Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment

Glucocorticoids (GCs) are metabolic hormones with immunosuppressive effects that have proven effective drugs against childhood acute lymphoblastic leukemia (ALL). Yet, the role of metabolic reprogramming in GC-induced ALL cell death is poorly understood. GCs efficiently block glucose uptake and meta...

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Veröffentlicht in:	Cell death & disease Jg. 9; H. 9; S. 846 - 13
Hauptverfasser:	Dyczynski, Matheus, Vesterlund, Mattias, Björklund, Ann-Charlotte, Zachariadis, Vasilios, Janssen, Jerry, Gallart-Ayala, Hector, Daskalaki, Evangelia, Wheelock, Craig E., Lehtiö, Janne, Grandér, Dan, Tamm, Katja Pokrovskaja, Nilsson, Roland
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 28.08.2018 Springer Nature B.V
Schlagworte:	13/2 38/1 82/58 Acute lymphoblastic leukemia Ammonia Antibodies Apoptosis Autophagy Bases (nucleic acids) Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell death Children Glucocorticoids Glucose metabolism Glutamine Glycolysis Immunology Immunosuppressive agents Ketoglutaric acid Lecithin Leukemia Life Sciences Lymphatic leukemia Metabolism Metabolomics Phagocytosis Phosphatidylcholine Proteomics Tricarboxylic acid cycle
ISSN:	2041-4889, 2041-4889
Online-Zugang:	Volltext
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