MHCquant2 refines immunopeptidomics tumor antigen discovery

Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. This integr...

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Vydané v:Genome Biology Ročník 26; číslo 1; s. 290 - 17
Hlavní autori: Scheid, Jonas, Lemke, Steffen, Hoenisch-Gravel, Naomi, Dengler, Anna, Sachsenberg, Timo, Declerq, Arthur, Gabriels, Ralf, Bauer, Jens, Wacker, Marcel, Bichmann, Leon, Martens, Lennart, Dubbelaar, Marissa L., Nahnsen, Sven, Walz, Juliane S.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 22.09.2025
Springer Nature B.V
BMC
Predmet:
Animal Genetics and Genomics
Antigens
Antigens, Neoplasm - immunology
Bioinformatics
Biomedical and Life Sciences
Cancer
Cancer immunotherapy
Data processing
Datasets
Evolutionary Biology
High performance computing
Histocompatibility antigen HLA
HLA
HLA Antigens - immunology
Human Genetics
Humans
Identification
Immunopeptidomics
Immunotherapy
Life Sciences
Mass spectrometry
Microbial Genetics and Genomics
Neoplasms - immunology
Nextflow
Nf-core
Peptides
Peptides - immunology
Pipeline
Plant Genetics and Genomics
Proteomics - methods
Search engines
Software
Open-source
Immunopeptidomics
Immunotherapy
Nextflow
Nf-core
HLA
Mass spectrometry
Pipeline
ISSN:1474-760X, 1474-7596, 1474-760X
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Abstract Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. This integration allows a community-driven, robust solution for high-throughput analyses across operating systems and cloud infrastructures. MHCquant2 integrates open-source tools including OpenMS, DeepLC, and MS 2 PIP, improving peptide identifications by up to 27% across diverse MS platforms, particularly enriching low-abundant peptides. MHCquant2 demonstrates state-of-the-art performance on our novel benign MHCquant2 dataset ( n  = 92) and expands the benign human immunopeptidome by over 160,000 unique naturally presented HLA peptides.
AbstractList Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. This integration allows a community-driven, robust solution for high-throughput analyses across operating systems and cloud infrastructures. MHCquant2 integrates open-source tools including OpenMS, DeepLC, and MS PIP, improving peptide identifications by up to 27% across diverse MS platforms, particularly enriching low-abundant peptides. MHCquant2 demonstrates state-of-the-art performance on our novel benign dataset (n = 92) and expands the benign human immunopeptidome by over 160,000 unique naturally presented HLA peptides.
Abstract Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. This integration allows a community-driven, robust solution for high-throughput analyses across operating systems and cloud infrastructures. MHCquant2 integrates open-source tools including OpenMS, DeepLC, and MS2PIP, improving peptide identifications by up to 27% across diverse MS platforms, particularly enriching low-abundant peptides. MHCquant2 demonstrates state-of-the-art performance on our novel benignMHCquant2 dataset (n = 92) and expands the benign human immunopeptidome by over 160,000 unique naturally presented HLA peptides.
Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. This integration allows a community-driven, robust solution for high-throughput analyses across operating systems and cloud infrastructures. MHCquant2 integrates open-source tools including OpenMS, DeepLC, and MS 2 PIP, improving peptide identifications by up to 27% across diverse MS platforms, particularly enriching low-abundant peptides. MHCquant2 demonstrates state-of-the-art performance on our novel benign MHCquant2 dataset ( n  = 92) and expands the benign human immunopeptidome by over 160,000 unique naturally presented HLA peptides.
Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. This integration allows a community-driven, robust solution for high-throughput analyses across operating systems and cloud infrastructures. MHCquant2 integrates open-source tools including OpenMS, DeepLC, and MS2PIP, improving peptide identifications by up to 27% across diverse MS platforms, particularly enriching low-abundant peptides. MHCquant2 demonstrates state-of-the-art performance on our novel benignMHCquant2 dataset (n = 92) and expands the benign human immunopeptidome by over 160,000 unique naturally presented HLA peptides.Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. This integration allows a community-driven, robust solution for high-throughput analyses across operating systems and cloud infrastructures. MHCquant2 integrates open-source tools including OpenMS, DeepLC, and MS2PIP, improving peptide identifications by up to 27% across diverse MS platforms, particularly enriching low-abundant peptides. MHCquant2 demonstrates state-of-the-art performance on our novel benignMHCquant2 dataset (n = 92) and expands the benign human immunopeptidome by over 160,000 unique naturally presented HLA peptides.
Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. This integration allows a community-driven, robust solution for high-throughput analyses across operating systems and cloud infrastructures. MHCquant2 integrates open-source tools including OpenMS, DeepLC, and MS 2 PIP, improving peptide identifications by up to 27% across diverse MS platforms, particularly enriching low-abundant peptides. MHCquant2 demonstrates state-of-the-art performance on our novel benign MHCquant2 dataset ( n = 92) and expands the benign human immunopeptidome by over 160,000 unique naturally presented HLA peptides.
Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. This integration allows a community-driven, robust solution for high-throughput analyses across operating systems and cloud infrastructures. MHCquant2 integrates open-source tools including OpenMS, DeepLC, and MS2PIP, improving peptide identifications by up to 27% across diverse MS platforms, particularly enriching low-abundant peptides. MHCquant2 demonstrates state-of-the-art performance on our novel benignMHCquant2 dataset (n = 92) and expands the benign human immunopeptidome by over 160,000 unique naturally presented HLA peptides.
ArticleNumber 290
Author Gabriels, Ralf
Bichmann, Leon
Hoenisch-Gravel, Naomi
Sachsenberg, Timo
Dubbelaar, Marissa L.
Walz, Juliane S.
Wacker, Marcel
Scheid, Jonas
Lemke, Steffen
Nahnsen, Sven
Martens, Lennart
Dengler, Anna
Declerq, Arthur
Bauer, Jens
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Cites_doi 10.1093/nar/gkaa379
10.1007/s13361-016-1460-7
10.1021/acs.jproteome.4c00609
10.1093/nar/gkad335
10.1038/s41467-021-23713-9
10.1093/bioinformatics/btp163
10.1126/science.271.5256.1734
10.1002/mas.21376
10.21203/rs.3.rs-5560023/v1
10.1038/s41587-024-02420-y
10.1038/s41467-023-42692-7
10.1158/2643-3230.BCD-23-0020
10.1016/j.mcpro.2021.100138
10.1002/pmic.201900362
10.1093/nar/gkab1038
10.1016/j.mcpro.2022.100266
10.1002/pmic.201700464
10.1038/s41467-023-42543-5
10.1074/mcp.R120.002309
10.1093/nar/gkac776
10.1038/ncomms10238
10.1038/s41467-024-46380-y
10.5281/zenodo.822502
10.1038/s41467-024-48322-0
10.1038/s41587-020-0439-x
10.1016/0092-8674(78)90296-9
10.1038/s41467-024-49731-x
10.1021/acs.analchem.0c00233
10.1056/NEJMoa1509388
10.3389/fimmu.2021.705974
10.1158/2326-6066.CIR-19-0886
10.1016/j.mcpro.2024.100798
10.1021/acs.jproteome.7b00248
10.3389/fimmu.2022.883989
10.1136/jitc-2020-002071
10.1111/j.1365-2141.1982.tb03910.x
10.1038/s41592-021-01301-5
10.1016/j.mcpro.2021.100110
10.1021/acs.jproteome.9b00328
10.1136/jitc-2024-011366
10.1038/s41467-022-30867-7
10.1111/imm.12936
10.1073/pnas.1707658114
10.1016/j.mcpro.2021.100178
10.1084/jem.193.1.73
10.1186/1471-2105-7-153
10.1038/ncomms13404
10.1038/s41467-022-33746-3
10.1038/s41591-022-02163-w
10.1021/acs.jproteome.9b00313
10.1038/s41467-023-40129-9
10.5281/zenodo.15194162
10.1126/science.aaf1490
10.1056/NEJMoa1103849
10.1038/nmeth.4256
10.1038/s41586-018-0810-y
10.1093/nar/gkad1068
10.1016/0198-8859(85)90333-7
10.1038/s41587-021-01038-8
10.1038/nbt.3820
10.1038/s41592-024-02197-7
10.1074/mcp.R110.000133
10.1038/s41596-019-0133-y
10.1002/j.1460-2075.1992.tb05481.x
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Keywords Open-source
Immunopeptidomics
Immunotherapy
Nextflow
Nf-core
HLA
Mass spectrometry
Pipeline
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References AW Purcell (3763_CR6) 2019; 14
G Pawelec (3763_CR55) 1985; 12
A Marcu (3763_CR35) 2021; 9
H-H Bui (3763_CR67) 2006; 7
DR Leach (3763_CR3) 1996; 271
M Bassani-Sternberg (3763_CR8) 2016; 7
3763_CR38
N McGranahan (3763_CR48) 2016; 351
R Bouwmeester (3763_CR42) 2020; 92
