Limited sampling strategies for therapeutic drug monitoring of amikacin and kanamycin in patients with multidrug-resistant tuberculosis

•Amikacin and kanamycin are both used in the treatment of multidrug-resistant tuberculosis.•One combined model was designed based on the pooled data of all 30 plasma concentration curves.•An optimal sampling strategy was developed based on this combined model.•Sampling at 1h and 4h after drug admini...

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Bibliographic Details
Published in:	International journal of antimicrobial agents Vol. 46; no. 3; pp. 332 - 337
Main Authors:	Dijkstra, J.A., van Altena, R., Akkerman, O.W., de Lange, W.C.M., Proost, J.H., van der Werf, T.S., Kosterink, J.G.W., Alffenaar, J.W.C.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.09.2015
Subjects:	Adult Amikacin Amikacin - pharmacokinetics Amikacin - therapeutic use Antitubercular Agents - pharmacokinetics Antitubercular Agents - therapeutic use Biostatistics Drug Monitoring - methods drugs Female Humans Infectious Disease Kanamycin Kanamycin - pharmacokinetics Kanamycin - therapeutic use Limited sampling Male Models, Statistical monitoring multiple drug resistance patients Pharmacokinetic model Pharmacokinetics prediction Retrospective Studies Specimen Handling - methods therapeutics toxicity Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Young Adult Kanamycin Pharmacokinetic model Tuberculosis Amikacin Pharmacokinetics Limited sampling
ISSN:	0924-8579, 1872-7913, 1872-7913
Online Access:	Get full text
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