A genomic view of mosaicism and human disease

Key Points Mosaicism refers to the presence of genetically distinct cells within an organism that result from postzygotic mutational events. There are several different types of mosaicism at the organismal level that are categorized by the tissue distribution of the variant cells, including germline...

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Veröffentlicht in:	Nature reviews. Genetics Jg. 14; H. 5; S. 307 - 320
Hauptverfasser:	Biesecker, Leslie G., Spinner, Nancy B.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.05.2013 Nature Publishing Group
Schlagworte:	Agriculture Animal Genetics and Genomics Biomedicine Cancer Research Chromosome Deletion Cytogenetics - methods DNA Copy Number Variations Gene Function Gene mutations Genetic aspects Genome, Human Genomics - methods Health aspects Human Genetics Humans Mosaicism Mutation Oligonucleotide Array Sequence Analysis - methods Polymorphism, Single Nucleotide review-article Risk factors Sequence Analysis, DNA United States
ISSN:	1471-0056, 1471-0064, 1471-0064
Online-Zugang:	Volltext
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