Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling

Adaptor protein 2 (AP2) is a major constituent of clathrin-coated pits (CCPs). Whether it is essential for all forms of clathrin-mediated endocytosis (CME) in mammalian cells is an open issue. Here, we demonstrate, by live TIRF microscopy, the existence of a subclass of relatively short-lived CCPs l...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 27; no. 10; pp. 3049 - 3061.e6
Main Authors:	Pascolutti, Roberta, Algisi, Veronica, Conte, Alexia, Raimondi, Andrea, Pasham, Mithun, Upadhyayula, Srigokul, Gaudin, Raphael, Maritzen, Tanja, Barbieri, Elisa, Caldieri, Giusi, Tordonato, Chiara, Confalonieri, Stefano, Freddi, Stefano, Malabarba, Maria Grazia, Maspero, Elena, Polo, Simona, Tacchetti, Carlo, Haucke, Volker, Kirchhausen, Tom, Di Fiore, Pier Paolo, Sigismund, Sara
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 04.06.2019 Cell Press Elsevier
Subjects:	Adaptor Protein Complex 2 - antagonists & inhibitors Adaptor Protein Complex 2 - genetics Adaptor Protein Complex 2 - metabolism Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Vesicular Transport - antagonists & inhibitors Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Animals Cell Line Cell Movement Clathrin-Coated Vesicles - physiology Endocytosis Epidermal Growth Factor - metabolism ErbB Receptors - metabolism Gene Editing HeLa Cells Humans Life Sciences Mice Microscopy, Fluorescence Proto-Oncogene Proteins c-akt - metabolism RNA Interference RNA, Small Interfering - metabolism Signal Transduction Transcriptional Activation AP2 signaling transcription clathrin-coated pits receptor degradation endocytosis recycling EGFR epsin endocytic adaptors eps15
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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