Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis

Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized that S. aureus clearance during the first hours of infection was impaired in CF human Airway Surface Liquid (ASL) because...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; p. 6516
Main Authors:	Simonin, Juliette, Bille, Emmanuelle, Crambert, Gilles, Noel, Sabrina, Dreano, Elise, Edwards, Aurélie, Hatton, Aurélie, Pranke, Iwona, Villeret, Bérengère, Cottart, Charles-Henry, Vrel, Jean-Patrick, Urbach, Valérie, Baatallah, Nesrine, Hinzpeter, Alexandre, Golec, Anita, Touqui, Lhousseine, Nassif, Xavier, Galietta, Luis J. V, Planelles, Gabrielle, Sallenave, Jean-Michel, Edelman, Aleksander, Sermet-Gaudelus, Isabelle
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24.04.2019 Nature Publishing Group
Subjects:	13 13/106 631/326 631/80 Acidification Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Bicarbonates Bicarbonates - chemistry Bicarbonates - metabolism Bronchi - cytology Cell Line Cell lines Cells, Cultured Child Child, Preschool Cystic fibrosis Cystic Fibrosis - genetics Cystic Fibrosis - metabolism Cystic Fibrosis - microbiology Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Defects Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - microbiology H(+)-K(+)-Exchanging ATPase - metabolism Human health and pathology Humanities and Social Sciences Humans Hydrogen-Ion Concentration Immunology Infant Infant, Newborn Infections Life Sciences Morbidity multidisciplinary Neonates Ouabain Peptides pH effects Pulmonology and respiratory tract Respiratory Mucosa - chemistry Respiratory Mucosa - metabolism Respiratory Mucosa - microbiology Respiratory tract Science Science (multidisciplinary) Secretion Staphylococcal Infections - metabolism Staphylococcal Infections - microbiology Staphylococcal Infections - prevention & control Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Sulfate Transporters - metabolism
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!