N Niknafs (3763_CR50) 2023; 29
JP Becker (3763_CR40) 2022; 13
3763_CR71
AT Kong (3763_CR26) 2017; 14
D Gomez-Zepeda (3763_CR19) 2024; 15
C Chong (3763_CR7) 2022; 40
F Erhard (3763_CR13) 2020; 8
P Di Tommaso (3763_CR25) 2017; 35
A Nelde (3763_CR44) 1988
3763_CR72
3763_CR73
JK Eng (3763_CR31) 2020; 20
L Martens (3763_CR34) 2011; 10
M Kalhor (3763_CR41) 2024; 23
A Nelde (3763_CR12) 2021; 12
3763_CR69
F Huber (3763_CR51) 2024
E Van der Marliere (3763_CR45) 2013; 32
PA Ewels (3763_CR30) 2020; 38
Y Ishida (3763_CR4) 1992; 11
J Pfeuffer (3763_CR29) 2024; 21
H Weisser (3763_CR33) 2017; 16
3763_CR65
A Declercq (3763_CR39) 2022; 21
3763_CR68
3763_CR61
3763_CR62
J Bauer (3763_CR9) 2022; 13
3763_CR63
C Barnstable (3763_CR54) 1978; 14
CM Laumont (3763_CR14) 2016; 7
N Hilf (3763_CR1) 2019; 565
M Wilhelm (3763_CR22) 2021; 12
JH Kessler (3763_CR10) 2001; 193
3763_CR58
PJA Cock (3763_CR64) 2009; 25
Y Cai (3763_CR36) 2023; 51
F Meier (3763_CR17) 2021; 20
A Declercq (3763_CR21) 2023; 51
J Fritsche (3763_CR46) 2021; 20
S Lemke (3763_CR53) 2025; 13
KL Yang (3763_CR27) 2023; 14
DL Porter (3763_CR2) 2011; 365
P Faridi (3763_CR15) 2018; 18
N Hoenisch Gravel (3763_CR18) 2023; 14
JM Goldman (3763_CR56) 1982; 52
A Declercq (3763_CR37) 2025; 24
N Hulstaert (3763_CR60) 2020; 19
R Bouwmeester (3763_CR20) 2021; 18
M Yilmaz (3763_CR52) 2024; 15
KA Kovalchik (3763_CR43) 2022; 21
A Nelde (3763_CR70) 2021
A Nelde (3763_CR11) 2023; 4
A Nelde (3763_CR16) 2021; 20
L Bichmann (3763_CR24) 2019; 18
C Adams (3763_CR23) 2024; 15
T Claeys (3763_CR59) 2023; 14
JA Burger (3763_CR5) 2015; 373
Y Perez-Riverol (3763_CR57) 2022; 50
L Xin (3763_CR28) 2022; 13
M The (3763_CR32) 2016; 27
B Reynisson (3763_CR66) 2020; 48
LK Freudenmann (3763_CR49) 2018; 154
X Huang (3763_CR47) 2024; 52
References_xml – volume: 48
  start-page: W449
  year: 2020
  ident: 3763_CR66
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkaa379
– volume: 27
  start-page: 1719
  year: 2016
  ident: 3763_CR32
  publication-title: J Am Soc Mass Spectrom
  doi: 10.1007/s13361-016-1460-7
– volume: 24
  start-page: 1067
  year: 2025
  ident: 3763_CR37
  publication-title: J Proteome Res
  doi: 10.1021/acs.jproteome.4c00609
– volume: 51
  start-page: W338
  year: 2023
  ident: 3763_CR21
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkad335
– volume: 12
  year: 2021
  ident: 3763_CR22
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-23713-9
– volume: 25
  start-page: 1422
  year: 2009
  ident: 3763_CR64
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp163
– volume: 271
  start-page: 1734
  year: 1996
  ident: 3763_CR3
  publication-title: Science
  doi: 10.1126/science.271.5256.1734
– volume: 32
  start-page: 453
  year: 2013
  ident: 3763_CR45
  publication-title: Mass Spectrom Rev
  doi: 10.1002/mas.21376
– ident: 3763_CR61
  doi: 10.21203/rs.3.rs-5560023/v1
– year: 2024
  ident: 3763_CR51
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-024-02420-y
– ident: 3763_CR68
  doi: 10.1038/s41467-023-42692-7
– volume: 4
  start-page: 468
  issue: 6
  year: 2023
  ident: 3763_CR11
  publication-title: Blood Cancer Discov
  doi: 10.1158/2643-3230.BCD-23-0020
– volume: 20
  year: 2021
  ident: 3763_CR17
  publication-title: Mol Cell Proteomics
  doi: 10.1016/j.mcpro.2021.100138
– volume: 20
  start-page: 1900362
  year: 2020
  ident: 3763_CR31
  publication-title: Proteomics
  doi: 10.1002/pmic.201900362
– volume: 50
  start-page: D543
  year: 2022
  ident: 3763_CR57
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkab1038
– volume: 21
  year: 2022
  ident: 3763_CR39
  publication-title: Mol Cell Proteomics
