Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling

Guanine-rich DNA sequences occur throughout the human genome and can transiently form G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic instability. Here, we apply multi-color single-molecule localization microscopy (SMLM) coupled with robust data-mining algorithms t...

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Vydáno v:	Nature communications Ročník 12; číslo 1; s. 2525 - 14
Hlavní autoři:	Lee, Wei Ting C., Yin, Yandong, Morten, Michael J., Tonzi, Peter, Gwo, Pam Pam, Odermatt, Diana C., Modesti, Mauro, Cantor, Sharon B., Gari, Kerstin, Huang, Tony T., Rothenberg, Eli
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 05.05.2021 Nature Publishing Group Nature Portfolio
Témata:	13/106 13/89 14/1 14/34 14/63 631/337/151/2353 631/337/2265 631/80/2373/2238 96/33 Algorithms Animals Biophysics Cell Line Coupling (molecular) Damage accumulation Data mining Deoxyribonucleic acid DNA DNA - chemistry DNA biosynthesis DNA Damage DNA helicase DNA Helicases - metabolism DNA Replication - physiology DNA-binding protein DNA-Binding Proteins G-Quadruplexes Gene sequencing Genomes Genomic Instability Guanine Humanities and Social Sciences Humans Life Sciences Localization multidisciplinary Nucleotide sequence Recombinant Proteins Replication Replication forks Science Science (multidisciplinary) Sf9 Cells Signaling Single Molecule Imaging - methods Synthesis Super-resolution microscopy Replisome Single-molecule biophysics
ISSN:	2041-1723, 2041-1723
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