Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

U4/U6.U5 tri-snRNP represents a substantial part of the spliceosome before activation. A cryo-electron microscopy structure of Saccharomyces cerevisiae U4/U6.U5 tri-snRNP at 3.7 Å resolution led to an essentially complete atomic model comprising 30 proteins plus U4/U6 and U5 small nuclear RNAs (snRN...

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Bibliographic Details
Published in:	Nature (London) Vol. 530; no. 7590; pp. 298 - 302
Main Authors:	Nguyen, Thi Hoang Duong, Galej, Wojciech P., Bai, Xiao-chen, Oubridge, Chris, Newman, Andrew J., Scheres, Sjors H. W., Nagai, Kiyoshi
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.02.2016 Nature Publishing Group
Subjects:	631/337/1645/1792 631/45/500 631/535/1258/1259 Base Pairing Catalytic Domain Cryoelectron Microscopy DNA Helicases - metabolism Exons - genetics Guanosine Triphosphate - metabolism Histidine Humanities and Social Sciences Hydrogen Bonding Influence Messenger RNA Microscopy Models, Molecular Molecular structure multidisciplinary Nucleic Acid Conformation Physiological aspects Polypeptides Proteins Ribonucleic acid Ribonucleoprotein, U4-U6 Small Nuclear - chemistry Ribonucleoprotein, U4-U6 Small Nuclear - metabolism Ribonucleoprotein, U5 Small Nuclear - chemistry Ribonucleoprotein, U5 Small Nuclear - metabolism Ribonucleoproteins, Small Nuclear - chemistry Ribonucleoproteins, Small Nuclear - genetics Ribonucleoproteins, Small Nuclear - metabolism Ribonucleoproteins, Small Nuclear - ultrastructure RNA RNA Splice Sites RNA, Small Nuclear - chemistry RNA, Small Nuclear - genetics RNA, Small Nuclear - metabolism Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - ultrastructure Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Saccharomyces cerevisiae Proteins - ultrastructure Science Spliceosomes - metabolism Yeast Yeast fungi Yeasts
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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