SELENBP1 overexpression in the prefrontal cortex underlies negative symptoms of schizophrenia

The selenium-binding protein 1 (SELENBP1) has been reported to be up-regulated in the prefrontal cortex (PFC) of schizophrenia patients in postmortem reports. However, no causative link between SELENBP1 and schizophrenia has yet been established. Here, we provide evidence linking the upregulation of...

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Vydáno v:Proceedings of the National Academy of Sciences - PNAS Ročník 119; číslo 51; s. e2203711119
Hlavní autoři: Kim, Soojin, Kim, Seong-Wook, Bui, Mai Anh Thi, Kim, Yeji, Kim, Minsoo, Park, Jung-Cheol, Kim, Nam-Heon, Pyeon, Gyeong Hee, Jo, Yong Sang, Jang, Jaewon, Koh, Hae-Young, Jeong, Chae-Hong, Kang, Moonkyung, Kang, Hyo Jung, Lee, Yong-Woo, Stockmeier, Craig A, Seong, Je Kyung, Woo, Dong Ho, Han, Jung-Soo, Kim, Yeon-Soo
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 20.12.2022
Témata:
Animals
Brain - metabolism
Humans
Mice
Mice, Transgenic
Prefrontal Cortex - metabolism
Pyramidal Cells - metabolism
Schizophrenia - genetics
Schizophrenia - metabolism
Selenium-Binding Proteins - genetics
Selenium-Binding Proteins - metabolism
SELENBP1
frontal cortex
schizophrenia
Brodmann area 9
social behavior
ISSN:1091-6490, 1091-6490
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Shrnutí:The selenium-binding protein 1 (SELENBP1) has been reported to be up-regulated in the prefrontal cortex (PFC) of schizophrenia patients in postmortem reports. However, no causative link between SELENBP1 and schizophrenia has yet been established. Here, we provide evidence linking the upregulation of SELENBP1 in the PFC of mice with the negative symptoms of schizophrenia. We verified the levels of transcripts in postmortem PFC brain tissues from patients with schizophrenia and matched healthy controls. We also generated transgenic mice expressing human SELENBP1 (hSELENBP1 Tg) and examined their neuropathological features, intrinsic firing properties of PFC 2/3-layer pyramidal neurons, and frontal cortex (FC) electroencephalographic (EEG) responses to auditory stimuli. Schizophrenia-like behaviors in hSELENBP1 Tg mice and mice expressing in the FC were assessed. transcript levels were higher in the brains of patients with schizophrenia than in those of matched healthy controls. The hSELENBP1 Tg mice displayed negative endophenotype behaviors, including heterotopias- and ectopias-like anatomical deformities in upper-layer cortical neurons and social withdrawal, deficits in nesting, and anhedonia-like behavior. Additionally, hSELENBP1 Tg mice exhibited reduced excitabilities of PFC 2/3-layer pyramidal neurons and abnormalities in EEG biomarkers observed in schizophrenia. Furthermore, mice overexpressing in FC showed deficits in sociability. These results suggest that upregulation of SELENBP1 in the PFC causes asociality, a negative symptom of schizophrenia.
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ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.2203711119