  doi: 10.1016/j.mcpro.2022.100266
– volume: 18
  start-page: 1700464
  year: 2018
  ident: 3763_CR15
  publication-title: Proteomics
  doi: 10.1002/pmic.201700464
– volume: 14
  year: 2023
  ident: 3763_CR59
  publication-title: Nat Commun
  doi: 10.1038/s41467-023-42543-5
– volume: 20
  year: 2021
  ident: 3763_CR16
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.R120.002309
– volume: 51
  start-page: D409
  year: 2023
  ident: 3763_CR36
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkac776
– volume: 7
  year: 2016
  ident: 3763_CR14
  publication-title: Nat Commun
  doi: 10.1038/ncomms10238
– volume: 15
  year: 2024
  ident: 3763_CR19
  publication-title: Nat Commun
  doi: 10.1038/s41467-024-46380-y
– ident: 3763_CR73
  doi: 10.5281/zenodo.822502
– volume: 15
  year: 2024
  ident: 3763_CR23
  publication-title: Nat Commun
  doi: 10.1038/s41467-024-48322-0
– volume: 38
  start-page: 276
  year: 2020
  ident: 3763_CR30
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-020-0439-x
– volume: 14
  start-page: 9
  year: 1978
  ident: 3763_CR54
  publication-title: Cell
  doi: 10.1016/0092-8674(78)90296-9
– volume: 15
  year: 2024
  ident: 3763_CR52
  publication-title: Nat Commun
  doi: 10.1038/s41467-024-49731-x
– volume: 92
  start-page: 6571
  year: 2020
  ident: 3763_CR42
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.0c00233
– volume: 373
  start-page: 2425
  year: 2015
  ident: 3763_CR5
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1509388
– volume: 12
  year: 2021
  ident: 3763_CR12
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.705974
– volume: 8
  start-page: 1018
  year: 2020
  ident: 3763_CR13
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-19-0886
– volume: 23
  year: 2024
  ident: 3763_CR41
  publication-title: Mol Cell Proteomics
  doi: 10.1016/j.mcpro.2024.100798
– volume: 16
  start-page: 2964
  year: 2017
  ident: 3763_CR33
  publication-title: J Proteome Res
  doi: 10.1021/acs.jproteome.7b00248
– volume: 13
  year: 2022
  ident: 3763_CR40
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.883989
– ident: 3763_CR63
  doi: 10.1136/jitc-2020-002071
– volume: 52
  start-page: 411
  year: 1982
  ident: 3763_CR56
  publication-title: Br J Haematol
  doi: 10.1111/j.1365-2141.1982.tb03910.x
– volume: 18
  start-page: 1363
  year: 2021
  ident: 3763_CR20
  publication-title: Nat Methods
  doi: 10.1038/s41592-021-01301-5
– volume: 20
  year: 2021
  ident: 3763_CR46
  publication-title: Mol Cell Proteomics
  doi: 10.1016/j.mcpro.2021.100110
– volume: 19
  start-page: 537
  year: 2020
  ident: 3763_CR60
  publication-title: J Proteome Res
  doi: 10.1021/acs.jproteome.9b00328
– ident: 3763_CR58
  doi: 10.21203/rs.3.rs-5560023/v1
– volume: 13
  year: 2025
  ident: 3763_CR53
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2024-011366
– volume: 13
  start-page: 3108
  year: 2022
  ident: 3763_CR28
  publication-title: Nat Commun
  doi: 10.1038/s41467-022-30867-7
– volume: 154
  start-page: 331
  year: 2018
  ident: 3763_CR49
  publication-title: Immunology
  doi: 10.1111/imm.12936
– ident: 3763_CR38
  doi: 10.1073/pnas.1707658114
– volume: 21
  year: 2022
  ident: 3763_CR43
  publication-title: Mol Cell Proteomics
  doi: 10.1016/j.mcpro.2021.100178
– volume: 193
  start-page: 73
  year: 2001
  ident: 3763_CR10
  publication-title: J Exp Med
  doi: 10.1084/jem.193.1.73
– ident: 3763_CR65
– year: 2021
  ident: 3763_CR70
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.705974
– volume: 7
  year: 2006
  ident: 3763_CR67
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-7-153
– volume: 7
