Removing technical variability in RNA-seq data using conditional quantile normalization

The ability to measure gene expression on a genome-wide scale is one of the most promising accomplishments in molecular biology. Microarrays, the technology that first permitted this, were riddled with problems due to unwanted sources of variability. Many of these problems are now mitigated, after a...

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Vydáno v:	Biostatistics (Oxford, England) Ročník 13; číslo 2; s. 204
Hlavní autoři:	Hansen, Kasper D, Irizarry, Rafael A, Wu, Zhijin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.04.2012
Témata:	Algorithms Analysis of Variance Base Composition Biostatistics Databases, Nucleic Acid - statistics & numerical data Gene Expression Profiling - statistics & numerical data High-Throughput Nucleotide Sequencing - statistics & numerical data Humans Oligonucleotide Array Sequence Analysis - statistics & numerical data Sequence Analysis, RNA - statistics & numerical data
ISSN:	1468-4357, 1468-4357
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