MHCquant2 refines immunopeptidomics tumor antigen discovery

Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. This integr...

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Bibliographic Details
Published in:	Genome Biology Vol. 26; no. 1; pp. 290 - 17
Main Authors:	Scheid, Jonas, Lemke, Steffen, Hoenisch-Gravel, Naomi, Dengler, Anna, Sachsenberg, Timo, Declerq, Arthur, Gabriels, Ralf, Bauer, Jens, Wacker, Marcel, Bichmann, Leon, Martens, Lennart, Dubbelaar, Marissa L., Nahnsen, Sven, Walz, Juliane S.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 22.09.2025 Springer Nature B.V BMC
Subjects:	Animal Genetics and Genomics Antigens Antigens, Neoplasm - immunology Bioinformatics Biomedical and Life Sciences Cancer Cancer immunotherapy Data processing Datasets Evolutionary Biology High performance computing Histocompatibility antigen HLA HLA HLA Antigens - immunology Human Genetics Humans Identification Immunopeptidomics Immunotherapy Life Sciences Mass spectrometry Microbial Genetics and Genomics Neoplasms - immunology Nextflow Nf-core Peptides Peptides - immunology Pipeline Plant Genetics and Genomics Proteomics - methods Search engines Software Open-source Immunopeptidomics Immunotherapy Nextflow Nf-core HLA Mass spectrometry Pipeline
ISSN:	1474-760X, 1474-7596, 1474-760X
Online Access:	Get full text
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