  year: 2016
  ident: 3763_CR8
  publication-title: Nat Commun
  doi: 10.1038/ncomms13404
– volume: 13
  start-page: 6401
  year: 2022
  ident: 3763_CR9
  publication-title: Nat Commun
  doi: 10.1038/s41467-022-33746-3
– volume: 29
  start-page: 440
  year: 2023
  ident: 3763_CR50
  publication-title: Nat Med
  doi: 10.1038/s41591-022-02163-w
– ident: 3763_CR69
– volume: 18
  start-page: 3876
  year: 2019
  ident: 3763_CR24
  publication-title: J Proteome Res
  doi: 10.1021/acs.jproteome.9b00313
– volume: 14
  year: 2023
  ident: 3763_CR27
  publication-title: Nat Commun
  doi: 10.1038/s41467-023-40129-9
– ident: 3763_CR62
  doi: 10.5281/zenodo.15194162
– volume: 351
  start-page: 1463
  year: 2016
  ident: 3763_CR48
  publication-title: Science
  doi: 10.1126/science.aaf1490
– volume: 365
  start-page: 725
  year: 2011
  ident: 3763_CR2
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1103849
– ident: 3763_CR72
  doi: 10.1038/ncomms13404
– volume: 14
  start-page: 513
  year: 2017
  ident: 3763_CR26
  publication-title: Nat Methods
  doi: 10.1038/nmeth.4256
– volume: 565
  start-page: 240
  year: 2019
  ident: 3763_CR1
  publication-title: Nature
  doi: 10.1038/s41586-018-0810-y
– volume: 52
  start-page: D1062
  year: 2024
  ident: 3763_CR47
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkad1068
– volume: 12
  start-page: 165
  year: 1985
  ident: 3763_CR55
  publication-title: Hum Immunol
  doi: 10.1016/0198-8859(85)90333-7
– volume: 40
  start-page: 175
  year: 2022
  ident: 3763_CR7
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-021-01038-8
– volume: 35
  start-page: 316
  year: 2017
  ident: 3763_CR25
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.3820
– start-page: 123
  volume-title: Purification and Identification of Naturally Presented MHC Class I and II Ligands
  year: 1988
  ident: 3763_CR44
– volume: 21
  start-page: 365
  year: 2024
  ident: 3763_CR29
  publication-title: Nat Methods
  doi: 10.1038/s41592-024-02197-7
– volume: 9
  year: 2021
  ident: 3763_CR35
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-002071
– volume: 10
  start-page: R110.000133.
  year: 2011
  ident: 3763_CR34
  publication-title: Mol Cell Proteomics.
  doi: 10.1074/mcp.R110.000133
– volume: 14
  start-page: 1687
  year: 2019
  ident: 3763_CR6
  publication-title: Nat Protoc
  doi: 10.1038/s41596-019-0133-y
– volume: 11
  start-page: 3887
  year: 1992
  ident: 3763_CR4
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1992.tb05481.x
– volume: 14
  year: 2023
  ident: 3763_CR18
  publication-title: Nat Commun
  doi: 10.1038/s41467-023-42692-7
– ident: 3763_CR71
  doi: 10.1073/pnas.1707658114
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Snippet Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable...
Abstract Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a...
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SubjectTerms Animal Genetics and Genomics
Antigens
Antigens, Neoplasm - immunology
Bioinformatics
Biomedical and Life Sciences
Cancer
Cancer immunotherapy
Data processing
Datasets
Evolutionary Biology
High performance computing
Histocompatibility antigen HLA
HLA
HLA Antigens - immunology
Human Genetics
Humans
Identification
Immunopeptidomics
Immunotherapy
Life Sciences
Mass spectrometry
Microbial Genetics and Genomics
Neoplasms - immunology
Nextflow
Nf-core
Peptides
Peptides - immunology
Pipeline
Plant Genetics and Genomics
Proteomics - methods
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Title MHCquant2 refines immunopeptidomics tumor antigen discovery
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