Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation

The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock. In the present manuscript, we provide a comprehensive review of the pathophy...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 22; no. 1; pp. 283 - 7
Main Authors:	Moskowitz, Ari, Andersen, Lars W., Huang, David T., Berg, Katherine M., Grossestreuer, Anne V., Marik, Paul E., Sherwin, Robert L., Hou, Peter C., Becker, Lance B., Cocchi, Michael N., Doshi, Pratik, Gong, Jonathan, Sen, Ayan, Donnino, Michael W.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 29.10.2018 BMC
Subjects:	Adrenal Cortex Hormones - pharmacology Adrenal Cortex Hormones - therapeutic use Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Ascorbic acid Ascorbic Acid - pharmacology Ascorbic Acid - therapeutic use Corticosteroids Critical Care Medicine Drug Therapy, Combination - methods Drug Therapy, Combination - standards Emergency Medicine Humans Hydrocortisone - pharmacology Hydrocortisone - therapeutic use Intensive Medicine Medicine & Public Health Metabolic resuscitation Models, Biological Review Sepsis Sepsis - drug therapy Thiamine Thiamine - pharmacology Thiamine - therapeutic use Sepsis Ascorbic acid Corticosteroids Thiamine Metabolic resuscitation
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X
Online Access:	Get full text
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