Discordance between PAM50 intrinsic subtyping and immunohistochemistry in South African women with breast cancer

Purpose Breast cancer is a heterogeneous disease with different gene expression profiles, treatment options and outcomes. In South Africa, tumors are classified using immunohistochemistry. In high-income countries multiparameter genomic assays are being utilized with implications for tumor classific...

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Bibliographic Details
Published in:	Breast cancer research and treatment Vol. 199; no. 1; pp. 1 - 12
Main Authors:	Dix-Peek, Thérèse, Phakathi, Boitumelo P., van den Berg, Eunice J., Dickens, Caroline, Augustine, Tanya N., Cubasch, Herbert, Neugut, Alfred I., Jacobson, Judith S., Joffe, Maureen, Ruff, Paul, Duarte, Raquel A. B.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.05.2023 Springer Springer Nature B.V
Subjects:	Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - pathology Cancer research Care and treatment Discordance ErbB-2 protein Female Gene expression Genes Genomics Humans Immunohistochemistry Ki-67 Antigen - genetics Medical research Medicine Medicine & Public Health Medicine, Experimental Oncology Patients Preclinical Study Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptors, Progesterone - genetics Receptors, Progesterone - metabolism South Africa - epidemiology Tumors Women South Africa Immunohistochemistry PAM50 Subtypes Breast cancer Sub-Saharan Africa
ISSN:	0167-6806, 1573-7217, 1573-7217
Online Access:	Get full text
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