Comprehensive metabolomics expands precision medicine for triple-negative breast cancer

Metabolic reprogramming is a hallmark of cancer. However, systematic characterizations of metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the polar metabolome and lipidome in 330 TNBC samples and 149 paired normal breast tissues to construct a large metabolo...

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Veröffentlicht in:	Cell research Jg. 32; H. 5; S. 477 - 490
Hauptverfasser:	Xiao, Yi, Ma, Ding, Yang, Yun-Song, Yang, Fan, Ding, Jia-Han, Gong, Yue, Jiang, Lin, Ge, Li-Ping, Wu, Song-Yang, Yu, Qiang, Zhang, Qing, Bertucci, François, Sun, Qiuzhuang, Hu, Xin, Li, Da-Qiang, Shao, Zhi-Ming, Jiang, Yi-Zhou
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Singapore Springer Nature Singapore 01.05.2022 Nature Publishing Group
Schlagworte:	631/67/1347 631/67/2327 Androgen receptors Biomarkers, Tumor - genetics Biomedical and Life Sciences Breast cancer Cancer Cell Biology Ceramide Datasets Fatty acids Genomics Humans Life Sciences Machine learning Metabolism Metabolites Metabolomics Organoids Oxidation Precision Medicine Sphingosine 1-phosphate Subgroups Therapeutic applications Therapeutic targets Transcriptome Transcriptomics Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Tumors Xenografts Xenotransplantation
ISSN:	1748-7838, 1001-0602, 1748-7838
Online-Zugang:	Volltext
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