Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities

Aortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections, as well as for other cardiovascular and cerebrovascular diseases. We present genome-wide associations of ascending and descending aortic distensibility and area derived from cardiac magnetic resonance ima...

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Vydáno v:	Nature communications Ročník 13; číslo 1; s. 4505 - 18
Hlavní autoři:	Francis, Catherine M., Futschik, Matthias E., Huang, Jian, Bai, Wenjia, Sargurupremraj, Muralidharan, Teumer, Alexander, Breteler, Monique M. B., Petretto, Enrico, Ho, Amanda S. R., Amouyel, Philippe, Engelter, Stefan T., Bülow, Robin, Völker, Uwe, Völzke, Henry, Dörr, Marcus, Imtiaz, Mohammed-Aslam, Aziz, N. Ahmad, Lohner, Valerie, Ware, James S., Debette, Stephanie, Elliott, Paul, Dehghan, Abbas, Matthews, Paul M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 03.08.2022 Nature Publishing Group Nature Portfolio
Témata:	45/43 59/57 631/208/205/2138 631/208/480 631/443/1338/1287 692/4019/592/2727 692/617/375/1370 Aorta Aorta - diagnostic imaging Aortic Aneurysm - diagnostic imaging Aortic Aneurysm - genetics Aortic aneurysms Blood vessels Brain Cardiology and cardiovascular system Cardiovascular diseases Cerebrovascular diseases Etiology Extracellular matrix Female Genetic diversity Genetic variance Genetics Genome-Wide Association Study Genomes Human genetics Human health and pathology Humanities and Social Sciences Humans Insulin-like growth factors Life Sciences Magnetic resonance imaging Male multidisciplinary Muscle contraction Muscles Neuroimaging Neurons and Cognition Phenomics Platelet-derived growth factor Risk analysis Risk factors Science Science (multidisciplinary) Signal transduction Smooth muscle Substantia alba Vascular diseases Vascular endothelial growth factor White Matter - diagnostic imaging
ISSN:	2041-1723, 2041-1723
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