science/hal-04032437
https://pubmed.ncbi.nlm.nih.gov/PMC9998636
https://doaj.org/article/7387aac48d504e85822deaab022fb0cb
Volume 13
WOSCitedRecordID wos000955919300072&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: DOA
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: M~E
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: M7P
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: 7X7
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: BENPR
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: PIMPY
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Science Database
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: M2P
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/sciencejournals
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagBYkL4k2grAziBlGd2I7tY4taFaldrRBIy8ly_NBGLWm1j0r99x072W1DBVy4WEo8Tqx5eMbx5BuEPgZDHXc85CQQmbOKm7y2sYaG44L5gntGXCo2IcZjOZ2qya1SXzEnrIMH7hi3K6gUxlgmHSfMSw4OzXljavA9oSa2jqsvEerWZqpD9S4VK1T_lwyhcncBnir-TVbSnMZcxFwMPFEC7Af_MovpkHdjzbspk7-dmyZ3dPgEPe7jSLzXzf8puufbZ-hhV1ny6jk6Oz6PhYhWLha9whE5CBvbODwzC9x26Bhmjs2NbHD8IItPG9f6KxxME7PVsWkd_pXic4jVcdNi20Hprun6050X6MfhwfcvR3lfWCG3IIFlXjtgqRFC1oZb6ipHKrgsLCuDkspwCCJJMKwyFPZPwfOqpg6MVQUelIMVgL5EWzBX_xrhWhXKQwwCgQJj1pd15amzxhdlHUoYmqFizWRte9TxWPziTKfTbyp1JxgNgtFJMFpk6NNmzEWHufFX6v0ouw1lxMtON0CLdK9F-l9alKEPIPnBM472jnW8B6scjaiNl0WGdtaKoXtLX-hSSB5h6YnM0PtNN9hoPHgxrT9fJZqKKNirAs2rTo82r6KVVIzLKkNioGGDuQx72maWcMAhtpcVhZGf17p4M60_8-vN_-DXW_SojKYUk_HUDtpazlf-HXpgL5fNYj5C98VUpFaO0Pb-wXjybZTsE9qTchJbAe325OvJ5Oc1bVc-4Q
linkProvider Directory of Open Access Journals
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELZKAcGF9yNQwCA4QdQkjhPngFB5VFt1WfVQpN6M4wcbUbJls1u0f4rfyIyT7Gqp6K0HjpuMEzv7zcszniHkpVPMcMNdGLlIhGnGVVhq7KFheJ7amNs0Mr7ZRD4aiaOj4mCD_O7PwmBaZS8TvaA2E4175NtJLjiW_47Eu5OfIXaNwuhq30KjhcW-XfwCl615u_cR_t9XSbL76fDDIOy6CoQaXj8LS5MrpfJclIprZjITZfAz1mniClEoDhZU5FSaKQbOg7M8K5kBpBaOu8IA_Bk89xK5nGJlMUwVTA6WezoYNUvjojubEzGx3YB-xDNsCQsZZkCG-Zr-820CQKuNMQnzrIV7NlHzr2itV4K7N_-3z3eL3OjMbbrT8sdtsmHrO-Rq24BzcZccDyfYr2lusDcYxQJLVOnK0LFqaN0WEVFTqlYQprhvTb9XprYL6lSFSf1U1Yb-8G4MuDS0qqluKw73dF0Q7B75ciFLvU82Ya72IaFlERcWTDWwp9JU26TMLDNa2TgpXQJDAxL3qJC6K86OPUKOpU8SYEK2SJKAJOmRJPOAvF6OOWlLk5xL_R7BtqTEsuL-wmT6TXZSSuZMwJJ1KgyAxQoO1qOxSpVg6Lky0mVAXgBU154x2BlKvAbKgGFxy9M4IFs9BGUnEBu5wl9Ani9vgyjD-JSq7WTuabKoAJceaB60wF--imWiSLnIApKvscTaXNbv1NXYl0sHF0hkDEa-6ZlnNa1_f69H56_iGbk2OPw8lMO90f5jcj1BDsfMxGKLbM6mc_uEXNGns6qZPvUigpKvF81UfwDGrqJZ
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VFCouvB-GAguCE1ixvV57fUCoUKJGDVEOIJXTst5HY1GckkdR_hq_jlk_EoWK3nrgGHvW2bW_ee3MzgC8tJJqppn1AxtwP06Y9HPlemholsYmZCYOdNVsIh0O-dFRNtqC3-1ZGJdW2crESlDriXJ75N0o5cyV_w541zZpEaP93rvTn77rIOUirW07jRoih2b5C9232dv-Pn7rV1HU-_j5w4HfdBjwFU5l7uc6lVKmKc8lU1QnOkjwZ6jiyGY8kwytqcDKOJEUHQlrWJJTjajNLLOZRlag-NwrsI0meRx1YHvU_zT6utrhcTG0OMyakzoB5d0Zakt3oi2iPnX5kH66oQ2rpgGo48YuJfO8vXs-bfOv2G2lEns3_-eXeQtuNIY42as55zZsmfIOXKtbcy7vwslg4jo5LbTrGkZc6SUiVaHJWM5IWZcXkVMi1-AmbkebfC90aZbEysKl-xNZavKjcnDQ2SFFSVRdi7ila8Jj9-DLpSz1PnRwruYhkDwLM4NGHFpacaxMlCeGaiVNGOU2wqEehC1ChGrKtrvuISeiSh-gXNSoEogqUaFKpB68Xo05rYuWXEj93gFvRekKjlcXJtNj0cgvkVKOS1Yx1wgcwxnaldpImaMJaPNA5R68QNhuPONgbyDcNVQT1JW9PAs92G3hKBpRORNrLHrwfHUbhZyLXMnSTBYVTRJk6OwjzYOaCVZ_RROexYwnHqQb7LExl807ZTGuCqmjc8QTiiPftIy0nta_39eji1fxDHaQl8SgPzx8DNcjx-wuZTHbhc58ujBP4Ko6mxez6dNGXhD4dtlc9QeGsayi
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Longitudinal+uric+acid+has+nonlinear+association+with+kidney+failure+and+mortality+in+chronic+kidney+disease&rft.jtitle=Scientific+reports&rft.au=Prezelin-Reydit%2C+Mathilde&rft.au=Combe%2C+Christian&rft.au=Fouque%2C+Denis&rft.au=Frimat%2C+Luc&rft.date=2023-03-09&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=13&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-023-30902-7&rft.externalDocID=10_1038_s41598_023_30902_7
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon